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1. 发明申请

WO2007124920A1 PROCESS FOR THE PREPARATION OF [4(S,R)-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)-NAPHTHALEN-1-YLIDENE]METHYLAMINE 审中-公开
标题翻译：制备[4（S，R） - （3,4-二氯苯基）-3,4-二氢-1（2H） - 壬基] - 哒嗪]甲基胺的方法
公开(公告)号：WO2007124920A1
公开(公告)日：2007-11-08
申请号：PCT/EP2007/003710
申请日：2007-04-26
申请人： SANDOZ AG , KINTALI, Ramana, Venkata , FISCHER, Erik , NAIR, Raji , BARVE, Pravin
发明人： KINTALI, Ramana, Venkata , FISCHER, Erik , NAIR, Raji , BARVE, Pravin
IPC分类号： C07C209/52 , C07C211/42 , C07C209/88 , C07C249/02 , C07C251/20
CPC分类号： C07C209/52 , C07C209/88 , C07C249/02 , C07C251/20 , C07C2602/10 , C07C211/42
摘要： The present invention relates to a process for making substantially pure racemic sertraline or its pharmaceutically acceptable salts having a cis/trans ratio of greater than about 85: 15% and which is substantially free of its deschloro impurities. The process comprises catalytically hydrogenation (Schiff base compound) in the presence of amine salt or amide salt or mixture of amine salt and amide salt using a catalyst selected from the group consisting of palladium and platinum.
摘要翻译：本发明涉及一种制备基本上纯的外消旋舍曲林或其药学上可接受的盐，其顺式/反式比大于约85:15％且基本上不含其脱氯杂质的方法。该方法包括使用选自钯和铂的催化剂在胺盐或酰胺盐或胺盐和酰胺盐的混合物的存在下催化氢化（席夫碱化合物）。

2. 发明申请

WO2007042048A3 METHOD FOR PREPARING CRYSTALLINE SODIUM RISEDRONATE 审中-公开
公开(公告)号：WO2007042048A3
公开(公告)日：2007-04-19
申请号：PCT/DK2006/050054
申请日：2006-10-05
申请人： SANDOZ A/S , PREIKSCHAT, Herbert Fritz , FISCHER, Erik , BECK, Frederick , BENNEKOU, Jacob
发明人： PREIKSCHAT, Herbert Fritz , FISCHER, Erik , BECK, Frederick , BENNEKOU, Jacob
IPC分类号： C07F9/58 , A61K31/675
摘要： A new procedure for preparing crystalline sodium risedronate is disclosed, which procedure takes place under conditions where the availability of water is strictly limited. New sodium risedronate forms prepared according to the new procedure are also disclosed. The new sodium risedronate forms are useful for the preparation of pharmaceutical compositions for the treatment of diseases of bone and calcium metabolism.

3. 发明申请

WO2006021216A1 NOVEL POLYMORPHS OF THE POTASSIUM SALT OF ATORVASTATIN 审中-公开
标题翻译：盐酸阿托伐他汀的新型多糖
公开(公告)号：WO2006021216A1
公开(公告)日：2006-03-02
申请号：PCT/DK2005/000544
申请日：2005-08-26
申请人： HEXAL A/S , BECK, Frederik, Barfoed , FISCHER, Erik
发明人： BECK, Frederik, Barfoed , FISCHER, Erik
IPC分类号： C07D207/40
CPC分类号： C07D207/416
摘要： Novel polymorphs Forms I, II and III of the potassium salt of Atorvastatin, (βR,δR)-2-(pfluorophenyl)-( β,δ-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-l -heptanoic acid, are obtained directly by precipitation of the potassium salt of Atorvastatin with ethanol (polymorph I), with 1-propanol (polymorph II) and by recrystallisation of polymorph I from 2-propanol (polymorph III).
摘要翻译：新型多晶型物阿托伐他汀钾盐（（βR，dR）-2-（氟氟苯基） - （β，d-二羟基-5-异丙基-3-苯基-4-（苯基氨基甲酰基）吡咯-1 通过用乙醇（多晶型物I）与1-丙醇（多晶型物II）沉淀阿托伐他汀的钾盐和通过从2-丙醇（多晶型物III）重结晶多晶型物I而直接获得 - 庚酸。

