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1. 发明申请

WO2009111056A1 CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译：适用于治疗代谢障碍的有约束力的羧酸衍生物
公开(公告)号：WO2009111056A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/001435
申请日：2009-03-04
申请人： AMGEN INC. , BROWN, Sean, P. , DRANSFIELD, Paul, J. , HOUZE, Jonathan , KOHN, Todd, J. , LIU, Jiwen , MEDINA, Julio , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , YU, Ming , ZHU, Liusheng
发明人： BROWN, Sean, P. , DRANSFIELD, Paul, J. , HOUZE, Jonathan , KOHN, Todd, J. , LIU, Jiwen , MEDINA, Julio , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , YU, Ming , ZHU, Liusheng
IPC分类号： C07C59/72 , C07D213/64 , A61K31/192 , A61P3/10 , A61P9/00 , A61K31/435
CPC分类号： C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I或通式III：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

2. 发明申请

WO2009048527A1 SUBSTITUTED BIPHENYL GPR40 MODULATORS 审中-公开
标题翻译：取代的BIPHENYL GPR40调节器
公开(公告)号：WO2009048527A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/011422
申请日：2008-10-03
申请人： AMGEN INC. , KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng
发明人： KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng
IPC分类号： C07C59/68 , C07C217/54 , C07C323/19 , C07D213/64 , A61K31/192 , A61K31/4415 , A61P3/10
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

4. 发明申请

WO2012094735A1 WHITE BOARD OPERABLE BY VARIABLE PRESSURE INPUTS 审中-公开
标题翻译：白板由可变压力输入操作
公开(公告)号：WO2012094735A1
公开(公告)日：2012-07-19
申请号：PCT/CA2012/000017
申请日：2012-01-09
申请人： EGAN TEAMBOARD INC. , BROWN, Sean Rigby , EGAN, James Arthur , LONG, James G. , PATEL, Jitesh Kumar , WALMSLEY, John Goeffrey
发明人： BROWN, Sean Rigby , EGAN, James Arthur , LONG, James G. , PATEL, Jitesh Kumar , WALMSLEY, John Goeffrey
IPC分类号： B43L1/00 , G06F3/041 , G06F3/048
CPC分类号： B43L1/00 , G06F3/0414 , G06F3/045
摘要： A dry erase whiteboard, or other writing or projection surface assembly, is formed from a substrate having a surface and a pressure sensitive composite layer supported by the surface of the substrate. The pressure sensitive composite layer has an electrical characteristic that varies in response to the application of pressure to a contact surface of the composite layer. A control system coupled to the composite layer generates input commands for a computer system based on varying values of the electrical characteristic resulting from the application of pressure to the contact surface. Different input commands may be generated based on the number of currently applied pressures, as well as the degree of applied force associated with each different touch.
摘要翻译：干基板或其他书写或投影表面组件由具有由基板表面支撑的表面和压敏复合层的基板形成。压敏复合层具有响应于对复合层的接触表面施加压力而变化的电特性。耦合到复合层的控制系统基于由于对接触表面施加压力而导致的电特性的变化值，为计算机系统生成输入命令。可以基于当前施加的压力的数量以及与每个不同触摸相关联的施加的力的程度来生成不同的输入命令。

5. 发明申请

WO2010045258A2 SPIROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译：螺旋GPR40调制器
公开(公告)号：WO2010045258A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/060549
申请日：2009-10-13
申请人： AMGEN INC. , BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
发明人： BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
IPC分类号： C07C62/34 , C07D249/00 , C07D277/00 , C07D311/00 , C07D231/00 , C07D271/00 , C07D221/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式IA，IB，I'A或I'B，其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

