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1. 发明申请

WO2015135511A1 CONJUGATES OF OLIGOMER OF HYALURONIC ACID OR OF A SALT THEREOF, METHOD OF PREPARATION THEREOF AND USE THEREOF 审中-公开
标题翻译：盐酸或其盐的低聚物结合体，其制备方法及其用途
公开(公告)号：WO2015135511A1
公开(公告)日：2015-09-17
申请号：PCT/CZ2015/000018
申请日：2015-03-10
申请人： CONTIPRO BIOTECH S.R.O.
发明人： BUFFA, Radovan , BASARABOVA, Ivana , NESPOROVA, Kristina , EHLOVA, Tereza , KOTLAND, Ondrej , SEDOVA, Petra , HROMEK, Leos , VELEBNY, Vladimir
IPC分类号： A61K47/48 , A61K31/728 , A61P35/00 , C08B37/00
CPC分类号： C08B37/0072 , A61K31/728 , A61K47/61
摘要： The invention relates to conjugates of hyaluronic acid oligomer according to the general formulae I, II III or IV, or a salt thereof, the method of preparation thereof and use thereof, where the oligomer is bonded to the respective substrate by its ending anomeric center via a bi-functional amino linker by means of an amino or imino bond. This type of conjugates allows releasing oligomers in their native form. The prepared systems exhibited an enhanced biological activity against selected lines of cancer cells.
摘要翻译：本发明涉及根据通式I，II III或IV的透明质酸低聚物或其盐，其制备方法和用途的缀合物，其中低聚物通过其末端异头中心经由通过氨基或亚氨基键的双官能氨基接头。这种类型的缀合物允许以其天然形式释放低聚物。所制备的系统对选定的癌细胞系表现出增强的生物活性。

2. 发明申请

WO2015074631A1 VOLUMINOUS NANOFIBROUS MATERIAL BASED ON HYALURONIC ACID, ITS SALT OR THEIR DERIVATIVES, METHOD OF PREPARATION THEREOF, METHOD OF MODIFICATION THEREOF, MODIFIED NANOFIBROUS MATERIAL, NANOFIBROUS STRUCTURE AND USE THEREOF 审中-公开
标题翻译：基于盐酸，其盐或其衍生物的制备的纳米材料，其制备方法，其改性方法，改性的纳米材料，纳米结构及其用途
公开(公告)号：WO2015074631A1
公开(公告)日：2015-05-28
申请号：PCT/CZ2014/000137
申请日：2014-11-21
申请人： CONTIPRO BIOTECH S.R.O.
发明人： RUZICKOVA, Jana , NOVAK, Jindrich , PRAVDA, Martin , BOBULA, Tomas , HUERTA-ANGELES, Gloria , BUFFA, Radovan , POKORNY, Marek , SLEZINGEROVA, Klara , VELEBNY, Vladimir
IPC分类号： D01F9/00 , D01D5/00 , C08B37/08
CPC分类号： D01F9/00 , C08B37/0072 , C08L5/08 , D01D5/0007
摘要： The invention relates to voluminous nanofibrous materials based on hyaluronic acid, salts thereof or their derivatives, wherein the volumetric weight is within the range of 1 kg.m -3 to 100 kg.m -3 . The preparation of such materials is conditioned especially by the relative humidity in the spinning chamber and the viscosity of the spinning solution. The voluminous nanofibrous materials prepared from photoactive derivatives of hyaluronic acid may be crosslinked by means of UV radiation or by heat treatment. The voluminous nanofibrous materials may be shaped to any nanofibrous structure by means of a weld. The disclosed materials and structures may be used in medicine or cosmetics.
摘要翻译：本发明涉及基于透明质酸，其盐或其衍生物的体积大的纳米纤维材料，其中体积重量在1kg.m-3至100kg.m-3的范围内。这种材料的制备特别是通过纺丝室中的相对湿度和纺丝溶液的粘度来调节。由透明质酸的光活性衍生物制备的大量纳米纤维材料可以通过UV辐射或通过热处理而交联。大量的纳米纤维材料可以通过焊缝成形为任何纳米纤维结构。所公开的材料和结构可以用于医药或化妆品。