4. 发明申请

WO2005066190A1 NEW RISEDRONATE SALTS 审中-公开
标题翻译：新升级销售
公开(公告)号：WO2005066190A1
公开(公告)日：2005-07-21
申请号：PCT/DK2004/000923
申请日：2004-12-29
申请人： HEXAL A/S , PREIKSCHAT, Herbert, Fritz , FISCHER, Erik , TRANEKJER, Michael , NIELSEN, Lotte, Basse
发明人： PREIKSCHAT, Herbert, Fritz , FISCHER, Erik , TRANEKJER, Michael , NIELSEN, Lotte, Basse
IPC分类号： C07F9/58
CPC分类号： C07F9/584 , A61K31/4406 , C07C215/08 , C07D295/027 , C07D295/088 , Y02A50/409 , Y02A50/411 , Y02A50/414
摘要： New risedronate salts selected among disodium risedronate, monopotassium risedronate, dipotassium risedronate, monoammonium risedronate, diammonium risedronate, hemipiperazine risedronate, ethanolamine risedronate and morpholinoethanolamine risedronate and hydrates thereof are disclosed. The new salts have a very low tendency to incorporate additional water into their crystals, which make these salts stable during storage in ambient air. Further pharmaceutical compositions comprising the new risedronate salts and hydrates thereof are disclosed.
摘要翻译：新的利塞膦酸盐选自利塞膦酸二钠，利塞膦酸单钾，利塞膦酸二钾，利塞膦酸二铵，利塞膦酸二铵，利塞膦酸二哌嗪，利塞膦酸二乙醇胺和利塞膦酸吗啉代乙醇胺及其水合物。新的盐具有将额外的水掺入其晶体的非常低的趋势，这使得这些盐在环境空气中储存期间稳定。公开了包含新的利塞膦酸盐及其水合物的其它药物组合物。

5. 发明申请

WO2012072689A1 OPTIMIZED SYNTHESIS OF PURE, NON-POLYMORPHIC, CRYSTALLINE BILE ACIDS WITH DEFINED PARTICLE SIZE 审中-公开
标题翻译：纯化，非多晶，具有定义粒度的晶体酸的优化合成
公开(公告)号：WO2012072689A1
公开(公告)日：2012-06-07
申请号：PCT/EP2011/071406
申请日：2011-11-30
申请人： DR. FALK PHARMA GMBH , WILHELM, Rudolf , PRÖLS, Markus , FISCHER, Erik , WAENERLUND POULSEN, Heidi
发明人： WILHELM, Rudolf , PRÖLS, Markus , FISCHER, Erik , WAENERLUND POULSEN, Heidi
IPC分类号： C07J9/00 , A61K31/575 , A61P1/16
CPC分类号： C07J9/005 , C07B2200/13 , C07J7/008 , Y10T428/2982
摘要： The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The invention further provides a pharmaceutical composition comprising the polymorph of the invention, and a method for preparing the polymorph. The invention includes the pharmaceutical use of the polymorph or of the pharmaceutical composition of the invention.
摘要翻译：本发明涉及Nor-UDCA或Bis-nor-UDCA或其药学上可接受的盐的纯多晶型物。本发明还提供了包含本发明多晶型物的药物组合物和制备该多晶型物的方法。本发明包括本发明的多晶型物或药物组合物的药物用途。