6. 发明申请

WO2008049091A3 APPARATUS AND SYSTEM FOR AUTOMATIC CENTRIFUGAL ENGAGEMENT OF A PRESSURE PLATE 审中-公开
公开(公告)号：WO2008049091A3
公开(公告)日：2008-04-24
申请号：PCT/US2007/081863
申请日：2007-10-18
申请人： REKLUSE MOTOT SPORTS , YOUNGWERTH, Albert, J. , DOUGHERTY, Michael, E. , PATTERSON, Zane , BROWN, Sean , YOUNGWERTH, Danny, S.
发明人： YOUNGWERTH, Albert, J. , DOUGHERTY, Michael, E. , PATTERSON, Zane , BROWN, Sean , YOUNGWERTH, Danny, S.
IPC分类号： F16D23/10
摘要： An apparatus and system are disclosed for automatic centrifugal engagement of a pressure plate. The apparatus includes a clutch basket (104), a clutch pack (112) capable of coupling the clutch basket (104) with a center clutch (108), a pressure plate (138) axially moveable toward the clutch pack (112), and a top plate (144) coupled to a rotating hub (128). The rotating hub (128) is configured to pass through an opening in the pressure plate (138). The apparatus also includes at least one centrifugal actuating member (142) disposed between the pressure plate (138) and the top plate (144), and at least one spring (118) disposed between the rotating hub (128) and the center clutch (108) to bias the pressure plate (138) relative to the top plate (144). The system includes the apparatus and a rotating hub lifter (602) coupled with the rotating hub (612).

7. 发明申请

WO2008049091A2 APPARATUS AND SYSTEM FOR AUTOMATIC CENTRIFUGAL ENGAGEMENT OF A PRESSURE PLATE 审中-公开
标题翻译：压力板自动离心装置的装置和系统
公开(公告)号：WO2008049091A2
公开(公告)日：2008-04-24
申请号：PCT/US2007081863
申请日：2007-10-18
申请人： REKLUSE MOTOT SPORTS , YOUNGWERTH ALBERT J , DOUGHERTY MICHAEL E , PATTERSON ZANE , BROWN SEAN , YOUNGWERTH DANNY S
发明人： YOUNGWERTH ALBERT J , DOUGHERTY MICHAEL E , PATTERSON ZANE , BROWN SEAN , YOUNGWERTH DANNY S
IPC分类号： F16D43/08
CPC分类号： F16D43/10
摘要： An apparatus and system are disclosed for automatic centrifugal engagement of a pressure plate. The apparatus includes a clutch basket (104), a clutch pack (112) capable of coupling the clutch basket (104) with a center clutch (108), a pressure plate (138) axially moveable toward the clutch pack (112), and a top plate (144) coupled to a rotating hub (128). The rotating hub (128) is configured to pass through an opening in the pressure plate (138). The apparatus also includes at least one centrifugal actuating member (142) disposed between the pressure plate (138) and the top plate (144), and at least one spring (118) disposed between the rotating hub (128) and the center clutch (108) to bias the pressure plate (138) relative to the top plate (144). The system includes the apparatus and a rotating hub lifter (602) coupled with the rotating hub (612) and configured to position the rotating hub (612) in one of a manual clutch mode position and an automatic clutch mode position.
摘要翻译：公开了用于压力板的自动离心接合的装置和系统。该装置包括离合器筐（104），能够将离合器筐（104）与中心离合器（108）联接的离合器组件（112），可朝向离合器组件（112）可轴向移动的压力板（138），以及耦合到旋转毂（128）的顶板（144）。旋转毂（128）构造成穿过压板（138）中的开口。设备还包括设置在压力板（138）和顶板（144）之间的至少一个离心致动构件（142）和设置在旋转毂（128）和中心离合器（144）之间的至少一个弹簧 108）相对于顶板（144）偏置压板（138）。该系统包括装置和与旋转轮毂（612）联接的旋转轮毂升降器（602），并且构造成将旋转轮毂（612）定位在手动离合器模式位置和自动离合器模式位置之一中。

