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1. 发明申请

WO2008152816A1 METHODS OF IDENTIFYING AGENTS THAT MODULATE METHYLATION OF VEGFR1 BY SMYD3 审中-公开
标题翻译：鉴定SMYD3调节VEGFR1甲基化的试剂的方法
公开(公告)号：WO2008152816A1
公开(公告)日：2008-12-18
申请号：PCT/JP2008/001516
申请日：2008-06-13
申请人： ONCOTHERAPY SCIENCE, INC. , NAKAMURA, Yusuke , FURUKAWA, Yoichi , HAMAMOTO, Ryuji , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi , HAMAMOTO, Ryuji , NAKATSURU, Shuichi
IPC分类号： C12Q1/48 , C07K16/28 , G01N33/53 , G01N33/566 , C12N15/09
CPC分类号： C12Q1/48 , C12N9/1007 , G01N33/57415 , G01N33/57419 , G01N33/57438 , G01N33/57446 , G01N2333/71 , G01N2333/91011 , G01N2500/02
摘要： The present invention relates to methods for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of VEGFR1 by SMYD3. The invention further provides methods and pharmaceutical compositions for treating and preventing colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified.
摘要翻译：本发明涉及确定多肽的甲基转移酶活性并筛选甲基转移酶活性的调节剂的方法，更具体地涉及SMYD3对VEGFR1甲基化的调节剂的方法。本发明还提供了使用所鉴定的调节剂治疗和预防结肠直肠癌，肝细胞癌，膀胱癌和/或乳腺癌的方法和药物组合物。

2. 发明申请

WO2007013576A1 COLON CANCER RELATED GENE TOM34 审中-公开
标题翻译：结肠癌相关基因TOM34
公开(公告)号：WO2007013576A1
公开(公告)日：2007-02-01
申请号：PCT/JP2006/314947
申请日：2006-07-21
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , FURUKAWA, Yoichi , TAHARA, Hideaki , TSUNODA, Takuya , MATSUSHIMA, Satoshi
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi , TAHARA, Hideaki , TSUNODA, Takuya , MATSUSHIMA, Satoshi
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57419 , C07K16/18 , C07K16/3046 , G01N2500/00
摘要： Objective methods for detecting and diagnosing colon cancer are described herein. In one embodiment, the diagnostic method involves determining the expression level of TOM34 that discriminates between colon cancer cells and normal cells. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of colon cancer, methods of treating colon cancer and method for vaccinating a subject against colon cancer.
摘要翻译：本文描述了用于检测和诊断结肠癌的客观方法。在一个实施方案中，诊断方法包括确定区分结肠癌细胞和正常细胞的TOM34的表达水平。最后，本发明提供筛选可用于治疗结肠癌的治疗剂，治疗结肠癌的方法和接种个体对结肠癌的方法。

3. 发明申请

WO2006121208A1 POLYMORPHISMS OF THE E2F-1 BINDING ELEMENT AND METHODS OF DETERMINING CANCER SUSCEPTIBILITY 审中-公开
标题翻译： E2F-1结合单元的多态性和确定癌症可疑性的方法
公开(公告)号：WO2006121208A1
公开(公告)日：2006-11-16
申请号：PCT/JP2006/309887
申请日：2006-05-11
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , FURUKAWA, Yoichi , NAKATSURU, Shuichi
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi , NAKATSURU, Shuichi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/16 , C12Q2600/178
摘要： Up-regulated ZNFN3A1, a histone methyltransferase, is a critical promoter of cell growth in a great majority of the human colorectal, liver, and breast cancers. Herein, transcriptional regulatory regions in the 5' flanking region of ZNFN3A1 that contains four E2F-1 binding motifs and one Nrf1 binding motif are identified. In particular, experimental data disclosed herein suggest that E2F-1 induces of ZNFN3A1 expression by transcriptional activation through a binding to the promoter region. In addition, a significant association between a variable number tandem repeat (VNTR) polymorphism of a CCGCC unit in the regulatory region of the ZNFN3A1 gene and an increased risk of colorectal cancer ( Chi-square=17.86, p=3.8 x 10^-5, odds ratio=2.20), hepatocellular carcinoma ( Chi-square=25.39, p=4.7 x 10^-7, odds ratio=2.74) and also breast cancer ( Chi-square=38.91, p=3.4 x 10^-9, odds ratio=3.79) was discovered. This tandem-repeated sequence was shown to be a binding-site for the transcriptional factor E2F-1 and the common VNTR polymorphism in ZNFN3A1 is shown herein to be a susceptibility factor for certain types of human cancer.
摘要翻译：上调的ZNFN3A1是一种组蛋白甲基转移酶，是绝大多数人结肠直肠癌，肝癌和乳腺癌细胞生长的关键促进剂。本文中鉴定了含有四个E2F-1结合基序和一个Nrf1结合基序的ZNFN3A1的5'侧翼区的转录调控区。特别地，本文公开的实验数据表明E2F-1通过与启动子区结合的转录激活诱导ZNFN3A1表达。此外，ZNFN3A1基因调控区CCGCC单位的可变数串联重复（VNTR）多态性与结肠直肠癌风险增加之间的显着关联（卡方= 17.86，p = 3.8×10 ^ -5 ，优势比= 2.20），肝细胞癌（卡方= 25.39，p = 4.7×10 ^ -7，优势比= 2.74），乳腺癌（卡方= 38.91，p = 3.4×10 ^ 优势比= 3.79）被发现。该串联重复序列显示为转录因子E2F-1的结合位点，并且ZNFN3A1中的常见VNTR多态性在本文中显示为某些类型的人类癌症的易感因子。

