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1. 发明申请

WO2003033568A1 OPTICAL BRIGHTENERS, THEIR COMPOSITION, THEIR PRODUCTION AND THEIR USE 审中-公开
标题翻译：光学亮片，它们的组成，它们的生产及其使用
公开(公告)号：WO2003033568A1
公开(公告)日：2003-04-24
申请号：PCT/IB2002/004316
申请日：2002-10-18
申请人： CLARIANT INTERNATIONAL LTD , FARRAR, John, Martin
发明人： FARRAR, John, Martin
IPC分类号： C08G73/02
CPC分类号： C08G73/0226 , B41M5/5227 , D21H21/30
摘要： Optical brighteners (P AB ) of formula (I) wherein each n independently signifies 1 or 2, the group SO 3 M shown with the floating bond is linked to the position 4 or 5, each M independently signifies an equivalent of a non-chromophoric cation, each M' independently signifies hydrogen or M, at least a part of the cations M of (P AB ) are cationic groups of a polycationic polyol/epi-chlorohydrin/amine polymer (P A ), which contains quaternary ammonium groups in salt form as heteroatomic ring members or chain members, any others being cations selected from alkali metal cations, unsubstituted ammonium and ammonium substituted with C 1-3 -alkyl or/and C 2-3 -hydroxyalkyl, the polycationic polymer (P A ) is a polymer which is at least in part crosslinked over one or more of its quaternary ammonium groups, any other counterions to the cationic groups of (P A ) being non-chromophoric anions of low molecular acids,and the ratio of the total anionic groups in the anionic optical brightener portion of (P AB ) to the total of cationic ammonium groups in the polycationic polymer (P A ) portion of (P AB ) is ≥ 80/100,and their aqueous compositions (W), their production and their use, also in combination with white pigments or fillers, in particular for the production of optically brightened paper.
摘要翻译：式（I）的荧光增白剂（PAB）其中每个n独立地表示1或2，用浮动键显示的基团SO 3 M连接到位置4或5，每个M独立地表示非发色阳离子的当量， M'独立地表示氢或M，（PAB）的阳离子M的至少一部分是聚阳离子多元醇/表 - 氯醇/胺聚合物（PA）的阳离子基团，其含有盐形式的季铵基团作为杂原子环成员或链状构件，其它任何其它物质是选自碱金属阳离子，未取代的铵和被C 1-3 - 烷基或/和C 2-3 - 羟烷基取代的铵的阳离子，聚阳离子聚合物（PA）是至少部分交联在其一个或多个季铵基团中，（PA）的阳离子基团的任何其它抗衡离子是低分子量的非发色阴离子，以及（PAB）的阴离子荧光增白剂部分中的总阴离子基团与（PAB）的聚阳离子聚合物（PA）部分中的阳离子铵基团的总量为> / = 80/100，并且它们的水性组合物（W），它们的制备及其用途也与白色颜料或填料组合特别用于生产光学增亮纸。

2. 发明申请

WO9709973A3 PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES 审中-公开
标题翻译：外部活性抗高血压药物
公开(公告)号：WO9709973A3
公开(公告)日：1997-06-05
申请号：PCT/US9614727
申请日：1996-09-12
申请人： UNIV CALIFORNIA , ADOLOR CORP , YAKSH TONY L , FARRAR JOHN J , MAYCOCK ALAN L , LEWIS MICHAEL E , DOW GORDON J
发明人： YAKSH TONY L , FARRAR JOHN J , MAYCOCK ALAN L , LEWIS MICHAEL E , DOW GORDON J
IPC分类号： C07D211/52 , A61K31/00 , A61K31/17 , A61K31/439 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/485 , A61K31/5377 , A61K31/55 , A61K38/04 , A61K38/07 , A61K38/08 , A61K38/22 , A61K38/33 , A61K45/00 , A61P1/12 , A61P25/00 , A61P25/02 , A61P43/00 , A61K31/41 , A61K31/415 , A61K31/435 , A61K31/535
CPC分类号： A61K31/17 , A61K9/0048 , A61K9/06 , A61K31/00 , A61K31/439 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/485
摘要： Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit substantial central nervous system effects. The anti-diarrheal compound 4-(p-chlorophenyl)-4-hydroxy-N-N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the compositions and methods.