3. 发明申请

WO2014082608A1 PHOTOREACTIVE DERIVATIVE OF HYALURONIC ACID, METHOD OF PREPARATION THEREOF, 3D-CROSSLINKED DERIVATIVE OF HYALURONIC ACID, METHOD OF PREPARATION AND USE THEREOF 审中-公开
标题翻译：羟丙酸的光敏衍生物，其制备方法，三羟甲基丙酸的交联衍生物，其制备方法及其用途
公开(公告)号：WO2014082608A1
公开(公告)日：2014-06-05
申请号：PCT/CZ2013/000155
申请日：2013-11-26
申请人： CONTIPRO BIOTECH S.R.O.
发明人： BOBULA, Tomas , POSPISIL, Robert , BUFFA, Radovan , RUZICKOVA, Jana , MORAVCOVA, Martina , KLEIN, Pavel , VELEBNY, Vladimir
IPC分类号： C08B37/08 , A61L27/20 , A61L31/04 , A61K47/36 , A61L15/28 , C08J3/24 , C08J3/28 , C08L5/08 , C08J3/075
CPC分类号： C08B37/0072 , A61K8/0212 , A61K8/735 , A61K9/0019 , A61K47/36 , A61L15/28 , A61L26/0023 , A61L27/20 , A61L31/042 , A61L2300/236 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C08J3/075 , C08J3/24 , C08J2305/08 , C08L5/08
摘要： The subject-matter of the invention is a photoreactive derivative of hyaluronic acid (formula I) and the method of preparation thereof, where first an aldehyde derivative of hyaluronic acid is prepared, oxidized in the position 6 of the glucosamine cycle and then the oxidized derivative reacts with an amine carrying a photoreactive species, for example l-(2- aminoethyl)pyridine-2(lH)-one, in the presence of a reducing agent, forming a photoreactive derivative. The prepared photoreactive derivative may be then photocrosslinked, wherein the reaction is based on [4+4] photocycloaddition. Moreover, the invention relates to a 3D- crosslinked derivative of hyaluronic acid (formula II) which exhibits an increased hydrolytic stability and improved sorption properties, with the possibility of a further design of the physical properties thereof according to the requirements of the final applications, and moreover, to the use thereof in tissue engineering, regenerative medicine, medical agents or formulations or cosmetics.
摘要翻译：本发明的主题是透明质酸（式I）的光反应性衍生物及其制备方法，其中首先制备透明质酸的醛衍生物，在葡糖胺循环的位置6被氧化，然后氧化的衍生物与携带光反应物质的胺（例如1-（2-氨基乙基）吡啶-2（1H） - 酮）在还原剂存在下反应，形成光反应衍生物。然后将制备的光反应性衍生物光交联，其中反应基于[4 + 4]光环加成。此外，本发明涉及透明质酸（式II）的3D交联衍生物，其表现出增加的水解稳定性和改善的吸附性能，可以根据最终应用的要求进一步设计其物理性能，此外，其在组织工程，再生医学，医药或制剂或化妆品中的应用。

