专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2023092006A1 COMPOSITIONS OF PROTEIN COMPLEXES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2023092006A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/080043
申请日：2022-11-17
申请人： GOOD THERAPEUTICS, INC. , F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： MULLIGAN, John, Thomas , OKADA, Shannon, Lee , KILLEBREW, Justin, Richard , HOLLENBAUGH, Diane, Louise
IPC分类号： A61K47/68 , A61P35/00
摘要： Provided herein are protein complexes comprising a sensor domain and a therapeutic domain linked by a linker, and methods of use thereof. In aspects of the present disclosure, activity of the therapeutic domain comprises a dependence on sensor domain binding to target markers.

2. 发明申请

WO2023089005A1 METHOD FOR CONTROLLING AN ANTI DROPLET SYSTEM OF A PIPETTOR AND PIPETTOR WITH ANTI DROPLET SYSTEM CONTROL 审中-公开
公开(公告)号：WO2023089005A1
公开(公告)日：2023-05-25
申请号：PCT/EP2022/082220
申请日：2022-11-17
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE MOLECULAR SYSTEMS, INC.
发明人： DALCANALE, Federico , GOUDIE, Simon , HRADETZKY, David , LEWANDOWSKA, Dagmar Wanda , MEIER, Alexander , ZGRAGGEN, Sabrina
IPC分类号： G01N35/10
摘要： A method for controlling an anti droplet system of a laboratory system or device comprising at least one air displacement pipettor with a pressure sensor and a control unit for controlling operation of the pipettor, the method comprising the following steps controlling the pipettor to be moved such that the pipettor tip is immerged in a fluid to be aspirated, aspirate a predetermined volume of fluid, move the pipettor such that the pipettor tip is emerged from the fluid, continuously monitoring the pressure above the fluid column in the pipettor tip and generating pressure curve over time, and determining if a pressure increase above the fluid column has been detected.

3. 发明申请

WO2023088856A1 HETEROCYCLIC NLRP3 INHIBITORS 审中-公开
公开(公告)号：WO2023088856A1
公开(公告)日：2023-05-25
申请号：PCT/EP2022/081866
申请日：2022-11-15
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： AITKEN, Lewis Scott , BOUCHE, Lea Aurelie , GUBA, Wolfgang , JAESCHKE, Georg , MESCH, Stefanie Katharina , STEINER, Sandra , TOSSTORFF, Andreas Michael
IPC分类号： C07D487/04 , C07D495/04 , A61K31/5025 , A61P3/00 , A61P9/00 , A61P11/00 , A61P29/00 , A61P35/00
摘要： The invention relates to novel compounds having the general formula Ib wherein R1, R1b, R2, R3, and Z are as described herein, composition including the compounds and methods of using the compounds.

4. 发明申请

WO2023088600A1 METHOD AND SYSTEM FOR OPERATING A LABORATORY AUTOMATION SYSTEM 审中-公开
公开(公告)号：WO2023088600A1
公开(公告)日：2023-05-25
申请号：PCT/EP2022/077134
申请日：2022-09-29
申请人： ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： REIN, Michael
IPC分类号： G06V20/69 , G06V10/764 , G01N35/00 , G06T7/00
摘要： The present disclosure pertains to a method for operating a laboratory automation system (1), the laboratory automation system (1) comprising a carrier (10) comprising a reception place (11) for receiving a sample container (12) configured to contain a sample to be analyzed by a laboratory device (13); a placement device (14) configured to pick and place the sample container (12); an imaging device (15); and a data processing device (16) comprising at least one processor (17) and a memory (18). The method comprises detecting an image of the reception place (11) by the imaging device (15); determining whether the reception place (11) is free for receiving the sample container (12) and the reception place (11) is configured to receive the sample container (12), by applying a machine learning algorithm for image analysis of the image of the reception place (11) in the data processing device (16); and placing the sample container (12) in the reception place (11) by the placement device (14) if the reception place (11) is determined as free and configured to receive the sample container (12). Further, a laboratory automation system (1) is disclosed.

