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1. 发明申请

WO2008148047A3 IMPROVEMENTS IN METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE 审中-公开
标题翻译：方法和设备中的改进，以提示和/或减少食物摄取
公开(公告)号：WO2008148047A3
公开(公告)日：2010-01-28
申请号：PCT/US2008064771
申请日：2008-05-23
申请人： ENDOSPHERE INC , BINMOELLER KENNETH F , YUREK MATTHEW , KECK ZHENYONG , MCKINLEY JAMES T
发明人： BINMOELLER KENNETH F , YUREK MATTHEW , KECK ZHENYONG , MCKINLEY JAMES T
IPC分类号： A61L27/58 , A61B17/00 , A61F2/00
CPC分类号： A61F5/0076 , A61F2002/044 , A61F2002/045 , A61F2210/0014 , A61N1/36007
摘要： The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.
摘要翻译：本发明涉及操作有助于抑制食欲和/或减少食物摄取的装置的装置和方法。在一些实施方案中，本发明的方法和装置包括肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可以引起一种或多种饱腹感的生物学信号的刺激。插入的装置的一些实施例通过驻留在胃中的锚固构件锚定在十二指肠部位，装置的其它实施例通过适当的长度尺寸以及对应的装置的一个或多个成角度的部分而被稳定在目标部位到达目标地点的角部分。该装置的实施方案由于物理存在以及通过更积极的干预形式（包括释放生物活性物质和电刺激神经元）而发挥作用。

2. 发明申请

WO2009012335A1 A CONFORMATIONALLY-STABILIZED INTRALUMINAL DEVICE FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：一种用于医疗应用的协调稳定的内科手术
公开(公告)号：WO2009012335A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/070226
申请日：2008-07-16
申请人： ENDOSPHERE, INC. , BINMOELLER, Kenneth , MCKINLEY, James, T. , YUREK, Matt , SANDER, Fiona, M.
发明人： BINMOELLER, Kenneth , MCKINLEY, James, T. , YUREK, Matt , SANDER, Fiona, M.
IPC分类号： A61F5/00
CPC分类号： A61F5/0076
摘要： The invention relates to devices (20) that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.
摘要翻译：本发明涉及通过其构象（包括长度和曲率的尺寸）稳定在胃肠道内腔内停留部位的装置（20）。整个装置对应于居住地点的构造; 更具体地，弯曲或成角度的部分对应于居住部位的弯曲或成角度部分，并且不符合直接近端或远端部位。在一些实施例中，构象稳定的装置可以影响驻留位置形状的变化，这有助于装置的稳定性。一些实施例旨在限制食欲和/或减少食物摄取，其他实施方案可以针对其他治疗目的。设备的一些实施例被设计为完全驻留在十二指肠中; 其他的主要存在于十二指肠内，但是向近端延伸到胃窦内，而其它实施例被设计为驻留在胃肠道内的其他地方。

3. 发明申请

WO2007075396A3 METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE 审中-公开
标题翻译： CURB的方法和设备提示和/或减少食物摄入
公开(公告)号：WO2007075396A3
公开(公告)日：2009-02-26
申请号：PCT/US2006047874
申请日：2006-12-15
申请人： ENDOSPHERE INC , BINMOELLER KENNETH F
发明人： BINMOELLER KENNETH F
IPC分类号： A61F2/04 , A61F5/00 , A61M29/00
CPC分类号： A61M25/04 , A61F5/0076 , A61F5/0079 , A61F2002/045 , A61M25/1011
摘要： The present invention relates to methods and devices that help to curb appetite and/or reduce food intake. In one embodiment, the methods and devices of the present invention include a small intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety.
摘要翻译：本发明涉及有助于抑制食欲和/或减少食物摄取的方法和装置。在一个实施方案中，本发明的方法和装置包括小肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可引起一种或多种饱腹感的生物学信号的刺激。

4. 发明申请

WO2008148047A2 IMPROVEMENTS IN METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE 审中-公开
标题翻译：对库尔伯吸食者和/或减少食物摄入的方法和装置的改进
公开(公告)号：WO2008148047A2
公开(公告)日：2008-12-04
申请号：PCT/US2008/064771
申请日：2008-05-23
申请人： ENDOSPHERE, INC. , BINMOELLER, Kenneth, F. , YUREK, Matthew , KECK, Zhenyong , MCKINLEY, James, T.
发明人： BINMOELLER, Kenneth, F. , YUREK, Matthew , KECK, Zhenyong , MCKINLEY, James, T.
IPC分类号： A61L27/58 , A61F2/00 , A61B17/00
CPC分类号： A61F5/0076 , A61F2002/044 , A61F2002/045 , A61F2210/0014 , A61N1/36007
摘要： The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.
摘要翻译：本发明涉及操作有助于抑制食欲和/或减少食物摄取的装置的装置和方法。在一些实施方案中，本发明的方法和装置包括肠/十二指肠插入物，其包括具有至少一个流动减少元件的细长构件，所述流动减少元件可引起一种或多种饱腹感生物信号的刺激。插入装置的一些实施例通过驻留在胃中的锚定构件锚定在十二指肠部位，装置的其他实施例通过合适的长度尺寸稳定在目标位置以及相应装置的一个或多个成角度的部分到十二指肠靶向部位的成角部分。该装置的实施方案通过物理存在以及更积极的干预形式（包括生物活性物质的释放和神经元的电刺激）发挥作用。

