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1. 发明申请

WO2005022128A3 DEVICE AND METHOD FOR THE NON-INVASIVE DETECTION AND MEASUREMENT OF THE PROPERTIES OF A MEDIUM 审中-公开
标题翻译：非侵入性检测的设备和方法以及介质特性的测量
公开(公告)号：WO2005022128A3
公开(公告)日：2005-06-16
申请号：PCT/FR2004002157
申请日：2004-08-18
申请人： CENTRE NAT RECH SCIENT , ECOLE NORM SUPERIEURE CACHAN , TOURY TIMOTHEE POL JEAN , ZYSS JOSEPH
发明人： TOURY TIMOTHEE POL JEAN , ZYSS JOSEPH
IPC分类号： G01B9/02 , G01N21/45
CPC分类号： G01N21/45 , G01B9/02011 , G01B9/02024 , G01B9/02042 , G01B2290/45 , G01B2290/65 , G01B2290/70
摘要： The invention relates to a device (1) which is used for the non-invasive detection of the properties of a medium by means of interferometry. The inventive device (1) comprises: an optical source (3) which is used to illuminate at least one zone of the medium that is to be probed (34) with a light beam (19); and an interferometer (5) which is used to split the light beam (19) into a reference beam (21) and a probe beam (23), said interferometer (5) having a cutoff frequency fc for the automatic control of the respective lengths of the reference beam (21) and the probe beam (23). The device (1) also comprises scanning means (33) which, together with the probe beam (23), are used to scan the zone to be probed (34) and a reference zone at a frequency f (frequency of the acquisition of images recorded by the means for measuring variations in the phase of the light beam (7)) greater than the cutoff frequency fc.
摘要翻译：本发明涉及一种用于通过干涉测量法非侵入性地检测介质性质的装置（1）。本发明的装置（1）包括：光源（3），其用于用光束（19）照亮待探测的介质（34）的至少一个区域; 以及用于将光束（19）分割为参考光束（21）和探测光束（23）的干涉仪（5），所述干涉仪（5）具有用于自动控制各个长度的截止频率fc 的参考光束（21）和探测光束（23）。装置（1）还包括扫描装置（33），其与探测光束（23）一起用于扫描被探测的区域（34）和以频率f（拍摄图像的频率）的参考区域通过用于测量光束（7）的相位变化的装置记录）大于截止频率fc。

2. 发明申请

WO02102846B1 PHARMACEUTICAL COMPOSITION FOR DIAGNOSIS, PREVENTION OR TREATMENT OF A TUMOROUS STATE, COMPRISING A MODULATOR OF THE ACTIN POLYMERISATION STATE 审中-公开
标题翻译：用于诊断，预防或治疗肿瘤状态的药物组合物，包含ACTIN聚合状态的调节剂
公开(公告)号：WO02102846B1
公开(公告)日：2004-06-03
申请号：PCT/FR0202106
申请日：2002-06-18
申请人： BIOALLIANCE PHARMA , ECOLE NORM SUPERIEURE CACHAN , INST GUSTAVE ROUSSY IGR , CENTRE NAT RECH SCIENT , AUCLAIR CHRISTIAN , AMSELLEM VALERIE , HERVY MARTIAL , SUBRA FREDERIC
发明人： AUCLAIR CHRISTIAN , AMSELLEM VALERIE , HERVY MARTIAL , SUBRA FREDERIC
IPC分类号： A01K67/027 , A61K35/12 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P35/00 , C07K14/47 , C12N5/10 , C12N15/09 , C12N15/113 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68 , A61K31/713 , A61K38/12 , A61K38/17 , C12N15/11
CPC分类号： C12N15/113 , C07K14/47
摘要： The invention relates to a pharmaceutical composition in the field of oncology, for diagnosis, prevention or treatment of a tumorous state, said pharmaceutical composition comprising an active agent capable of stabilising the actin network of the cellular cytoskeleton, in particular a DNA, coding for the zyxin gene. The invention also relates to a method for identification of compounds capable of stabilising the actin network of the cellular cytoskeleton and, furthermore, a diagnostic method for a tumorous state and a method for analysing the tumoral phenotype of a patient, based on quantification of the expression of zyxin by the cells.
摘要翻译：本发明涉及肿瘤学领域的药物组合物，用于诊断，预防或治疗肿瘤状态，所述药物组合物包含能够稳定细胞骨架的肌动蛋白网络的活性剂，特别是DNA，其编码为 zyxin基因。本发明还涉及一种用于鉴定能够稳定细胞骨架的肌动蛋白网络的化合物的方法，此外，基于定量表达的肿瘤状态的诊断方法和分析患者的肿瘤表型的方法的zyxin细胞。

