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1. 发明申请

WO2012122281A3 CAPSULAR MEMBRANE TREATMENTS TO INCREASE ACCOMMODATIVE AMPLITUDE 审中-公开
标题翻译： CAPSULAR膜治疗增加舒张功能
公开(公告)号：WO2012122281A3
公开(公告)日：2012-11-15
申请号：PCT/US2012028090
申请日：2012-03-07
申请人： ABBOTT MEDICAL OPTICS INC , BOR ZSOLT , BRADY DANIEL G , GERAGHTY EDWARD , REISIN CARINA R , CALI DOUGLAS
发明人： BOR ZSOLT , BRADY DANIEL G , GERAGHTY EDWARD , REISIN CARINA R , CALI DOUGLAS
IPC分类号： A61F9/007
CPC分类号： A61F9/013 , A61F2/16 , A61F9/00 , A61F9/0008 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F9/0079 , A61F9/008 , A61F9/00838 , A61F2009/0087 , A61F2009/00889 , A61F2009/00895
摘要： Methods and apparatus treat the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL. The treatment of the eye to stiffen the intermediate portion may comprise application of one or more of an energy or a substance to the intermediate portion.
摘要翻译：方法和装置处理晶状体囊以增加眼睛的适应性。透镜胶囊的治疗可以包括处理透镜胶囊的一部分，以便加强经处理的部分并改善眼睛的适应性。透镜胶囊的中间部分可以位于透镜胶囊的光学使用的中心部分和与眼睛的小区连接的透镜胶囊的周边部分之间。透镜胶囊的加强的中间部分可以改善透镜胶囊的周边部分与透镜胶囊的中心部分的联接，使得透镜的光学中心部分的调节量增加。当透镜胶囊对设置在透镜胶囊内的透镜的力增加时，透镜可以包括眼睛的天然晶状体或诸如调节性IOL的人造镜片。治疗眼睛以加强中间部分可以包括向中间部分施加一种或多种能量或物质。

2. 发明申请

WO2010135685A1 OPHTHALMIC LENSES WITH ENHANCED SURFACE AND METHODS OF FABRICATION THEREOF 审中-公开
标题翻译：具有增强表面的眼镜及其制造方法
公开(公告)号：WO2010135685A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035832
申请日：2010-05-21
申请人： ABBOTT MEDICAL OPTICS INC. , BUMBALOUGH, Timothy, R. , GERAGHTY, Edward , BRADY, Daniel, G.
发明人： BUMBALOUGH, Timothy, R. , GERAGHTY, Edward , BRADY, Daniel, G.
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1616 , A61F2/1618 , A61F2/1648 , A61F2002/1681 , A61F2002/1699 , A61F2210/0076 , A61F2240/001 , A61F2250/0053 , B29D11/023
摘要： An ophthalmic lens (100) for providing enhanced vision includes a finished optic (105) comprising a base optic (115) and a shell (135). The base optic has an anterior surface (120) and an opposing posterior surface (125), at least one of the surfaces having a first value of a surface quality parameter. The shell includes a membrane (140, 150) including an inner surface and an outer surface, the inner surface covering one or more of the surfaces of the base optic. The outer surface has a second value of the surface quality parameter, wherein the second value is greater than the first value.
摘要翻译：用于提供增强视觉的眼用透镜（100）包括包括基底光学元件（115）和外壳（135）的成品光学元件（105）。基部光学元件具有前表面（120）和相对的后表面（125），至少一个表面具有表面质量参数的第一值。壳体包括包括内表面和外表面的膜（140,150），内表面覆盖基底光学元件的一个或多个表面。外表面具有表面质量参数的第二值，其中第二值大于第一值。

