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1. 发明申请

WO2012062713A1 CXCR2 BINDING POLYPEPTIDES 审中-公开
标题翻译： CXCR2结合多糖
公开(公告)号：WO2012062713A1
公开(公告)日：2012-05-18
申请号：PCT/EP2011/069571
申请日：2011-11-07
申请人： NOVARTIS AG , BRADLEY, Michelle , BROWN, Zarin , CHARLTON, Steven John , CROMIE, Karen , DOMBRECHT, Bruno , STEFFENSEN, Soren , VAN HEEKE, Gino
发明人： BRADLEY, Michelle , BROWN, Zarin , CHARLTON, Steven John , CROMIE, Karen , DOMBRECHT, Bruno , STEFFENSEN, Soren , VAN HEEKE, Gino
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译：本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

2. 发明申请

WO2013168108A2 CHEMOKINE RECEPTOR BINDING POLYPEPTIDES 审中-公开
标题翻译：化合物受体结合多肽
公开(公告)号：WO2013168108A2
公开(公告)日：2013-11-14
申请号：PCT/IB2013/053711
申请日：2013-05-08
申请人： NOVARTIS AG , BROWN, Zarin , BRADLEY, Michelle , CHARLTON, Steven John , VAN HEEKE, Gino Anselmus , CROMIE, Karen , DOMBRECHT, Bruno , STEFFENSEN, Soren , BAUMEISTER, Judith , BOUCHE, Marie-Paule , BOUTTON, Carlo , BUYSE, Marie-Ange , SNOECK, Veerle , STAELENS, Stephanie
发明人： BROWN, Zarin , BRADLEY, Michelle , CHARLTON, Steven John , VAN HEEKE, Gino Anselmus , CROMIE, Karen , DOMBRECHT, Bruno , STEFFENSEN, Soren , BAUMEISTER, Judith , BOUCHE, Marie-Paule , BOUTTON, Carlo , BUYSE, Marie-Ange , SNOECK, Veerle , STAELENS, Stephanie
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译：本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

3. 发明申请

WO2012007539A9 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS 审中-公开
公开(公告)号：WO2012007539A9
公开(公告)日：2012-01-19
申请号：PCT/EP2011/062028
申请日：2011-07-14
申请人： NOVARTIS AG , CHARLTON, Steven, John , LEBLANC, Catherine , MCKEOWN, Stephen, Carl
发明人： CHARLTON, Steven, John , LEBLANC, Catherine , MCKEOWN, Stephen, Carl
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/00 , A61P11/00
摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.

4. 发明申请

WO2012007539A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译： IP受体激动剂杂环化合物
公开(公告)号：WO2012007539A1
公开(公告)日：2012-01-19
申请号：PCT/EP2011/062028
申请日：2011-07-14
申请人： NOVARTIS AG , CHARLTON, Steven, John , LEBLANC, Catherine , MCKEOWN, Stephen, Carl
发明人： CHARLTON, Steven, John , LEBLANC, Catherine , MCKEOWN, Stephen, Carl
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/00 , A61P11/00
CPC分类号： A61K31/4985 , A61K31/4375 , C07D471/04
摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译：本发明提供活化IP受体的杂环衍生物。激活IP受体信号通路可用于治疗多种形式的PAH，肺纤维化，并在动物模型和患者的各种器官的纤维化病症中发挥有益作用。还包括包含这些衍生物的药物组合物。

5. 发明申请

WO2013168108A3 BIPARATOPIC BINDING POLYPEPTIDES FOR CXCR2 AND USES THEREOF 审中-公开
标题翻译：用于CXCR2的双相结合聚合物及其用途
公开(公告)号：WO2013168108A3
公开(公告)日：2014-02-13
申请号：PCT/IB2013053711
申请日：2013-05-08
申请人： NOVARTIS AG , BROWN ZARIN , BRADLEY MICHELLE , CHARLTON STEVEN JOHN , VAN HEEKE GINO ANSELMUS , CROMIE KAREN , DOMBRECHT BRUNO , STEFFENSEN SOREN , BAUMEISTER JUDITH , BOUCHE MARIE-PAULE , BOUTTON CARLO , BUYSE MARIE-ANGE , SNOECK VEERLE , STAELENS STEPHANIE
发明人： BROWN ZARIN , BRADLEY MICHELLE , CHARLTON STEVEN JOHN , VAN HEEKE GINO ANSELMUS , CROMIE KAREN , DOMBRECHT BRUNO , STEFFENSEN SOREN , BAUMEISTER JUDITH , BOUCHE MARIE-PAULE , BOUTTON CARLO , BUYSE MARIE-ANGE , SNOECK VEERLE , STAELENS STEPHANIE
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译：本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

6. 发明申请

WO2014125413A1 IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译： IP受体激动剂杂环化合物
公开(公告)号：WO2014125413A1
公开(公告)日：2014-08-21
申请号：PCT/IB2014/058905
申请日：2014-02-11
申请人： NOVARTIS AG , BUTLER, Rebecca , LEBLANC, Catherine , MCKEOWN, Stephen Carl , CHARLTON, Steven John
发明人： BUTLER, Rebecca , LEBLANC, Catherine , MCKEOWN, Stephen Carl , CHARLTON, Steven John
IPC分类号： C07D471/04 , A61K31/4375 , A61P7/02 , A61P9/10 , A61P11/06 , A61P3/10 , A61P29/00 , A61P19/04
CPC分类号： C07D471/04 , A61K31/4375
摘要： The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译：本发明提供活化IP受体的杂环衍生物。激活IP受体信号通路可用于治疗多种形式的PAH，肺纤维化，并在动物模型和患者的各种器官的纤维化病症中发挥有益作用。还包括包含这些衍生物的药物组合物。

7. 发明申请

WO1995014164A1 CARBURETTOR 审中-公开
标题翻译：化油器
公开(公告)号：WO1995014164A1
公开(公告)日：1995-05-26
申请号：PCT/GB1994002536
申请日：1994-11-17
申请人： BRITISH GAS PLC , JAGER, Dennis, John , SLOWLEY, John , CHARLTON, Steven, John
发明人： BRITISH GAS PLC
IPC分类号： F02M21/04
CPC分类号： F02M19/035 , F02B43/00 , F02M21/047 , F02M35/10262 , Y02T10/146 , Y02T10/32
摘要： A carburettor (2) to supply a mixture of fuel gas and combustion air to a reciprocating internal combustion engine. The carburettor comprises a venturi (4) and a throttle (10) including a throttle valve (24). A tear-drop shaped obstruction (36) is mounted in the venturi throat (18) on diametrically opposed radial arms (66). The narrowest part of the tubular gap (46) between the walls of venturi (4) and the obstruction (36) is at (48). A continuous slot (50) in the throat wall (18) encircles the obstruction and opens into gap (48). Another continuous slot (70) encircling the obstruction (36) is formed therein and also opens into the gap (48). Fuel gas is supplied to the slots (50) and (70) through passages (52, 74 and 72).
摘要翻译：一种化油器（2），用于向往复式内燃机提供燃料气体和燃烧空气的混合物。化油器包括文丘里管（4）和包括节流阀（24）的节流阀（10）。泪滴形阻塞物（36）安装在径向相对的径向臂（66）上的文丘里喉部（18）中。文氏管（4）的壁与阻塞物（36）之间的管状间隙（46）的最窄部分在（48）处。喉部壁（18）中的连续狭槽（50）围绕障碍物并且打开到间隙（48）中。围绕障碍物（36）的另一连续槽（70）形成在其中并且还通向间隙（48）。燃料气体通过通道（52,74和72）供应到槽（50）和（70）。

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