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1. 发明申请

WO2010082037A3 ACOUSTIC OSCILLATOR WITH ELECTRONIC FEED-BACK INCLUDING NON-LINEAR CONTROL 审中-公开
标题翻译：具有电子反馈的声学振荡器包括非线性控制
公开(公告)号：WO2010082037A3
公开(公告)日：2010-10-21
申请号：PCT/GB2010000069
申请日：2010-01-18
申请人： ISIS INNOVATION , GREGG JOHN FRANCIS , KARENOWSKA ALEXY DAVISON , COUSSIOS CONSTANTIN-CASSIOS
发明人： GREGG JOHN FRANCIS , KARENOWSKA ALEXY DAVISON , COUSSIOS CONSTANTIN-CASSIOS
IPC分类号： H03B5/12 , G01N29/036
CPC分类号： H03B5/30
摘要： An acoustic oscillator arrangement includes an acoustic system having at least one acoustic transmission path through it, and at least one mode. The acoustic transmission path is of variable length. A controller is provided with an amplifier and a feedback network which together provide a positive feedback oscillator for exciting a mode of the acoustic system. The feedback network comprises a non linear amplitude control element (N-LACE), a frequency dependent gain element with an electronic transfer function, and a phase compensator. The acoustic oscillator arrangement also includes an acoustic transmitter which launches an acoustic signal into the acoustic system based upon an output from the controller, and an acoustic receiver which receives an acoustic signal from the acoustic system which is fed back to the controller. Such a stabilized positive feedback arrangement is self exciting at the effective resonance frequency of the acoustic system and avoids the need for an external fixed or variable frequency driver.
摘要翻译：声振荡器装置包括具有通过其的至少一个声传播路径的声学系统和至少一种模式。声传播路径长度可变。控制器设置有放大器和反馈网络，其一起提供用于激励声学系统的模式的正反馈振荡器。反馈网络包括非线性幅度控制元件（N-LACE），具有电子传递函数的频率相关增益元件和相位补偿器。声振荡器装置还包括声发射器，其基于来自控制器的输出将声信号发射到声系统中;以及声接收器，其接收来自声系的声信号，该声接收器被反馈到控制器。这种稳定的正反馈装置在声学系统的有效谐振频率处是自激的，并且避免了对外部固定或可变频率驱动器的需要。

2. 发明申请

WO2012066334A1 SONOSENSITIVE NANOPARTICLES 审中-公开
标题翻译：苯基纳米粒子
公开(公告)号：WO2012066334A1
公开(公告)日：2012-05-24
申请号：PCT/GB2011/052244
申请日：2011-11-17
申请人： ISIS INNOVATION LIMITED , WAGSTAFFE, Sarah, Jayne , SCHIFFTER-WEINLE, Heiko, Alexander , MOLINARI, Michael, Bernard , ARORA, Manish , COUSSIOS, Constantin-Cassios
发明人： WAGSTAFFE, Sarah, Jayne , SCHIFFTER-WEINLE, Heiko, Alexander , MOLINARI, Michael, Bernard , ARORA, Manish , COUSSIOS, Constantin-Cassios
IPC分类号： A61K9/00 , A61K9/51
CPC分类号： A61K41/0033 , A61K9/0009 , A61K9/5115 , A61K9/5153 , A61K41/0028 , A61K49/222 , Y10T428/2982 , Y10T428/2998
摘要： A method of delivering a therapeutic substance to tissue comprises delivering the therapeutic substance and nanoparticles to the tissue, the nanoparticles having a diameter in the range from 10 to 1000nm and surface features having a depth in the range from 5 to 50nm, and insonating the tissue with pressure waves. Corresponding particles, and associated methods of controlling and imaging the treatment and delivery are also disclosed.
摘要翻译：将治疗物质递送到组织的方法包括将治疗物质和纳米颗粒递送至组织，纳米颗粒直径在10至1000nm范围内，表面特征具有5至50nm的深度，并且使组织与压力波。还公开了相应的颗粒以及控制和成像治疗和递送的相关方法。