6. 发明申请

WO2008058722A1 REAGENT AND USE THEREOF FOR THE PRODUCTION OF BISPHOSPHONATES 审中-公开
标题翻译：用于生产二磷酸酯的试剂和用途
公开(公告)号：WO2008058722A1
公开(公告)日：2008-05-22
申请号：PCT/EP2007/009841
申请日：2007-11-14
申请人： SANDOZ A/S , LERSTRUP, Knud , PREIKSCHAT, Herbert, Fritz , FISCHER, Erik
发明人： LERSTRUP, Knud , PREIKSCHAT, Herbert, Fritz , FISCHER, Erik
IPC分类号： C07F9/38 , C07F9/58 , C07F9/6506 , C08K5/52
CPC分类号： C07F9/3873 , C07F9/582 , C07F9/65061 , C08K5/5205
摘要： A new liquid reagent is disclosed in form of an ionic liquid containing phosphorous acid and a tertiary amine. The reagent can be used as a replacement of phosphorous acid, where the new reagent as a liquid reagent can be handled using usual equipment for handling liquids and the dosing of the reagent can therefore be controlled more precisely in industrial plants compared to phosphorous acid, which is a solid at ambient temperature. The new liquid reagent is particular suitable for the synthesis of bisphosphonates.
摘要翻译：以含有亚磷酸和叔胺的离子液体的形式公开了新的液体试剂。该试剂可用作亚磷酸的替代物，其中作为液体试剂的新试剂可以使用通常的处理液体的设备进行处理，因此与亚磷酸相比，可以在工业装置中更准确地控制试剂的投加量，在环境温度下是固体。新的液体试剂特别适用于双膦酸盐的合成。

7. 发明申请

WO2007147547A1 PROCESS FOR PREPARATION OF 3-(2-HYDROXY-5-SUBSTITUTED PHENYL)-N-ALKYL-3-PHENYLPROPYLAMINES 审中-公开
标题翻译：制备3-（2-羟基-5-取代苯基）-N-烷基-3-苯基丙烯酰胺的方法
公开(公告)号：WO2007147547A1
公开(公告)日：2007-12-27
申请号：PCT/EP2007/005357
申请日：2007-06-18
申请人： LEK PHARMACEUTICALS D.D. , FISCHER, Erik
发明人： FISCHER, Erik
IPC分类号： C07C213/08 , C07C215/54 , C07C253/30 , C07C255/59
CPC分类号： C07C213/08 , C07B2200/07 , C07C253/30 , C07C215/54 , C07C255/59
摘要： A new process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N,alkyl-3- phenylpropylamiηes from cinamoyl chloride via N-alky-3-phenylprop-2-en-1 -amine has been developed.
摘要翻译：已经开发了通过N-烷基-3-苯基丙-2-烯-1-胺从氯化氨基氯制备3-（2-羟基-5-取代的苯基）-N，烷基-3-苯基丙基的新方法。

8. 发明申请

WO1997028656A1 INTERMEDIATE COUPLING 审中-公开
标题翻译：中间联系
公开(公告)号：WO1997028656A1
公开(公告)日：1997-08-07
申请号：PCT/SE1997000156
申请日：1997-02-01
申请人： TELEFONAKTIEBOLAGET LM ERICSSON (publ) , ROOS, Sture, Gösta , FISCHER, Erik , NILSSON, Uno, Sigurd
发明人： TELEFONAKTIEBOLAGET LM ERICSSON (publ)
IPC分类号： H04Q01/14
CPC分类号： H04Q1/14 , H01R12/7082 , H01R12/75 , H01R13/5833 , H01R13/629 , H01R2201/16
摘要： The invention relates to a cross-connection arrangement for a telephone exchange. The arrangement includes a frame (1), a number of frame-mounted subscriber-associated connection pins (24, 24') in one or more terminal units (2a), and a number of frame-mounted telephone-exchange-related line-circuit-associated connection pins in one or more terminal units (3a'). The terminal units are disposed close together and have necessary jumpers (23) for connecting selected subscriber connection pins with selected telephone-exchange connection pins via contact devices (33, 34) connected to the ends of said conductors. The contact devices (33, 34) and the conductors (31, 32) extend into an open space (26) defined by a bar (20) to which the subscriber terminal units (2a) are related.
摘要翻译：本发明涉及一种用于电话交换机的交叉连接装置。该装置包括一个框架（1），一个或多个终端单元（2a）中的多个框架安装的用户相关联的连接引脚（24,24'），以及多个框架安装的电话交换相关线路一个或多个终端单元（3a'）中的电路相关连接引脚。终端单元靠近在一起设置，并且具有必需的跳线（23），用于通过连接到所述导体的端部的接触装置（33,34）将所选择的用户连接引脚与所选择的电话交换连接引脚相连。接触装置（33,34）和导体（31,32）延伸到由用户终端单元（2a）所关联的条（20）限定的开放空间（26）中。

