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1. 发明申请

WO2013078254A1 BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS 审中-公开
标题翻译：双相异构体衍生物作为激酶抑制剂
公开(公告)号：WO2013078254A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/066153
申请日：2012-11-20
申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , SKELTON, Nicholas , GRADL, Stefan , BLAKE, James F. , GRAHAM, James M. , GUNAWARDANA, Indrani W. , HENTEMANN, Martin , MARLOW, Allison L. , TANG, Tony P.
发明人： SKELTON, Nicholas , GRADL, Stefan , BLAKE, James F. , GRAHAM, James M. , GUNAWARDANA, Indrani W. , HENTEMANN, Martin , MARLOW, Allison L. , TANG, Tony P.
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R 1 and R 2 are as defined herein.
摘要翻译：本发明提供包括拆分的对映异构体，分解的非对映异构体，溶剂化物和药学上可接受的盐的化合物，其包含式1：其中Het，X，R 1和R 2如本文所定义。

2. 发明申请

WO2012021319A1 SHARING DATA ON MOBILE DEVICES 审中-公开
标题翻译：在移动设备上共享数据
公开(公告)号：WO2012021319A1
公开(公告)日：2012-02-16
申请号：PCT/US2011/046111
申请日：2011-08-01
申请人： IANYWHERE SOLUTIONS, INC. , SLEE, Thomas Stephen , GRAHAM, James David , HURST, Adam
发明人： SLEE, Thomas Stephen , GRAHAM, James David , HURST, Adam
IPC分类号： G06F17/30
CPC分类号： G06F17/30575 , G06F17/30
摘要： System, methods and articles of manufacture for replicating relational data on multiple nodes. An embodiment comprises receiving an update request message from a node, wherein the update request message comprises a node identification and an application identification, accessing an application schema based on the application identification, identifying a partition residing in the application schema based on the node identification, accessing a server schema, identifying a second partition residing in the server schema based on the application identification, determining at least one data change stored in the second partition that changes data associated with the first partition, retrieving at least one data change from the second partition, formatting data change in an update response message, and transmitting the update response message to the node.
摘要翻译：在多个节点上复制关系数据的系统，方法和制造。一个实施例包括从节点接收更新请求消息，其中所述更新请求消息包括节点标识和应用标识，基于所述应用标识访问应用模式，基于所述节点标识识别驻留在所述应用模式中的分区，访问服务器模式，基于所述应用标识来识别驻留在所述服务器模式中的第二分区，确定存储在所述第二分区中的至少一个数据改变，其改变与所述第一分区相关联的数据，从所述第二分区中检索至少一个数据改变，在更新响应消息中格式化数据变化，以及将所述更新响应消息发送到所述节点。

3. 发明申请

WO2008122122A1 APPARATUS AND METHODOLOGY FOR COMMINUTING MATERIALS 审中-公开
标题翻译：装置和材料的方法学
公开(公告)号：WO2008122122A1
公开(公告)日：2008-10-16
申请号：PCT/CA2008/000644
申请日：2008-04-04
申请人： AEROSION LTD. , TESSIER, Lynn P. , GRAHAM, James B. , GRAHAM, Russell M.
发明人： TESSIER, Lynn P. , GRAHAM, James B. , GRAHAM, Russell M.
IPC分类号： B02C19/00 , B24C5/06
CPC分类号： B02C19/0025 , B02C13/1835 , B02C2013/1857
摘要： A comminuting apparatus has a coaxial throwing wheel and impact rotor, the throwing wheel preferably comprising a plurality of channels for conducting particles from a central axis inlet to a plurality of particle exits to impact the impact rotor. The throwing wheel can be an assembly of wear-resistant inserts forming the channels. Flow channels through the throwing wheel can be configured, such as converging towards the particle exits to minimize energy loss during acceleration of the particles. Further, the comminuting apparatus can include a housing for ready access to the throwing wheel and impact rotor. A two-part housing is reversibly separable for accessing the comminuting chamber, throwing wheel and impact rotor within.
摘要翻译：粉碎设备具有同轴投掷轮和冲击转子，抛掷轮优选地包括多个通道，用于将颗粒从中心轴入口传导到多个颗粒出口以冲击冲击转子。抛掷轮可以是形成通道的耐磨插件的组件。可以配置通过投掷轮的流动通道，例如朝着颗粒出口收敛，以最小化加速颗粒期间的能量损失。此外，粉碎设备可以包括用于准备进入投掷轮和冲击转子的壳体。两部分壳体可逆地分离，用于进入粉碎室，投掷轮和冲击转子。