3. 发明申请

WO2005122086A3 DIGITAL IMAGE NOISE REDUCTION 审中-公开
标题翻译：数字图像噪声减少
公开(公告)号：WO2005122086A3
公开(公告)日：2006-12-21
申请号：PCT/FR2005000897
申请日：2005-04-13
申请人： CENTRE NAT RECH SCIENT , ECOLE NORM SUPERIEURE CACHAN , UNIV ILLES BALEARS , MOREL JEAN-MICHEL , COLL BARTOMEU , BUADES ANTONIO
发明人： MOREL JEAN-MICHEL , COLL BARTOMEU , BUADES ANTONIO
IPC分类号： G06T5/00 , G06K9/40 , G06T5/50 , H04N1/409
CPC分类号： G06T5/50 , G06T5/002 , G06T2207/20076
摘要： The invention concerns image data processing, through noise reduction comprising the following steps: associating a learning zone (ZA) with a reference point (Pref) of the image (IM); for each variable point (PC, PC', ) of the learning zone, evaluating a distance (d, d', ) between: values of points in a first window (f1) of the image, centered on the reference point, and values of points in a second window (f2, f'2, ), of similar format as the format of the first window and centered on the variable point; repeating said distance calculation for all the points of the learning zone as successive variable points and estimating an average value to assign to the reference point, said average being weighted on the basis of the distances evaluated for each variable point.
摘要翻译：本发明涉及通过降噪的图像数据处理，包括以下步骤：将学习区域（ZA）与图像（IM）的参考点（Pref）相关联; 对于学习区域的每个可变点（PC，PC'），评估以下之间的距离（d，d'）：以参考点为中心的图像的第一窗口（f1）中的点的值和值（f2，f'2，）中的点与第一窗口的格式类似，并以可变点为中心; 将所述学习区域的所有点的所述距离计算重复为连续可变点，并且估计分配给参考点的平均值，所述平均值基于针对每个可变点评估的距离进行加权。

4. 发明申请

WO2005095046A3 IMPROVED OPTICAL SURFACE ROUGHNESS MEASURING DEVICE, DEVICE FOR CONTROLLING THE POSITIONING OF THE PRISM THEREOF, METHOD FOR CONTROLLING THE PRISM POSITIONING AND METHOD FOR POSITIONING SAID PRISM 审中-公开
标题翻译：改进的光学表面粗糙度测量装置，用于控制其位置的装置，用于控制原始位置的方法和用于定位所述原始图像的方法
公开(公告)号：WO2005095046A3
公开(公告)日：2006-04-20
申请号：PCT/FR2005000772
申请日：2005-03-30
申请人： ECOLE NORM SUPERIEURE CACHAN , ABOU-KANDIL HISHAM , GAFFARD JEAN-PAUL , MESTRE MANUEL
发明人： ABOU-KANDIL HISHAM , GAFFARD JEAN-PAUL , MESTRE MANUEL
IPC分类号： B23Q1/62 , G01B11/27 , G01B11/30 , G01B5/00
CPC分类号： G01B11/303
摘要： The inventive optical measuring device comprises a system (14) for illuminating a surface area (12) connected upstream of a light source by light transmitting means (18) and a system (22) for receiving the image of said surface area (12). The light source comprises a laser source and said light transmitting means (18) comprises a single-mode transmission optical fibre (20). A device for controlling the positioning of the prism (34) of said device, a method for controlling the prism (34) positioning and method for positioning said prism using the method for controlling said positioning are also disclosed.
摘要翻译：本发明的光学测量装置包括用于照亮通过光发射装置（18）连接在光源上游的表面区域（12）的系统（14）和用于接收所述表面区域（12）的图像的系统（22）。光源包括激光源，所述光发射装置（18）包括单模传输光纤（20）。还公开了一种用于控制所述装置的棱镜（34）的定位的装置，用于控制棱镜（34）定位的方法以及使用用于控制所述定位的方法来定位所述棱镜的方法。

5. 发明申请

WO2009047298A3 DIMERS OF HARMOL OR OF ITS DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：哈默尔或其衍生物的二者及其用途
公开(公告)号：WO2009047298A3
公开(公告)日：2009-07-30
申请号：PCT/EP2008063546
申请日：2008-10-09
申请人： BIOALLIANCE PHARMA , ECOLE NORM SUPERIEURE CACHAN , CENTRE NAT RECH SCIENT , UNIV PARIS 11 PARIS SUD , DESMAELE DIDIER , AUCLAIR CHRISTIAN , ZOUHIRI FATIMA , POLARD VALERIE , MAKSIMENKO ANDREI
发明人： DESMAELE DIDIER , AUCLAIR CHRISTIAN , ZOUHIRI FATIMA , POLARD VALERIE , MAKSIMENKO ANDREI
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to a compound of formula (II)A-X-A wherein: A represents in particular a radical of formula (1): wherein R1 represents in particular a methyl group, R2 represents in particular an alkyl group of 1 to 10 carbon atoms, and R3 to R7 represent preferably H, X represents in particular an alkyl radical having 1 to 10 carbon atoms, for the treatment of cancer.
摘要翻译：本发明涉及式（II）的化合物AXA，其中：A特别表示式（1）的基团：其中R 1特别表示甲基，R 2特别表示1-10个碳原子的烷基， R3至R7优选表示H，X表示特别是具有1-10个碳原子的烷基用于治疗癌症。

