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1. 发明申请

WO2007038291A1 BLACK TEA POLYPHENOLS AND USES THEREOF 审中-公开
标题翻译：黑茶多酚及其用途
公开(公告)号：WO2007038291A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/037015
申请日：2006-09-21
申请人： MITSUI NORIN CO., LTD , ANNAMALAI UNIVERSITY , FISH, Robert, D. , HARA, Yukihiko , SIDDAVARAM, Nagini
发明人： HARA, Yukihiko , SIDDAVARAM, Nagini
IPC分类号： A61K36/82 , A61K38/16 , A61K31/35
CPC分类号： A61K36/82 , A61K31/35 , A61K38/40 , A61K2300/00
摘要： Contemplated compositions and methods include a combination of a tea polyphenol composition and lactoferrin and are effective to prevent and/or treat oral cancer at efficiencies significantly higher than treatments with either tea polyphenol compositions or lactoferrin alone. Such improved efficiency is also reflected in various clinical and systemic parameters, including modulated activity of phase I/II enzymes, expression of cytokeratins, NF-kB, Bcl-2, PCNA, and changes in cellular proliferation and induction of apoptosis.
摘要翻译：考虑的组合物和方法包括茶多酚组合物和乳铁蛋白的组合，并且有效地预防和/或治疗口服癌症，其效率显着高于用单独的茶多酚组合物或乳铁蛋白的治疗。这种提高的效率也体现在各种临床和系统参数中，包括相I / II酶的调节活性，细胞角蛋白，NF-kB，Bcl-2，PCNA的表达，细胞增殖和凋亡诱导的变化。

2. 发明申请

WO2006065933A3 OXYGEN-CONTROLLED ENVIRONMENT FOR CELL- AND TISSUE CULTURE 审中-公开
公开(公告)号：WO2006065933A3
公开(公告)日：2006-06-22
申请号：PCT/US2005/045308
申请日：2005-12-13
申请人： BIOTECH PHARMA ADVISORY, LLC , ROTHENBERG, Barry, E. , ZEYTIN, Füsûn, N. , FISH, Robert, D.
发明人： ROTHENBERG, Barry, E. , ZEYTIN, Füsûn, N. , FISH, Robert, D.
IPC分类号： C12N15/86
摘要： A primary mammalian cell which may be infected with a pathogen is cultivated under reduced oxygen to improve susceptibility to infection with a pathogen, pathogen propagation, and/or to change or maintain a degree of differentiation of the cell in a predetermined manner. In preferred aspects, the cell is a hepatocyte, optionally infected with HCV, or a blastomere from a single-cell biopsied blastocyst. Such biopsied cell may then be expanded to a population of stem cells under concurrent cultivation of the blastocyst, which is then used for IVF implantation.

3. 发明申请

WO2015054352A1 USING VOICE COMMANDS TO EXECUTE CONTINGENT INSTRUCTIONS 审中-公开
标题翻译：使用语音指令执行同步指令
公开(公告)号：WO2015054352A1
公开(公告)日：2015-04-16
申请号：PCT/US2014/059634
申请日：2014-10-08
申请人： FISH, Robert D.
发明人： FISH, Robert D.
IPC分类号： H04M1/725 , G10L15/22
CPC分类号： H04M1/72569 , G06F3/167 , G10L15/00 , G10L2015/223 , H04M1/7255 , H04M2250/74
摘要： Apparatus, systems and/or methods can be configured to identify a desired action from a user input, identify a contingency from an audible verbal instruction, initiate a check for satisfaction of the contingency, and initiate the desired action if the contingency is deemed to be satisfied.
摘要翻译：设备，系统和/或方法可以被配置为从用户输入识别期望的动作，从可听见的口头指令识别意外情况，启动对满足该意外事件的检查，并且如果应急被认为是启动期望的动作满意。

4. 发明申请

WO2020236838A1 FIBER-CONTAINING LID WITH HIGH POLYMER MATING REGION 审中-公开
公开(公告)号：WO2020236838A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/033643
申请日：2020-05-19
申请人： FISH, Robert D.
发明人： FISH, Robert D.
IPC分类号： B65D43/02 , B65D65/40 , A47G19/22
摘要： A lid having body and side, each of which comprises a fibrous material. The side is configured to mate with a container having an upper rim bead, and wherein the side has a higher weight percentage of a polymer than the body. The higher weight percentage in the side can be present as an extra thick coating, and/or an extra layer of polymer relative to the body. The body and side can comprise the same or different fibrous materials, and independently can comprise the same of different polymers. The side of the lid preferably has at least 20wt%, more preferably at least 40wt%, and most preferably at least 60wt% of fibrous material in their respective sides.

