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1. 发明申请

WO2009045753A1 TRIAZOLOPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS 审中-公开
标题翻译：三唑基吡啶11-羟基甾体脱氢酶I型抑制剂
公开(公告)号：WO2009045753A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/076984
申请日：2008-09-19
申请人： BRISTOL-MYERS SQUIBB COMPANY , LI, Jun , ROBL, Jeffrey A. , LI, James J. , KENNEDY, Lawrence J. , WANG, Haixia , LI, Jie Jack , QIAN, Xinhua , DESHPANDE, Rajendra P. , KOLLA, Laxma R. , CANN, Reginald O. , WEI, Chenkou , GALELLA, Michael
发明人： LI, Jun , ROBL, Jeffrey A. , LI, James J. , KENNEDY, Lawrence J. , WANG, Haixia , LI, Jie Jack , QIAN, Xinhua , DESHPANDE, Rajendra P. , KOLLA, Laxma R. , CANN, Reginald O. , WEI, Chenkou , GALELLA, Michael
IPC分类号： C07D471/04 , A61K31/437 , A61P3/10 , A61P19/02
CPC分类号： C07D471/04
摘要： Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I: or stereoisomers or pharmaceutically acceptable salts thereof, wherein G, Q, X, Y, R 3 , R 3a , and R 3b are defined herein.
摘要翻译：提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。这些新颖的式I化合物或其立体异构体或其药学上可接受的盐，其中G，Q，X，Y，R 3，R 3a和R 3b在本文中定义。

2. 发明申请

WO2006069202A3 COMPOSITIONS COMPRISING ANTI-IGF-I RECEPTOR ANTIBODIES AND METHODS FOR OBTAINING SAID ANTIBODIES 审中-公开
标题翻译：包含抗IGF-I受体抗体的组合物和获得抗体的方法
公开(公告)号：WO2006069202A3
公开(公告)日：2007-02-22
申请号：PCT/US2005046493
申请日：2005-12-20
申请人： AMGEN INC , CALZONE FRANK J , DESHPANDE RAJENDRA V , TSAI MEI-MEI
发明人： CALZONE FRANK J , DESHPANDE RAJENDRA V , TSAI MEI-MEI
IPC分类号： C07K16/22 , A61K39/395 , A61P5/00 , A61P9/10 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/22 , C07K2317/14 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric antiIGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.
摘要翻译：本发明提供与抗IGF-1R抗体有关或衍生自抗IGF-1R抗体的组合物和方法。在具体实施方案中，本发明提供了结合人IGF-1R，IGF-1R结合片段和此类抗体衍生物的完整的人，人源化或嵌合抗-IGF-1R抗体，以及包含此类片段的IGF-1R结合多肽。其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断患有IGF-1R相关疾病或病症的受试者。

3. 发明申请

WO2005016904A1 PROCESS FOR PREPARING 4-ALKYL-OR 4-ARYL-OXYCARBONYL PACLITAXEL ANALOGS AND NOVEL INTERMEDIATES 审中-公开
标题翻译：制备4-烷基 - 或4-芳基 - 氧代羰基苯并噻唑类似物和新型中间体的方法
公开(公告)号：WO2005016904A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/025204
申请日：2004-08-03
申请人： BRISTOL-MYERS SQUIBB COMPANY , GIBSON, Frank, S. , KANT, Joydeep , DESHPANDE, Rajendra, P. , TENHUISEN, Karen, L. , LIANG, Jing , LI, Jun , BOETTGER, Susan, D. , GUBLO, Edward, J. , DHOKTE, Ulhas, P.
发明人： GIBSON, Frank, S. , KANT, Joydeep , DESHPANDE, Rajendra, P. , TENHUISEN, Karen, L. , LIANG, Jing , LI, Jun , BOETTGER, Susan, D. , GUBLO, Edward, J. , DHOKTE, Ulhas, P.
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , Y02P20/55
摘要： A process is provided for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs which includes the steps of converting paclitaxel into a C-7 acylprotected paclitaxel employing an electrophilic protecting group, such as benzoyloxycarbonyl, and converting the C-7 protected analog into the 4-alkyloxycarbonyl or 4-aryloxycarbonyl paclitaxel analog. Novel intermediates produced in the process are also provided.
摘要翻译：提供了一种制备4-烷基 - 或4-芳基 - 氧羰基紫杉醇类似物的方法，其包括使用亲电保护基如苯甲酰氧基羰基将紫杉醇转化为C-7酰基保护的紫杉醇的步骤，并将C-7保护的类似物进入4-烷氧基羰基或4-芳氧基羰基紫杉醇类似物。还提供了在该方法中生产的新型中间体。

