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1. 发明申请

WO2011153962A1 APPARATUS FOR SINGLE-MOLECULE DETECTION 审中-公开
标题翻译：单分子检测装置
公开(公告)号：WO2011153962A1
公开(公告)日：2011-12-15
申请号：PCT/CN2011/075598
申请日：2011-06-10
申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE , CHIOU, Chung-Fan , TSAI, Rung-Ywan , LI, Yu-Tang , SHIH, Chih-Tsung , LI, Ming-Chia , CHU, Chang-Sheng , CHUNG, Shuang-Chao , CHEN, Jung-Po , PU, Ying-Chih
发明人： CHIOU, Chung-Fan , TSAI, Rung-Ywan , LI, Yu-Tang , SHIH, Chih-Tsung , LI, Ming-Chia , CHU, Chang-Sheng , CHUNG, Shuang-Chao , CHEN, Jung-Po , PU, Ying-Chih
IPC分类号： G01N21/63 , B82B1/00 , C12Q1/68
CPC分类号： G01N21/6486 , B82Y15/00 , G01N21/645 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6482 , G01N2021/6484 , G01N2201/088 , Y10S977/954 , Y10S977/957 , Y10S977/958 , Y10T436/143333 , Y10T436/145555
摘要： An apparatus for detecting an object capable of emitting light. The apparatus includes a light source (102) and a waveguide (110). The waveguide (110) includes a core layer (112) and a first cladding layer (114). At least one nanowell (120) is formed in at least the first cladding layer (114). The apparatus further includes a light detector (106). The light detector (106) can detect light emitted from a single molecule object contained in the at least one nanowell (120).
摘要翻译：一种用于检测能够发光的物体的装置。该装置包括光源（102）和波导（110）。波导（110）包括芯层（112）和第一覆层（114）。至少一个纳米线（120）形成在至少第一包覆层（114）中。该装置还包括光检测器（106）。光检测器（106）可以检测从包含在至少一个纳米线（120）中的单个分子物体发射的光。

2. 发明申请

WO2009056065A1 BIOASSAY SYSTEM INCLUDING OPTICAL DETECTION APPARATUSES, AND METHOD FOR DETECTING BIOMOLECULES 审中-公开
标题翻译：包括光学检测装置的生物系统和检测生物分子的方法
公开(公告)号：WO2009056065A1
公开(公告)日：2009-05-07
申请号：PCT/CN2008/072824
申请日：2008-10-24
申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE , YAO, Bin-Cheng , CHANG, Shang-Chia , PAN, Chao-Chi , CHIOU, Chung-fan , LI, Yu-Tang , CHU, Cheng-Wei
发明人： YAO, Bin-Cheng , CHANG, Shang-Chia , PAN, Chao-Chi , CHIOU, Chung-fan , LI, Yu-Tang , CHU, Cheng-Wei
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6804 , C12Q1/6874 , G01N21/6454 , C12Q2565/607 , C12Q2565/518 , C12Q2535/101
摘要： A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule.
摘要翻译：公开了生物测定系统。生物测定系统可以包括多个光学检测装置，每个光学检测装置包括具有光检测器的基板和在光检测器上形成的连接部位，所述连接部位被处理以将生物分子固定到连接部位。接头位置靠近光检测器，并且与光检测器间隔开小于或等于100微米的距离。光检测器以大于或等于0.8SI steridian的立体角收集从生物分子发射的光。光学检测装置还可以包括形成在衬底上的激发光源，以便提供用于激发与生物分子相连的荧光团的光源。