9. 发明申请

WO2007042048A2 IMPROVED METHOD FOR PREPARING CRYSTALLINE SODIUM RISEDRONATE 审中-公开
标题翻译：制备晶体钠阳离子的改进方法
公开(公告)号：WO2007042048A2
公开(公告)日：2007-04-19
申请号：PCT/DK2006050054
申请日：2006-10-05
申请人： SANDOZ AS , PREIKSCHAT HERBERT FRITZ , FISCHER ERIK , BECK FREDERICK , BENNEKOU JACOB
发明人： PREIKSCHAT HERBERT FRITZ , FISCHER ERIK , BECK FREDERICK , BENNEKOU JACOB
IPC分类号： C07F9/58 , A61K31/675
CPC分类号： C07F9/582
摘要： A new procedure for preparing crystalline sodium risedronate is disclosed, which procedure takes place under conditions where the availability of water is strictly limited. New sodium risedronate forms prepared according to the new procedure are also disclosed. The new sodium risedronate forms are useful for the preparation of pharmaceutical compositions for the treatment of diseases of bone and calcium metabolism.
摘要翻译：公开了制备结晶的利塞膦酸钠的新方法，该方法在严格限制水的可用性的条件下进行。还公开了根据新方法制备的新的利塞膦酸钠形式。新的利塞膦酸钠形式可用于制备用于治疗骨和钙代谢疾病的药物组合物。

10. 发明申请

WO1997028655A1 BOX OR FRAME RELATED LINE RESISTORS 审中-公开
标题翻译： BOX或FRAME相关线路电阻
公开(公告)号：WO1997028655A1
公开(公告)日：1997-08-07
申请号：PCT/SE1997000157
申请日：1997-02-01
申请人： TELEFONAKTIEBOLAGET LM ERICSSON (publ) , ROOS, Sture, Gösta , FISCHER, Erik
发明人： TELEFONAKTIEBOLAGET LM ERICSSON (publ)
IPC分类号： H04Q01/02
CPC分类号： H04M19/001 , H04M3/005 , H04Q1/035 , H05K1/0203 , H05K1/18 , H05K2201/10022 , H05K2203/1572
摘要： The invention relates to a telephone exchange adapted line circuit connection that includes a predetermined number of line circuits (10a) each capable of being allocated to a telephone exchange subscriber, wherein the line circuits are coordinated on a printed circuit board (10'), wherein the circuit board has mounted thereon discrete components in the form of subscriber-conductor resistances (70) for each of the line circuits, and wherein the resistances are dimensioned for high heat dissipation. Each of the resistances (70) is comprised of a conductor, having an adapted resistivity and resistance, being mounted to a foil (71), and the foils are related to one or more heat-absorbing surfaces for effective heat transfer to the surfaces. Said conductors (70) in said foils (71) are connected to one or more contact devices (72) adapted for coaction with corresponding contact devices on the printed circuit board (73).
摘要翻译：本发明涉及一种电话交换机适配的线路电路连接，其包括预定数量的线路电路（10a），每个线路电路均可分配给电话交换机用户，其中线路电路在印刷电路板（10'）上协调，其中电路板已经以每个线路电路的用户导体电阻（70）的形式安装有分立部件，并且其中电阻的尺寸设计用于高散热。每个电阻（70）由具有适应的电阻率和电阻的导体组成，安装在箔（71）上，并且箔与一个或多个吸热表面有关，以有效地传递到表面。所述箔（71）中的所述导体（70）连接到适于与印刷电路板（73）上的对应接触装置共同作用的一个或多个接触装置（72）。

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