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1. 发明申请

WO2008017025A2 COMBINATION THERAPY 审中-公开
标题翻译：联合治疗
公开(公告)号：WO2008017025A2
公开(公告)日：2008-02-07
申请号：PCT/US2007075064
申请日：2007-08-02
申请人： GENZYME CORP , BRIDGER GARY , PELUS LOUIS M
发明人： BRIDGER GARY , PELUS LOUIS M
IPC分类号： A61K31/401
CPC分类号： A61K45/06 , A61K31/401 , A61K2300/00
摘要： Methods to mobilize progenitor and/or stem cells from the bone marrow to the bloodstream by administering a combination of at least one CXCR4 inhibitor and at least one VLA-4 inhibitor are described. The combinations may also be used to treat multiple myeloma.
摘要翻译：描述了通过施用至少一种CXCR4抑制剂和至少一种VLA-4抑制剂的组合来将祖细胞和/或干细胞从骨髓移动到血流中的方法。这些组合也可以用于治疗多发性骨髓瘤。

2. 发明申请

WO2007022371A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS 审中-公开
标题翻译：化合物接头结合化合物
公开(公告)号：WO2007022371A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/032170
申请日：2006-08-16
申请人： ANORMED INC. , ZHOU, Yuanxi , BOURQUE, Elyse , ZHU, Yongbao , MCEACHERN, Ernest, J. , HARWIG, Curtis , SKERLJ, Renato, T. , BRIDGER, Gary, J. , LI, Tong-Shuang , METZ, Markus
发明人： ZHOU, Yuanxi , BOURQUE, Elyse , ZHU, Yongbao , MCEACHERN, Ernest, J. , HARWIG, Curtis , SKERLJ, Renato, T. , BRIDGER, Gary, J. , LI, Tong-Shuang , METZ, Markus
IPC分类号： A61K31/496 , A61K31/454 , C07D403/14 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/08
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译：本发明涉及趋化因子受体结合化合物，药物组合物及其用途。更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR4或CCR5的调节剂。一方面，这些化合物表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。

3. 发明申请

WO2006020891A2 CHEMOKINE COMBINATIONS TO MOBILIZE PROGENITOR/STEM CELLS 审中-公开
标题翻译： CHEMOKINE组合移动原核生物/干细胞
公开(公告)号：WO2006020891A2
公开(公告)日：2006-02-23
申请号：PCT/US2005028783
申请日：2005-08-11
申请人： ANORMED INC , BRIDGER GARY J , PELUS LOUIS M
发明人： BRIDGER GARY J , PELUS LOUIS M
IPC分类号： A61K38/19 , A61K31/33
CPC分类号： A61K31/33 , A61K38/195 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 in combination with the CXCR2 chemokine GROß, including its modified forms, are disclosed.
摘要翻译：公开了使用与趋化因子受体CXCR4结合CXCR2趋化因子GROβ（包括其修饰形式）结合的化合物来提高动物受试者中祖细胞和干细胞计数的方法。

4. 发明申请

WO2004091518A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS 审中-公开
标题翻译： CXCR4 CHEMOKINE RECEPTOR BINDING化合物
公开(公告)号：WO2004091518A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011328
申请日：2004-04-12
申请人： ANORMED INC. , BRIDGER, Gary, J. , MCEACHERN, Ernest, J. , SKERLJ, Renato , SCHOLS, Dominique , BAIRD, Ian , KALLER, Al , HARWIG, Curtis , ZHU, Yongbao , CHEN, Gang , SKUPINSKA, Krystyna
发明人： BRIDGER, Gary, J. , MCEACHERN, Ernest, J. , SKERLJ, Renato , SCHOLS, Dominique , BAIRD, Ian , KALLER, Al , HARWIG, Curtis , ZHU, Yongbao , CHEN, Gang , SKUPINSKA, Krystyna
IPC分类号： A61K
CPC分类号： C07D413/14 , C07D213/38 , C07D213/61 , C07D213/65 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/82 , C07D213/89 , C07D401/12 , C07D401/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D451/04 , C07D471/06
摘要： The present invention relates to compounds that bind to chemokine receptors, and having the formula (I) wherein each A, X, Y, R 1 , R 2 and R 3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.
摘要翻译：本发明涉及结合趋化因子受体的化合物，并且具有式（I），其中每个A，X，Y，R 1，R 2和R 3是取代基。本发明还涉及使用这些化合物的方法，例如用于治疗HIV感染和炎性病症如类风湿性关节炎。此外，本发明涉及使用这些化合物提高祖细胞和干细胞计数的方法以及升高白细胞计数的方法。