3. 发明申请

WO2011076130A8 METHOD AND APPARATUS FOR COMPRESSING NUCLEOTIDE SEQUENCE DATA 审中-公开
标题翻译：用于压缩核苷酸序列数据的方法和装置
公开(公告)号：WO2011076130A8
公开(公告)日：2011-09-15
申请号：PCT/CN2010080165
申请日：2010-12-23
申请人： IND TECH RES INST , HWANG BAI-KUANG , FANN JENN-YEH , CHIOU CHUNG-FAN
发明人： HWANG BAI-KUANG , FANN JENN-YEH , CHIOU CHUNG-FAN
IPC分类号： G06F19/22 , C12Q1/68
CPC分类号： G06F19/22
摘要： The invention provides a data compression method, comprising: (a) obtaining a first reading sequence and a second reading sequence from an identical source by a receiving unit; (b) comparing the first reading sequence with the second reading sequence according to a comparison condition to generate a sequence comparison result by the processor; (c) outputting a final template sequence according to the sequence comparison result by the processor; (d) comparing the final template sequence to each of the first and second reading sequences, to generate a respective difference between the final template sequence and each of the first and second reading sequences by the processor; and (e) compressing the first and second reading sequences according to the final template sequences and all generated differences between the final template sequence and the first and second reading sequences, to generate a compression file by the processor.
摘要翻译：本发明提供了一种数据压缩方法，包括：（a）由接收单元从相同的源获得第一读取序列和第二读取序列; （b）根据比较条件将第一读取序列与第二读取序列进行比较，以生成处理器的序列比较结果; （c）根据处理器的序列比较结果输出最终模板序列; （d）将最终模板序列与第一和第二读取序列中的每一个比较，以由处理器产生最终模板序列与第一和第二读取序列中的每一个之间的相应差异; 以及（e）根据最终模板序列压缩第一和第二读取序列以及最终模板序列与第一和第二读取序列之间的所有生成的差异，以由处理器生成压缩文件。

4. 发明申请

WO2011113345A4 SINGLE-MOLECULE DETECTION SYSTEM AND METHODS 审中-公开
标题翻译：单分子检测系统和方法
公开(公告)号：WO2011113345A4
公开(公告)日：2011-11-17
申请号：PCT/CN2011071814
申请日：2011-03-15
申请人： IND TECH RES INST , CHIOU CHUNG-FAN , PU YING-CHIH , PAN CHAO-CHI , SHIH CHIH-TSUNG , LI MING-CHIA , KUO CHEIN-SHIU , CHIEN HUNG-CHI , CHU CHANG-SHENG
发明人： CHIOU CHUNG-FAN , PU YING-CHIH , PAN CHAO-CHI , SHIH CHIH-TSUNG , LI MING-CHIA , KUO CHEIN-SHIU , CHIEN HUNG-CHI , CHU CHANG-SHENG
IPC分类号： G01N21/64 , C12Q1/68
CPC分类号： C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/6454 , G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2201/08 , G01N2201/12 , C12Q2563/155 , C12Q2561/113
摘要： A single-molecule detection system and a plurality of methods of detecting a single-molecule object or sequencing a nucleic acid are provided. The single-molecule detection system comprises: a movable light coupler (100), a waveguide (110) and a light detector (102). The waveguide (110) comprises: a core layer (112) and a first cladding layer (114), wherein at least one adapter site (104) for the movable light coupler (100) is formed in at least the first cladding layer (114). In the methods, the detection system is used to detect a single-molecule object or sequence a nucleic acid.
摘要翻译：提供了单分子检测系统和检测单分子对象或测序核酸的多种方法。单分子检测系统包括：可移动光耦合器（100），波导（110）和光检测器（102）。波导（110）包括：芯层（112）和第一包层（114），其中用于可移动光耦合器（100）的至少一个适配器部位（104）形成在至少第一包层（114））。在这些方法中，检测系统用于检测单分子物体或核酸序列。

