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1. 发明申请

WO2005110446A1 PROCESS TO OBTAIN EXTRACTS, FRACTIONS AND ISOLATED COMPOUNDS FROM COPAIFER SPECIES AND THEIR USE FOR THE TREATMENT OF URINARY LITHIASIS IN HUMAN BEINGS AND ANIMALS 审中-公开
标题翻译：从复方物种中获取提取物，分离物和分离化合物的方法及其用于治疗人类和动物中尿路感染的用途
公开(公告)号：WO2005110446A1
公开(公告)日：2005-11-24
申请号：PCT/BR2005/000052
申请日：2005-04-12
申请人： BRUNHAROTO, Aurita Rodrigues Flores , BRUNHAROTO JR., Claudino , BRUNHAROTO, Luis Paulo Flores , BASTOS, Jairo Kenupp , CARVALHO, José Carlos Tavares
发明人： BRUNHAROTO, Aurita Rodrigues Flores , BRUNHAROTO JR., Claudino , BRUNHAROTO, Luis Paulo Flores , BASTOS, Jairo Kenupp , CARVALHO, José Carlos Tavares
IPC分类号： A61K35/78
CPC分类号： A61K36/48
摘要： Process to obtain and use extracts, fractions and isolated compounds from the Copaifer species for the treatment of urinary lithiasis in human beings and animals, which comprises the following steps: a) drying of aerial parts, leaves and branches from Copaifer species in a circulating hot air stove at 40 °C; b) milling of the dry material in a knife mill until a fine powder is obtained; c) extraction by cold or hot maceration in water or hydro-alcohol solution 7:3 in ethanol; d) filtration of extracts through filtration canvas to separate the plant cake; e) lyophilization of the water extract; f) concentration of hydro-alcohol extract in concentrators under reduced pressure; g) fractioning of crude extracts, obtained from the aerial parts of Copaifera species or from crude copaiba oil, by filtration processes in packing columns with stationary phases based on silica gel; or; h) obtainment of fractions rich in the active principles by liquid-liquid partition processes from the hydro-alcohol extract from the branches of the Copaifera species, using hexane, chloroform and n-butanol in sequence; i) fractioning of the fraction in hexane by using a liquid column containing silica gel and elution with hexane and hexane-ethyl acetate mixtures in increasing polarity order to isolate sesquiterpenes; i) fractioning of the fraction in chloroform by using a liquid column containing silica gel and elution with hexane, dichloromethane and methanol in increasing polarity order to isolate diterpenes of the types chlerodane, labdane and low polarity derivatives from cinnamic acid; k) fractioning of the butanol extract by using a liquid column containing silica gel and modified with the addition of acetic acid and elution with mixtures of dichloromethane and methanol to isolate acid diterpenes and polar derivatives from cinnamic acid.
摘要翻译：获得并使用来自Copaifer物种的提取物，级分和分离的化合物用于治疗人类和动物中的尿结石的方法，其包括以下步骤：a）在循环热中从Copaifer物种干燥地上部分，叶和分枝空气炉为40°C; b）在刀磨机中研磨干材料直到获得细粉末; c）通过冷或热浸渍在水或醇溶液中7：3在乙醇中提取; d）通过过滤帆布过滤提取物以分离植物蛋糕; e）冻干水提取物; f）减压浓缩液中的醇醇提取物的浓度; g）通过基于硅胶的固定相填充柱中的过滤方法从Copaifera物种的地上部分或粗Copaiba油获得的粗提取物的分馏; 要么; h）依次使用己烷，氯仿和正丁醇从Copaifera物种的分支中提取液 - 液分离液液分离方法获得富含活性成分的馏分; i）通过使用含有硅胶的液体柱在己烷中分馏馏分，并用己烷和己烷 - 乙酸乙酯混合物以增加的极性洗脱以分离倍半萜; i）通过使用含有硅胶的液柱并用己烷，二氯甲烷和甲醇以极性极性逐步洗脱来分馏氯仿中的级分，从而从肉桂酸中分离出己烷，二氯甲烷和甲醇。 k）使用含有硅胶的液柱分馏丁醇提取物，并加入乙酸进行改性，用二氯甲烷和甲醇的混合物洗脱，从肉桂酸中分离出酸二萜烯和极性衍生物。

2. 发明申请

WO2011120118A1 PROCESSO DE OBTENÇÃO DE MICROPARTÍCULAS MATRICIAIS DE COPAÍFERA LANGSDORFFII (PARTES AÉREAS) E ISOLAMENTO DOS PRINCÍPIOS ATIVOS; MICROPARTÍCULAS E COMPOSTOS ASSIM OBTIDOS, COM ATIVIDADE ANTILITIÁSICA (CÁLCULO RENAL), ANALGÉSICA, ANTI-ESPASMÓDICA, ANTI-INFLAMATÓRIA, DIURÉTICA E ANTI-SÉPTICA, SUAS FORMULAÇÕES, PRODUTOS E USOS. 审中-公开
标题翻译：制备酚醛树脂（食品部件）的基质微粒和分离其活性原子的方法; THUS制备的分析，抗体，抗炎，抗微生物和抗微生物微粒和化合物
公开(公告)号：WO2011120118A1
公开(公告)日：2011-10-06
申请号：PCT/BR2011/000090
申请日：2011-03-29
申请人： APIS FLORA INDUSTRIAL E COMERCIAL LTDA. , UNIVERSIDADE DE SÃO PAULO , BRUNHAROTO, Aurita Rodrigues Flores , BASTOS, Jairo Kenupp , SILVA, Andresa Aparecida Berreta e
发明人： BRUNHAROTO, Aurita Rodrigues Flores , BASTOS, Jairo Kenupp , SILVA, Andresa Aparecida Berreta e
IPC分类号： A61K36/48 , A61K127/00 , A61P13/04 , A61P13/06 , A61P7/10
CPC分类号： A61K36/48
摘要： Refere-se o presente invento a um processo de obtenção de micropartículas matriciais de Copaífera langsdorffii (partes aéreas) e do isolamento dos compostos ativos e/ou marcadores das partes aéreas da referida planta, bem como as atividades biológicas encontradas para tais micropartículas matriciais e dos compostos isolados, quais sejam: atividade antilitiásica (cálculo renal), analgésica, anti-espasmódica, anti-inflamatória, diurética e anti-séptica, bem como a utilização destes nos tratamentos de litíase renal (cálculo renal), artrites, tártaros, dores musculares e espasmódicas em geral (cólicas abdominais, renais, etc.). Refere-se também as demais doenças relacionadas às atividades previamente citadas, além das formulações que podem ser originadas com as micropartículas matriciais de Copaífera langsdorffii ; e/ou seus compostos isolados, como medicamentos, produtos de higiene pessoal, cosméticos, alimentos, produtos veterinários e odontológicos, etc
摘要翻译：本发明涉及一种用于制备红花虱（地高分子）的基质微粒并分离所述植物的地上部分的活性化合物和/或标记物的方法，以及这些基质微粒子的生物活性已经发现分离的化合物具有，即：抗结石活性（肾结石），镇痛，抗痉挛，消炎，利尿和防腐活性。还公开了其用于治疗肾结石（肾结石），关节炎，牙垢，肌肉和一般痉挛性疼痛（腹部和肾绞痛等）的用途。本发明还涉及与前述活性相关的其它疾病，以及可以使用Copaíferalangsdorffii的基质微粒和/或用作药物的分离化合物，个人卫生用品，化妆品，营养，兽医和牙科产品等。

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