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1. 发明申请

WO2004032846A3 TRIAZOLONE AND TRIAZOLETHIONE DERIVATIVES 审中-公开
标题翻译：三唑酮和三唑衍生物衍生物
公开(公告)号：WO2004032846A3
公开(公告)日：2004-07-15
申请号：PCT/US0331537
申请日：2003-10-03
申请人： SQUIBB BRISTOL MYERS CO , KING BRYAN W , SHEPPECK JAMES , GILMORE JOHN L
发明人： KING BRYAN W , SHEPPECK JAMES , GILMORE JOHN L
IPC分类号： C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14 , C07D215/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14
摘要： The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, L, and R11 are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-a converting enzyme (TACE), aggrecanase, or a combination thereof.
摘要翻译：本申请描述了式（I）的新型乙内酰脲衍生物或其药学上可接受的盐或前药形式，其中A，L和R 11在本说明书中定义，其可用作基质金属蛋白酶（MMP），TNF- 转化酶（TACE），聚集蛋白聚糖蛋白聚糖酶或其组合。

2. 发明申请

WO2018126203A1 REMOTE CONTROL OF LESSON SOFTWARE BY TEACHER 审中-公开
公开(公告)号：WO2018126203A1
公开(公告)日：2018-07-05
申请号：PCT/US2017/069082
申请日：2017-12-29
申请人： MCCARTHY MUSIC CORP. , MCCARTHY, Kevin Michael , GILMORE, John , MCVEY, Jason Michael
发明人： MCCARTHY, Kevin Michael , GILMORE, John , MCVEY, Jason Michael
IPC分类号： G09B15/00 , G09B15/02 , G09B15/04 , G09B15/08
CPC分类号： G09B15/04 , G09B5/14 , G09B15/08
摘要： A system, comprising one or more processors; and memory storing instructions executable by the one or more processors to causes the system to associate together streams of data from at least three devices separated by a network, the at least three devices comprising a first device of a first user, a second device of the first user, and a third device of a second user, wherein association of the streams of data together enables the first device to receive data from the third device and the third device to receive data from the first device and the second device, wherein the data from the first device and the second device indicate playing of a first musical instrument by the first user and the data from the third device indicates playing of a second musical instrument by the second user, update a first user interface of the first device according to an event that occurred on the third device, and update a second user interface of the third device according to an event that occurred on the third device.

3. 发明申请

WO2011017578A1 SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS 审中-公开
标题翻译：丝氨酸1-磷酸酯受体激动剂
公开(公告)号：WO2011017578A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/044627
申请日：2010-08-06
申请人： BRISTOL-MYERS SQUIBB COMPANY , GILMORE, John L. , SHEPPECK, James E.
发明人： GILMORE, John L. , SHEPPECK, James E.
IPC分类号： C07D413/14 , C07D417/14 , A61P29/00 , A61K31/4245 , A61K31/454 , A61K31/5377 , A61K31/496
CPC分类号： C07D413/14 , C07D417/14
摘要： Disclosed are compounds of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: A is formula (II) Q is a substituted 5-membered monocyclic heteroaryl group; W is CH 2 , O, or NH; and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m, n, t, and x are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P 1 , and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
摘要翻译：公开了式（I）化合物或其立体异构体或其药学上可接受的盐，其中：A为式（II）Q为取代的5元单环杂芳基; W是CH 2，O或NH; 并且R 1，R 2，R 3，R 4，R 5，R 6，m，n，t和x在本文中定义。还公开了使用这种化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫疾病和血管疾病）中的疾病或病症的进展。

4. 发明申请

WO2005072132A3 TRICYCLIC MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-κB ACTIVITY AND USE THEREOF 审中-公开
公开(公告)号：WO2005072132A3
公开(公告)日：2005-08-11
申请号：PCT/US2005/001180
申请日：2005-01-14
申请人： BRISTOL-MYERS SQUIBB COMPANY , WEINSTEIN, David, S. , YANG, Bingwei Vera , KIM, Soong-Hoon , VACCARO, Wayne , SHEPPECK, James , GILMORE, John
发明人： WEINSTEIN, David, S. , YANG, Bingwei Vera , KIM, Soong-Hoon , VACCARO, Wayne , SHEPPECK, James , GILMORE, John
IPC分类号： C07C233/58
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I): or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein B, J, K, Z, R, R a , R b , R c , R d , R q , R w , m and n are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