4. 发明申请

WO2008051633A3 CROPPING SYSTEMS FOR MANAGING WEEDS 审中-公开
标题翻译：用于管理杂草的农作物系统
公开(公告)号：WO2008051633A3
公开(公告)日：2008-08-07
申请号：PCT/US2007070510
申请日：2007-06-06
申请人： MONSANTO TECHNOLOGY LLC , ARNEVIK CINDY L , BRINKER RONALD J , ELMORE GREG , GRAHAM JAMES C , SAMMONS ROBERT D , STARKE MICHELLE , VOTH RICHARD D
发明人： ARNEVIK CINDY L , BRINKER RONALD J , ELMORE GREG , GRAHAM JAMES C , SAMMONS ROBERT D , STARKE MICHELLE , VOTH RICHARD D
IPC分类号： A01N27/00 , C12N15/82
CPC分类号： C12N15/8275 , A01N25/00 , A01N61/00 , A01N2300/00
摘要： The invention provides cropping systems for managing weeds in crop environments. The cropping systems comprise, in one embodiment, transgenic plants that display tolerance to an auxin-like herbicide such as dicamba. Method for minimizing the development of herbicide resistant weeds are also provided.
摘要翻译：本发明提供了用于在作物环境中管理杂草的种植系统。在一个实施方案中，该种植系统包含显示对生长素样除草剂如麦草畏的耐受性的转基因植物。还提供了用于最小化除草剂抗性杂草发展的方法。

5. 发明申请

WO2007112012A3 PROTEIN ISOFORM DISCRIMINATION AND QUANTITATIVE MEASUREMENTS THEREOF 审中-公开
标题翻译：蛋白质异形性鉴别及其定量测量
公开(公告)号：WO2007112012A3
公开(公告)日：2007-11-22
申请号：PCT/US2007007268
申请日：2007-03-23
申请人： EPITOME BIOSYSTEMS INC , GORDON NEAL F , GRAHAM JAMES R
发明人： GORDON NEAL F , GRAHAM JAMES R
IPC分类号： G01N33/68 , C40B30/04
CPC分类号： G01N33/6878 , G01N33/6803
摘要： The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents to identify the isoforms to be detected / measured.
摘要翻译：本发明涉及用于检测样品中的蛋白质同种型（例如，由于选择性剪接或不同的疾病蛋白质同种型或降解产物引起的那些）的方法，试剂和设备，包括使用捕获剂的组合来鉴定待检测/测量的同种型。

6. 发明申请

WO2007123708A2 POST TRANSLATIONAL MODIFICATION PATTERN ANALYSIS 审中-公开
标题翻译：后翻译修改模式分析
公开(公告)号：WO2007123708A2
公开(公告)日：2007-11-01
申请号：PCT/US2007007947
申请日：2007-03-30
申请人： EPITOME BIOSYSTEMS INC , GORDON NEAL F , GRAHAM JAMES R , NADLER TIMOTHY KENNETH
发明人： GORDON NEAL F , GRAHAM JAMES R , NADLER TIMOTHY KENNETH
IPC分类号： G01N33/50
CPC分类号： G01N33/6842
摘要： This invention relates to methods and apparatus for detecting the pattern of post translational modification in a protein or in a plurality of proteins in a sample. One or more target proteins are subjected to predetermined proteolysis to yield plural peptide fragments comprising potential post translational modification sites. The fragments and the state of such sites are analyzed to yield a post translational pattern for the protein or proteins.
摘要翻译：本发明涉及用于检测样品中蛋白质或多种蛋白质中翻译后修饰的模式的方法和装置。对一种或多种靶蛋白进行预定的蛋白水解以产生包含潜在翻译后修饰位点的多个肽片段。分析这些位点的片段和状态以产生蛋白质或蛋白质的翻译后模式。

7. 发明申请

WO2004026864A1 HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA 审中-公开
标题翻译：用于治疗精神病药物的杂环替代哌嗪
公开(公告)号：WO2004026864A1
公开(公告)日：2004-04-01
申请号：PCT/IB2003/003902
申请日：2003-09-05
申请人： WARNER-LAMBERT COMPANY LLC , ANDREANA, Tonja, Lynn , CHO, Stephen, Sung, Yong , GRAHAM, James, Michael , GREGORY, Tracy, Fay , HOWARD, Jr., Harry, Ralph , KORNBERG, Brian, Edward , NIKAM, Sham, Shridhar , PFLUM, Derek, Andrew
发明人： ANDREANA, Tonja, Lynn , CHO, Stephen, Sung, Yong , GRAHAM, James, Michael , GREGORY, Tracy, Fay , HOWARD, Jr., Harry, Ralph , KORNBERG, Brian, Edward , NIKAM, Sham, Shridhar , PFLUM, Derek, Andrew
IPC分类号： C07D413/14
CPC分类号： C07D409/12 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D455/04 , C07D471/04 , C07D471/06 , C07D491/04
摘要： This invention relates to compounds of the formula 1 wherein X, Y, Z, A, R', R2, R3, R4, R9, W' and W2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.
摘要翻译：本发明涉及式1的化合物，其中X，Y，Z，A，R'，R 2，R 3，R 4，R 9，W'和W 2如说明书中所定义，含有它们的药物组合物及其在治疗中的用途的中枢神经系统和其他疾病。