5. 发明申请

WO2011076130A1 METHOD AND APPARATUS FOR COMPRESSING NUCLEOTIDE SEQUENCE DATA 审中-公开
标题翻译：用于压缩核苷酸序列数据的方法和设备
公开(公告)号：WO2011076130A1
公开(公告)日：2011-06-30
申请号：PCT/CN2010/080165
申请日：2010-12-23
申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE , HWANG, Bai-Kuang , FANN, Jenn-Yeh , CHIOU, Chung-Fan
发明人： HWANG, Bai-Kuang , FANN, Jenn-Yeh , CHIOU, Chung-Fan
IPC分类号： G06F19/22 , C12Q1/68
CPC分类号： G06F19/22
摘要： The invention provides a data compression method, comprising: (a) obtaining a first reading sequence and a second reading sequence from an identical source by a receiving unit; (b) comparing the first reading sequence with the second reading sequence according to a comparison condition to generate a sequence comparison result by the processor; (c) outputting a final template sequence according to the sequence comparison result by the processor; (d) comparing the final template sequence to each of the first and second reading sequences, to generate a respective difference between the final template sequence and each of the first and second reading sequences by the processor; and (e) compressing the first and second reading sequences according to the final template sequences and all generated differences between the final template sequence and the first and second reading sequences, to generate a compression file by the processor.
摘要翻译：本发明提供了一种数据压缩方法，包括：（a）由接收单元从相同的源获得第一读取序列和第二读取序列; （b）根据比较条件比较第一读取序列与第二读取序列以产生处理器的序列比较结果; （c）根据处理器的序列比较结果输出最终模板序列; （d）将最终模板序列与第一和第二读取序列中的每一个进行比较，以由处理器在最终模板序列与第一和第二读取序列中的每一个之间产生相应差异; （e）根据最终模板序列和最终模板序列与第一和第二读取序列之间的所有生成的差异来压缩第一和第二读取序列，以由处理器生成压缩文件。

6. 发明申请

WO2011150852A1 COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS 审中-公开
标题翻译：用于测序核酸的组合物和方法
公开(公告)号：WO2011150852A1
公开(公告)日：2011-12-08
申请号：PCT/CN2011/075106
申请日：2011-06-01
申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE , CHIOU, Chung-Fan , PAN, Chao-Chi , FANN, Jenn-Yeh , CHANG, Shang-Chia , FU, Tsu-Ju
发明人： CHIOU, Chung-Fan , PAN, Chao-Chi , FANN, Jenn-Yeh , CHANG, Shang-Chia , FU, Tsu-Ju
IPC分类号： C12Q1/68
CPC分类号： C07H21/00 , C07H21/04 , C12Q1/6869 , C12Q2525/117 , C12Q2525/119 , C12Q2565/101
摘要： The present invention provides a method for sequencing nucleic acids, comprising the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex with proofreading activity. The nucleotide analogs may be incorporated into a replicating strand and induce the proofreading activity of the polymerase enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation.
摘要翻译：本发明提供了一种核酸测序方法，其包括使用核苷酸类似物和具有校对活性的核酸聚合酶或酶复合物。核苷酸类似物可以并入复制链中并诱导聚合酶的校对活性，从而延长与核苷酸掺入相关信号的持续时间。

7. 发明申请

WO2011113345A1 SINGLE-MOLECULE DETECTION SYSTEM AND METHODS 审中-公开
标题翻译：单分子检测系统及方法
公开(公告)号：WO2011113345A1
公开(公告)日：2011-09-22
申请号：PCT/CN2011/071814
申请日：2011-03-15
申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE , CHIOU, Chung-Fan , PU, Ying-Chih , PAN, Chao-Chi , SHIH, Chih-Tsung , LI, Ming-Chia , KUO, Chein-Shiu , CHIEN, Hung-Chi , CHU, Chang-Sheng
发明人： CHIOU, Chung-Fan , PU, Ying-Chih , PAN, Chao-Chi , SHIH, Chih-Tsung , LI, Ming-Chia , KUO, Chein-Shiu , CHIEN, Hung-Chi , CHU, Chang-Sheng
IPC分类号： G01N21/64 , C12Q1/68
CPC分类号： C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/6454 , G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2201/08 , G01N2201/12 , C12Q2563/155 , C12Q2561/113
摘要： A single-molecule detection system and a plurality of methods of detecting a single-molecule object or sequencing a nucleic acid are provided. The single-molecule detection system comprises: a movable light coupler (100), a waveguide (110) and a light detector (102). The waveguide (110) comprises: a core layer (112) and a first cladding layer (114), wherein at least one adapter site (104) for the movable light coupler (100) is formed in at least the first cladding layer (114). In the methods, the detection system is used to detect a single-molecule object or sequence a nucleic acid.
摘要翻译：提供单分子检测系统和检测单分子对象或测序核酸的多种方法。单分子检测系统包括：可移动光耦合器（100），波导（110）和光检测器（102）。所述波导（110）包括：芯层（112）和第一覆层（114），其中至少一个用于所述可移动光耦合器（100）的适配器位置（104）至少形成在所述第一覆层）。在该方法中，检测系统用于检测单分子物体或序列核酸。