3. 发明申请

WO2004065456A1 POLYMERIC ETHERAMINES, THEIR PRODUCTION AND USE 审中-公开
标题翻译：聚合物，其生产和使用
公开(公告)号：WO2004065456A1
公开(公告)日：2004-08-05
申请号：PCT/IB2004/000123
申请日：2004-01-15
申请人： CLARIANT INTERNATIONAL LTD , FARRAR, John Martin , HALMSHAW, Benjamin, M.
发明人： FARRAR, John Martin , HALMSHAW, Benjamin, M.
IPC分类号： C08G65/24
CPC分类号： D21H17/53 , C08G65/24 , C08G65/33306 , C08L71/03 , D06P1/607 , D21H21/10 , D21H21/28
摘要： Polymeric etheramines (P) obtainable by reaction of (A) an oligohydroxycompound which is an oligohydroxyalkane of molecular weight ≥ 92 and with x hydroxygroups, wherein x is a number in the range of 3 to 6, or a mixture of two or more thereof, or a mixture of one or more thereof with at least one alkanediol containing 2 to 4 carbon atoms, with (B) epichlorohydrin, in the ratio of more than two moles of (B) per mole of (A) and on average not more than 1.2 molecules of (B) per hydroxygroup of (A), to give a chloro-terminated adduct (E), and exhaustive reaction of (E) with (C) at least one aliphatic oligoamine containing at least one primary amino group and at least one further amino group which is primary or secondary, in the molar ratio of n moles of (C) for every mole of (E), wherein n > 1 and smaller than the number of linked chlorine atoms in (E) present on average per molecule of (E), and optionally (D) at least one aliphatic mono- or diamine containing only one primary or secondary amino group any further amino group being tertiary, in the molar ratio of p moles of (D) for every mole of (E), wherein p is sufficient for reacting any available chlorine of (E) not reacted with (C), and in such a ratio of [(C) + (D)] to (E) that the total number t of basic amino groups in [(C) + (D)] is higher than the total number of linked chlorine atoms in (E), and which are optionally protonated, and aqueous compositions thereof, their production and their use as multifunctional adjuvants in the processing of cellulosic fibres in aqueous medium, especially as flocculants, drainage or retention assistants, dye fixatives and trash quenchers in paper and tissue production.
摘要翻译：通过（A）低分子量> = 92的低聚羟基烷烃的低聚羟基化合物与x羟基反应获得的聚合醚胺（P），其中x为3至6的数，或其两个或多个的混合物，或其一种或多种与至少一种含有2-4个碳原子的链烷二醇的混合物与（B）表氯醇以每摩尔（A）多于两摩尔（B）的比例混合，平均不更多（A）的每个羟基的1.2分子（B），得到氯端基加合物（E），和（E）与（C）至少一种含有至少一个伯氨基的脂族低聚胺和（C）至少一个为伯或次的另外的氨基，（C）的每摩尔（E）的n摩尔的摩尔比，其中n≥1且小于平均存在的（E）中连接的氯原子数（E）的每分子，和任选地（D）至少一种仅包含一个伯或仲二烷基的脂族单或二胺（D）对于每摩尔（E）的摩尔数摩尔比，其中p足以使未与C反应的（E）的任何可用的氯反应，和 [（C）+（D）]中的碱性氨基的总数t高于（（C）+（D）]至（E）），并且其任选被质子化，其水性组合物，它们的生产及其在水性介质中纤维素纤维加工中的多功能助剂的用途，特别是作为絮凝剂，排水或保留助剂，染色固定剂和纸和纸巾生产中的垃圾猝灭剂。

