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1. 发明申请

WO2015184224A1 APTAMER TARGETING MAGE-A3 PEPTIDE AND USES THEREOF 审中-公开
标题翻译： APTAMER靶向MAGE-A3肽及其用途
公开(公告)号：WO2015184224A1
公开(公告)日：2015-12-03
申请号：PCT/US2015/033115
申请日：2015-05-29
申请人： ACADEMIA SINICA , CHEN, Chung-Hsuan
发明人： CHEN, Chung-Hsuan , LIN, Bai-Ling , WANG, Chin-Yu
IPC分类号： C12N15/10 , C07K14/47 , C07K14/435
CPC分类号： C12N15/115 , A61K47/55 , C12N2310/16 , C12N2310/315 , C12N2310/3517 , C12N2320/13 , C12N2320/31 , C12N2320/32
摘要： Disclosed herein is an aptamer targeting a MHC-presented peptide and its uses thereof. The MHC-presented peptide is expressed in various cancer cells; therefor, the aptamer of the disclosure is useful as a bio-tool to label and/or treat peptide-presenting cancer cells. Also disclosed herein is a pharmaceutical composition containing the aptamer.
摘要翻译：本文公开了靶向MHC-呈递肽的适体及其用途。 MHC呈递的肽在各种癌细胞中表达; 因此，本公开的适体可用作标记和/或治疗肽呈递癌细胞的生物工具。本文还公开了含有适体的药物组合物。

2. 发明申请

WO2009076535A1 SYSTEM AND METHOD FOR PERFORMING CHARGE-MONITORING MASS SPECTROMETRY 审中-公开
标题翻译：用于执行电荷监测质谱分析的系统和方法
公开(公告)号：WO2009076535A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/086441
申请日：2008-12-11
申请人： CHEN, Chung Hsuan , PENG, Wen-Ping , CHU, Ming Lee , CHANG, Huan Cheng , LIN, Huan-Chang
发明人： CHEN, Chung Hsuan , PENG, Wen-Ping , CHU, Ming Lee , CHANG, Huan Cheng , LIN, Huan-Chang
IPC分类号： G01J3/40
CPC分类号： H01J49/4265 , H01J49/0077 , H01J49/025
摘要： A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 10 15 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.
摘要翻译：提供了一种电荷监测质谱的新型系统和方法。质谱仪可用于测量质量在约几道尔顿至大于约1015道尔顿范围内的一种或多种分析物的质量。本发明可用于快速质量分布测量。例如，当它们的质量分布不同时，系统和方法可以用于区分癌细胞与正常细胞。

3. 发明申请

WO2008042949A2 DUAL-POLARITY MASS SPECTROMETER 审中-公开
标题翻译：双极性质谱分析仪
公开(公告)号：WO2008042949A2
公开(公告)日：2008-04-10
申请号：PCT/US2007080284
申请日：2007-10-03
申请人： ACADEMIA SINICA , WANG YI-SHENG , CHEN CHUNG-HSUAN , TSAI SHANG-TING , CHEN CHIU WEN
发明人： WANG YI-SHENG , CHEN CHUNG-HSUAN , TSAI SHANG-TING , CHEN CHIU WEN
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , H01J49/0095
摘要： A dual-polarity mass spectrometer includes an ion source, a negative ion mass analyzer, and a positive ion mass analyzer to measure both the negative and positive ion spectra of a sample material simultaneously. The ion source includes a sample surface on which the sample material is positioned, the sample material providing positive ions and negative ions when excited by a laser beam or an energetic particle stream. A first extraction electrode is connected to a voltage higher than the sample surface to attract the negative ions from the sample electrode. A second extraction electrode is connected to a voltage lower than the sample surface to attract the positive ions from the sample electrode. The negative and positive ions are analyzed simultaneously by the negative ion mass analyzer and the positive ion mass analyzer, respectively.
摘要翻译：双极性质谱仪包括离子源，负离子质量分析仪和正离子质量分析仪，可同时测量样品材料的负离子和正离子谱。离子源包括其上放置样品材料的样品表面，样品材料在被激光束或高能粒子流激发时提供正离子和负离子。第一引出电极连接到高于样品表面的电压以吸引来自样品电极的负离子。第二引出电极连接到低于样品表面的电压以吸引来自样品电极的正离子。负离子质量分析仪和正离子质量分析仪分别同时分析负离子和正离子。