5. 发明申请

WO2015196157A3 DUODENAL GASTROINTESTINAL DEVICES AND DELIVERY MECHANISMS 审中-公开
标题翻译： DUODENAL GASTROINTESTINAL设备和交付机制
公开(公告)号：WO2015196157A3
公开(公告)日：2016-02-11
申请号：PCT/US2015036812
申请日：2015-06-19
申请人： ENDOSPHERE INC
发明人： SANDER FIONA M , LUNSFORD JOHN , PATCH STACY , BORLAN ADRIAN
IPC分类号： A61B17/00 , A61B17/04 , A61B17/11
CPC分类号： A61F5/0076 , A61F5/0089
摘要： A system for delivering an endolumenal device through an endoscope includes a delivery tool and an adaptor. The delivery tool has an elongate tube configured to hold a portion of the endolumenal device therein and a first connecting feature on a distal end of the elongate tube. The adaptor is configured to attach to a handle of the endoscope. The adaptor includes a channel therethrough and a second connecting feature configured to mate with the first connecting feature of the delivery tool. The elongate tube of the delivery tool is configured to align with the channel of the adaptor when the first and second connecting features are mated.
摘要翻译：用于通过内窥镜递送腔内装置的系统包括递送工具和适配器。递送工具具有细长管，该细长管构造成将其中的腔内装置的一部分保持在其中，并且在细长管的远端上具有第一连接特征。适配器被配置为附接到内窥镜的手柄。适配器包括穿过其中的通道和被配置为与输送工具的第一连接特征配合的第二连接特征。输送工具的细长管配置成当第一和第二连接特征配合时与适配器的通道对准。

6. 发明申请

WO2015196157A2 DUODENAL GASTROINTESTINAL DEVICES AND DELIVERY MECHANISMS 审中-公开
标题翻译： DUODENAL GASTROINTESTINAL设备和传送机制
公开(公告)号：WO2015196157A2
公开(公告)日：2015-12-23
申请号：PCT/US2015/036812
申请日：2015-06-19
申请人： ENDOSPHERE, INC.
发明人： SANDER, Fiona, M. , LUNSFORD, John , PATCH, Stacy , BORLAN, Adrian
IPC分类号： A61B17/94
CPC分类号： A61F5/0076 , A61F5/0089
摘要： A system for delivering an endolumenal device through an endoscope includes a delivery tool and an adaptor. The delivery tool has an elongate tube configured to hold a portion of the endolumenal device therein and a first connecting feature on a distal end of the elongate tube. The adaptor is configured to attach to a handle of the endoscope. The adaptor includes a channel therethrough and a second connecting feature configured to mate with the first connecting feature of the delivery tool. The elongate tube of the delivery tool is configured to align with the channel of the adaptor when the first and second connecting features are mated.
摘要翻译：用于通过内窥镜输送腔内装置的系统包括输送工具和适配器。递送工具具有细长管，该细长管构造成将其中的腔内装置的一部分保持在其中，并且在细长管的远端上具有第一连接特征。适配器被配置为附接到内窥镜的手柄。适配器包括穿过其中的通道和被配置为与输送工具的第一连接特征配合的第二连接特征。输送工具的细长管配置成当第一和第二连接特征配合时与适配器的通道对齐。

7. 发明申请

WO2007075396A2 METHODS AND DEVICES TO CURB APPETITE AND/OR REDUCE FOOD INTAKE 审中-公开
标题翻译： CURB的方法和设备提示和/或减少食物摄入
公开(公告)号：WO2007075396A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/047874
申请日：2006-12-15
申请人： ENDOSPHERE, INC. , BINMOELLER, Kenneth, F.
发明人： BINMOELLER, Kenneth, F.
IPC分类号： A61M29/00
CPC分类号： A61M25/04 , A61F5/0076 , A61F5/0079 , A61F2002/045 , A61M25/1011
摘要： The present invention relates to methods and devices that help to curb appetite and/or reduce food intake. In one embodiment, the methods and devices of the present invention include a small intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety.
摘要翻译：本发明涉及有助于抑制食欲和/或减少食物摄取的方法和装置。在一个实施方案中，本发明的方法和装置包括小肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可引起一种或多种饱腹感的生物学信号的刺激。

