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1. 发明申请

WO2018183800A1 SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE AND (4'-HYDROXYPHENYL)CYCLOALKENE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM FOR ENHANCED MEMORY CONSOLIDATION 审中-公开
公开(公告)号：WO2018183800A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025342
申请日：2018-03-30
申请人： MARQUETTE UNIVERSITY , CONCORDIA UNIVERSITY, INC. , UWM RESEARCH FOUNDATION, INC.
发明人： DONALDSON, William A. , SEM, Daniel S. , FRICK, Karyn
IPC分类号： C07C39/17 , C07D311/00 , A61K31/05 , A61K31/351 , A61P25/28
摘要： Disclosed are substituted (4'-hydroxylphenyl)cycloalkane compounds and substituted (4'-hydroxylphenyl)cycloalkene compounds and there use as selective agonists of the estrogen receptor beta isoform (ERβ). The disclosed compounds may be formulated as pharmaceutical compositions and administered for treating diseases associated with ER activity, such as neurological, psychiatric, and/or cell proliferative diseases and disorders as well as for enhancing memory consolidation in subjects in need thereof.

2. 发明申请

WO2019032589A1 EPLERENONE FOR PHENOTYPING OF CYP3A5 ENZYME ACTIVITY IN SALIVA SAMPLES 审中-公开
公开(公告)号：WO2019032589A1
公开(公告)日：2019-02-14
申请号：PCT/US2018/045618
申请日：2018-08-07
申请人： CONCORDIA UNIVERSITY, INC.
发明人： MCGRAW, Joseph , GERHARDT, Armin
IPC分类号： A61K31/192 , A61K31/4439 , A61K31/522 , A61K31/585 , C12Q1/00 , G01N33/50
摘要： Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize substrate for CYP3A5 comprising eplerenone which may be administered orally to a subject. Subsequently, metabolites of eplereone may be detected in the subject's saliva as well as any non- metabolized eplerenone to calculate a metabolic ratio for CYP3A5 enzyme in order to generate a phenytopic CYP3A5 enzyme profile for the subject.

3. 发明申请

WO2014140171A1 NOVEL CELL WALL DECONSTRUCTION ENZYMES OF THIELAVIA AUSTRALIENSIS AND USES THEREOF 审中-公开
标题翻译：泰利亚澳大利亚新型细胞壁分解酶及其用途
公开(公告)号：WO2014140171A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054954
申请日：2014-03-13
申请人： DSM IP ASSETS B.V. , CONCORDIA UNIVERSITY
发明人： TSANG, Adrian , BUTLER, Gregory , POWLOWSKI, Justin
IPC分类号： C12P19/02 , C12P19/14 , C13K1/02 , C12N9/42 , C12P7/10
CPC分类号： C12P19/02 , C12P7/10 , C12P19/14 , C12Y302/01091 , C13K1/02 , Y02E50/16
摘要： The present invention relates to a novel process for degrading biomass or pretreated biomass to sugars wherein an enzyme is used comprising a. a polypeptide comprising an amino acid sequence of any one of SEQ ID NOs: 7- 9; b. a polypeptide comprising an amino acid sequence that is at least 85%, preferably at least 90%, more preferably at least 95%, even more preferably at least 96%, 97%, 98% or 99% amino acid sequence identity to the polypeptide defined in (a); c. a polypeptide comprising an amino acid sequence encoded by the nucleic acid sequence of any one of SEQ ID NOs: 1 -6; d. a polypeptide comprising an amino acid sequence encoded by a polynucleotide molecule that hybridizes under medium-high stringency conditions, high stringency conditions, or very high stringency conditions with the full-length complement of a polynucleotide molecule comprising the nucleic acid sequence of any one of SEQ ID NOs: 1 -6; e. a polypeptide comprising an amino acid sequence encoded by a polynucleotide molecule having at least 85%, at least 90%, at least 91 %, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% nucleic acid sequence identity to a polynucleotide comprising the nucleic acid sequence of any one of SEQ ID NOs: 1 -6; or f. a polypeptide comprising an amino acid sequence encoded by any one of the exonic nucleic acid sequences corresponding to positions: 1-92, 150-654, 815-1385, 1452-1714 of SEQ ID NO: 2; 1 -246, 324-1007, 1082-1 135 of SEQ ID NO: 1; 1-394, 506-789 of SEQ ID NO: 3.
摘要翻译：本发明涉及将生物质或预处理的生物质降解成糖的新方法，其中使用的酶包括a。包含SEQ ID NO：7-9中任一个的氨基酸序列的多肽; 湾一种多肽，其包含与多肽的至少85％，优选至少90％，更优选至少95％，甚至更优选至少96％，97％，98％或99％氨基酸序列同一性的氨基酸序列（a）中定义; C。包含由SEQ ID NO：1-6中任一个的核酸序列编码的氨基酸序列的多肽; 天。包含由多核苷酸分子编码的氨基酸序列的多肽，其在中高度严格条件，高严格条件或非常高严格条件下与包含SEQ ID NO中任一个核酸序列的多核苷酸分子的全长互补序列杂交身份证号：1 -6; 即包含由多核苷酸分子编码的氨基酸序列的多肽，所述多核苷酸分子至少具有85％，至少90％，至少91％，至少92％，至少93％，至少94％，至少95％与包含SEQ ID NO：1-6中任一个的核酸序列的多核苷酸的核酸序列同一性为96％，至少97％，至少98％或至少99％或f。包含由对应于SEQ ID NO：2的1-92,150-654,815-1385,1452-1714位置的任何一个外显子核酸序列编码的氨基酸序列的多肽; SEQ ID NO：1的1 -246,324-1007,1028-135; SEQ ID NO：3的1-394,506-789。