4. 发明申请

WO2013127374A1 DERIVATES BASED ON HYALURONIC ACID, CAPABLE OF FORMING HYDROGELS, METHOD OF PREPARATION THEREOF, HYDROGELS BASED ON SAID DERIVATIVES, METHOD OF PREPARATION THEREOF AND USE 审中-公开
标题翻译：基于羟丙酸，可形成水凝胶的制剂，其制备方法，基于该衍生物的氢化物，其制备方法和用途
公开(公告)号：WO2013127374A1
公开(公告)日：2013-09-06
申请号：PCT/CZ2013/000023
申请日：2013-02-26
申请人： CONTIPRO BIOTECH S.R.O.
发明人： WOLFOVA, Lucie , PRAVDA, Martin , FOGLAROVA, Marcela , MEMCOVA, Miroslava , NIEDOBA, Krzystof , VELEBNY, Vladimir
IPC分类号： C08B37/08 , A61L27/52 , A61K8/73 , A61K47/36 , A61K47/48
CPC分类号： A61L27/20 , A61K8/735 , A61K2800/10 , A61L15/28 , A61L26/0023 , A61L31/042 , A61L2430/02 , A61L2430/06 , A61L2430/34 , A61Q19/00 , A61Q19/08 , C08B37/0072 , C08L5/08
摘要： The invention relates to a new hyaluronan derivative according to the general formula (I), the method of preparation thereof, a hydrogel based on the new derivative, method of preparation of the hydrogel and the use of the hydrogel in tissue engineering, cosmetics, medicine or regenerative medicine, especially in the form of scaffolds for the tratment of articular cartilage or bone tissue defects.
摘要翻译：本发明涉及根据通式（I）的新型透明质酸衍生物，其制备方法，基于新衍生物的水凝胶，水凝胶的制备方法和组合工程中的水凝胶的使用，化妆品，医药或再生医学，特别是用于关节软骨或骨组织缺损的支架的形式。

5. 发明申请

WO2014082610A1 ENDLESS FIBRES ON THE BASIS OF HYALURONAN SELECTIVELY OXIDIZED IN THE POSITION 6 OF THE N-ACETYL-D-GLUCOSAMINE GROUP, PREPARATION AND USE THEREOF, THREADS, STAPLES, YARNS, FABRICS MADE THEREOF AND METHOD FOR MODIFYING THE SAME 审中-公开
标题翻译：在N-乙酰-D-葡萄糖胺基团的位置6中选择性氧化的基础上的无丝纤维，其制备和用途，螺纹，织物，纱线及其制造方法及其修饰方法
公开(公告)号：WO2014082610A1
公开(公告)日：2014-06-05
申请号：PCT/CZ2013/000157
申请日：2013-11-26
申请人： CONTIPRO BIOTECH S.R.O.
发明人： BETAK, Jiri , BUFFA, Radovan , NEMCOVA, Miroslava , PITUCHA, Tomas , KULHANEK, Jaromir , MATEJKOVA, Ilona , NOVAKOVA, Jana , VISTEJNOVAK, Lucie , KLEIN, Pavel , KUBICKOVA, Gabriela , BROULIKOVA, Marketa , FELGROVA, Michaela , VELEBNY, Vladimir
IPC分类号： D01D5/06 , A61L27/20 , C08B37/08 , D06M13/332 , D06M13/422 , D06M23/10 , D01F9/00 , D02J13/00
CPC分类号： D01F11/00 , A61L27/20 , A61L27/50 , C08B37/0072 , C08L5/08 , D01D5/06 , D01F9/00 , D03D3/02 , D03D25/00 , D04H13/00 , D06M13/144 , D06M13/422 , D06M23/10 , D10B2331/06
摘要： The present invention relates to the preparation of textile processable endless monofilaments and multifilaments on the basis of hyaluronan which has been selectively oxidized to aldehyde in the position 6 of its /V-acetyl-D-glucosamine group and to the subsequent modification of such filaments with low molecular dihydrazides. The fibres as well as the fabrics, which are subsequently prepared from the former, exhibit a time-varying solubility in saline depending on the external modification of the fibres. After having been externally modified, the fibres as well as the fabrics exhibit a prolong period of transition into an evenly distributed gel layer. The externally modified fibrous materials retain their full biocompatibility.
摘要翻译：本发明涉及以透明质酸为基础的可纺加工无端单丝和复丝的制备方法，该透明质酸已经在其N-乙酰基-D-葡糖胺基团的位置6选择性氧化成醛，低分子二酰肼。随后由前者制备的纤维以及织物随着纤维的外部改性而在盐水中表现出时变的溶解性。在经过外部改性之后，纤维以及织物表现出延长的过渡到均匀分布的凝胶层的时间段。外部改性的纤维材料保持其完全的生物相容性。