3. 发明申请

WO2011161463A2 ACOUSTIC SEPARATORS 审中-公开
标题翻译：声音分离器
公开(公告)号：WO2011161463A2
公开(公告)日：2011-12-29
申请号：PCT/GB2011/051189
申请日：2011-06-24
申请人： ISIS INNOVATION LIMITED , COUSSIOS, Constantin , VENTIKOS, Yiannis , TRIPPA, Giuliana , TAGGART, David
发明人： COUSSIOS, Constantin , VENTIKOS, Yiannis , TRIPPA, Giuliana , TAGGART, David
IPC分类号： B01D21/28
CPC分类号： B01D21/28 , A61M1/363 , A61M1/3633 , A61M1/3678 , A61M1/3693 , B01D21/283 , B01D2221/10 , Y10T29/49826
摘要： An acoustic separator comprises: two parallel chamber walls defining a separation chamber therebetween, each chamber wall defining one side of the chamber; inlet means through which fluid can flow into the chamber; and outlet means through which fluid can flow out of the chamber. One of the chamber walls includes a transducer arranged to transmit pressure waves across the chamber towards the other of the chamber walls which in turn is arranged to reflect the pressure waves to set up a standing wave in the chamber. The outlet means defines an opening in one of the sides of the chamber.
摘要翻译：声分离器包括：两个平行的室壁，在其间限定分隔室，每个室壁限定室的一侧; 流体可以通过该入口装置流入腔室; 以及流体可以通过其流出室的出口装置。腔壁之一包括一个换能器，其被布置成将压力波穿过腔室朝向腔室壁中的另一个，这又被布置成反射压力波，以在腔室中建立驻波。出口装置在腔室的一个侧面中限定开口。

4. 发明申请

WO2011161463A3 ACOUSTIC SEPARATORS 审中-公开
标题翻译：声音分离器
公开(公告)号：WO2011161463A3
公开(公告)日：2012-05-03
申请号：PCT/GB2011051189
申请日：2011-06-24
申请人： ISIS INNOVATION , COUSSIOS CONSTANTIN , VENTIKOS YIANNIS , TRIPPA GIULIANA , TAGGART DAVID
发明人： COUSSIOS CONSTANTIN , VENTIKOS YIANNIS , TRIPPA GIULIANA , TAGGART DAVID
IPC分类号： B01D21/28 , A61M1/36
CPC分类号： B01D21/28 , A61M1/363 , A61M1/3633 , A61M1/3678 , A61M1/3693 , B01D21/283 , B01D2221/10 , Y10T29/49826
摘要： An acoustic separator comprises: two parallel chamber walls defining a separation chamber therebetween, each chamber wall defining one side of the chamber; inlet means through which fluid can flow into the chamber; and outlet means through which fluid can flow out of the chamber. One of the chamber walls includes a transducer arranged to transmit pressure waves across the chamber towards the other of the chamber walls which in turn is arranged to reflect the pressure waves to set up a standing wave in the chamber. The outlet means defines an opening in one of the sides of the chamber.
摘要翻译：声分离器包括：两个平行的室壁，在其间限定分隔室，每个室壁限定室的一侧; 流体可以通过该入口装置流入腔室; 以及流体可以通过其流出室的出口装置。腔壁之一包括一个换能器，其被布置成将压力波穿过腔室朝向腔室壁中的另一个，这又被布置成反射压力波，以在腔室中建立驻波。出口装置在腔室的一个侧面中限定开口。

