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1. 发明申请

WO2015073910A1 NONINVASIVE HYDRATION MONITORING 审中-公开
标题翻译：非侵入性水文监测
公开(公告)号：WO2015073910A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065820
申请日：2014-11-14
申请人： FLASHBACK TECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： MULLIGAN, Isobel Jane , GRUDIC, Gregory Zlatko , MOULTON, Steven L.
IPC分类号： A61B5/1455 , G06Q50/22
CPC分类号： A61B5/7275 , A61B5/002 , A61B5/02042 , A61B5/0205 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/031 , A61B5/0402 , A61B5/0476 , A61B5/0496 , A61B5/4836 , A61B5/4875 , A61B5/7267 , A61B2562/0219 , G06F19/00 , G16H50/50
摘要： Novel tools and techniques for assessing, predicting and/or estimating effectiveness of hydration of a patient and/or an amount of fluid needed for effective hydration of the patient, in some cases, noninvasively.
摘要翻译：用于评估，预测和/或估计患者的水合的有效性和/或患者有效水合所需的流体量的新型工具和技术在某些情况下非侵入性地。

2. 发明申请

WO2015069940A1 NONINVASIVE PREDICTIVE AND/OR ESTIMATIVE BLOOD PRESSURE MONITORING 审中-公开
标题翻译：非预期和/或估计血压监测
公开(公告)号：WO2015069940A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/064413
申请日：2014-11-06
申请人： FLASHBACK TECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： MULLIGAN, Isobel Jane , GRUDIC, Gregory Zlatko , MOULTON, Steven L.
IPC分类号： A61B5/021 , A61B5/0215 , A61B5/0235 , A61B8/04 , G06Q50/22
CPC分类号： A61B5/021 , A61B5/0205 , A61B5/7267 , A61B5/7275 , G06F19/00 , G06Q50/22 , G16H50/50
摘要： Tools and techniques for estimating and/or predicting a patient's current and/or future blood pressure. In some cases, the tools will analyze physiological data captured from the patient against a model of blood pressure values to estimate/predict the patient's blood pressure value. In particular cases, derived parameters, such as a patient's compensatory reserve index ("CRI") can be analyzed against such models, while in other cases, data captured from sensors can be directly analyzed against such models.
摘要翻译：用于估计和/或预测患者当前和/或未来血压的工具和技术。在某些情况下，这些工具将分析从患者获得的生理数据与血压值模型，以估计/预测患者的血压值。在特定情况下，可以针对这些模型分析衍生参数，例如患者补偿储备指数（“CRI”），而在其他情况下，可以针对这些模型直接分析从传感器获取的数据。

3. 发明申请

WO2013016212A1 HEMODYNAMIC RESERVE MONITOR AND HEMODIALYSIS CONTROL 审中-公开
标题翻译： HEMODYNAMIC RESERVE MONITOR和HEMODIALYSIS CONTROL
公开(公告)号：WO2013016212A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047659
申请日：2012-07-20
申请人： FLASHBACK TECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , GRUDIC, Gregory Zlatko , MOULTON, Steven Lee , MULLIGAN, Isobel Jane
发明人： GRUDIC, Gregory Zlatko , MOULTON, Steven Lee
IPC分类号： A61B5/0295
CPC分类号： A61B5/02028 , A61B5/02042 , A61B5/021 , A61B5/029 , A61B5/0402 , A61B5/14551 , A61B5/7275 , G06F19/00
摘要： Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index.
摘要翻译：用于估计患者出血或持续血管内体积损失（例如由于血液透析或脱水）和/或估计患者当前血液动力学储备指数的概率的工具和技术，跟踪患者随时间的血液动力储备指数，和/ 或预测患者未来的血液动力储备指数。用于估计和/或预测患者脱水状态的工具和技术。基于患者估计和/或预测的血液动力学储备指数来控制血液透析机的工具和技术。

4. 发明申请

WO2016061542A1 RAPID DETECTION OF BLEEDING BEFORE, DURING, AND AFTER FLUID RESUSCITATION 审中-公开
标题翻译：在流体破坏之前，之后和之后快速检测
公开(公告)号：WO2016061542A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/056074
申请日：2015-10-16
申请人： FLASHBACK TECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： MULLIGAN, Isobel Jane , GRUDIC, Gregory Zlatko , MOULTON, Steven L.
IPC分类号： G06F19/00 , G06Q50/22
CPC分类号： G16H50/50 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patent is bleeding, in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid detection of bleeding before, during, and after fluid resuscitation, in some instances, in real-time.
摘要翻译：提供了新颖的工具和技术来评估，预测和/或估计专利出血的可能性，在某些情况下是非侵入性的。在各种实施例中，提供了在一些实例中实现在液体复苏之前，期间和之后快速检测出血的工具和技术。