6. 发明申请

WO2013167098A2 METHOD OF PREPARATION OF POLYSACCHARIDE FIBERS, WOUND COVERS THAT CONTAIN THEM, METHOD OF MANUFACTURING OF WOUND COVERS, AND APPARATUS FOR PREPARATION OF POLYSACCHARIDE FIBERS 审中-公开
标题翻译：多糖纤维的制备方法，包含它们的包围物，制造覆盖物的方法以及制备多糖纤维的装置
公开(公告)号：WO2013167098A2
公开(公告)日：2013-11-14
申请号：PCT/CZ2013/000063
申请日：2013-05-10
申请人： CONTIPRO BIOTECH S.R.O.
发明人： BURGERT, Ladislav , HRDINA, Radim , VELEBNY, Vladimir , ABDEL-LATTIF, Abdel Mohsen , SULAKOVA, Romana , SOBOTKA, Lubos , BETAK, Jiri , SMIRNOU, Dzianis
IPC分类号： D01D5/40
CPC分类号： A61L15/28 , A61F13/00063 , A61F13/00995 , A61L2300/60 , A61L2300/802 , C08L1/04 , C08L1/286 , C08L5/00 , C08L5/04 , C08L5/08 , D01D1/02 , D01D1/06 , D01D5/06 , D01D5/40 , D01F2/24 , D01F9/00 , D01F9/04 , D06M11/83 , D06M2101/02
摘要： The invention relates to the method of the preparation of polysaccharide fibres based on hyaluronic acid, a compound comprising hyaluronic acid and metal ions, schizophylan, chitin/chitosan-glucan complex, a compound comprising chitin/chitosan-glucan complex and metal ions, internal mixture of chitin and chitosan, a compound comprising internal mixture of chitin and metal ions, sodium alginate, potassium alginate, ammonium alginate, xanthane, xanthane sodium salt, xanthane potassium salt, oxycellulose, oxycellulose sodium salt, oxycellulose potassium salt, carboxymethyl cellulose, carboxymethyl cellulose sodium salt, and carboxymethyl cellulose potassium salt, or a mixture of polysaccharides, in a non-stationary coagulation bath. Further the invention relates to covers of internal and external wounds and skin defects based on these fibres, and a method of production thereof, and the apparatus for the preparation of polysaccharide fibres.
摘要翻译：本发明涉及制备基于透明质酸的多糖纤维的方法，包括透明质酸和金属离子的化合物，分枝杆菌素，壳多糖/壳聚糖 - 葡聚糖复合物，包含甲壳质/壳聚糖 - 葡聚糖复合物和金属离子的化合物，内部混合物几丁质和壳聚糖的组合物，包括壳多糖和金属离子的内部混合物，藻酸钠，藻酸钾，藻酸铵，黄原酸钠，黄原钠盐，黄烷钾盐，氧化纤维素，氧化纤维素钠盐，氧化纤维素钾盐，羧甲基纤维素，羧甲基纤维素钠盐和羧甲基纤维素钾盐，或多糖的混合物，在非固定凝固浴中。此外，本发明涉及基于这些纤维的内部和外部伤口和皮肤缺陷的覆盖物及其制备方法，以及制备多糖纤维的装置。