5. 发明申请

WO2011036475A1 ULTRASOUND SYSTEMS 审中-公开
标题翻译：超声波系统
公开(公告)号：WO2011036475A1
公开(公告)日：2011-03-31
申请号：PCT/GB2010/051570
申请日：2010-09-20
申请人： ISIS INNOVATION LIMITED , COUSSIOS, Constantin , ARORA, Manish , HOCKHAM, Natalie , ROY, Ronald Aurele
发明人： COUSSIOS, Constantin , ARORA, Manish , HOCKHAM, Natalie , ROY, Ronald Aurele
IPC分类号： A61B8/00 , A61N7/02
CPC分类号： A61B8/00 , A61B17/22004 , A61B2018/00642 , A61B2018/00666 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0039 , B06B1/0207 , B06B2201/76
摘要： An ultrasound system comprises a transducer, a controller arranged to generate control signals arranged to control the transducer to generate pressure waves directed at a target volume, and sensing means arranged to sense cavitation in the target volume. The controller is arranged to receive sensing signals from the sensing means and to vary the control signals in response to the sensing signals thereby to control the cavitation.
摘要翻译：超声系统包括换能器，控制器，其布置成产生控制信号，所述控制信号被布置成控制所述换能器以产生指向目标体积的压力波;以及感测装置，其布置成感测所述目标体积中的空化。控制器被布置成从感测装置接收感测信号并且响应于感测信号改变控制信号，从而控制空化。

6. 发明申请

WO2010052494A1 MAPPING AND CHARACTERIZATION OF CAVITATION ACTIVITY 审中-公开
标题翻译：导航活动的映射和表征
公开(公告)号：WO2010052494A1
公开(公告)日：2010-05-14
申请号：PCT/GB2009/051482
申请日：2009-11-04
申请人： ISIS INNOVATION LIMITED , COUSSIOS, Constantin, C. , GYONGY, Miklos , ARORA, Manish , ROY, Ronald, Aurele
发明人： COUSSIOS, Constantin, C. , GYONGY, Miklos , ARORA, Manish , ROY, Ronald, Aurele
IPC分类号： A61N7/02
CPC分类号： A61B8/08 , A61B2017/00106 , A61B2017/22008 , A61B2090/378 , A61N7/00 , A61N7/02 , A61N2007/0052
摘要： Apparatus for locating bubbles in a subject comprises a plurality of pressure wave detectors arranged to operate as passive detectors to generate output signals in response to the receipt of pressure waves generated at a source comprising at least one bubble, and processing means arranged to receive signals from the detectors and to determine from the signals the position of the source.
摘要翻译：用于在对象中定位气泡的装置包括多个压力波检测器，其布置成响应于在包括至少一个气泡的源的接收到的压力波的接收而作为无源检测器而产生输出信号，以及处理装置，检测器并根据信号确定源的位置。

7. 发明申请

WO2012131383A1 INTERVERTEBRAL DISC TREATMENT APPARATUS 审中-公开
标题翻译：椎间盘治疗装置
公开(公告)号：WO2012131383A1
公开(公告)日：2012-10-04
申请号：PCT/GB2012/050714
申请日：2012-03-30
申请人： ISIS INNOVATION LIMITED , MOLINARI, Michael , SIVAN, Sarit , GIBBONS, Dare-Sean , ARORA, Manish , URBAN, Jill , COUSSIOS, Constantin
发明人： MOLINARI, Michael , SIVAN, Sarit , GIBBONS, Dare-Sean , ARORA, Manish , URBAN, Jill , COUSSIOS, Constantin
IPC分类号： A61B17/16 , A61B17/32
CPC分类号： A61B17/320068 , A61B17/22004 , A61B17/3472 , A61B2017/00261 , A61B2017/22008 , A61B2017/564 , A61B2018/00339 , A61B2090/378 , A61B2217/005 , A61N7/02 , A61N2007/0078
摘要： A method of at least partially removing the nucleus pulposus of an intervertebral disc comprising the nucleus and an annulus surrounding the nucleus is described. The method comprises the steps of : insonating the nucleus with ultrasound thereby to cause at least partial fragmentation of the nucleus; and extracting at least part of the fragmented nucleus. A system for performing the method is also described.
摘要翻译：描述了至少部分地去除包括核的椎间盘的髓核和围绕细胞核的环的方法。该方法包括以下步骤：用超声引发细胞核，从而使细胞核至少部分分裂; 并提取碎片核的至少一部分。还描述了用于执行该方法的系统。