5. 发明申请

WO0234745A8 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：化合物受体结合杂环化合物
公开(公告)号：WO0234745A8
公开(公告)日：2003-09-18
申请号：PCT/US0129590
申请日：2001-09-17
申请人： ANORMED INC , BRIDGER GARY , SKERLJ RENATO , KALLER AL , HARWIG CURTIS , BOGUCKI DAVID , WILSON TREVOR R , CRAWFORD JASON , MCEACHERN ERNEST J , ATSMA BEM , NAN SIQIAO , ZHOU YUANXI , SCHOLS DOMINIQUE , SMITH CHRISTOPHER DENNIS , DI FLURI ROSARIA MARIA
发明人： BRIDGER GARY , SKERLJ RENATO , KALLER AL , HARWIG CURTIS , BOGUCKI DAVID , WILSON TREVOR R , CRAWFORD JASON , MCEACHERN ERNEST J , ATSMA BEM , NAN SIQIAO , ZHOU YUANXI , SCHOLS DOMINIQUE , SMITH CHRISTOPHER DENNIS , DI FLURI ROSARIA MARIA
IPC分类号： A61P31/18 , C07D213/38 , C07D213/65 , C07D213/81 , C07D215/40 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D493/04 , C07D521/00 , C07D403/12 , A61K31/47 , C07D403/14
CPC分类号： C07D213/81 , A61K31/4709 , C07D213/38 , C07D213/65 , C07D215/40 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/04 , C07D493/04
摘要： Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.
摘要翻译：公开了调节趋化因子受体活性的化合物。这些化合物优选为包含四氢喹啉和苯并咪唑的叔胺。

6. 发明申请

WO2003011277A2 METHODS TO MOBILIZE PROGENITOR/STEM CELLS 审中-公开
标题翻译：移动祖细胞/干细胞的方法
公开(公告)号：WO2003011277A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024212
申请日：2002-07-30
申请人： ANORMED INC. , BRIDGER, Gary, J. , ABRAMS, Michael, J. , HENSON, Geoffrey, W. , MACFARLAND, Ronald, Trevor , CALANDRA, Gary, B.
发明人： BRIDGER, Gary, J. , ABRAMS, Michael, J. , HENSON, Geoffrey, W. , MACFARLAND, Ronald, Trevor , CALANDRA, Gary, B.
IPC分类号： A61K31/33
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z' (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of formula (a), wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z' may be embodied in a form as defined by Z above, or alternatively may be of the formula -N(R)-(CR 2 ) n -X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; "linker" represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
摘要翻译：公开了使用结合趋化因子受体CXCR4的化合物提高动物受试者的祖细胞和干细胞计数的方法。这些化合物的优选实施方案具有式Z-接头-Z'（1）或其药学上可接受的盐，其中Z为含有9-32个环成员的环多胺，其中3-8个为氮原子，所述氮原子与其它至少2个碳原子，并且其中所述杂环可以任选地包含除了氮之外的另外的杂原子和/或可以与另外的环系统稠合; 或Z具有式（a），其中A包含含有至少一个N的单环或双环稠合环体系，B是H或1-20个原子的有机部分，Z'可以以如Z 或可选地可以具有式-N（R） - （CR 2）n -X其中每个R独立地为H或直链，支链或环状的烷基（ n为1或2，并且X为芳环，包括杂芳环，或为硫醇; ＆QUOT;接头＆QUOT; 表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合的芳基，氧原子，或可含有酮基或氮或硫原子。

7. 发明申请

WO1995018808A1 CYCLIC POLYAMINES 审中-公开
标题翻译：环状聚氨酯
公开(公告)号：WO1995018808A1
公开(公告)日：1995-07-13
申请号：PCT/GB1995000019
申请日：1995-01-06
申请人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY , BRIDGER, Gary, James , PADMANABHAN, Sreenivasan , SKERLJ, Renato, Tony
发明人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY
IPC分类号： C07D519/00
CPC分类号： C07D273/00
摘要： Linked polyamine cyclic compounds of general formula V - R - A - R' - W where V and W are independently cyclic polyamine moieties having from 9 to 32 ring members and 3 to 8 amine nitrogens and having either one or more aromatic rings fused thereto or a heteroatom other than nitrogen incorporated in the ring, A is an aliphatic or aromatic moiety and R and R' are each a linking chain, possess improved partition coefficients at biologically relevant pH compared to known compounds, and possess high anti-HIV activity.
摘要翻译：具有通式V-R-A-R'-W的连接多胺环状化合物，其中V和W独立地为具有9至32个环成员和3至8个胺氮并具有一个或多个芳环稠合的环状多胺部分， A是脂环族或芳族部分，R和R'各自为连接链，与已知化合物相比，在生物相关pH下具有改善的分配系数，并且具有高抗HIV活性。