7. 发明申请

WO2012146218A1 AMPHOTERIC MATERIALS BASED ON CROSSLINKED HYALURONIC ACID, METHOD OF PREPARATION THEREOF, MATERIALS CONTAINING ENTRAPPED ACTIVE AGENTS, METHOD OF PREPARATION THEREOF, AND USE OF SAID MATERIALS 审中-公开
标题翻译：基于交联的羟丙酸的农药材料，其制备方法，含有活化剂的材料，其制备方法和使用的材料
公开(公告)号：WO2012146218A1
公开(公告)日：2012-11-01
申请号：PCT/CZ2012/000035
申请日：2012-04-19
申请人： CONTIPRO BIOTECH S.R.O. , HUERTA-ANGELES, Gloria , CHLADKOVA, Drahomira , BUFFA, Radovan , KETTOU, Sofiane , VELEBNY, Vladimir
发明人： HUERTA-ANGELES, Gloria , CHLADKOVA, Drahomira , BUFFA, Radovan , KETTOU, Sofiane , VELEBNY, Vladimir
IPC分类号： C08B37/00 , A61K9/20 , A61K47/36
CPC分类号： A61K47/36 , A61K9/06 , A61K31/416 , A61K31/704 , A61K35/32 , C08B37/0072
摘要： The present invention describes novel amphoteric materials based on crosslinked hyaluronic acid, according to the general formula (I), and a method of preparation of said materials. Further, the invention relates to the material containing entrapped active agents (e.g. drugs, growth factors etc.) and a method of preparation thereof. Moreover, the present invention relates to the use of said materials for controlled release systems, in tissue engineering, wound dressing or tissue regeneration.
摘要翻译：本发明描述了根据通式（I）的基于交联透明质酸的新型两性材料及其制备方法。此外，本发明涉及包含截留的活性剂（例如药物，生长因子等）的材料及其制备方法。此外，本发明涉及所述材料用于控释系统，组织工程，伤口敷料或组织再生中的用途。

8. 发明申请

WO2014180455A1 METHOD OF PREPARATION OF 2-OXOGLUTARATE ESTER, PREPARATION CONTAINING 2-OXOGLUTARATE ESTER AND USE THEREOF 审中-公开
标题翻译： 2-氧代苹果酸酯的制备方法，含有2-氧代苹果酸酯的制备及其用途
公开(公告)号：WO2014180455A1
公开(公告)日：2014-11-13
申请号：PCT/CZ2014/000050
申请日：2014-05-05
申请人： CONTIPRO BIOTECH S.R.O.
发明人： KLEIN, Pavel , PRAVDA, Martin , BUFFA, Radovan , MATEJKOVA, Ilona , VELEBNY, Vladimir
IPC分类号： C07C67/08 , C07C69/716 , C07D333/16 , C07D295/088 , A61K8/37 , A61K8/49 , A61Q19/00
CPC分类号： C07D333/16 , A61K8/37 , A61K8/4926 , A61K8/4986 , A61Q19/08 , C07C67/08 , C07C2601/14 , C07C2601/16 , C07D295/088 , C07C69/716
摘要： The invention relates to a method of preparation of 2-oxoglutarate ester, a preparation containing 2-oxoglutarate ester and use thereof for supporting collagen biosynthesis.
摘要翻译：本发明涉及2-氧戊二酸酯的制备方法，含有2-氧戊二酸酯的制剂及其用于支持胶原生物合成的方法。