4. 发明申请

WO2014140165A1 CELL WALL DECONSTRUCTION ENZYMES OF PAECILOMYCES BYSSOCHLAMYDOIDES AND USES THEREOF 审中-公开
标题翻译：细胞壁分解酶的分解及其用途
公开(公告)号：WO2014140165A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054946
申请日：2014-03-13
申请人： DSM IP ASSETS B.V. , CONCORDIA UNIVERSITY
发明人： TSANG, Adrian , POWLOWSKI, Justin , BUTLER, Gregory
IPC分类号： C12P19/02 , C12P19/14 , C12N9/24 , C12P7/10
CPC分类号： C12P19/02 , C12N9/2402 , C12N9/2445 , C12P7/10 , C12P19/14 , C12P2201/00 , C12P2203/00 , C12Y302/01021 , Y02E50/16
摘要： The present invention relates to a process for degrading biomass or pretreated biomass to sugars wherein an enzyme is used comprising a.a polypeptide comprising an amino acid sequence of any one of SEQ ID NOs: or 6; b.a polypeptide comprising an amino acid sequence that is at least 85%, preferably at least 90%, more preferably at least 95%, even more preferably at least 96%, 97%, 98% or 99%amino acid sequence identity to the polypeptide defined in (a); c.a polypeptide comprising an amino acid sequence encoded by the nucleic acid sequence of any one of SEQ ID NOs: 1-4; d.a polypeptide comprising an amino acid sequence encoded by a polynucleotide molecule that hybridizes under medium-high stringency conditions, high stringency conditions, or very high stringency conditions with the full-length complement of a polynucleotide molecule comprising the nucleic acid sequence of any one of SEQ ID NOs: 1-4; e.a polypeptide comprising an amino acid sequence encoded by a polynucleotide molecule having at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% nucleic acid sequence identity to a polynucleotide comprising the nucleic acid sequence of any one of SEQ ID NOs: 1-4; or f.a polypeptide comprising an amino acid sequence encoded by any one of the exonic nucleic acid sequences corresponding to positions: 1-60, 139-278, 341-385, 445- 497, 556-2834 of SEQ ID NO: 1; 1-101, 154-823 SEQ ID NO: 2.
摘要翻译：本发明涉及将生物质或预处理的生物质降解成糖的方法，其中使用包含a.a多肽的酶，所述多肽包含SEQ ID NO：或6中任一个的氨基酸序列; ba多肽，其包含与多肽的至少85％，优选至少90％，更优选至少95％，甚至更优选至少96％，97％，98％或99％氨基酸序列同一性的氨基酸序列（a）中定义; c.a多肽，其包含由SEQ ID NO：1-4中任一个的核酸序列编码的氨基酸序列; da多肽，其包含由多核苷酸分子编码的氨基酸序列，其在中高度严格条件，高严格条件或非常高严格条件下与包含SEQ ID NO中任一个核酸序列的多核苷酸分子的全长互补序列杂交身份证号：1-4; ea多肽，其包含由多核苷酸分子编码的氨基酸序列，所述多核苷酸分子至少具有85％，至少90％，至少91％，至少92％，至少93％，至少94％，至少95％与包含SEQ ID NO：1-4中任一个的核酸序列的多核苷酸的核酸序列同一性为96％，至少97％，至少98％或至少99％或f.a多肽，其包含由对应于SEQ ID NO：1的1-60,139-278,341-385,445-497,556-2834的任一个的外显子核酸序列编码的氨基酸序列; 1-101,154-823 SEQ ID NO：2。