4. 发明申请

WO2017195220A1 PROCESS FOR EXTRACTION OF CURCUMINOIDS 审中-公开
标题翻译：提取姜黄素的方法
公开(公告)号：WO2017195220A1
公开(公告)日：2017-11-16
申请号：PCT/IN2017/050174
申请日：2017-05-10
申请人： DESHPANDE, Rajendra Sham
发明人： DESHPANDE, Rajendra Sham , KULKARNI, Roshan Rajan
IPC分类号： A61K36/9066 , A61K36/00
CPC分类号： A61K36/9066 , A61K2236/00
摘要： A process (100/200/300/400) for extraction of curcuminoids is disclosed. The process (100/200/300/400) extracts curcuminoids finely powdered turmeric as a raw material using solvents such as supercritical fluid and acetic acid with a time tested human use that leaves no trace in the extract after conversion to the gaseous state. The process (100/200/300/400) results in extraction of solvent and heavy metal free nutraceuticals such as curcuminoids which may also be in a nanoparticle form.
摘要翻译：公开了用于提取姜黄色素的方法（100/200/300/400）。该方法（100/200/300/400）使用超临界流体和乙酸等溶剂提取姜黄素细粉状姜黄作为原料，并且经时间测试人类使用，在转化为气态后萃取物中不留痕迹。该方法（100/200/300/400）导致提取溶剂和不含重金属的营养食品，例如也可以纳米颗粒形式的姜黄色素。

5. 发明申请

WO2008006044A2 SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译：用作抗糖尿病药和抗衰老药的取代酸衍生物和方法
公开(公告)号：WO2008006044A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/072897
申请日：2007-07-06
申请人： BRISTOL-MYERS SQUIBB COMPANY , CHENG, Peter T.w. , CHEN, Sean , QIAN, Xinhua , DESHPANDE, Rajendra P. , TANG, Erqing
发明人： CHENG, Peter T.w. , CHEN, Sean , QIAN, Xinhua , DESHPANDE, Rajendra P. , TANG, Erqing
IPC分类号： C07D263/32 , A61K31/421 , A61P1/04 , A61P3/10 , A61P9/10 , A61P17/06 , A61P19/10
CPC分类号： C07D263/32
摘要： Compounds are provided which have the structure of Formula (I): wherein R is hydrogen or C1-C4 alkyl; and each of R1 and R2 is independently hydrogen, C1-C4 alkyl, halo or C1-C4 alkoxy, and salts thereof, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.
摘要翻译：提供了具有式（I）结构的化合物：其中R为氢或C 1 -C 4烷基; 并且每个R 1和R 2独立地为氢，C 1 -C 4烷基，卤代或C 1 -C 4烷氧基及其盐，所述化合物可用作抗糖尿病药，降血脂药和抗肥胖症药。