8. 发明申请

WO2013067221A8 DUODENAL GASTROINTESTINAL DEVICES AND RELATED TREATMENT METHODS 审中-公开
标题翻译： DUODENAL GASTROINTESTINAL设备及相关治疗方法
公开(公告)号：WO2013067221A8
公开(公告)日：2014-05-30
申请号：PCT/US2012063117
申请日：2012-11-01
申请人： ENDOSPHERE INC
发明人： BINMOELLER KENNETH F , MCKINLEY JAMES T , SANDER FIONA M , LUNSFORD JOHN P , PHAN HOANG G M , THORNE CHRISTOPHER , NGUYEN NAM Q
IPC分类号： A61F2/04 , A61F2/02
CPC分类号： A61F5/0076 , A61F5/0079
摘要： An intragastric device includes an elongated member having a proximal end and a distal end and an anchor connected to the elongated member. The anchor includes a stem, a first arch and a second arch, and a curvilinear element. The stem includes a proximal end and a distal end. The distal end of the stem is attached to the proximal end of the elongated member. Each arch has first and second ends and a proximal peak therebetween. The first end of each arch is attached to the proximal end of the stem, and the second end of each arch extends radially away from the stem. The curvilinear element connects the second end of the first arch to the second end of the second arch.
摘要翻译：胃内装置包括具有近端和远端的细长构件和连接到细长构件的锚固件。锚固件包括杆，第一拱和第二拱，以及曲线元件。杆包括近端和远端。杆的远端附接到细长构件的近端。每个拱顶具有第一和第二端以及它们之间的近端顶点。每个拱的第一端附接到杆的近端，并且每个拱的第二端沿径向远离杆延伸。曲线元件将第一拱的第二端连接到第二拱的第二端。

9. 发明申请

WO2013067221A1 DUODENAL GASTROINTESTINAL DEVICES AND RELATED TREATMENT METHODS 审中-公开
标题翻译： DUODENAL GASTROINTESTINAL设备及相关治疗方法
公开(公告)号：WO2013067221A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/063117
申请日：2012-11-01
申请人： ENDOSPHERE, INC.
发明人： BINMOELLER, Kenneth, F. , MCKINLEY, James, T. , SANDER, Fiona, M. , LUNSFORD, John, P. , PHAN, Hoang, G.m. , THORNE, Christopher , NGUYEN, Nam, Q.
IPC分类号： A61F2/04 , A61F2/02
CPC分类号： A61F5/0076 , A61F5/0079
摘要： An intragastric device includes an elongated member having a proximal end and a distal end and an anchor connected to the elongated member. The anchor includes a stem, a first arch and a second arch, and a curvilinear element. The stem includes a proximal end and a distal end. The distal end of the stem is attached to the proximal end of the elongated member. Each arch has first and second ends and a proximal peak therebetween. The first end of each arch is attached to the proximal end of the stem, and the second end of each arch extends radially away from the stem. The curvilinear element connects the second end of the first arch to the second end of the second arch.
摘要翻译：胃内装置包括具有近端和远端的细长构件和连接到细长构件的锚固件。锚固件包括杆，第一拱和第二拱，以及曲线元件。杆包括近端和远端。杆的远端附接到细长构件的近端。每个拱顶具有第一和第二端以及它们之间的近端顶点。每个拱的第一端附接到杆的近端，并且每个拱的第二端沿径向远离杆延伸。曲线元件将第一拱的第二端连接到第二拱的第二端。

10. 发明申请

WO2010003097A3 METHODS AND DEVICES FOR DELIVERING OR DELAYING LIPIDS WITHIN A DUODENUM 审中-公开
公开(公告)号：WO2010003097A3
公开(公告)日：2010-01-07
申请号：PCT/US2009/049586
申请日：2009-07-02
申请人： ENDOSPHERE, INC. , McKINLEY, James T. , KECK, Zhenyong , SANDER, Fiona M.
发明人： McKINLEY, James T. , KECK, Zhenyong , SANDER, Fiona M.
IPC分类号： A61M31/00 , A61M37/00
摘要： Devices are described that are adapted and configured for use within the duodenum of a mammal. One aspect of the device includes a spine having a proximal end and a distal end; an atraumatic feature positioned on at least one of the proximal end and the distal end of the spine; and a flow reduction element positioned along the spine and having a variable porosity along its length. In another aspect, there is a flow reduction device adapted and configured for use within the duodenum of a mammal having a spine having a length, a proximal end and a distal end; a first atraumatic feature positioned adjacent to the spine proximal end; a second atraumatic feature positioned adjacent to the spine distal end wherein the length of the spine is selected so that when the first atraumatic feature is in the stomach the second atraumatic feature is in the fourth portion of the duodenum; and a flow reduction element having a proximal end, a distal end, an interior portion, an exterior portion and a variable porosity between the proximal end and the distal end. Additionally or alternatively, some or all of the components of the device may be formed from or coated with a lipid-philic material. There is also provided a method for adjusting the passage of ingesta through the duodenum of a mammal. The method includes placing the distal end of a flow reduction device in the duodenum of a mammal; placing the proximal end of the flow reduction device in a stomach of the mammal; expanding within the duodenum of the mammal a variable porosity flow reduction element supported by the flow reduction device; and directing at least a portion of the flow of ingesta through the duodenum through the proximal end of the variable porosity flow reduction element and into an interior portion of the variable porosity flow reduction element.

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