9. 发明申请

WO2014048406A1 ENZYME HYALURONAN-LYASE, METHOD OF PRODUCTION THEREOF, USE THEREOF AND METHOD OF PREPARATION OF LOW-MOLECULAR HYALURONAN 审中-公开
标题翻译： ENZYME HYALURONAN-LYASE，其生产方法，其用途及其制备低分子羟基磷灰石的方法
公开(公告)号：WO2014048406A1
公开(公告)日：2014-04-03
申请号：PCT/CZ2013/000116
申请日：2013-09-26
申请人： CONTIPRO BIOTECH S.R.O.
发明人： KNOROVA, Lenka , SMIRNOU, Dzianis , LEIEROVA, Veronika , KRCMAR, Martin , FRANKE, Lukas , VELEBNY, Vladimir
IPC分类号： C12N9/88 , C07K14/375 , C12P19/04
CPC分类号： C12P19/26 , C12N9/88 , C12P19/04 , C12P19/12 , C12Y402/02001
摘要： The invention relates to an enzyme which is able to degrade hyaluronic acid and which is produced by fungi of the genus Fistulina (especially Fistulina hepatica ). The degradation proceeds by lyase mechanism in which double bonds between C4 and C5 of glucuronic acid are formed. The invention also includes the process of preparation and purification of the enzyme and a possible practical use thereof for the preparation of low-molecular hyaluronan or of cosmetic or pharmaceutical devices. Further, the invention relates to the method of preparation of low-molecular hyaluronan.
摘要翻译：本发明涉及一种能够降解透明质酸并由瘘管真菌（特别是肝瘘）产生的酶。通过裂解酶机理进行降解，其中形成葡萄糖醛酸的C4和C5之间的双键。本发明还包括酶的制备和纯化方法及其可用于制备低分子透明质酸或化妆品或药物装置的实际应用。此外，本发明涉及低分子透明质酸的制备方法。

10. 发明申请

WO2014023272A1 HYALURONIC ACID DERIVATIVE, METHOD OF PREPARATION THEREOF, METHOD OF MODIFICATION THEREOF AND USE THEREOF 审中-公开
标题翻译：羟丙酸衍生物，其制备方法，其改性方法及其用途
公开(公告)号：WO2014023272A1
公开(公告)日：2014-02-13
申请号：PCT/CZ2013/000091
申请日：2013-08-05
申请人： CONTIPRO BIOTECH S.R.O.
发明人： BUFFA, Radovan , SEDOVA, Petra , WOLFOVA, Lucie , BASARABOVA, Ivana , POSPISIL, Robert , HASOVA, Martina , NESPOROVA, Kristina , VELEBNY, Vladimir
IPC分类号： C08B37/00 , A61K31/728 , C08G81/00
CPC分类号： C08B37/0072 , A61K47/61 , C07K17/10 , C08J3/075 , C08J2305/00
摘要： The invention relates to the preparation and use of α,β-unsaturated aldehyde of hyaluronan having a double bond in the positions 4 and 5 and an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. The method of preparation is based on dehydration of hyaluronan having an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. Two methods have been described, which are dehydration in a solution or heating in solid state in absence of solvents, bases or other additives. This derivative allows stabilization of conjugates of hyaluronan with amino compounds by means of a multiple bond from the aldehyde side, and therefore, it is possible to effectively immobilize practically any compound containing an amino group to such modified hyaluronan in physiological conditions. In case of using a diamine or compounds or polymers containing three or more amino groups, it is possible to prepare crosslinked hyaluronan derivatives. The described solution brings along a significant advantage not only in the field of carriers of biologically active substances, but also in tissue engineering where crosslinking with biologically acceptable amino compounds in physiological conditions is very much demanded.
摘要翻译：本发明涉及在位置4和5具有双键的透明质酸的α，β-不饱和醛和多糖的葡糖胺部分6位的醛基的制备和用途。制备方法是基于在多糖的葡糖胺部分的位置6中具有醛基的透明质酸的脱水。已经描述了两种方法，其在溶液中脱水或在没有溶剂，碱或其它添加剂的情况下以固态加热。该衍生物允许透明质酸与氨基化合物的缀合物通过来自醛侧的多重键进行稳定化，因此，有可能在生理条件下实际上将含有氨基的任何化合物有效地固定在这种修饰的透明质酸上。在使用二胺或含有三个以上氨基的化合物或聚合物的情况下，可以制备交联的透明质酸衍生物。所描述的解决方案不仅在生物活性物质的载体领域具有显着的优点，而且在组织工程中，其中非常需要在生理条件下与生物可接受的氨基化合物进行交联。

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