6. 发明申请

WO2005120727A1 COATER WITH SONIC OSCILLATOR METHOD AND APPARATUS 审中-公开
标题翻译：带有SONIC振荡器方法和装置的涂层
公开(公告)号：WO2005120727A1
公开(公告)日：2005-12-22
申请号：PCT/US2003/031949
申请日：2003-10-08
申请人： STORA ENSO NORTH AMERICA CORP. , DAMRAU, Wayne, A. , DESHPANDE, Rajendra, , PIONTEK, Michael
发明人： DAMRAU, Wayne, A. , DESHPANDE, Rajendra, , PIONTEK, Michael
IPC分类号： B06B1/00
CPC分类号： B05C5/0283 , B05B15/522 , D21H23/48 , D21H23/50
摘要： A coater for (450) a moving paper web (452), preferably of the jet type, is disclosed and provided with a sonic oscillator (520) forming a portion of the discharge orifice or exit tip (475), which is preferably adjacent the discharge of the coater (450) and which is opposite the side of the discharge likely to be applied the moving web (452). The sonic oscillator (520) keeps the orifice or tip (475) clean while minimizing any effect of the oscillator (520) on the coating actually applied to the web (452). The invention covers both a method and apparatus. A method, apparatus, system, and computer program product for clearing flow disruptions in the coating applicator and a web inspection system are also disclosed. The latter is downstream of the applicator (450) to detect coating defects and communicate a cross-machine location of the defect to activate vibrations at that location to clear the flow disruption.
摘要翻译：公开了一种用于（450）移动纸幅（452）的涂布机，优选地为喷射型，其具有形成排出孔或出口尖端（475）的一部分的声波振荡器（520），其优选地邻近于涂布机（450）的排出并且与可能被施加到移动幅材（452）的排出物的相反侧。声音振荡器（520）保持孔或尖端（475）清洁，同时使实际施加到幅材（452）的涂层上的振荡器（520）的任何影响最小化。本发明涵盖方法和装置。还公开了一种用于清除涂布器和卷材检查系统中的流动中断的方法，装置，系统和计算机程序产品。后者在施加器（450）的下游，以检测涂层缺陷并传达缺陷的跨机器位置以激活该位置处的振动，以清除流动中断。

7. 发明申请

WO2008006044A3 SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译：替代的酸衍生物作为抗真菌剂和抗菌药物和方法有用
公开(公告)号：WO2008006044A3
公开(公告)日：2008-04-10
申请号：PCT/US2007072897
申请日：2007-07-06
申请人： SQUIBB BRISTOL MYERS CO , CHENG PETER T W , CHEN SEAN , QIAN XINHUA , DESHPANDE RAJENDRA P , TANG ERQING
发明人： CHENG PETER T W , CHEN SEAN , QIAN XINHUA , DESHPANDE RAJENDRA P , TANG ERQING
IPC分类号： C07D263/32 , A61K31/421
CPC分类号： C07D263/32
摘要： Compounds are provided which have the structure of Formula (I): wherein R is hydrogen or C1-C4 alkyl; and each of R1 and R2 is independently hydrogen, C1-C4 alkyl, halo or C1-C4 alkoxy, and salts thereof, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.
摘要翻译：提供具有式（I）结构的化合物：其中R是氢或C 1 -C 4烷基; 并且R 1和R 2各自独立地为氢，C 1 -C 4烷基，卤素或C 1 -C 4烷氧基及其盐，所述化合物可用作抗糖尿病，降血脂药和抗肥胖剂。

8. 发明申请

WO2006069202A2 COMPOSITIONS AND METHODS RELATING TO ANTI IGF-1 RECEPTOR ANTIBODIES 审中-公开
标题翻译：与IGF-1受体抗体相关的组合物和方法
公开(公告)号：WO2006069202A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/046493
申请日：2005-12-20
申请人： AMGEN INC. , CALZONE, Frank, J. , DESHPANDE, Rajendra, V. , TSAI, Mei-Mei
发明人： CALZONE, Frank, J. , DESHPANDE, Rajendra, V. , TSAI, Mei-Mei
IPC分类号： C07K16/22 , A61K39/395 , A61P5/00 , A61P9/10 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/22 , C07K2317/14 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric antiIGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF-1R-related disorders or conditions.
摘要翻译：本发明提供与抗IGF-1R抗体有关或衍生自抗IGF-1R抗体的组合物和方法。在具体实施方案中，本发明提供了结合人IGF-1R，IGF-1R结合片段和此类抗体的衍生物的完整的人，人源化或嵌合抗-IGF-1R抗体，以及包含这些片段的IGF-1R结合多肽。其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断具有IGF-1R相关疾病或病症的受试者。

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