4. 发明申请

WO2013022747A1 STEP-SCAN ION TRAP MASS SPECTROMETRY FOR HIGH SPEED PROTEOMICS 审中-公开
标题翻译：用于高速度保护的步进扫描质谱分析
公开(公告)号：WO2013022747A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049516
申请日：2012-08-03
申请人： ACADEMIA SINICA , CHEN, Chung-Hsuan , LIN, Jung-Lee , CHU, Ming-Lee
发明人： CHEN, Chung-Hsuan , LIN, Jung-Lee , CHU, Ming-Lee
IPC分类号： H01J49/34 , H01J49/26 , H01J49/36
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/424
摘要： An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by step scanning the driving frequency in frequency increments over a bandwidth, wherein for each step a specific frequency is held for a fixed number of complete cycles, wherein each specific frequency is changed continuously to the frequency in the next step, and wherein each specific frequency in each step starts at phase zero position.
摘要翻译：一种离子阱质谱仪和用于通过在带宽上以频率增量扫描驱动频率来获得离子质谱的方法，其中对于每个步骤，特定频率保持固定数量的完整循环，其中每个特定频率被改变在下一步骤中连续地进入频率，并且其中每个步骤中的每个特定频率从相位零位置开始。

5. 发明申请

WO2011079202A1 APPARATUSES AND METHODS FOR PORTABLE MASS SPECTROMETRY 审中-公开
标题翻译：便携式质谱仪的装置和方法
公开(公告)号：WO2011079202A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061821
申请日：2010-12-22
申请人： ACADEMIA SINICA , CHEN, Chung-Hsuan , LIN, Jung-Lee , CHU, Ming-Lee
发明人： CHEN, Chung-Hsuan , LIN, Jung-Lee , CHU, Ming-Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/0022 , H01J49/424 , H01J49/429
摘要： Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 10 5 , or analyte with a molecular weight of at least 10 5 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.
摘要翻译：公开了便携式质谱法的方法和装置。该装置包括至少一个离子化分析物源，至少一个频率扫描子系统，至少一个检测器和可选的至少一个真空泵，并且是便携式的。在一些实施方案中，装置包括多个电离分析物源和/或配置成获得大分析物的质谱，例如m / z比至少为105的分析物，或分子量至少为105的分析物 Da，以及小分子分析物的质谱。在一些实施例中，所述方法包括使用上述便携式装置获得质谱。

6. 发明申请

WO2011123479A1 QUANTITATIVE MEASUREMENT OF NANO / MICRO PARTICLE ENDOCYTOSIS WITH CELL MASS SPECTROMETRY 审中-公开
标题翻译：纳米/微粒子内毒素与细胞质谱的定量测量
公开(公告)号：WO2011123479A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030407
申请日：2011-03-29
申请人： ACADEMIA SINICA , LIN, Huan-Chang , LIN, Hsin-Hung , KAO, Cai-Yu , YU, Alice , PENG, Wen-Ping , CHEN, Chung-Hsuan
发明人： LIN, Huan-Chang , LIN, Hsin-Hung , KAO, Cai-Yu , YU, Alice , PENG, Wen-Ping , CHEN, Chung-Hsuan
IPC分类号： G01N33/569 , G01N33/68 , G01N33/50
CPC分类号： G01N33/5091 , G01N33/5008 , G01N33/569 , G01N33/6848
摘要： Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided.
摘要翻译：提供了通过细胞质谱法（CMS）检测纳米颗粒或微粒的存在的方法。提供CMS方法用于确定每个细胞中纳米颗粒或微粒的数量。通过本发明的CMS方法可以确定其细胞内浓度的纳米颗粒包括聚合物纳米颗粒（NP），脂质体，基于病毒的NP，碳纳米管，金刚石NP，聚合胶束，纳米载体，脂质体和病毒纳米颗粒。公开了根据本发明的药物递送效率和病原体细胞内滴度的测定。提供了确定病毒颗粒的细胞内吸收的方法。