5. 发明申请

WO2014060380A1 CELL WALL DECONSTRUCTION ENZYMES OF THERMOASCUS AURANTIACUS AND USES THEREOF 审中-公开
标题翻译：热门微生物细胞壁分解酶及其用途
公开(公告)号：WO2014060380A1
公开(公告)日：2014-04-24
申请号：PCT/EP2013/071466
申请日：2013-10-15
申请人： DSM IP ASSETS B.V. , CONCORDIA UNIVERSITY
发明人： TSANG, Adrian , POWLOWSKI, Justin , BUTLER, Gregory
IPC分类号： C12P19/14 , C12P7/10
CPC分类号： C12P7/10 , C12P19/14 , C12P2201/00 , Y02E50/16
摘要： The present invention relates tonovel Thermoascus aurantiacus enzymes or proteins for cell wall deconstruction, polynucleotide sequences encoding the polypeptides according to the invention, a production process for the enzymes according to the invention and the use of the enzymes according to the invention in various industrial processes.
摘要翻译：本发明涉及用于细胞壁解构的tonovel辣根过氧化物酶或蛋白质，编码根据本发明的多肽的多核苷酸序列，根据本发明的酶的制备方法和根据本发明的酶在各种工业过程中的用途。

6. 发明申请

WO2014059541A1 NOVEL CELL WALL DECONSTRUCTION ENZYMES OF THERMOASCUS AURANTIACUS, MYCELIOPHTHORA FERGUSII (CORYNASCUS THERMOPHILUS), AND PSEUDOCERCOSPORELLA HERPOTRICHOIDES, AND USES THEREOF 审中-公开
标题翻译：热环孢菌素（MYCELIOPHTHORA FERGUSII，CORYNASCUS THERMOPHILUS）的新型细胞壁分解酶及其衍生物及其用途
公开(公告)号：WO2014059541A1
公开(公告)日：2014-04-24
申请号：PCT/CA2013/050778
申请日：2013-10-15
申请人： CONCORDIA UNIVERSITY
发明人： TSANG, Adrian , POWLOWSKI, Justin , BUTLER, Gregory
IPC分类号： C12N15/55 , A21D13/06 , A23K1/16 , A23L1/28 , A23L1/305 , C07K14/37 , C07K16/14 , C07K16/40 , C12N15/31 , C12N15/52 , C12N15/53 , C12N15/63 , C12N15/80 , C12N9/00 , C12N9/02 , C12N9/14 , C12P7/06 , D06M16/00 , D06P5/00 , D21C5/00 , D21C9/00
CPC分类号： D06M16/003 , A21D8/042 , A23K10/14 , A23K10/30 , A23K20/189 , A23K50/30 , A23K50/75 , A23L29/06 , C07K14/37 , C12N9/00 , C12N9/14 , C12N9/16 , C12N9/24 , C12N15/52 , C12P7/10 , C12P19/02 , C12P19/14 , D06P5/02 , D06P5/158 , D21C5/005 , D21C11/0007 , D21H17/005 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to novel polypeptides and enzymes (e.g., thermostable proteins and enzymes) having activities relating to biomass processing and/or degradation (e.g., cell wall deconstruction), as well as polynucleotides, vectors, cells, compositions and tools relating to same, or functional variants thereof. More particularly, the present invention relates to secreted enzymes that may be isolated from the fungi, Thermoascus aurantiacus strain CBS 181.67, Myceliophthora fergusii (Corynascus thermophilus) strain CBS 405.69, and Pseudocercosporella herpotrichoides strain 494.80. Uses thereof in various industrial processes such as in biofuels, food preparation, animal feed, pulp and paper, textiles, detergents, waste treatment and others are also disclosed.
摘要翻译：本发明涉及具有与生物量加工和/或降解（例如，细胞壁解构）有关的活性的新型多肽和酶（例如热稳定蛋白和酶），以及与其相关的多核苷酸，载体，细胞，组合物和工具，或其功能变体。更具体地说，本发明涉及可从真菌分离的分泌的酶，例如嗜热黄曲霉菌株CBS 181.67，嗜热丝孢杆菌（Corynascus thermophilus）菌株CBS 405.69和假铁孢杆菌菌株494.80。还公开了在生物燃料，食品制备，动物饲料，纸浆和纸，纺织品，洗涤剂，废物处理等各种工业过程中的应用。