8. 发明申请

WO1993005209A1 CRUSHING MECHANISM 审中-公开
标题翻译：破碎机制
公开(公告)号：WO1993005209A1
公开(公告)日：1993-03-18
申请号：PCT/GB1992001613
申请日：1992-09-04
申请人： THE MINISTER OF AGRICULTURE FISHERIES AND FOOD IN , ALDRIDGE, Graham, James , GILBERTSON, Harry, James
发明人： THE MINISTER OF AGRICULTURE FISHERIES AND FOOD IN
IPC分类号： D01B01/14
CPC分类号： D01B1/22 , D01B1/14 , D21B1/02
摘要： A crushing mechanism (57) contains a number of pairs (78) of co-acting rollers (58), each having a plurality of teeth (83) extending round the circumference (82) of a hub (81), each tooth being, at least at its outermost position, in the form of a plate having a face (84) at an angle to a radius (88) of the hub (81). The rollers (78) are mounted in open cage arrangement on brackets (79), such that a material pathway (77) therethrough is at an angle, preferably 45 DEG , to the horizontal.
摘要翻译：破碎机构（57）包含多个（78）的共同作用辊（58），每个共同作用辊（58）具有沿轮毂（81）的圆周（82）延伸的多个齿（83）至少在其最外位置，具有与毂（81）的半径（88）成一定角度的面（84）的板的形式。辊（78）以敞开的保持架布置在支架（79）上，使得穿过其中的材料路径（77）相对于水平面成一角度，优选为45°。

9. 发明申请

WO1990006191A1 APPARATUS FOR USE IN AND A METHOD OF REMOVING ASBESTOS 审中-公开
标题翻译：使用装置和去除ASBESTOS的方法
公开(公告)号：WO1990006191A1
公开(公告)日：1990-06-14
申请号：PCT/GB1989001449
申请日：1989-12-04
申请人： GWILLIAM, Graham, James
IPC分类号： B08B17/00
CPC分类号： B08B15/026 , B08B17/00
摘要： The apparatus comprises one or more hollow needles (10) for insertion into asbestos to be removed and a source of pressurised liquid connected to the inside of the or each needle. The or each needle has a maximum cross-sectional dimension which is not greater than 4 mm, a closed pointed end (12) and a peripheral wall provided with one or more apertures (13) for discharging liquid fed to the inside of the needle into the asbestos to be removed.
摘要翻译：该装置包括一个或多个用于插入待除去的石棉的中空针（10）和连接到针或每针的内部的加压液体源。该针或每个针具有不大于4mm的最大横截面尺寸，封闭的尖端（12）和设置有一个或多个孔（13）的周壁，用于将进料到针的内部的液体排出要清除的石棉

10. 发明申请

WO2011147050A1 DOCUMENT SCANNER 审中-公开
标题翻译：文件扫描仪
公开(公告)号：WO2011147050A1
公开(公告)日：2011-12-01
申请号：PCT/CN2010/000755
申请日：2010-05-27
申请人： COLORTRAC LIMITED , CULLUM, Andrew, Roy , TINN, Graham, James, Ohn , ZUO, Jianjun , LI, Feng , JIANG, Peng , BADGER, David , WANG, Jun
发明人： CULLUM, Andrew, Roy , TINN, Graham, James, Ohn , ZUO, Jianjun , LI, Feng , JIANG, Peng , BADGER, David , WANG, Jun
IPC分类号： H04N1/03 , H04N1/04
CPC分类号： H04N1/03 , H04N1/12 , H04N1/191 , H04N1/1917 , H04N1/1918
摘要： A document scanner comprises first and second image sensor units (30,32), each having an array of electromagnetic radiation detectors (44) situated adjacent circuitry (42) for operating the detectors. A scanning mechanism (70,72,76,78,80) causes relative movement between the detectors and a document to cause the detectors to scan the document along a scanning direction. The array of detectors of the first unit (30) is situated ahead of the array of detectors of the second unit (32) in said scanning direction, the orientation of the detectors of the first unit with respect to their circuitry thus being the reverse of that of the detectors of the second unit, thereby to reduce the distance, in the scanning direction, between the two arrays.
摘要翻译：文件扫描仪包括第一和第二图像传感器单元（30,32），每个图像传感器单元具有位于电路（42）附近的用于操作检测器的电磁辐射检测器阵列（44）。扫描机构（70,72,76,78,80）引起检测器和文件之间的相对移动，使得检测器沿着扫描方向扫描文件。第一单元（30）的检测器阵列在所述扫描方向上位于第二单元（32）的检测器阵列之前，第一单元的检测器相对于它们的电路的取向因此是第二单元的检测器的距离，从而减小扫描方向在两个阵列之间的距离。

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