5. 发明申请

WO2022240812A1 NON-INVASIVE DETECTION AND DIFFERENTIATION OF SEPSIS 审中-公开
公开(公告)号：WO2022240812A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/028493
申请日：2022-05-10
申请人： FLASHBACK TECHNOLOGIES, INC.
发明人： JEDZINIAK, John , JAIANTILAL, Abhishek , HALPERIN, Mike
IPC分类号： A61B5/00 , A61B5/026 , A61B5/0205 , A61B5/412 , A61B5/4839 , G16H50/20
摘要： Novel tools and techniques are provided for detecting and differentiating sepsis are provided A system includes one or more sensors configured to obtain non-invasive physiological data from a patient, and estimate a compensatory reserve index based on the physiological data. A computer system may determine, based on the compensatory reserve index, whether the patient is septic by applying a sepsis model configured to relate hemodynamic parameters over time to a determination of sepsis. Hemodynamic parameters may include a compensatory reserve index (CRI).

6. 发明申请

WO2017218431A1 RAPID DETECTION OF BLEEDING FOLLOWING INJURY 审中-公开
标题翻译：快速检测出血后的出血
公开(公告)号：WO2017218431A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037067
申请日：2017-06-12
申请人： FLASHBACK TECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： MULLIGAN, Isobel Jane , GRUDIC, Gregory Zlatko , MOULTON, Steven L.
IPC分类号： A61B5/00 , A61B5/024 , A61M37/00
摘要： Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patient is bleeding, in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid detection of bleeding of the patient or implementing assessment, prediction, or estimation of a probability of bleeding of the patient following injury, in some instances, in real-time before, during, and after fluid resuscitation. According to some embodiments, one or more sensors might monitor physiological data of the patient before, during, and after resuscitation following injury. A computer system might receive and analyze the physiological data, and might estimate a probability that the patient is bleeding, based at least in part on the analyzed physiological data. An indication of at least one of an assessment, prediction, or estimate of a probability that the patient is bleeding may then be displayed on a display device.
摘要翻译：提供了新的工具和技术，用于评估，预测和/或估计患者出血的可能性，在某些情况下是非侵入性的。在各种实施例中，提供了工具和技术，用于实现患者出血的快速检测或在某些情况下实时评估，预测或估计受伤后患者出血的可能性，以及液体复苏后。根据一些实施例，一个或多个传感器可以在受伤之后在复苏之前，之中和之后监测患者的生理数据。计算机系统可以接收和分析生理数据，并且可以至少部分基于分析的生理数据来估计患者出血的可能性。然后可以在显示设备上显示评估，预测或患者出血概率的估计中的至少一个的指示。

7. 发明申请

WO2017044868A1 ESTIMATING PHYSIOLOGICAL STATES BASED ON CHANGES IN CRI 审中-公开
标题翻译：基于CRI变化估计生理状态
公开(公告)号：WO2017044868A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/051130
申请日：2016-09-09
申请人： FLASHBACK TECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： MULLIGAN, Isobel Jane , GRUDIC, Gregory Zlatko , MOULTON, Steven L.
IPC分类号： A61B5/00
CPC分类号： A61B5/7275 , A61B5/021 , A61B5/02416 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/4884 , A61B5/6826 , A61B5/7246 , G06F19/00 , G16H20/17 , G16H50/20 , G16H50/30 , G16H50/50
摘要： Novel tools and techniques are provided for assessing, predicting and/or estimating a physiological state of a patient, based on variance of the patient's compensatory reserve index ("CRI") before, during, and/or after a physical perturbation. In some embodiments, the system might receive a first set of physiological data from one or more sensors at a first time relative to a physical perturbation of the patient, and might calculate a first set of CRI values of the patient. The system might receive a second set of physiological data at a second time relative to the physical perturbation, calculate a second set of CRI values, analyze the two sets of CRI values against a pre-existing model, estimate a physiological state (e.g., hydration, etc.) of the patient, and display the estimate on a display device. The system might also control an infusion device to infuse fluids into the patient based on estimated hydration state.
摘要翻译：基于物理扰动之前，期间和/或之后的患者补偿储备指数（“CRI”）的变化，提供了用于评估，预测和/或估计患者生理状态的新型工具和技术。在一些实施例中，系统可以相对于患者的物理扰动在第一时间从一个或多个传感器接收第一组生理数据，并且可以计算患者的第一组CRI值。该系统可以在相对于物理扰动的第二时间接收第二组生理数据，计算第二组CRI值，根据预先存在的模型分析两组CRI值，估计生理状态（例如水合等），并且在显示装置上显示估计。该系统还可以基于估计的水合状态来控制输注装置将流体输入患者体内。