4. 发明申请

WO2005071102A2 METHODS OF DETECTING METHYL TRANSFERASE ACTIVITY AND METHODS OF SCREENING FOR METHYL TRANSFERASE ACTIVITY MODULATORS 审中-公开
标题翻译：检测甲基转移酶活性的方法和筛选甲基转移酶活性调节剂的方法
公开(公告)号：WO2005071102A2
公开(公告)日：2005-08-04
申请号：PCT/JP2005/001172
申请日：2005-01-21
申请人： ONCOTHERAPY SCIENCE, INC. , THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , FURUKAWA, Yoichi
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi
IPC分类号： C12Q1/48
CPC分类号： C12Q1/48 , G01N33/57419 , G01N33/57438 , G01N2333/91011 , G01N2500/02
摘要： The invention features a method for determining methyl transferase activity of a polypeptide and screening for modulators of methyl transferase activity. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer or hepatocellular carcinoma using the modulator.
摘要翻译：本发明的特征在于确定多肽的甲基转移酶活性和筛选甲基转移酶活性调节剂的方法。本发明还提供了使用该调节剂预防或治疗结肠直肠癌或肝细胞癌的方法或药物组合物。

5. 发明申请

WO2004076623A2 COMPOSITIONS AND METHODS OF INHIBITING CELL GROWTH 审中-公开
标题翻译：抑制细胞生长的组合物和方法
公开(公告)号：WO2004076623A2
公开(公告)日：2004-09-10
申请号：PCT/JP2004/002446
申请日：2004-02-27
申请人： ONCOTHERAPY SCIENCE, INC. , JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , FURUKAWA, Yoichi
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi
IPC分类号： C12N
CPC分类号： C12N15/1135 , C12N2310/14 , C12N2310/531 , C12Y201/01043
摘要： The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of a ZNFN3A1 siRNA. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumer cell, for example liver or colon cancer cell, particularly HCC or colorectal adenocarcinoma.
摘要翻译：本发明的特征在于通过使细胞与ZNFN3A1 siRNA的组合物接触来抑制癌细胞生长的方法。治疗癌症的方法也在本发明的范围内。本发明还包括可用于所提供的方法的产品，包括核酸序列和载体以及包含它们的组合物。本发明还提供抑制肿瘤细胞的方法，例如肝脏或结肠癌细胞，特别是HCC或结肠直肠腺癌。

6. 发明申请

WO03104276A9 GENES AND POLYPEPTIDES RELATING TO HEPATOCELLULAR OR COLORECTAL CARCINOMA 审中-公开
标题翻译：与肝细胞癌或染色体癌相关的基因和多肽
公开(公告)号：WO03104276A9
公开(公告)日：2004-05-27
申请号：PCT/JP0307070
申请日：2003-06-04
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , FURUKAWA YOICHI
发明人： NAKAMURA YUSUKE , FURUKAWA YOICHI
IPC分类号： C07K14/47 , C12N15/12
CPC分类号： C07K16/303 , A61K38/00 , C07K14/4748 , C07K16/3046 , G01N33/57419 , G01N33/57438 , G01N33/6893 , G01N2500/00
摘要： The present application provides novel human genes WDRPUH and KRZFPUH, and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in response to the transduction of wild-type APC1 into colon-cancer cells. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译：本申请提供了新的人类基因WDRPUH和KRZFPUH，和PPIL1，其表达在大多数HCC和结肠直肠癌中分别与相应的非癌组织相比显着升高，以及新型人基因APCDD1，其表达升高原发性结肠癌并且响应于野生型APC1转导入结肠癌细胞而下调。由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。