8. 发明申请

WO2003087769A2 METHOD FOR IDENTIFYING MODULATORS OF ION CHANNELS 审中-公开
标题翻译：识别离子通道调制器的方法
公开(公告)号：WO2003087769A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/011014
申请日：2003-04-11
申请人： JANSSEN PHARMACEUTICA, N.V. , BROWN, Sean , CHAPLAN, Sandra , DUBIN, Adrienne , KAFTAN, Edward
发明人： BROWN, Sean , CHAPLAN, Sandra , DUBIN, Adrienne , KAFTAN, Edward
IPC分类号： G01N
CPC分类号： G01N33/6872 , A61K31/203 , C07K14/705 , G01N2500/02 , G01N2500/10
摘要： The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Na v expression is either Na v 1.3 in IMR-32 cells exposed to retinoic acid or Na v 1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Na v 1.3 and/or Na v 1.7.
摘要翻译：本发明提供了操纵神经母细胞瘤细胞系（IMR-32）的分化的方法，使得主要的Nav表达是在不分化条件下生长的细胞中暴露于视黄酸或Nav 1.7的IMR-32细胞中的Nav 1.3。本发明的细胞可用于发现调节Nav 1.3和/或Nav 1.7的功能的新化合物。

9. 发明申请

WO2010045258A3 SPIROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译： SPIROCYCLIC GPR40调节剂
公开(公告)号：WO2010045258A3
公开(公告)日：2010-07-01
申请号：PCT/US2009060549
申请日：2009-10-13
申请人： AMGEN INC , BROWN SEAN P , DRANSFIELD PAUL , DU XIAOHUI , FU ZICE , HOUZE JONATHAN , JIAO XIANYUN , LAI SUJEN , LI AN-RONG , LIU JIWEN , MA ZHIHUA , MEDINA JULIO C , PATTAROPONG VATEE , SHEN WANG , VIMOLRATANA MARC , WANG YINGCAI , WANG ZHONGYU , YU MING , ZHU LIUSHENG
发明人： BROWN SEAN P , DRANSFIELD PAUL , DU XIAOHUI , FU ZICE , HOUZE JONATHAN , JIAO XIANYUN , LAI SUJEN , LI AN-RONG , LIU JIWEN , MA ZHIHUA , MEDINA JULIO C , PATTAROPONG VATEE , SHEN WANG , VIMOLRATANA MARC , WANG YINGCAI , WANG ZHONGYU , YU MING , ZHU LIUSHENG
IPC分类号： C07C62/34 , A61K31/185 , A61K31/33 , A61P3/10 , C07D221/00 , C07D231/00 , C07D249/00 , C07D271/00 , C07D277/00 , C07D311/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供可用于例如治疗受试者的代谢紊乱的化合物。这样的化合物具有通式IA，IB，I'A或I'B，其中变量的定义在本文中提供。本发明还提供组合物，其包括所述化合物在制备药物和用于治疗代谢病症例如II型糖尿病中的用途以及所述化合物的使用方法。

10. 发明申请

WO2008130514A1 SUBSTITUTED BIPHENYL PHENOXY-, THIOPHENYL- AND AMINOPHENYLPROPANOIC ACID GPR40 MODULATORS 审中-公开
标题翻译：取代二苯基苯氧基 - ，十二烯基和氨基亚氨基丙酸GPR40调节剂
公开(公告)号：WO2008130514A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004701
申请日：2008-04-10
申请人： AMGEN INC. , BROWN, Sean, P. , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, Xian, Yun , KOHN, Todd, J. , PATTAROPONG, Vatee , VIMOLRATANA, Marc , SCHMITT, Michael, J.
发明人： BROWN, Sean, P. , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, Xian, Yun , KOHN, Todd, J. , PATTAROPONG, Vatee , VIMOLRATANA, Marc , SCHMITT, Michael, J.
IPC分类号： C07C59/68 , C07C59/72 , C07D261/08 , A61K31/41 , A61K31/19 , A61P3/00
CPC分类号： C07C59/68 , C07C59/72 , C07D261/08
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula (I) where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式（I），其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

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