8. 发明申请

WO2016061545A1 ASSESSING EFFECTIVENESS OF CPR 审中-公开
标题翻译：评估CPR的有效性
公开(公告)号：WO2016061545A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/056078
申请日：2015-10-16
申请人： FLASHBACK TECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： MULLIGAN, Isobel Jane , GRUDIC, Gregory Zlatko , MOULTON, Steven L.
IPC分类号： A61N1/39
CPC分类号： G16H50/50 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Novel tools and techniques are provided for assessing, predicting and/or effectiveness of cardiopulmonary resuscitation ("CPR"), in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid estimation of a patient's compensatory reserve index ("CRI") before, during, and after CPR is performed, and using the CRI and variations in CRI values to determine, in some instances, in real-time, the effectiveness of CPR that is performed.
摘要翻译：提供了新的工具和技术来评估，预测和/或有效的心肺复苏（“CPR”），在某些情况下，非侵入性。在各种实施例中，提供了用于在执行CPR之前，期间和之后快速估计患者补偿储备指数（“CRI”）的工具和技术，并且使用CRI和CRI值的变化来确定在某些情况下，实时性，CPR的有效性。

9. 发明申请

WO2015073909A1 NONINVASIVE MONITORING FOR FLUID RESUSCITATION 审中-公开
标题翻译：无损检测用于流体破坏
公开(公告)号：WO2015073909A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065818
申请日：2014-11-14
申请人： FLASHBACK TECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： MULLIGAN, Isobel Jane , GRUDIC, Gregory Zlatko , MOULTON, Steven L.
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/021 , A61B5/1455
CPC分类号： A61B5/7275 , A61B5/002 , A61B5/02042 , A61B5/0205 , A61B5/021 , A61B5/02108 , A61B5/029 , A61B5/031 , A61B5/0402 , A61B5/0476 , A61B5/0496 , A61B5/4836 , A61B5/4875 , A61B5/7267 , A61B2562/0219 , G06F19/00 , G16H50/50
摘要： Novel tools and techniques for assessing, predicting and/or estimating effectiveness of fluid resuscitation of a patient and/or an amount of fluid needed for effective resuscitation of the patient, in some cases, noninvasively.
摘要翻译：用于评估，预测和/或估计患者的液体复苏的有效性的新型工具和技术和/或有效地复苏患者所需的一定量的液体，在某些情况下是非侵入性的。

10. 发明申请

WO2011109734A1 ACTIVE PHYSICAL PERTURBATIONS TO ENHANCE INTELLIGENT MEDICAL MONITORING 审中-公开
标题翻译：积极的物理刺激，以增强智能医学监测
公开(公告)号：WO2011109734A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/027237
申请日：2011-03-04
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO , FLASHBACK TECHNOLOGIES, INC. , GRUDIC, Gregory Zlatko , MOULTON, Steven Lee
发明人： GRUDIC, Gregory Zlatko , MOULTON, Steven Lee
IPC分类号： A61B5/02
CPC分类号： A61B5/4884 , A61B5/412 , G06F19/00 , G06N99/005
摘要： Tools and techniques for enhancing intelligent medical monitoring, and in particular monitoring that employs models for estimating and/or predicting physiological conditions. In an aspect, some of these tools and techniques employ active physical perturbation of a test subject (or patient), to induce physiological changes in the subject. By monitoring one or more of the patient's physiological parameters shortly before, during, and/or after the physical perturbation, the subject's reaction to the perturbation can be determined, and this reaction can be used to estimate and/or predict the subject's physiological state and/or clinical condition. In a particular case, the subject's response to the physical perturbation can be used to construct and/or refine a model that can be applied to analyze the subject's physiological parameters to produce such predications and/or estimations.
摘要翻译：用于增强智能医疗监测的工具和技术，特别是使用用于估计和/或预测生理条件的模型的监测。在一方面，这些工具和技术中的一些使用测试对象（或患者）的活动物理扰动来诱导受试者的生理变化。通过在物理扰动之前，之中和/或之后监测患者的生理参数中的一个或多个，可以确定受试者对扰动的反应，并且该反应可以用于估计和/或预测受试者的生理状态和 /或临床状况。在特定情况下，受试者对物理扰动的反应可用于构建和/或改进可用于分析受试者的生理参数以产生此类预测和/或估计的模型。

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