5. 发明申请

WO2023083895A1 HYDROPHILIC AZADIBENZOCYCLOOCTYNE DERIVATIVES AND METAL-FREE CLICK REACTIONS WITH THESE HYDROPHILIC AZADIBENZOCYCLOOCTYNE DERIVATIVES 审中-公开
公开(公告)号：WO2023083895A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/081339
申请日：2022-11-09
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BERGMANN, Frank , HEINDL, Dieter , WINTER, Nils
IPC分类号： C07D225/08 , A61K47/50
摘要： The invention relates in a first aspect to an azadibenzocyclooctyne derivative according to formula (I) or a salt thereof having specific substituents at the benzo rings of the DIBAC structure and having specific substituents connected to the nitrogen atom of the DIBAC structure. A second aspect of the invention is directed to a conjugate of formula (II), wherein a substituent R6 is connected to the N atom of the 8 membered ring of the DIBAC structure via a linker structure –C(=O)-[L]n-Z-. A third aspect of the invention relates to a method for the modification of a target molecule, wherein a conjugate according to the second aspect is reacted with a target molecule comprising a 1,3-dipole group or a 1,3-(hetero)diene group. In a fourth aspect, the invention is directed to the use of the conjugate according to the second aspect for bioorthogonal labeling and/or modification of a target molecule. A fifth aspect of the invention relates to a modified target molecule comprising the reaction product of a conjugate according to the second aspect and a target molecule comprising a 1,3-dipole group or a 1,3-(hetero)diene group, obtained or obtainable from the method of the third aspect. In a sixth aspect, the invention is related to a kit comprising a modified target molecule according to the fifth aspect as detector reagent and a suitable capture reagent.

6. 发明申请

WO2023083789A1 INSTRUMENT FOR AUTOMATICALLY DISSECTING A BIOLOGICAL SPECIMEN ON A SLIDE 审中-公开
公开(公告)号：WO2023083789A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/081087
申请日：2022-11-08
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE MOLECULAR SYSTEMS, INC.
发明人： WIETZORREK, Joachim
IPC分类号： G02B21/36 , G02B21/26 , G02B21/24
摘要： An instrument (110) for automatically dissecting a biological specimen (112) on a slide (114) is proposed. The instrument (110) comprises at least one imaging system (116). The imaging system (116) comprises at least one camera (118) configured for sequentially imaging at least one image of the slide (114) at a plurality of slide positions. The imaging system (116) com- prises a relay lens system (120) having a fixed focal length. The relay lens system (120) is configured for relaying an impinging light beam (122) from the slide (114) to the camera (118). The instrument (110) further comprises a movable xy-stage (150) configured for setting the slide (114) position. The instrument (110) further comprises at least one processing unit (162) configured for generating a full slide (114) image by stitching the sequentially imaged images of the slide (114). Further, a method for automatically dissecting a biological specimen (112) on a slide (114) is proposed.

7. 发明申请

WO2023083723A1 NOVEL MONOCLONAL ANTIBODIES DIRECTED AGAINST L-THYROXINE AND DIAGNOSTIC USES THEREOF 审中-公开
公开(公告)号：WO2023083723A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/080897
申请日：2022-11-07
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GERG, Michael , HIRZEL, Klaus , HOJER, Caroline Dorothea , JOSEL, Hans-Peter , JUCKNISCHKE, Ute , LEHMANN, Holger , MARKINA, Anastasia , PRENCIPE, Giuseppe , VON PROFF, Leopold , SCHRAEML, Michael , HALLDÓRSSON, Steinar
IPC分类号： C07K16/26 , G01N33/53 , G01N33/78
摘要： The present invention provides a novel monoclonal antibody specifically binding to L-Thyroxine (T4) and compositions and kits comprising such antibodies. Furthermore, provided are polynucleotides encoding such monoclonal antibodies, host cells expressing said antibodies, methods of producing such antibodies and diagnostic methods using such monoclonal antibodies. The monoclonal antibody of the invention comprises a heavy chain variable domain (VH) comprising V or A in position 33; Y in position 50; W in position 52; I in position 98, G, A or V in position 99; Y in position 100; and I in position 100b; and a light chain variable domain (VL) comprising amino acids H or Y in position 28; N or K in position 29; W in position 32; G or A in position 91; Y, W or F in position 92; S or T in position 93;Y or F in position 95b; N, S, T or Q in position 95c; and H in position 96, wherein the positions of the amino acids in the VH and the VL are indicated according to the Kabat numbering scheme, respectively.

