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1. 发明申请

WO1997028275A1 ELECTROCHEMILUMINESCENCE ENZYME ASSAY 审中-公开
标题翻译：电子荧光测定
公开(公告)号：WO1997028275A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001916
申请日：1997-02-05
申请人： IGEN INTERNATIONAL, INC. , MARTIN, Mark, T. , DONG, Liwen
发明人： IGEN INTERNATIONAL, INC.
IPC分类号： C12Q01/34
CPC分类号： C12Q1/34 , C12Q2334/00 , Y10S435/817 , Y10S435/968 , Y10S435/975
摘要： A rapid single step assay suitable for the detection or quantification of enzymes, in particular, hydrolases, such as aminopeptidases and esterases is described. The enzymatic reaction causes the cleavage of a metal ligand labeled hydrolase substrate. The cleavec ligand alters the electrochemiluminescence of bidentate aromatic heterocyclic nitrogen-containing ligand reagent. The change in electrochemiluminescence correlates to the presence of hydrolase activity present in the sample. The assay can be performed on an IGEN Origen Analyzer. The figure illustrates ECL detection of mixtures of ruthenium (II) tris(bipyridyl) and various concentrations of either picolinic acid (1) (black bars) or 2-pyridinecarboxylic acid ethyl ester (4) (white bars).
摘要翻译：描述了适用于检测或定量酶，特别是水解酶如氨基肽酶和酯酶的快速单步测定法。酶反应导致金属配体标记的水解酶底物的裂解。裂解配体改变二齿芳族杂环含氮配体试剂的电化学发光。电化学发光的变化与样品中存在的水解酶活性的存在相关。该测定可以在IGEN Origen分析仪上进行。该图示出了钌（II）三（联吡啶）和各种浓度的吡啶甲酸（1）（黑条）或2-吡啶羧酸乙酯（4）（白色条）的混合物的ECL检测。

2. 发明申请

WO1997032571A1 FUNCTIONALIZED NANOTUBES 审中-公开
标题翻译：功能性纳米粒子
公开(公告)号：WO1997032571A1
公开(公告)日：1997-09-12
申请号：PCT/US1997003553
申请日：1997-03-05
申请人： HYPERION CATALYSIS INTERNATIONAL, INC. , FISCHER, Alan , HOCH, Robert , MOY, David , LU, Ming , MARTIN, Mark , NIU, Chun, Ming , OGATA, Naoya , TENNENT, Howard , DONG, Liwen , SUN, Ji , HELMS, Larry , JAMEISON, Fabian , LIANG, Pam , SIMPSON, David
发明人： HYPERION CATALYSIS INTERNATIONAL, INC.
IPC分类号： A61K09/00
CPC分类号： G01N33/54346 , B01D15/08 , B01D15/3804 , B01D15/3857 , B01J20/28004 , B01J20/28009 , B01J20/28014 , B01J20/28019 , B01J20/28023 , B01J20/3204 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3257 , B01J20/3259 , B01J20/3261 , B01J20/3265 , B01J20/3274 , B01J20/3293 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B2202/34 , C01B2202/36 , C07K1/1075 , C07K1/1077 , C09C1/46 , C12N11/02 , C12Q1/26 , C12Q1/28 , C12Q1/37 , C12Q1/42 , C12Q1/44 , Y02P20/588
摘要： Graphitic nanotubes, which include tubular fullerenes (commonly called "buckytubes") and fibrils, which are functionalized by chemical substitution or by adsorption of functional moieties. More specifically the invention relates to graphitic nanotubes which are uniformly or non-uniformly substituted with chemical moieties or upon which certain cyclic compounds are adsorbed and to complex structures comprised of such functionalized nanotubes linked to one another. The invention also relates to methods for introducing functional groups onto the surface of such nanotubes. The invention further relates to uses for functionalized nanotubes.
摘要翻译：石墨纳米管，其包括管状富勒烯（通常称为“buckytubes”）和原纤维，其通过化学取代或功能部分的吸附官能化。更具体地，本发明涉及被化学部分均匀或不均匀地取代或其上吸附某些环状化合物的石墨纳米管以及由相互连接的这种官能化纳米管组成的复合结构。本发明还涉及在这种纳米管的表面上引入官能团的方法。本发明还涉及功能化纳米管的用途。

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