5. 发明申请

WO9934313A3 COMPARATIVE VISUAL ASSESSMENT METHOD & SYSTEM 审中-公开
标题翻译：比较视觉评估方法与系统
公开(公告)号：WO9934313A3
公开(公告)日：1999-08-19
申请号：PCT/US9827609
申请日：1998-12-24
申请人： COMPARATIVE VISUAL ASSESSMENTS , GILMORE JOHN T JR
发明人： GILMORE JOHN T JR
IPC分类号： G06Q30/02 , G06T11/20 , G06F17/60
CPC分类号： G06T11/206 , G06Q30/02
摘要： A comparative visual assessment system including an input device, an output device, a computer system, the computer system connected to the input device and the output device, the computer system having a user interface connected to a comparative visual assessment engine, the comparative visual assessment engine including assigning a plurality of weights to a corresponding plurality of components representing a subject, assigning a plurality of scores to the corresponding plurality of components representing the subject, determining a functional score for each of the plurality of components, determining an angle to be used for an output to the output device of a vector for each of the plurality of components, assigning the functional score to the horizontal length of the vector for each of the plurality of components, and displaying the vector on the output device.
摘要翻译：比较视觉评估系统，包括输入装置，输出装置，计算机系统，连接到输入装置的计算机系统和输出装置，计算机系统具有连接到比较视觉评估引擎的用户界面，比较视觉评估引擎，包括将多个权重分配给表示对象的相应多个分量，将多个分数分配给表示对象的相应多个分量，确定多个分量中的每个分量的功能分数，确定要使用的角度为了输出到多个分量中的每一个的向量的输出装置，将功能分数分配给多个分量中的每个分量的矢量的水平长度，并将该矢量显示在输出装置上。

6. 发明申请

WO2006076632A1 SUBSTITUTED HETEROARYL AMIDE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NFκB ACTIVITY AND USE THEREOF 审中-公开
标题翻译：替代的胆固醇受体，AP-1和/或NF-κB活性的异构体调节剂及其用途
公开(公告)号：WO2006076632A1
公开(公告)日：2006-07-20
申请号：PCT/US2006/001328
申请日：2006-01-13
申请人： BRISTOL-MYERS SQUIBB COMPANY , SHEPPECK, James E. , DHAR, T. G. Murali , DOWEYKO, Arthur M. P. , DOWEYKO, Lidia M. , GILMORE, John L. , WEINSTEIN, David S. , XIAO, Hai-Yun , YANG, Bingwei Vera
发明人： SHEPPECK, James E. , DHAR, T. G. Murali , DOWEYKO, Arthur M. P. , DOWEYKO, Lidia M. , GILMORE, John L. , WEINSTEIN, David S. , XIAO, Hai-Yun , YANG, Bingwei Vera
CPC分类号： C07D233/91 , C07D277/46 , C07D417/06
摘要： The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NFκB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure (I) including all stereoisomers thereof, tautomers thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein X is selected from N, O, and S; Y is N or CR 6 ; Z is a ring; and where R, R a , R b , R c , R d , R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
摘要翻译：本发明涉及新类型的非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-B活性的调节相关的疾病，包括肥胖症，糖尿病，炎性和免疫相关疾病，并且具有包括其所有立体异构体，其互变异构体或其前药或其药学上可接受的盐的结构（I），其中X选自N，O和S; Y是N或CR 6; Z是一个戒指并且其中R，R a，R b，R b，R c，R d，R 1， R 2，R 3，R 4和R 5如本文所定义。还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

7. 发明申请

WO2005073221A1 HETEROCYCLIC MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-κB ACTIVITY AND USE THEREOF 审中-公开
标题翻译： GLUCOCORTICOID受体，AP-1和/或NF-κB活性的杂环调节剂及其用途
公开(公告)号：WO2005073221A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/001293
申请日：2005-01-14
申请人： BRISTOL-MYERS SQUIBB COMPANY , WEINSTEIN, David, S. , SHEPPECK, James , GILMORE, John, L.
发明人： WEINSTEIN, David, S. , SHEPPECK, James , GILMORE, John, L.
IPC分类号： C07D403/12
CPC分类号： C07D471/18
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of Formula (I) or stereoisomers or prodrugs or solvates or pharmaceutically acceptable salts thereof, wherein A, B, J, K, Z, R, R a , R b , R c , and R d , are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
摘要翻译：提供了新的非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性（包括肥胖症，糖尿病，炎症和免疫疾病）的调节相关的疾病，并且具有式（I ）或其立体异构体或前药或溶剂合物或其药学上可接受的盐，其中A，B，J，K，Z，R，R a，R b，R c和R d在本文中定义。还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