8. 发明申请

WO2023079128A1 CATALYTIC HYDROGENATION OF AROMATIC NITRO COMPOUNDS 审中-公开
公开(公告)号：WO2023079128A1
公开(公告)日：2023-05-11
申请号：PCT/EP2022/080899
申请日：2022-11-07
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： TOSATTI, Paolo
IPC分类号： C07D265/30 , C07D413/12
摘要： The invention provides a process for manufacturing an aniline (2), wherein PG denotes hydrogen or an amino protective group, that is suitable for large-scale manufacturing of said aniline (2).

9. 发明申请

WO2023072794A1 PIPERAZINYLSULFONYLARYL COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS 审中-公开
公开(公告)号：WO2023072794A1
公开(公告)日：2023-05-04
申请号：PCT/EP2022/079506
申请日：2022-10-24
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： DEY, Fabian , DING, Xiao , SHI, Houguang , TAN, Xuefei , WU, Jun , ZHENG, Jiamin , ZHOU, Mingwei
IPC分类号： A61P31/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D498/04 , C07D498/10
摘要： The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4, Y, Q1, Q2, Q3, Q4 and Q5 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

10. 发明申请

WO2023062123A1 ENHANCED METHOD FOR THE DETERMINATION OF AN ANALYTE CONCENTRATION IN BODILY FLUID 审中-公开
公开(公告)号：WO2023062123A1
公开(公告)日：2023-04-20
申请号：PCT/EP2022/078495
申请日：2022-10-13
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE GMBH , ROCHE DIABETES CARE, INC.
发明人： LIMBURG, Bernd , BERG, Max , HAILER, Fredrik , ALPEROWITZ, Lukas , BODLÉE, Florian
IPC分类号： G01N21/78 , G01S17/88
摘要： The present invention relates to an analytical method for determining a concentration of an analyte in a bodily fluid by using a mobile device having at least one camera, at least one lidar sensor, at least one processor, and at least one display, wherein the at least one camera and the at least one lidar sensor comprise an at least partially overlapping field of view, the method comprising the following steps: a) providing at least one object, the at least one object being selected from the list comprising: an optical test element having a reagent test region, a color reference card having a reagent test region, a color reference card adapted to be associated with an optical test element having a reagent test region; wherein the reagent test region is adapted for application of a sample of the bodily fluid, and wherein the reagent test region is adapted to undergo, at least partially, a color formation reaction when the sample of the bodily fluid is applied to the reagent test region; b1) prompting, by the display, a user to apply a drop of the bodily fluid to the reagent test region and/or prompting, by the display, a user to confirm application of a drop of the bodily fluid to the reagent test region; b2) prompting, by the display, the user to provide the at least one object within the at least partially overlapping field of view of the at least one camera and the at least one lidar sensor; c) generating, by the processor, a lidar measurement data set at least for the object by receiving output data from the at least one lidar sensor, the lidar measurement data set representing a three-dimensional structure of at least a part of the object; d) comparing, by the processor, the lidar measurement data set from step c) to a pre-generated lidar data set for the object, the pre-generated lidar data set representing a three-dimensional structure of the entire object, thereby obtaining an item of information on a degree of congruence of the lidar measurement data set and the pre-generated lidar data set; and e1) if the item of information from step d) indicates a degree of congruence equal to or above a pre-determined minimum degree of congruence: capturing, by the at least one camera, a measurement image of at least a part of the reagent test region having the sample of the bodily fluid applied thereto, and determining the concentration of the analyte in the bodily fluid based at least on the measurement image captured; or e2) if the item of information from step d) indicates a degree of congruence below a pre-determined minimum degree of congruence: - at least temporarily not allowing the capturing, by the at least one camera, of a measurement image of at least a part of the reagent test region having the sample of the bodily fluid applied thereto; and/or - indicating, by the display, a warning to the user; and/or - indicating, by the display, instractions to the user to take some appropriate action in order to capture, by the at least one camera, a measurement image of at least a part of the reagent test region having the sample of the bodily fluid applied thereto.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式