3. 发明申请

WO2008082855A3 HAPTIC FOR ACCOMMODATING INTRAOCULAR LENS 审中-公开
标题翻译：适合摄入镜片
公开(公告)号：WO2008082855A3
公开(公告)日：2009-09-11
申请号：PCT/US2007086840
申请日：2007-12-07
申请人： ADVANCED MEDICAL OPTICS INC , CALI DOUGLAS S , NGUYEN TUYET HOC , BRADY DANIEL G , WEEBEER HENDRIK A
发明人： CALI DOUGLAS S , NGUYEN TUYET HOC , BRADY DANIEL G , WEEBEER HENDRIK A
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2002/1681 , A61F2002/169 , A61F2230/0095 , A61F2250/0018
摘要： An intraocular lens is disclosed, with an optic that changes shape in response to a deforming force exerted by the zonules of the eye. A haptic (120) supports the optic around its equator and couples the optic to the capsular bag of the eye. The region of contact between the optic and the haptic extends into the edge of the optic (130), similar to the interface between a bicycle tire and the rim that holds it in place. The haptic may be stiffer than the optic. The haptic may have the same refractive index as the optic. The haptic may include a saddle-shaped portion in contact with the adjustable optic, with a convex profile along an optical axis; and a concave profile in a plane perpendicular to the optical axis.
摘要翻译：公开了一种眼内透镜，其具有响应于由眼睛的小环施加的变形力而改变形状的光学元件。触觉（120）支撑其赤道附近的光学器件，并将光学元件耦合到眼睛的囊袋。光学元件和触觉件之间的接触区域延伸到光学元件（130）的边缘，类似于自行车轮胎和将其保持在适当位置的边缘之间的界面。触觉可能比光学元件更硬。触觉可以具有与光学元件相同的折射率。触觉件可以包括与可调节光学元件接触的鞍形部分，具有沿着光轴的凸形轮廓; 以及在垂直于光轴的平面中的凹形轮廓。

4. 发明申请

WO2007053374A3 HAPTIC FOR ACCOMMODATING INTRAOCULAR LENS 审中-公开
标题翻译：适合摄入镜片
公开(公告)号：WO2007053374A3
公开(公告)日：2007-10-11
申请号：PCT/US2006041500
申请日：2006-10-23
申请人： ADVANCED MEDICAL OPTICS INC , BRADY DANIEL G , WEEBER HENK A
发明人： BRADY DANIEL G , WEEBER HENK A
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1613 , A61F2/1624 , A61F2002/1682 , A61F2002/1683 , A61F2002/1686 , A61F2002/169
摘要： A haptic (30, 50, 59, 69, 89) is provided for use in an accommodating intraocular lens. The haptic has multiple filaments, each connected to the edge of the optic (28,48,58,68,88,98,108) at one end. Each filament has a shape that conforms to an equatorial region of the capsular bag (18). The haptic couples the forces exerted by the capsular bag of the eye (10) during accommodation radially to the edge of the optic, produce a diametric expansion or compression of the optic. This diametric motion distorts the optic, producing a change in any or all of the anterior radius, the posterior radius, and the thickness. These changes affect the power of the lens and/or location of the image. The haptic may optionally have a thin membrane (66) joining the filaments at the optic end, and may optionally have a connecting ring (62) that joins the filaments at the end opposite that of the optic.
摘要翻译：提供用于容纳人工晶状体的触觉（30,50,59,69,89）。触觉具有多个细丝，每个细丝在一端连接到光学元件的边缘（28,48,58,68,88,98,108）。每个细丝具有符合囊袋（18）的赤道区域的形状。触觉件将由眼睛（10）的囊袋施加的力在径向地放置到光学器件的边缘处，产生光学器件的直径膨胀或压缩。该直径运动扭曲光学元件，产生前半径，后半径和厚度中的任何或全部的变化。这些变化影响镜头的功率和/或图像的位置。触觉件可以可选地具有在光学端处连接细丝的薄膜（66），并且可以可选地具有连接环（62），所述连接环在与光学元件相对的端部连接长丝。

5. 发明申请

WO2007079315A1 ACCOMMODATING INTRAOCULAR LENS WITH OUTER SUPPORT STRUCTURE 审中-公开
标题翻译：配有外支撑结构的镜片镜片
公开(公告)号：WO2007079315A1
公开(公告)日：2007-07-12
申请号：PCT/US2006/061671
申请日：2006-12-06
申请人： ADVANCED MEDICAL OPTICS, INC. , BRADY, Daniel, G. , GWON, Arlene, E.
发明人： BRADY, Daniel, G. , GWON, Arlene, E.
IPC分类号： A61F2/16
CPC分类号： A61F2/1624 , A61F2/1629 , A61F2/1635 , A61F2/1648 , A61F2/1694 , A61F2002/1682 , A61F2002/169 , A61F2250/006
摘要： An intraocular lens (300) for insertion into the capsular bag of an eye contains an optic (302), an outer periphery, and an outer support structure (304). The optic has a periphery and centered about an optical axis. The outer periphery is disposed about the optic and configured to engage an equatorial region of the capsular bag of an eye. The outer support structure is disposed along the periphery and spaced from the optic with voids outer support structure and the optic. The intraocular lens further comprises a first intermediate member ( 308) and a weakened region (310) disposed along the outer periphery between the outer support structure and the first intermediate member. The first intermediate member operably couples the optic and the outer support structure. The weakened region is attached to and configured to provide relative motion between, the outer support structure and the first intermediate member in response to the ciliary muscle of the eye.
摘要翻译：用于插入眼睛囊袋的眼内透镜（300）包含光学元件（302），外周边和外支撑结构（304）。光学元件具有周边并且围绕光轴居中。外围围绕光学元件设置，并且被构造成接合眼睛囊袋的赤道区域。外部支撑结构沿着周边设置并与光学元件间隔开，具有空隙外部支撑结构和光学元件。眼内透镜还包括沿着外支撑结构和第一中间构件之间的外周布置的第一中间构件（308）和弱化区（310）。第一中间构件可操作地连接光学元件和外部支撑结构。弱化区域附接并构造成响应于眼睛的睫状肌而在外支撑结构和第一中间构件之间提供相对运动。