8. 发明申请

WO2004106493A3 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY 审中-公开
标题翻译：具有增强功效的化合物受体结合杂环化合物
公开(公告)号：WO2004106493A3
公开(公告)日：2005-08-25
申请号：PCT/US2004015977
申请日：2004-05-21
申请人： ANORMED INC , BRIDGER GARY J , KALLER AL , HARWIG CURTIS , SKERLJ RENATO , BOGUCKI DAVID , WILSON TREVOR R , CRAWFORD JASON , MCEACHERN ERNEST J , ATSMA BEM , NAN SIQIAO , ZHOU YUANXI , SCHOLS DOMINIQUE , SMITH CHRISTOPHER DENNIS , DI FLURI MARIA ROSARIA
发明人： BRIDGER GARY J , KALLER AL , HARWIG CURTIS , SKERLJ RENATO , BOGUCKI DAVID , WILSON TREVOR R , CRAWFORD JASON , MCEACHERN ERNEST J , ATSMA BEM , NAN SIQIAO , ZHOU YUANXI , SCHOLS DOMINIQUE , SMITH CHRISTOPHER DENNIS , DI FLURI MARIA ROSARIA
IPC分类号： A01N43/42 , A01N43/50 , A01N43/52 , A01N43/58 , A01N43/60 , A61K31/415 , A61K31/47 , A61K31/495 , A61K31/50 , C07D235/10 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04 , C12N20060101
CPC分类号： A61K31/4184 , A61K31/415 , A61K31/436 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/497 , A61K31/4985 , A61K31/50 , A61K31/502 , A61K31/506 , A61K31/5377 , C07D235/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D471/06 , C07D491/04 , C07D491/052
摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infections of target cells by a human immunodeficiency virus (HIV).
摘要翻译：本发明涉及由三个侧基包围的核心氮原子组成的杂环化合物，其中三个侧基中的两个优选为苯并咪唑基甲基和四氢喹啉基，第三侧基含有N并且任选地含有另外的环。这些化合物结合趋化因子受体，包括CXCR4和CCR5，并表现出针对人类免疫缺陷病毒（HIV）对靶细胞感染的保护作用。

9. 发明申请

WO2004093817A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY 审中-公开
标题翻译：具有增强功效的化合物受体结合杂环化合物
公开(公告)号：WO2004093817A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012627
申请日：2004-04-22
申请人： ANORMED INC. , BRIDGER, Gary, J. , MCEACHERN, Ernest, J. , SKERLJ, Renato , SCHOLS, Dominique
发明人： BRIDGER, Gary, J. , MCEACHERN, Ernest, J. , SKERLJ, Renato , SCHOLS, Dominique
IPC分类号： A61K
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds that interact with the CXCR4 receptor are described. The compounds are useful in treating for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well as asthma or cancer, and are useful in methods to elevate progenitor and stem cell counts as well as methods to elevate white blood cell counts.
摘要翻译：描述了与CXCR4受体相互作用的化合物。该化合物可用于治疗实例，HIV感染和炎性病症如类风湿性关节炎，以及哮喘或癌症，并且可用于提高祖细胞和干细胞计数的方法以及升高白细胞计数的方法。

10. 发明申请

WO03011277A3 METHODS TO MOBILIZE PROGENITOR/STEM CELLS 审中-公开
标题翻译：移动原核细胞/干细胞的方法
公开(公告)号：WO03011277A3
公开(公告)日：2003-05-22
申请号：PCT/US0224212
申请日：2002-07-30
申请人： ANORMED INC , BRIDGER GARY J , ABRAMS MICHAEL J , HENSON GEOFFREY W , MACFARLAND RONALD TREVOR , CALANDRA GARY B
发明人： BRIDGER GARY J , ABRAMS MICHAEL J , HENSON GEOFFREY W , MACFARLAND RONALD TREVOR , CALANDRA GARY B
IPC分类号： A61K45/00 , A61K20060101 , A61K31/33 , A61K31/395 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K38/00 , A61K38/19 , A61P7/00 , A61P7/06 , A61P17/02 , A61P31/04 , A61P35/02 , A61P37/00 , A61P37/04
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： The present invention is directed to methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4.
摘要翻译：本发明涉及使用结合趋化因子受体CXCR4的化合物来提高动物受试者中祖细胞和干细胞计数的方法。

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