8. 发明申请

WO2005072732A1 MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF 审中-公开
标题翻译： GLUCOCORTICOID受体的调节剂，AP-1和/或NF-κB活性及其用途
公开(公告)号：WO2005072732A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/001181
申请日：2005-01-14
申请人： BRISTOL-MYERS SQUIBB COMPANY , DUAN, Jingwu , SHEPPECK, James , JIANG, Bin , GILMORE, John, L.
发明人： DUAN, Jingwu , SHEPPECK, James , JIANG, Bin , GILMORE, John, L.
IPC分类号： A61K31/439
CPC分类号： C07D471/08 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14
摘要： A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-ĸB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR 1 R 2 or CH 2 NR 1 R 2 and where at least one of X 1 - X 8 is N, and R, R a , R b , R c and R d are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
摘要翻译：提供一类新型非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-kB活性的调节相关的疾病，包括肥胖症，糖尿病，炎症和免疫疾病，并且具有式（I）其立体异构体，或其溶剂合物或其前药，或其药学上可接受的盐，其中Z为CONR 1 R 2或CH 2 NR 1 R 2和其中X1-X8中的至少一个是N，并且R，R a，R b，R c和R d在本文中定义。还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

9. 发明申请

WO2005070207A1 MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF 审中-公开
标题翻译： GLUCOCORTICOID受体的调节剂，AP-1和/或NF-κB活性及其用途
公开(公告)号：WO2005070207A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/001411
申请日：2005-01-14
申请人： BRISTOL-MYERS SQUIBB COMPANY , DUAN, Jingwu , JIANG, Bin , SHEPPECK, James , GILMORE, John L.
发明人： DUAN, Jingwu , JIANG, Bin , SHEPPECK, James , GILMORE, John L.
IPC分类号： A01N43/58
CPC分类号： C07D403/12 , C07D241/36 , C07D417/12 , C07D417/14
摘要： A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I). Its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR 1 R 2 or CH 2 NR 1 R 2 and where at least two of X 1 - X 4 and/or X 5 - X 8 is N or NR 18 , and R, R a , R b , R c , R d , R 1 , R 2 and R 18 are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
摘要翻译：提供一类新型非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性的调节相关的疾病，包括肥胖症，糖尿病，炎症和免疫疾病，并且具有式（I）。其立体异构体或其溶剂合物或其前药，或其药学上可接受的盐，其中Z为CONR 1 R 2或CH 2 NR 1 R 2，并且其中至少两个的X 1 -X 4和/或X 5 -X 8是N或NR 18，并且R，R a，R b，R c，R d，R 1，R 2，和R 18在本文中定义。还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

10. 发明申请

WO1997026919A2 METHOD OF IMAGING AMYLOID DEPOSITS 审中-公开
标题翻译：成像淀粉沉积物的方法
公开(公告)号：WO1997026919A2
公开(公告)日：1997-07-31
申请号：PCT/US1997000251
申请日：1997-01-02
申请人： WARNER-LAMBERT COMPANY , CAPRATHE, Bradley, William , GILMORE, John, Lodge , HAYS, Sheryl, Jeanne , JAEN, Juan, Carlos , LEVINE, Harry, III
发明人： WARNER-LAMBERT COMPANY
IPC分类号： A61K47/48
CPC分类号： G01N33/6896 , A61K47/545 , A61K51/0453 , G01N2333/4709
摘要： The present invention provides a method of imaging amyloid deposits and radiolabeled compounds useful in imaging amyloid deposits. The invention also provides a method of delivering a therapeutic agent to amyloid deposits, a method of inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of determining a compound's ability to inhibit aggregation of amyloid proteins.
摘要翻译：本发明提供了淀粉样蛋白沉积物和用于成像淀粉样蛋白沉积物的放射性标记化合物的成像方法。本发明还提供了将治疗剂递送至淀粉样蛋白沉积物的方法，抑制淀粉样蛋白聚集形成淀粉样沉积物的方法，以及测定化合物抑制淀粉样蛋白聚集的能力的方法。

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