5. 发明申请

WO2020023183A1 USE OF LIPOSOMES TO DELIVER A PROTEIN AND A GENE ENCODING THE PROTEIN TO A LIVE CELL 审中-公开
公开(公告)号：WO2020023183A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/040156
申请日：2019-07-01
申请人： SO YOUNG LIFE SCIENCES CORPORATION , SETH, Avinash , FISH, Robert D.
发明人： SETH, Avinash , FISH, Robert D.
IPC分类号： A61K48/00 , A61P35/00 , A61K39/00
摘要： The present invention provides compositions and methods for treating a cancer using liposomes. Collectively, the liposomes contain a protein and a vector encoded for a gene corresponding to the protein. The amount of the protein and the vector in a plurality of liposome is sufficiently effective to treat cancer cells. At least some of the liposomes can contain an antibody that recognizes, and thereby targets, a protein expressed on the cancer cell.

6. 发明申请

WO2014039402A1 DIGITAL ADVISOR 审中-公开
标题翻译：数字顾问
公开(公告)号：WO2014039402A1
公开(公告)日：2014-03-13
申请号：PCT/US2013/057675
申请日：2013-08-30
申请人： FISH, Robert, D.
发明人： FISH, Robert, D.
IPC分类号： G06Q30/06 , G06Q50/10
CPC分类号： G06Q30/0609 , G06Q30/0621
摘要： A cell phone, tablet, laptop, TV or other device is configured to provide comments with respect to a user's prospective selection of a media item, a physical object, a service, or anything else. Comments are derived from user-specific preference information, (including e.g., selection history, rationale for prior selections, analysis of stored images, and persona), and can optionally be derived from comment templates. Comments are preferably made in a second person grammatical form, can be humorous, and can include derogatory remarks about a prospective selection and/or the user.
摘要翻译：手机，平板电脑，笔记本电脑，电视或其他设备被配置为提供关于用户对媒体项目，物理对象，服务或任何其他内容的预期选择的评论。评论来源于用户特定的偏好信息（包括例如选择历史，先前选择的理由，存储的图像和角色的分析），并且可以可选地从评论模板导出。评论最好以第二人称语法形式出现，可以是幽默的，并且可以包括关于预期选择和/或用户的贬损言论。

7. 发明申请

WO2014022230A2 ELECTRONIC PERSONAL COMPANION 审中-公开
标题翻译：电子个人伴侣
公开(公告)号：WO2014022230A2
公开(公告)日：2014-02-06
申请号：PCT/US2013/052306
申请日：2013-07-26
申请人： FISH, Robert D. , FISH, Skyler P.
发明人： FISH, Robert D. , FISH, Skyler P.
IPC分类号： G06F17/30
CPC分类号： G06Q30/0613 , G06F17/30241 , G06F17/30265 , G06F17/30702 , G06F17/30867 , G06F17/30997 , G06Q50/01 , H04N5/44
摘要： Personal companions crowd-source and/or crowd-share characterizations, and optionally raw data, from real-world, virtual and/or mixed-reality experiences. Characterizations can advantageously be stored in one or more self-evolving, structured databases, and can be organized according to objects, actions, events and thoughts. Characterizations can be weighted differently for different users, and "forgotten" over time, especially in favor of maintaining higher level characterizations. Personal companions can be used to obtain additional information, and conduct interpersonal, commercial, or other interactions or transactions.
摘要翻译：个人同伴来自真实世界，虚拟和/或混合现实体验的群众来源和/或群众分享特征，以及可选的原始数据。表征可以有利地存储在一个或多个自我演化的结构化数据库中，并且可以根据对象，动作，事件和想法来组织。对于不同的用户，表征可以被不同地加权，并且“忘记” 随着时间的推移，特别是有利于维持更高水平的表征。个人同伴可用于获取更多信息，并进行人际关系，商业或其他交互或交易。