8. 发明申请

WO2010102567A1 APPARATUS AND METHOD FOR DETECTION AND DISCRIMINATION MOLECULAR OBJECT 审中-公开
标题翻译：用于检测和分辨分子对象的装置和方法
公开(公告)号：WO2010102567A1
公开(公告)日：2010-09-16
申请号：PCT/CN2010/070973
申请日：2010-03-10
申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE , CHEN, Hung-Chun , LI, Ming-Chia , CHU, Chang-Sheng , LI, Yu-Tang , CHIOU, Chung-Fan
发明人： CHEN, Hung-Chun , LI, Ming-Chia , CHU, Chang-Sheng , LI, Yu-Tang , CHIOU, Chung-Fan
IPC分类号： G01N21/01 , G01N21/27 , C12Q1/68
CPC分类号： G01N21/6428 , C12Q1/6869 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607 , G01N15/1459 , G01N21/645 , G01N2015/1477 , G01N2015/149 , G01N2021/6441
摘要： An apparatus for detecting an object capable of emitting light. The apparatus comprises a light detector comprising at least two optical sensors capable of determining the intensity of the light; and a computer processing output signal generated by the optical sensors and comparing a processing result with a known result corresponding to a know type to determine whether the object belongs to the known type. A method for detecting an object capable of emitting light is also provided.
摘要翻译：一种用于检测能够发光的物体的装置。该装置包括光检测器，其包括能够确定光的强度的至少两个光学传感器; 以及由光学传感器生成的计算机处理输出信号，并将处理结果与对应于知道类型的已知结果进行比较，以确定对象是否属于已知类型。还提供了一种用于检测能够发光的物体的方法。

9. 发明申请

WO2010051773A1 METHODS FOR ACCURATE SEQUENCE DATA AND MODIFIED BASE POSITION DETERMINATION 审中-公开
标题翻译：精确序列数据和修正基位置确定方法
公开(公告)号：WO2010051773A1
公开(公告)日：2010-05-14
申请号：PCT/CN2009/074851
申请日：2009-11-06
申请人： INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE , PAN, Chao-Chi , FANN, Jenn-Yeh , CHIOU, Chung-Fan , CHIEN, Hung-Chi , CHEN, Hui-Ling
发明人： PAN, Chao-Chi , FANN, Jenn-Yeh , CHIOU, Chung-Fan , CHIEN, Hung-Chi , CHEN, Hui-Ling
IPC分类号： C12Q1/68 , G01N37/00
CPC分类号： G06F19/22 , C12Q1/6869 , C12Q2531/125 , C12Q2537/165
摘要： Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample.
摘要翻译：本文公开了在具有已知序列的核酸插入物的环状分子中存在的核酸样品中修饰碱基的序列和/或位置的方法，包括获得至少两个插入样品单元的序列数据。在一些实施方案中，所述方法包括使用环状双锁定分子获得序列数据。在一些实施方案中，所述方法包括通过将序列与核酸插入物的已知序列进行比较来计算核酸插入序列的分数，以及根据一个或多个核酸插入片段的得分接受或排除核酸样品序列的重复序列插入物的两个序列紧接着核酸样品序列的重复序列的上游或下游。

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