6. 发明申请

WO2010020674A2 METHOD FOR PRODUCING INSULATED ELECTRODES FOR APPLYING ELECTRIC FIELDS INTO CONDUCTIVE MATERIAL 审中-公开
标题翻译：用于生产用于将电场应用于导电材料的绝缘电极的方法
公开(公告)号：WO2010020674A2
公开(公告)日：2010-02-25
申请号：PCT/EP2009060787
申请日：2009-08-20
申请人： CENTRE NAT RECH SCIENT , ECOLE NORM SUPERIEURE CACHAN , ROUSSY INST GUSTAVE , VILLEMEJANE JULIEN , LE PIOUFLE BRUNO , MIR LUIS MARIA , FRANCAIS OLIVIER , LEFEVRE JEAN-PIERRE
发明人： VILLEMEJANE JULIEN , LE PIOUFLE BRUNO , MIR LUIS MARIA , FRANCAIS OLIVIER , LEFEVRE JEAN-PIERRE
IPC分类号： A61N1/32
CPC分类号： A61N1/32 , A61N1/0412 , A61N1/042 , A61N1/0472 , A61N1/325 , A61N1/327
摘要： The present invention relates to a method for producing an insulated electrode comprising a conductive material coated with an electrically insulating material. Said method comprises at least the following step of: - forming a mould in an electrically insulating material, said mould comprising at least one channel, said mould being adapted to confine a conductive material, - introducing the conductive material in a liquid state into the channel of said mould, said conductive material having a melting point that is lower than the melting point of the electrically insulating material.
摘要翻译：本发明涉及一种绝缘电极的制造方法，该绝缘电极包括涂有电绝缘材料的导电材料。所述方法至少包括以下步骤： - 在电绝缘材料中形成模具，所述模具包括至少一个通道，所述模具适于限制导电材料， - 将液态的导电材料引入通道的所述模具，所述导电材料的熔点低于电绝缘材料的熔点。

7. 发明申请

WO2005120620A3 DURABLE HYDROPHILIC MOULDABLE POLYMER COMPOSITION, AQUEOUS FLUID CHANNELS BASED ON SAID COMPOSITION, MICROFLUIDIC SYSTEM INCORPORATING SAID CHANNELS AND METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：耐久性水溶性聚合物组合物，基于组合物的水性流体通道，包含该通道的微流体系统及其生产方法
公开(公告)号：WO2005120620A3
公开(公告)日：2006-05-04
申请号：PCT/FR2005001162
申请日：2005-05-10
申请人： CENTRE NAT RECH SCIENT , ECOLE NORM SUPERIEURE CACHAN , ASS POUR LES TRANSFERTS DE TEC , GRISCOM LAURENT , LE PIOUFLE BRUNO , LEGEAY GILBERT
发明人： GRISCOM LAURENT , LE PIOUFLE BRUNO , LEGEAY GILBERT
IPC分类号： A61M25/00 , B29C41/18 , B81B1/00 , C08J7/04 , C12Q1/00 , G01N33/53
CPC分类号： C08J7/047
摘要： The invention relates to a durable hydrophilic non-porous surface-modified polymer composition, to aqueous fluid channels based on said composition, to a microfluidic system comprising said channels, to a method for the production thereof and to a microfluidic chip or cells incorporating said composition.
摘要翻译：本发明涉及耐久性亲水性无孔表面改性聚合物组合物，基于所述组合物的水性流体通道，包含所述通道的微流体系统，其生产方法和结合所述组合物的微流体芯片或细胞。