8. 发明申请

WO2009035476A1 RESONANCE ENERGY TRANSFER ASSAY WITH CLEAVAGE SEQUENCE AND SPACER 审中-公开
标题翻译：谐振能量传递测量与清除序列和间隔
公开(公告)号：WO2009035476A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/004252
申请日：2008-03-31
申请人： BIOSENTINEL, LLC , FISH, Robert D. , DONG, Min
发明人： FISH, Robert D. , DONG, Min
IPC分类号： G01N33/53
CPC分类号： C12Q1/37 , C07K14/00 , C07K14/47 , C07K19/00 , C07K2319/50 , C07K2319/60 , G01N21/6428 , G01N33/542 , G01N33/9406 , G01N2021/6432 , G01N2333/952
摘要： A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a spacer between at least one of (a) the donor and the cleavage site sequence and (b) the acceptor and the cleavage site sequence. Preferably, the construct is selected from the group consisting of CFP-(SGLRSRA)-SNAP-25-(SNS)-YFP, and CFP-(SGLRSRA)-synaptobrevin-(SNS)-YFP. In preferred embodiments, the linker peptide is a substrate of a botulinum neurotoxin selected from the group consisting of synaptobrevin (VAMP), syntaxin and SNAP-25, or a fragment thereof that can be recognized and cleaved by the botulinum neurotoxin. Advantageously, the spacer increases the electronic coupling between the donor label and the acceptor label relative to a corresponding construct without the spacer.
摘要翻译：分子构建体包括供体标记，受体标记，置于供体和受体之间的接头肽，接头具有切割位点序列，以及（a）供体和切割位点序列之间的间隔基和（b）受体和切割位点序列。优选地，构建体选自CFP-（SGLRSRA）-SNAP-25-（SNS）-YFP和CFP-（SGLRSRA）-Synaptobrevin-（SNS）-YFP。在优选的实施方案中，接头肽是肉毒杆菌神经毒素的底物，其选自由肉毒杆菌神经毒素可识别和切割的突触连锁蛋白（VAP），突触蛋白（S）或SNAP-25，或其片段。有利地，间隔物相对于没有间隔物的相应构建体增加了供体标签和受体标记之间的电子偶联。

9. 发明申请

WO2007075176A1 COMPOSITIONS AND METHODS OF SENSITIZING METHICILLIN RESISTANTSTAPHYLOCOCCUS AUREUS TO OXACILLIN 审中-公开
标题翻译：致敏甲基纤维素氧化酶对奥昔布林的组合物和方法
公开(公告)号：WO2007075176A1
公开(公告)日：2007-07-05
申请号：PCT/US2005/047570
申请日：2005-12-29
申请人： MITSUI NORIN CO., LTD , FISH, Robert D. , THE SCHOOL OF PHARMACY , STAPLETON, Paul , HARA, Yukihiko , TAYLOR, Peter
发明人： STAPLETON, Paul , HARA, Yukihiko , TAYLOR, Peter
IPC分类号： A61K31/05
CPC分类号： A61K31/353 , A61K31/05 , A61K45/06 , A61K2300/00
摘要： Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.
摘要翻译：考虑的方法和组合物进一步增加敏化MRSA对各种抗生素药物的敏感性。最优选地，MRSA已经被乳糖化儿茶素（例如ECG）敏化，并且通过暴露于非半乳糖化儿茶素（例如EC），最优选相应的非乙酰化儿茶素来实现进一步的敏化。

10. 发明申请

WO2005058278A1 DRUG DELIVERY COMPOSITIONS AND METHODS 审中-公开
标题翻译：药物输送组合物和方法
公开(公告)号：WO2005058278A1
公开(公告)日：2005-06-30
申请号：PCT/US2004/041994
申请日：2004-12-14
申请人： BIOTECH PHARMA ADVISORY, LLC , ZEYTIN, Füsûn, N. , ROTHENBERG, Barry, E. , FISH, Robert, D.
发明人： ZEYTIN, Füsûn, N. , ROTHENBERG, Barry, E. , FISH, Robert, D.
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0024 , A61K9/1075 , A61K47/585
摘要： Contemplated drug delivery systems allow controlled release of a drug in a manner that is independent of the physicochemical parameters of both the drug and its carrier. In one preferred aspect, the drug and the carrier are released from a second carrier that has a predefined release characteristics, which is predominantly determined by the physicochemical properties of the second carrier.
摘要翻译：考虑的药物递送系统允许以与药物及其载体的物理化学参数无关的方式控制释放药物。在一个优选的方面，药物和载体从具有预定释放特性的第二载体释放，其主要由第二载体的物理化学性质决定。

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