7. 发明申请

WO2013182671A1 CELL WALL DECONSTRUCTION ENZYMES OF AUREOBASIDIUM PULLULANS AND USES THEREOF 审中-公开
标题翻译：黄萎病菌细胞壁分解酶及其用途
公开(公告)号：WO2013182671A1
公开(公告)日：2013-12-12
申请号：PCT/EP2013/061769
申请日：2013-06-07
申请人： DSM IP ASSETS B.V. , CONCORDIA UNIVERSITY
发明人： TSANG, Adrian , POWLOWSKI, Justin , BUTLER, Gregory
IPC分类号： C07K14/37 , C12N9/42
CPC分类号： C12P7/10 , C12N9/2434 , C12N9/2437 , C12P19/02 , C12P19/14 , C12P2201/00 , C12P2203/00 , Y02E50/16
摘要： The present invention relates to process for degrading biomass or pretreated biomass to sugars wherein an enzyme is used comprising a polypeptide having a.a polypeptide sequence as set forth in any one of SEQ ID Nos:3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 44, 47 and 50; b.a polypeptide that is at least 60%, preferably at least 70%, more preferably at least 80%, even more preferably at least 90%, 95%, 96%, 97%,98% or 99% homologous to the any one of SEQ ID Nos:3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 44, 47 and 50; c.a polypeptide sequence encoded by nucleic acids sequence as set forth in any one of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 7, 19, 20, 22, 23, 25, 26, 28, 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 45, 46, 48 and 50, or nucleic acids that are at least 60%, preferably at least 70%, more preferably at least 80%, even more preferably at least 90%, 95%, 96%, 97%, 98% or 99% homologous to any one of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 17, 9, 20, 22, 23, 25, 26, 28, 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 45, 46, 48 and 50; d.a polypeptide sequence encoded by a nucleic acids sequence hybridizing under stringent conditions to the polynucleotide as set forth in any one of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 7, 19, 20, 22, 23, 25, 26, 28, 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 45, 46, 48 and 50; or e.a polypeptide sequence encoded by a nucleic acids sequence hybridizing under stringent conditions to the reverse complement of a polynucleotide as set forth in any one of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 17, 19, 20, 22, 23, 25, 26, 28, 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 45, 46, 48 and 50.
摘要翻译：本发明涉及将生物质或预处理的生物质降解成糖的方法，其中使用的酶包括具有如SEQ ID No：3,6,9,12,15,18,21中任一项所示的多肽序列的多肽，24,27,30,33,36,39,42,44,47和50; ba多肽，其与任何一种的至少60％，优选至少70％，更优选至少80％，甚至更优选至少90％，95％，96％，97％，98％或99％同源 SEQ ID No：3,6,9,12,15,18,21,24,27,30,33,36,39,42,44,47和50; 由SEQ ID NO：1,2,4,5,7,8,10,11,13,14,16,17,19,20,22,23中任一个所示的核酸序列编码的多肽序列，25,26,28,29,31,32,34,35,37,38,40,41,43,45,46,48和50，或至少60％，优选至少70％的核酸，，更优选至少80％，甚至更优选至少90％，95％，96％，97％，98％或99％同源于SEQ ID NO：1,2,4,5,7,8 ，10，11，13，14，16，17，9，20，22，23，25，26，28，29，31，32，34，35，37，38，40，41，43，45，46 ，48和50; da多肽序列，其由在严格条件下与如SEQ ID NO：2,4,5,7,8,10,11,13,14,16,7中任一个所述的多核苷酸杂交的核酸序列编码，19，20，22，23，25，26，28，29，31，32，34，35，37，38，40，41，43，45，46，48及50条; 或由在严格条件下杂交的核酸序列编码的ea多肽序列与如SEQ ID NO：1,2,4,5,7,8,10,11,13， 14，16，17，19，20，22，23，25，26，28，29，31，32，34，35，37，38，40，41，43，45，46，48及50条。