8. 发明申请

WO2010066711A9 METHOD FOR OPTIMISING THE ROUTING OF PIPES ON A STRUCTURE WITH SMALL DEFORMATIONS 审中-公开
标题翻译：在具有小变形的结构上优化管道路由的方法
公开(公告)号：WO2010066711A9
公开(公告)日：2010-09-30
申请号：PCT/EP2009066592
申请日：2009-12-08
申请人： EADS EUROP AERONAUTIC DEFENCE , ECOLE NORM SUPERIEURE CACHAN , FALGARONE HUGO , MOUNAUD MATHIEU , THIEBAUT FRANCOIS , BOURDET PIERRE
发明人： FALGARONE HUGO , MOUNAUD MATHIEU , THIEBAUT FRANCOIS , BOURDET PIERRE
IPC分类号： G06F17/50
CPC分类号： G06F17/509 , G06F2217/34
摘要： The invention relates to a method for validating a routing, including a pipe made of at least two elementary segments, as well as at least two connection points for securing the pipe at compulsory passage points of a bearing structure having a predefined shape, the pipe and the bearing structure optionally having, in terms of the real geometry thereof, small geometry errors relative to the nominal values, wherein said method includes a step of estimating maximum acceptable geometric defects of the pipe and the compulsory passage points, a step of calculating the stress and movements at the characteristic points and at the attachment points of the real pipe when they are secured on the compulsory passage points corresponding thereto by pairs on the bearing structure, wherein the pipe and said compulsory passage points are assumed to be deformable under a mechanical stress, and a step of comparing a value based on said stress and movements with a threshold value.
摘要翻译：本发明涉及一种用于验证路线的方法，包括由至少两个基本段构成的管道，以及至少两个连接点，用于将管道固定在具有预定形状的轴承结构的强制通过点处，管道和根据其实际几何形状，轴承结构可以相对于标称值具有小的几何误差，其中所述方法包括估计管道和强制通过点的最大可接受的几何缺陷的步骤，计算应力的步骤以及在真实管道的特征点和连接点处的运动，当它们通过轴承结构上的对固定在与其对应的强制通道点上时，其中管道和所述强制通道点被假定为在机械应力下可变形以及将基于所述应力和运动的值与阈值进行比较的步骤。

9. 发明申请

WO2007135538A2 REVERSION OF MALIGNANT PHENOTYPE WITH 9-HYDROXY ELLIPTICINE DERIVATIVES 审中-公开
标题翻译：恶唑基衍生物与9-羟基衍生物的反应
公开(公告)号：WO2007135538A2
公开(公告)日：2007-11-29
申请号：PCT/IB2007001307
申请日：2007-05-21
申请人： BIOALLIANCE PHARMA , ECOLE NORM SUPERIEURE CACHAN , CENTRE NAT RECH SCIENT , AUCLAIR CHRISTIAN , POLARD VALERIE , MAKSIMENKO ANDREI
发明人： AUCLAIR CHRISTIAN , POLARD VALERIE , MAKSIMENKO ANDREI
CPC分类号： A61K31/475 , C07D471/04
摘要： The invention relates to the use of 9-hydroxy ellipticine derivatives for the treatment of cancer. 9-hydroxy ellipticine derivatives may prove particularly useful for the treatment of metastatic cancers or cancers escaping conventional cytotoxic chemotherapies.
摘要翻译：本发明涉及9-羟基玫瑰树碱衍生物用于治疗癌症的用途。 9-羟基玫瑰树碱衍生物可以证明对于治疗转移性癌症或逃避常规细胞毒性化学疗法的癌症特别有用。

10. 发明申请

WO2006016044B1 NOVEL MICROFLUIDIC SYSTEM AND METHOD FOR CAPTURING CELLS 审中-公开
标题翻译：新型微流体系统和捕获细胞的方法
公开(公告)号：WO2006016044B1
公开(公告)日：2006-04-06
申请号：PCT/FR2005001753
申请日：2005-07-07
申请人： CENTRE NAT RECH SCIENT , ECOLE NORM SUPERIEURE CACHAN , UNIV BORDEAUX 1 , BENNETAU BERNARD , TRAN PHUONG-LAN
发明人： BENNETAU BERNARD , TRAN PHUONG-LAN
IPC分类号： G01N33/566 , A61B10/00 , B01L3/00 , C12N5/06 , G01N33/543
CPC分类号： B01L3/5027 , B01L2300/0877 , B01L2400/0481 , G01N33/54366 , G01N33/574 , G01N35/1095 , G01N2035/00158 , G01N2035/1034
摘要： The invention concerns a microfluidic device and its uses for capturing subset of cells in a biological fluid. Said device comprises a chamber (1) for circulating fluids whereof an inner wall (5) is provided with a covalent immobilization surface in the form of an organized self-assembled silane layer, whereto is fixed a layer of biomolecules for specific identification of the population of cells.
摘要翻译：本发明涉及微流体装置及其用于捕获生物流体中的细胞的子集的用途。所述装置包括用于循环流体的腔室（1），其中内壁（5）设置有有组织的自组装硅烷层形式的共价固定表面，其中固定有一层生物分子用于特定的群体识别的细胞。

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