7. 发明申请

WO2004038045A2 METHOD FOR DIAGNOSING DIFFUSE-TYPE GASTRIC CANCERS 审中-公开
标题翻译：诊断DIFFUSE型胃癌的方法
公开(公告)号：WO2004038045A2
公开(公告)日：2004-05-06
申请号：PCT/JP2003/011975
申请日：2003-09-19
申请人： ONCOTHERAPY SCIENCE, INC. , JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , FURUKAWA, Yoichi
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi
IPC分类号： C12Q1/68
CPC分类号： G01N33/57446 , A61K48/00 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00
摘要： Objective methods for detecting and diagnosing diffuse-type gastric cancer (DGC) are described herein. In one embodiment, the diagnostic method involves the determining an expression level of DGC -associated gene that discriminate between DGC and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of DGC, methods of treating DGC and method of vaccinating a subject against DGC.
摘要翻译：本文描述了弥漫性胃癌（DGC）的检测和诊断的客观方法。在一个实施方案中，诊断方法涉及确定区分DGC和正常细胞的DGC相关基因的表达水平。本发明还提供筛选用于治疗DGC的治疗剂的方法，DGC治疗方法和疫苗接种DGC的方法。

8. 发明申请

WO2004007770A3 METHOD FOR DIAGNOSIS OF INTESTINAL-TYPE GASTRIC TUMORS 审中-公开
标题翻译：肠型胃肠肿瘤诊断方法
公开(公告)号：WO2004007770A3
公开(公告)日：2004-04-29
申请号：PCT/JP0308651
申请日：2003-07-08
申请人： ONCOTHERAPY SCIENCE INC , JAPAN AS REPRESENTED BY THE PR , NAKAMURA YUSUKE , FURUKAWA YOICHI
发明人： NAKAMURA YUSUKE , FURUKAWA YOICHI
IPC分类号： G01N33/53 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P35/00 , A61P35/04 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , G01N37/00
CPC分类号： A61K39/0011 , A61K2039/53 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57446
摘要： Objective methods for detecting and diagnosing intestinal-type gastric cancers are described herein. Also described is method for predicting the presence or absence of lymph node metastasis (i.e., identifying the metastatic phenotype). In one embodiment, the diagnostic method involves the scoring of gene expression profiles that discriminate between lymph node positive tumors and lymph node negative tumors. The predictive score calculated acts as diagnostic indicator that can objectively indicate whether a sample tissue has the metastatic phenotype. The present invention further provides methods of diagnosing intestinal-type gastric cancer in a subject, methods of screening for therapeutic agents useful in the treatment of intestinal-type gastric cancer, methods of treating intestinal-type gastric cancer and method of vaccinating a subject against intestinal-type gastric cancer.
摘要翻译：本文描述了用于检测和诊断肠型胃癌的客观方法。还描述了用于预测淋巴结转移的存在或不存在（即，鉴定转移表型）的方法。在一个实施方案中，诊断方法包括区分淋巴结阳性肿瘤和淋巴结阴性肿瘤的基因表达谱的评分。计算出的预测分数作为诊断指标，可以客观地指示样本组织是否具有转移表型。本发明还提供了诊断受试者肠型胃癌的方法，筛选用于治疗肠型胃癌的治疗剂的方法，肠胃型胃癌的治疗方法以及针对肠道接种受试者的方法型胃癌。

9. 发明申请

WO2004031775A2 METHOD FOR TREATING OR PREVENTING METASTASIS OF COLORECTAL CANCERS 审中-公开
标题翻译：治疗或预防色素沉着病的方法
公开(公告)号：WO2004031775A2
公开(公告)日：2004-04-15
申请号：PCT/JP2003/010339
申请日：2003-08-14
申请人： ONCOTHERAPY SCIENCE, INC. , JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , FURUKAWA, Yoichi
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi
IPC分类号： G01N33/574
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/5023 , G01N33/57419 , G01N2500/04
摘要： Disclosed are methods of identifying agents for treating metastatic lesions of colorectal cancer. Also disclosed are methods for treating metastatic lesions of colorectal cancer and preventing metastasis of colorectal cancer.
摘要翻译：公开了鉴定用于治疗结肠直肠癌转移性病变的药物的方法。还公开了治疗结肠直肠癌转移性病变和预防结肠直肠癌转移的方法。

10. 发明申请

WO2004021010A2 METHOD OF DIAGNOSING COLON AND GASTRIC CANCERS 审中-公开
标题翻译：诊断结肠癌和胃癌的方法
公开(公告)号：WO2004021010A2
公开(公告)日：2004-03-11
申请号：PCT/JP2003/010436
申请日：2003-08-19
申请人： ONCOTHERAPY SCIENCE, INC. , JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO , NAKAMURA, Yusuke , FURUKAWA, Yoichi
发明人： NAKAMURA, Yusuke , FURUKAWA, Yoichi
IPC分类号： G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12Q1/6886 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/57419 , G01N33/57446 , G01N2500/00
摘要： Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer -associated gene that discriminate between colon or gastric cancer and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of colonic cancer and method of vaccinating a subject against colon or gastric cancer.
摘要翻译：本文描述了用于检测和诊断结肠直肠癌和胃癌的客观方法。在一个实施方案中，诊断方法涉及确定区分结肠癌或胃癌和正常细胞的结肠癌或胃癌相关基因的表达水平。本发明进一步提供筛选用于治疗结肠癌的治疗剂的方法以及接种对抗结肠癌或胃癌的方法。

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