8. 发明申请

WO2013182670A2 NOVEL CELL WALL DECONSTRUCTION ENZYMES OF SCYTALIDIUM THERMOPHILUM AND USES THEREOF 审中-公开
标题翻译：新型细胞壁分解酶及其用途
公开(公告)号：WO2013182670A2
公开(公告)日：2013-12-12
申请号：PCT/EP2013/061768
申请日：2013-06-07
申请人： DSM IP ASSETS B.V. , CONCORDIA UNIVERSITY
发明人： TSANG, Adrian , POWLOWSKI, Justin , BUTLER, Gregory
IPC分类号： C12N9/88
CPC分类号： C12N9/24 , C07K14/37 , C12N9/18 , C12N9/2402
摘要： The present invention relates to process for degrading biomass or pretreated biomass to sugars wherein an enzyme is used comprising a polypeptide having a. a polypeptide sequence as set forth in any one of SEQ ID Nos:3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 51, 54, 57, 60, 62 and 64; b. a polypeptide that is at least 60%, preferably at least 70%, more preferably at least 80%, even more preferably at least 90%, 95%, 96%, 97%, 98% or 99% homologous to the any one of SEQ ID Nos:3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 51, 54, 57, 60, 62 and 64; c. a polypeptide sequence encoded by nucleic acids sequence as set forth in any one of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 7, 19, 20, 22, 23, 25, 26, 28, 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 44, 46, 47, 49, 50, 52, 53, 55, 56, 58, 59, 61 and 63, or nucleic acids that are at least 60%, preferably at least 70%, more 2 preferably at least 80%, even more preferably at least 90%, 95%, 96%, 97%, 98% or 99% homologous to any one of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 17, 19, 20, 22, 23, 25, 26, 28, 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 44, 46, 47, 49, 50, 52, 53, 55, 56, 8, 59, 61 and 63;30 d. a polypeptide sequence encoded by a nucleic acids sequence hybridizing under stringent conditions to the polynucleotide as set DSM IP Assets B.V. 28984-WO-PCT forth in any one of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 7, 19, 20, 22, 23, 25, 26, 28, 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 44, 46, 47, 49, 50, 52, 53, 55, 56, 58, 59, 61 and 63; or e. a polypeptide sequence encoded by a nucleic acids sequence hybridizing under stringent conditions to the reverse complement of a polynucleotide as set forth in any one of SEQ ID NOs: 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 17, 19, 20, 22, 23, 25, 26, 28, 29, 31, 32, 34, 35, 37, 38, 40, 41, 43, 44, 46, 47, 49, 50,52, 53, 55, 56, 58, 59, 61 and 63.
摘要翻译：本发明涉及将生物质或预处理的生物质降解成糖的方法，其中使用的酶包括具有α的多肽。 3，6，9，12，15，18，21，24，27，30，33，36，39，42，45，48，51，54， 57，60，62和64; 湾与下列任何一种的至少60％，优选至少70％，更优选至少80％，甚至更优选至少90％，95％，96％，97％，98％或99％同源的多肽 SEQ ID No：3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,62和64; C。由SEQ ID NO：1,2,4,5,7,8,10,11,13,14,16,17,19,20,22,23中任一个所示的核酸序列编码的多肽序列，25,26,28,29,31,32,34,35,37,38,40,41,43,44,46,47,49,50,52,53,55,56,58,59,61 和63，或者至少60％，优选至少70％，更优选至少80％，甚至更优选至少90％，95％，96％，97％，98％或99％同源的核酸具有SEQ ID NO：1,2,4,5,7,8,10,11,13,14,16,17,19,20,22,23,25,26,28,29,31,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39,39 32，34，35，37，38，40，41，43，44，46，47，49，50，52，53，55，56，8，59，61和63; 30 d。由在严格条件下与多核苷酸杂交的核酸序列编码的多肽序列如SEQ ID NO：1,2,4,5,7,8,10， 11，13，14，16，7，19，20，22，23，25，26，28，29，31，32，34，35，37，38，40，41，43，44，46，47， 49，50，52，53，55，56，58，59，61和63; 或e。由在严格条件下与SEQ ID NO：2,4,5,7,8,10,11,13,14中任一项所示的多核苷酸的反向互补序列杂交的核酸序列编码的多肽序列，16，17，19，20，22，23，25，26，28，29，31，32，34，35，37，38，40，41，43，44，46，47，49，50,52 ，53,55,56,58,59,61和63。

