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1. 发明申请

WO1995027198A1 CONTROL OF TEMPERATURE GRADIENTS DURING GEL ELECTROPHORESIS USING TURBULENT COOLANT GAS FLOW 审中-公开
标题翻译：使用湍流冷却气流在凝胶电泳中控制温度梯度
公开(公告)号：WO1995027198A1
公开(公告)日：1995-10-12
申请号：PCT/US1995004065
申请日：1995-04-03
申请人： GENOMYX CORPORATION , SMITH, Douglas, H. , MIFSUD, Brian, J. , BURGI, Dean, S. , DAVIS, Thomas, E. , VANHUYSTEE, Steven, M.
发明人： GENOMYX CORPORATION
IPC分类号： G01N27/447
CPC分类号： G01N27/44708
摘要： A gel electrophoresis separation apparatus comprising, in combination, a gaseous heat-exchange medium, a gaseous heat-exchange medium driving means, and an impingement means, whereby the gaseous heat-exhange medium is driven by the gaseous heat-exchange medium driving means across the impingement means to provide a flow of the gaseous heat-exchange medium on the surface of the gel plates, whereby the flow induced by passage of the gaseous heat-exchange medium through the impingement means thereby minimizes temperature gradients within the gel by forced convection.
摘要翻译：一种凝胶电泳分离装置，其组合包括气体热交换介质，气体热交换介质驱动装置和冲击装置，由此气态热交换介质由气体热交换介质驱动装置驱动冲击意味着在凝胶板的表面上提供气态热交换介质的流动，由此通过气体热交换介质通过冲击装置引起的流动从而通过强制对流使凝胶内的温度梯度最小化。

2. 发明申请

WO1996008685A1 AIR IMPINGEMENT GEL DRYING 审中-公开
标题翻译：气压干燥
公开(公告)号：WO1996008685A1
公开(公告)日：1996-03-21
申请号：PCT/US1995012012
申请日：1995-09-12
申请人： GENOMYX CORPORATION , BURGI, Dean, S.
发明人： GENOMYX CORPORATION
IPC分类号： F26B09/06
CPC分类号： F26B9/003 , F26B9/06
摘要： A method for drying electrophoresis gel comprising, in combination, using a gaseous moisture removing medium, a gaseous moisture removing medium driving means (3), and an impingement means (7, 9), whereby the gaseous moisture removing medium is driven by the gaseous moisture removing medium driving means (3) across the impingement means (7, 9) to provide a flow of the gaseous moisture removing medium on the surface (8) of the gel plates (5), whereby the flow induced by passage of the gaseous moisture removing medium through the impigement means (7, 9) thereby minimizes temperature gradients within the gel (5) by forced convection and reduces drying time of the gel.
摘要翻译：一种用于干燥电泳凝胶的方法，其包括使用气体除湿介质，气体除湿介质驱动装置（3）和冲击装置（7,9）组合，由此气态除湿介质由气态除湿介质驱动装置（3）穿过冲击装置（7,9），以在凝胶板（5）的表面（8）上提供气态除湿介质的流动，由此通过气体通过压力装置（7,9）去除湿气的介质，从而通过强制对流使凝胶（5）内的温度梯度最小化并减少凝胶的干燥时间。

3. 发明申请

WO2013130910A1 SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEMS 审中-公开
标题翻译：样品制备，处理和分析系统
公开(公告)号：WO2013130910A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028462
申请日：2013-02-28
申请人： INTEGENX INC. , EBERHART, David , LI, Yuan , OGG, James , VAN GELDER, Ezra , WILLIAMS, Stephen, J. , WOUDENBERG, Timothy , BURGI, Dean, S. , NIELSEN, William, D.
发明人： EBERHART, David , LI, Yuan , OGG, James , VAN GELDER, Ezra , WILLIAMS, Stephen, J. , WOUDENBERG, Timothy , BURGI, Dean, S. , NIELSEN, William, D.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , B01L3/502715 , B01L7/52 , B01L2200/04 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0861 , B01L2300/123 , B01L2300/1805 , B01L2300/1822 , B01L2300/1838 , B01L2400/0478 , B01L2400/0616 , B01L2400/0655 , B01L2400/0683 , C12Q1/686 , C12Q2565/629
摘要： This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
摘要翻译：本公开提供了一种集成且自动化的样本到回答系统，其从包含生物材料的样本开始，在不到两个小时内生成遗传图谱。在某些实施方案中，生物材料是DNA并且遗传谱涉及确定受试者的一个或多个基因座（例如遗传基因座）处的等位基因，例如STR（短串联重复序列）分布，例如如在 CODIS系统。该系统可以执行多种操作，包括（a）提取和分离核酸; （b）扩增选定基因座的核苷酸序列（例如遗传基因座）; 和（c）扩增产物的检测和分析。这些操作可以在包含几个集成模块的系统中执行，包括分析物准备模块; 一个检测和分析模块以及一个控制模块。

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