6. 发明申请

WO2003059196A2 ACCOMMODATING INTRAOCULAR LENS WITH ELONGATED SUSPENSION STRUCTURE 审中-公开
标题翻译：具有延长悬挂结构的内窥镜镜片
公开(公告)号：WO2003059196A2
公开(公告)日：2003-07-24
申请号：PCT/US2003/001268
申请日：2003-01-14
申请人： ADVANCED MEDICAL OPTICS, INC. , BRADY, Daniel, G. , GWON, Arlene , GLICK, Robert, E.
发明人： BRADY, Daniel, G. , GWON, Arlene , GLICK, Robert, E.
IPC分类号： A61F
CPC分类号： A61F2/1613 , A61F2/1629 , A61F2/1694 , A61F2002/1681
摘要： An intraocular lens (IOL) for insertion in a capsular bag of an eye includes an optic for focusing light and a movement assembly coupled to the optic. The movement assembly is adapted to cooperate with the capsular bag to effect accommodating movement of the optic. The movement assembly includes one or more elongated fixation members coupled to a periphery of the optic and adapted to convert radial movement of the capsular bag to axial movement of the optic. The fixation members extend spirally at least half-way around the optic. Angled transition sections may be provided between each fixation member and the optic periphery. The anterior and posterior edges of the optic periphery may have relatively sharp angles to reduce epithelial cell growth.
摘要翻译：用于插入眼袋的眼内透镜IOL包括用于聚焦光的光学元件和耦合到光学元件的移动组件。移动组件适于与胶囊袋配合以实现光学元件的容纳运动。移动组件包括联接到光学元件的周边的一个或多个细长的固定构件，并且适于将囊袋的径向移动转换成光学元件的轴向移动。固定构件至少在光学元件周围一半地螺旋延伸。可以在每个固定构件和光学周边之间设置有角度的过渡部分。光学周边的前边缘和后边缘可以具有相对尖锐的角度以减少上皮细胞生长。

7. 发明申请

WO2003020170A2 IRIS-SUPPORTED INTRAOCULAR LENSES 审中-公开
标题翻译： IRIS支持的人工晶状体
公开(公告)号：WO2003020170A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/025634
申请日：2002-08-12
申请人： ADVANCED MEDICAL OPTICS, INC. , BRADY, Daniel, G.
发明人： BRADY, Daniel, G.
IPC分类号： A61F2/00
CPC分类号： A61F2/1602 , A61F2/16 , A61F2/1608 , A61F2002/1681
摘要： An iris-supported intraocular lens having an optic portion and a plurality of fixation members coupled thereto. Each fixation member has a pair of pincer arms that separate outward of the optic and converge toward one another at aligned end tips. One or both of the end tips are covered with a soft sleeve or cap. The IOL is fixed in the anterior chamber of the eye by pinching the iris tissue between the end tips of each pair of pincer arms. The soft sleeves eliminate damage to the iris tissue.
摘要翻译：具有光学部分和与其连接的多个固定部件的虹膜支持的人工晶状体。每个固定构件具有一对夹钳臂，所述夹钳臂在光学器件外部分开并且在对准的末端尖端处朝向彼此会聚。一个或两个末端提示用柔软的套筒或帽子覆盖。通过在每对钳臂的末端之间夹紧虹膜组织，将IOL固定在眼睛的前房中。柔软的袖子消除了对虹膜组织的伤害。