7. 发明申请

WO2020093026A1 PROGNOSIS AND TREATMENT OF METASTATIC CANCER 审中-公开
公开(公告)号：WO2020093026A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/059561
申请日：2019-11-01
申请人： ACADEMIA SINICA , CHEN, Chung-Hsuan
发明人： CHEN, Chung-Hsuan , CHANG, Wei-Chao
IPC分类号： A61K31/713 , C12Q1/6886
摘要： Provided herein is a method for treating a subject afflicted with a metastatic cancer. The method includes, administering to the subject an effective amount of an agent capable of suppressing the expression of a nucleic of EF -hand domain-containing protein D2 (EFHD2) or a polypeptide encoded by the nucleic acid in the metastatic cancer of the subject. The agent may be a 2-aryl propionic acid (2-APA) compound, or a short hairpin ribonucleic acid (shRNA) that directs cleavage of EFHD2 gene RNA via RNA interference. Also provided herein is a method for detecting and/or diagnosing whether a subject having a metastatic cancer via a biological sample of the subject. The method includes steps of, measuring the level of EFHD2 nucleic acid or polypeptide in the biological sample; and comparing the amount of the EFHD2 nucleic acid or polypeptide present in the biological sample with that of a healthy subject; in which an elevated amount of EFHD2 nucleic acid or polypeptide in the biological sample relative to that of a healthy subject indicates that the cancer of the subject is likely to metastasize.

8. 发明申请

WO2014183105A1 NANOPARTICLE MEASUREMENT VIRUS MASS SPECTROMETRY 审中-公开
标题翻译：纳米尺度测定病毒质谱
公开(公告)号：WO2014183105A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/037608
申请日：2014-05-10
申请人： ACADEMIA SINICA , CHEN, Chung-Hsuan
发明人： CHEN, Chung-Hsuan , LIN, Jung-Lee , LIN, Huan Chang
IPC分类号： C12Q1/68 , C12Q1/02 , C12Q1/70
CPC分类号： H01J49/36 , G01N33/4833 , H01J49/164 , H01J49/4225 , H01J49/424
摘要： Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 10 5 to 10 10 , an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.
摘要翻译：用于进行纳米颗粒或病毒分析物的质谱分析的装置和方法。设备可以包括激光解吸板，质量分析器，被配置为测量从105到1010的m / z范围内的质量，围绕质量分析器的电屏蔽，以及电荷敏感检测器，其中激光点火与应用的射频电压。

9. 发明申请

WO2011090952A1 ANGLED DUAL-POLARITY MASS SPECTROMETER 审中-公开
标题翻译： ANGLED双极性质谱仪
公开(公告)号：WO2011090952A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/021595
申请日：2011-01-18
申请人： ACADEMIA SINICA , WANG, Yi-Sheng , CHEN, Chung-Hsuan
发明人： WANG, Yi-Sheng , CHEN, Chung-Hsuan
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/0095
摘要： An angled dual-polarity mass spectrometer includes a dual-polarity ion generator, a first mass analyzer, and a second mass analyzer. The dual-polarity ion generator includes an ion source to generate positive ions and negative ions from a sample, and electrodes to generate electric fields for guiding the negative ions into a beam of negative ions and guiding the positive ions into a beam of positive ions. The first mass analyzer can analyze the negative ions, and the second mass analyzer can analyze the positive ions. The central axes of the first and the second mass analyzers are at an angle between 0 to 179 degrees.
摘要翻译：角度双极性质谱仪包括双极性离子发生器，第一质量分析器和第二质量分析器。双极性离子发生器包括从样品产生正离子和负离子的离子源，以及用于产生电场的电极，用于将负离子引导到负离子束中并将正离子引导到正离子束中。第一个质谱仪可以分析负离子，第二个质谱仪可以分析正离子。第一和第二质量分析器的中心轴线在0至179度之间的角度。

10. 发明申请

WO2008042949A3 DUAL-POLARITY MASS SPECTROMETER 审中-公开
公开(公告)号：WO2008042949A3
公开(公告)日：2008-04-10
申请号：PCT/US2007/080284
申请日：2007-10-03
申请人： ACADEMIA SINICA , WANG, Yi-sheng , CHEN, Chung-hsuan , TSAI, Shang-ting , CHEN, Chiu Wen
发明人： WANG, Yi-sheng , CHEN, Chung-hsuan , TSAI, Shang-ting , CHEN, Chiu Wen
IPC分类号： H01J49/40 , H01J49/10
摘要： A dual-polarity mass spectrometer includes an ion source, a negative ion mass analyzer, and a positive ion mass analyzer to measure both the negative and positive ion spectra of a sample material simultaneously. The ion source includes a sample surface on which the sample material is positioned, the sample material providing positive ions and negative ions when excited by a laser beam or an energetic particle stream. A first extraction electrode is connected to a voltage higher than the sample surface to attract the negative ions from the sample electrode. A second extraction electrode is connected to a voltage lower than the sample surface to attract the positive ions from the sample electrode. The negative and positive ions are analyzed simultaneously by the negative ion mass analyzer and the positive ion mass analyzer, respectively.

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