4. 发明申请

WO0137785A2 NOVEL METHODS AND COMPOSITIONS INVOLVING OPIOIDS AND ANTAGONISTS THEREOF 审中-公开
标题翻译：涉及OPIOIDS和ANTAGONISTS的新方法和组合物
公开(公告)号：WO0137785A2
公开(公告)日：2001-05-31
申请号：PCT/US0042315
申请日：2000-11-29
申请人： ADOLOR CORP , FARRAR JOHN J
发明人： FARRAR JOHN J
IPC分类号： A61K45/00 , A61K31/439 , A61K31/445 , A61K31/451 , A61K31/4748 , A61K31/485 , A61P1/00 , A61P25/02 , A61P43/00 , A61K
CPC分类号： A61K31/4748 , A61K31/445 , A61K31/485 , A61K2300/00
摘要： Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea.
摘要翻译：包含阿片样物质和阿片样物质拮抗剂的新方法和组合物。在优选的实施方案中，所述方法和组合物包含阿片样物质和外周mu阿片样物质拮抗剂化合物。所述方法和组合物特别适用于治疗和/或预防与阿片样物质相关的副作用，包括例如便秘，呕吐和/或恶心。

5. 发明申请

WO1997009973A2 PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES 审中-公开
标题翻译：外部活性抗高血压药物
公开(公告)号：WO1997009973A2
公开(公告)日：1997-03-20
申请号：PCT/US1996014727
申请日：1996-09-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ADOLOR CORPORATION , YAKSH, Tony, L. , FARRAR, John, J. , MAYCOCK, Alan, L. , LEWIS, Michael, E. , DOW, Gordon, J.
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ADOLOR CORPORATION
IPC分类号： A61K31/00
CPC分类号： A61K31/17 , A61K9/0048 , A61K9/06 , A61K31/00 , A61K31/439 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/485
摘要： Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit substantial central nervous system effects. The anti-diarrheal compound 4-(p-chlorophenyl)-4-hydroxy-N-N-dimethyl- alpha , alpha -diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the compositions and methods.
摘要翻译：提供了使用组合物治疗周围痛觉过敏的组合物和方法。组合物含有抗痛觉过敏有效量的一种或多种与外周阿片剂受体直接或间接相互作用的化合物，但是在局部给药或局部给药时不引起显着的中枢神经系统作用。抗 - 腹泻化合物4-（对氯苯基）-4-羟基-N-N-二甲基-α，α-二苯基-1-哌啶丁酰胺盐酸盐优选用于组合物和方法。

6. 发明申请

WO2007017336A1 STORAGE STABLE SOLUTIONS OF OPTICAL BRIGHTENERS 审中-公开
标题翻译：光稳定器的存储稳定解决方案
公开(公告)号：WO2007017336A1
公开(公告)日：2007-02-15
申请号：PCT/EP2006/064152
申请日：2006-07-12
申请人： CLARIANT INTERNATIONAL LTD , FARRAR, John Martin , JACKSON, Andrew Clive , MAHON, Margaret
发明人： FARRAR, John Martin , JACKSON, Andrew Clive , MAHON, Margaret
IPC分类号： C07D251/68
CPC分类号： C07D251/68 , C08K5/0041 , Y10T442/2582
摘要： The instant invention relates to storage stable solutions of optical brighteners based on certain salt forms of anilino- substituted bistriazinyl derivatives of 4,4 ' -diaminostilbene-2, 2 ' -disulphonic acid of formula (I) wherein R , R 1 , R 2 , M + and n are as defined in the description, which do not need extra solubilising additives.
摘要翻译：本发明涉及基于某些盐形式的式（I）的4,4'-二氨基芪-2,2'-二磺酸的苯胺基取代双三嗪衍生物的荧光增白剂的储存稳定溶液，其中R 1，R 1 R 2，R 2，M +和/或N如说明书中所定义，其不需要额外的增溶添加剂。