9. 发明申请

WO2023028693A1 METHOD AND SYSTEM FOR COLD DEPOSITION OF POWDERED MATERIALS ON A SUBSTRATE 审中-公开
公开(公告)号：WO2023028693A1
公开(公告)日：2023-03-09
申请号：PCT/CA2022/051280
申请日：2022-08-24
申请人： CONCORDIA UNIVERSITY
发明人： MOREAU, Christian , DOLATABADI, Ali , JADIDI, Mehdi , BEN ETTOUIL, Fadhel , LEBLANC, Marc , DESAULNIERS, Sylvain , AKBARNOZARI, Ali , GARMEH, Saeed , BESSETTE, Eric , POULIOT, Luc
IPC分类号： C23C24/04
摘要： A method and a system for cold spray deposition of a solid material on a substrate, the system comprising a fluid jet unit; a heating unit; a nozzle, and a powder feeder; the fluid jet unit providing a fluid of a speed up to 1200 m/s and a pressure in a range between 150 and 620 MPa to the heating unit, the heating unit controlling a temperature of the fluid and outputting one of: a superheated and a supercritical fluid; the powder feeder injecting feedstock powder particles into a mixing chamber of the nozzle, the feedstock powder particles being accelerated to a speed above a critical velocity of the feedstock powder particles by the fluid within the nozzle, the nozzle being configured for acceleration of the fluid, mixing the fluid and the feedstock powder particles, and projecting the mixture onto the substrate.

10. 发明申请

WO2014140167A1 CELL WALL DECONSTRUCTION ENZYMES OF MALBRANCHEA CINNAMOMEA AND USES THEREOF 审中-公开
标题翻译：马铃薯细胞的细胞壁分解酶及其用途
公开(公告)号：WO2014140167A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054949
申请日：2014-03-13
申请人： DSM IP ASSETS B.V. , CONCORDIA UNIVERSITY
发明人： TSANG, Adrian , POWLOWSKI, Justin , BUTLER, Gregory
IPC分类号： C12P19/02 , C12P19/14 , C12N9/24 , C12P7/10
CPC分类号： C12P7/10 , C12N9/2437 , C12N9/2442 , C12P19/02 , C12P19/14 , C12P2201/00 , C12P2203/00 , C12Y302/01 , C12Y302/01014 , Y02E50/16
摘要： The present invention relates to a novel process for degrading biomass or pretreated biomass to sugars wherein an enzyme is used comprising: a. a polypeptide comprising an amino acid sequence of any one of SEQ ID NOs: 5 or 6; b. a polypeptide comprising an amino acid sequence that is at least 70%, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, 96%, 97%, 98% or 99% amino acid sequence identity to the polypeptide defined in (a); c. a polypeptide comprising an amino acid sequence encoded by the nucleic acid sequence of any one of SEQ ID NOs: 1-4; d. a polypeptide comprising an amino acid sequence encoded by a polynucleotide molecule that hybridizes under medium-high stringency conditions, high stringency conditions, or very high stringency conditions with the full-length complement of a polynucleotide molecule comprising the nucleic acid sequence of any one of SEQ ID NOs: 1-4; e. a polypeptide comprising an amino acid sequence encoded by a polynucleotide molecule having at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% nucleic acid sequence identity to a polynucleotide comprising the nucleic acid sequence of any one of SEQ ID NOs: 1-4; or f. a polypeptide comprising an amino acid sequence encoded by any one of the exonic nucleic acid sequences corresponding to positions: 1-194, 276-568, 639-809, 869-1143, 1235-1322, 1386-1797, 1872-2040of SEQ ID NO: 1; 1-729 of SEQ ID NO: 2.
摘要翻译：本发明涉及将生物质或预处理的生物质降解成糖的新方法，其中使用的酶包括：a。包含SEQ ID NO：5或6中任一个的氨基酸序列的多肽; 湾包含至少70％，优选至少80％，更优选至少90％，甚至更优选至少95％，96％，97％，98％或99％氨基酸序列同一性的氨基酸序列的多肽（a）中定义的多肽; C。包含由SEQ ID NO：1-4中任一个的核酸序列编码的氨基酸序列的多肽; 天。包含由多核苷酸分子编码的氨基酸序列的多肽，其在中高度严格条件，高严格条件或非常高严格条件下与包含SEQ ID NO中任一个核酸序列的多核苷酸分子的全长互补序列杂交身份证号：1-4; 即包含由多核苷酸分子编码的氨基酸序列的多肽，所述多核苷酸分子至少具有70％，至少75％，至少80％，至少85％，至少90％，至少91％，至少92％与包含SEQ ID NO中任一个核酸序列的多核苷酸的核酸序列同一性为93％，至少94％，至少95％，至少96％，至少97％，至少98％，或至少99％身份证号：1-4; 或f。包含由对应于SEQ ID NO：1-194,276-568,639-809,869-1143,1235-1322,1386-1797,1872-2040的任一个外显子核酸序列编码的氨基酸序列的多肽 NO：1; 1-729为SEQ ID NO：2。

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