8. 发明申请

WO02058596A3 APPARATUS AND METHOD FOR MULTIPLY FOLDING AND INSERTING AN INTRAOCULAR LENS IN AN EYE 审中-公开
标题翻译：用于在眼中多次折叠和插入眼内晶状体的装置和方法
公开(公告)号：WO02058596A3
公开(公告)日：2002-10-10
申请号：PCT/US0202217
申请日：2002-01-21
申请人： ADVANCED MEDICAL OPTICS INC , BRADY DANIEL G
发明人： BRADY DANIEL G
IPC分类号： A61F9/007 , A61F2/16
CPC分类号： A61F2/1664
摘要： An intraocular lens (IOL) insertion system, cartridge and/or combination cartridge and folding member that facilitates multiply folding an IOL within a load chamber of the cartridge prior to insertion in an eye. In the system embodiment, a folding member is provided in a handpiece that interacts with the cartridge to multiply fold the IOL therewithin. Alternatively, the cartridge may incorporate the folding member in its structure, or a separate folding member that interacts with the cartridge may be provided in a combination. The folding member may be a planar element that extends through a slot in the wall of the load chamber ot displace a midportion of the IOL away from the inner wall of the load chamber. Desirably, the multiply folded configuration that results is an M-shape or a W-shape, depending on orientation. The cartridge may further include structure that retains the multiply folded configuration of the IOL as it passes through an injection tube and into the eye.
摘要翻译：眼内透镜（IOL）插入系统，盒和/或组合盒和折叠构件，其有助于在插入眼中之前在盒的装载室内多次折叠IOL。在该系统实施例中，折叠构件被设置在与盒相互作用以在其中多倍折叠IOL的手持件中。可选地，盒可以将折叠构件结合在其结构中，或者可以以组合的方式提供与盒相互作用的单独的折叠构件。折叠构件可以是平面元件，其延伸穿过装载室的壁中的狭槽以使IOL的中间部分远离装载室的内壁移位。理想地，取决于取向，产生的多重折叠配置是M形或W形。药筒可进一步包括当IOL穿过注射管并进入眼睛时保持IOL的多重折叠构型的结构。

9. 发明申请

WO2002071982A1 TEPPED OIL INSERTION CARTRIDGE 审中-公开
标题翻译： TEPPED油封装盒
公开(公告)号：WO2002071982A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/002216
申请日：2002-01-21
申请人： ALLERGAN SALES, INC. , BRADY, Daniel, G.
发明人： BRADY, Daniel, G.
IPC分类号： A61F2/16
CPC分类号： A61F2/1664
摘要： An intraocular lens (IOL) insertion apparatus including a cartridge with an IOL-receiving chamber, a handpiece into which the cartridge is loaded, and a plunger rod that extends through a lumen in the cartridge to reliably engage the IOL therein. The chamber is stepped in one section to cause the IOL positioned therein to assume a complex curve. A lip or projection on the plunger rod is aligned with the complex curve and intersects the IOL to reliably engage the IOL across its thickness. The cartridge may be a folding type with a pair of arcuate walls and extension wings joined at a living hinge. The stepped section of the chamber may coincide with the location of the hinge.
摘要翻译：一种眼内透镜（IOL）插入装置，包括具有IOL接收室的盒，装有盒的手持件以及延伸穿过盒中的内腔的活塞杆，以可靠地接合IOL。腔室被分段成一个部分，以使位于其中的IOL呈现复杂的曲线。柱塞杆上的唇缘或突起与复合曲线对准，并与IOL相交，以可靠地将IOL与其厚度接合。盒可以是折叠式，其具有在活动铰链处连接的一对弓形壁和延伸翼。腔室的台阶部分可以与铰链的位置重合。

10. 发明申请

WO0193827B1 NEUROTOXIN IMPLANT 审中-公开
标题翻译：神经毒素植入物
公开(公告)号：WO0193827B1
公开(公告)日：2002-05-10
申请号：PCT/US0117164
申请日：2001-05-25
申请人： ALLERGAN SALES INC , DONOVAN STEPHEN , BRADY DANIEL G
发明人： DONOVAN STEPHEN , BRADY DANIEL G
IPC分类号： A61K9/16 , A61K9/00 , A61K9/22 , A61K31/28 , A61K38/00 , A61K38/48 , A61K47/32 , A61K47/34 , A61K47/42 , A61P21/02 , A61P25/00 , A61P25/14
CPC分类号： A61K9/0024 , A61K38/4893 , Y10S514/964
摘要： A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer, such as an ethyl vinyl acetate copolymer and the neurotoxin. The neurotoxin can be a botulinum toxin.
摘要翻译：一种生物相容的植入物，用于在一个月至五年的治疗期内连续体内释放神经毒素。植入物可以通过浇铸聚合物如乙酸乙烯酯共聚物和神经毒素的溶液来制备。神经毒素可以是肉毒杆菌毒素。

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