7. 发明申请

WO0142207A3 NOVEL METHODS FOR THE TREATMENT AND PREVENTION OF ILEUS 审中-公开
标题翻译：用于治疗和预防ILEUS的新方法
公开(公告)号：WO0142207A3
公开(公告)日：2002-05-02
申请号：PCT/US0042313
申请日：2000-11-29
申请人： ADOLOR CORP , FARRAR JOHN J , SCHIED PETER J , SCHMIDT WILLIAM K , CARPENTER RANDALL L
发明人： FARRAR JOHN J , SCHIED PETER J , SCHMIDT WILLIAM K , CARPENTER RANDALL L
IPC分类号： C07D221/26 , A61K31/00 , A61K31/439 , A61K31/445 , A61K31/451 , A61K31/473 , A61K31/485 , A61K45/00 , A61P1/00 , A61P43/00 , C07D211/22 , C07D489/00 , C07D489/02 , A61K31/4525 , A61K31/454 , A61K31/4748
CPC分类号： A61K31/485 , A61K31/439 , A61K31/445 , A61K31/451
摘要： Novel methods for the treatment and/or prevention of ileus. The methods may comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates, quaternary morphinans, opium alkaloid derivatives and quaternary benzomorphans. The methods are particularly suitable for treating and/or preventing postsurgical ileus and postpartum ileus.
摘要翻译：用于治疗和/或预防肠梗阻的新方法。所述方法可以包括向患者施用有效量的周围的阿片样物质拮抗剂化合物。用于该方法的优选化合物包括哌啶-N-烷基羧酸盐，季吗啡喃，鸦片生物碱衍生物和季苯并呋喃。该方法特别适用于治疗和/或预防术后肠梗阻和产后肠梗阻。

8. 发明申请

WO2001037785A3 NOVEL METHODS AND COMPOSITIONS INVOLVING OPIOIDS AND ANTAGONISTS THEREOF 审中-公开
公开(公告)号：WO2001037785A3
公开(公告)日：2001-05-31
申请号：PCT/US2000/042315
申请日：2000-11-29
申请人： ADOLOR CORPORATION , FARRAR, John, J.
发明人： FARRAR, John, J.
IPC分类号： A61K31/445
摘要： Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea. Figures 2A aand 2B are graphical representations of studies on the inhibition of nausea and vomiting employing methods according to an embodiment of the present invention,

9. 发明申请

WO1997032857A1 KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF 审中-公开
标题翻译： KAPPA激素化合物及其药物制剂
公开(公告)号：WO1997032857A1
公开(公告)日：1997-09-12
申请号：PCT/US1997003353
申请日：1997-03-01
申请人： ADOLOR CORPORATION , KRUSE, Lawrence, I. , CHANG, An-Chih , DEHAVEN-HUDKINS, Diane, L. , FARRAR, John, J. , GAUL, Forrest , MARELLA, Michael, Anthony , MAYCOCK, Alan, L. , ZHANG, Wei, Yuan
发明人： ADOLOR CORPORATION
IPC分类号： C07D241/04
CPC分类号： C07D295/073 , A61K31/404 , A61K31/4439 , C07D209/42 , C07D213/56 , C07D241/04
摘要： Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae (I), (II), (III) and (IV) have the structure wherein X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification.
摘要翻译：提供了具有κ阿片样物质激动剂活性的化合物，含有它们的组合物和使用它们作为止痛剂的方法。式（I），（II），（III）和（IV）的化合物具有其中X，X4，X5，X7，X9; R1，R2，R3，R4; Y，Z和n如说明书所述。

10. 发明申请

WO2009074548A3 STORAGE STABLE SOLUTIONS OF OPTICAL BRIGHTENERS 审中-公开
标题翻译：存储稳定的光学增白剂解决方案
公开(公告)号：WO2009074548A3
公开(公告)日：2009-10-01
申请号：PCT/EP2008067070
申请日：2008-12-09
申请人： CLARIANT INT LTD , FARRAR JOHN MARTIN , JACKSON ANDREW CLIVE , MAHON MARGARET , OBERHOLZER MARTIN
发明人： FARRAR JOHN MARTIN , JACKSON ANDREW CLIVE , MAHON MARGARET , OBERHOLZER MARTIN
IPC分类号： C07D251/68 , C08K5/00
CPC分类号： C07D251/68 , C08K5/0041 , C08K5/0091
摘要： The instant invention relates to storage stable solutions of optical brighteners based on certain salt forms of anilino-substituted bistriazinyl derivatives of 4,4'-diaminostilbene- 2,2'-disulphonic acid and of organic acids which do not need extra solubilising additives.
摘要翻译：本发明涉及基于某些盐形式的4,4'-二氨基二苯乙烯-2,2'-二磺酸的苯胺基取代的双三嗪基衍生物和不需要额外增溶添加剂的有机酸的储存稳定的荧光增白剂溶液。

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