8. 发明申请

WO2011036485A1 ULTRASOUND SYSTEMS 审中-公开
标题翻译：超声波系统
公开(公告)号：WO2011036485A1
公开(公告)日：2011-03-31
申请号：PCT/GB2010/051592
申请日：2010-09-22
申请人： ISIS INNOVATION LIMITED , COUSSIOS, Constantin , ROY, Ronald , ARORA, Manish , COLLIN, Jamie , TER HAAR, Gail , NANDLALL, Sacha D. , JACKSON, Edward
发明人： COUSSIOS, Constantin , ROY, Ronald , ARORA, Manish , COLLIN, Jamie , TER HAAR, Gail , NANDLALL, Sacha D. , JACKSON, Edward
IPC分类号： A61B8/00 , A61N7/02
CPC分类号： A61B8/00 , A61B2017/00084 , A61B2018/00642 , A61B2018/00666 , A61M37/0092 , A61N7/02 , A61N2007/0008 , A61N2007/0039
摘要： A sensing system for sensing the condition of an object comprises a transducer arranged to generate pressure waves directed at the object and detection means, such as a pressure wave detector, arranged to detect cavitation or other processes in the object. The system further comprises processing means arranged to receive detection signals from the detection means, to process the detection signals to measure a signal parameter of the detection signals that varies with a parameter of the object, and may generate a sensor output that varies in response to changes in the signal parameter.
摘要翻译：用于感测物体状态的感测系统包括一个传感器，其被配置成产生指向物体的压力波，以及检测装置，例如压力波检测器，其布置成检测物体中的空化或其它过程。该系统还包括处理装置，被配置为接收来自检测装置的检测信号，处理检测信号以测量根据对象的参数而变化的检测信号的信号参数，并且可以产生响应于信号参数的变化。

9. 发明申请

WO2010082037A2 ACOUSTIC OSCILLATOR 审中-公开
标题翻译：声学振荡器
公开(公告)号：WO2010082037A2
公开(公告)日：2010-07-22
申请号：PCT/GB2010/000069
申请日：2010-01-18
申请人： ISIS INNOVATION LIMITED , GREGG, John, Francis , KARENOWSKA, Alexy, Davison , COUSSIOS, Constantin-cassios
发明人： GREGG, John, Francis , KARENOWSKA, Alexy, Davison , COUSSIOS, Constantin-cassios
IPC分类号： H03B5/12 , G01N29/036
CPC分类号： H03B5/30
摘要： An acoustic oscillator arrangement includes an acoustic system having at least one acoustic transmission path through it, and at least one mode. The acoustic transmission path is of variable length. A controller is provided with an amplifier and a feedback network which together provide a positive feedback oscillator for exciting a mode of the acoustic system. The feedback network comprises a non linear amplitude control element (N-LACE), a frequency dependent gain element with an electronic transfer function, and a phase compensator. The acoustic oscillator arrangement also includes an acoustic transmitter which launches an acoustic signal into the acoustic system based upon an output from the controller, and an acoustic receiver which receives an acoustic signal from the acoustic system which is fed back to the controller. Such a stabilized positive feedback arrangement is self exciting at the effective resonance frequency of the acoustic system and avoids the need for an external fixed or variable frequency driver.
摘要翻译：声振荡器装置包括具有通过其的至少一个声传播路径的声学系统和至少一种模式。声传播路径长度可变。控制器设置有放大器和反馈网络，其一起提供用于激励声学系统的模式的正反馈振荡器。反馈网络包括非线性幅度控制元件（N-LACE），具有电子传递函数的频率相关增益元件和相位补偿器。声振荡器装置还包括声发射器，该声发射器基于来自控制器的输出将声信号发射到声系统中;以及声接收器，其接收来自声系的声信号，所述声信号被反馈到控制器。这种稳定的正反馈装置在声学系统的有效谐振频率处是自激的，并且避免了对外部固定或可变频率驱动器的需要。

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