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1. 发明申请

WO1988010118A1 EXPRESSION OF PROTEINS IN MILK 审中-公开
标题翻译：蛋白质在奶制品中的表达
公开(公告)号：WO1988010118A1
公开(公告)日：1988-12-29
申请号：PCT/US1988002134
申请日：1988-06-23
申请人： BIOGEN N.V. , MEADE, Harry , LONGBERG, Nils
发明人： BIOGEN N.V.
IPC分类号： A61K35/20
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/103 , A01K2227/105 , A01K2267/01 , C07K14/4732 , C07K2319/00 , C07K2319/02 , C12N9/6456 , C12N15/85 , C12N2830/008 , C12N2830/85 , C12N2840/44 , Y10S530/832 , Y10S530/833
摘要： This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desired recombinant protein in or along with its milk. This invention also relates to the transgenic mammal that produces the desired recombinant product in its milk.

2. 发明申请

WO1987003300A1 ENHANCED SECRETION OF HETEROLOGOUS PROTEINS BY HOSTS USING SUBSTITUTED PROMOTERS 审中-公开
标题翻译：通过使用替代促进剂的宿主增强异位蛋白的分泌
公开(公告)号：WO1987003300A1
公开(公告)日：1987-06-04
申请号：PCT/EP1986000675
申请日：1986-11-24
申请人： BIOGEN N.V.
发明人： BIOGEN N.V. , ERNST, Joachim, F. , SCHMEISSNER, Ursula
IPC分类号： C12N15/00
CPC分类号： C07K14/65 , C07K14/395 , C07K2319/02 , C12N15/69 , C12N15/81
摘要： Improved secretion of heterologous proteins by hosts such as yeast by using promoters of at most intermediate strength with heterologous DNA secretion signal sequences. A promoter of at most intermediate strength, such as the actin (ACT) or iso-l-cytochrome c (CYCl) promoter in S. cerevisiae is operatively linked to a DNA signal sequence, such as the MFalpha) signal sequence. A DNA sequence for a selected protein, such as somatomedin C (SMC), tissue plasminogen activator (TPA) or tumor necrosis factor (TNF), may be operatively linked to the DNA signal sequence.

3. 发明申请

WO1987000863A1 PRODUCTION OF A VITAMIN C PRECURSOR USING GENETICALLY MODIFIED ORGANISMS 审中-公开
标题翻译：维生素C前驱物的生产使用基因改造的有机体
公开(公告)号：WO1987000863A1
公开(公告)日：1987-02-12
申请号：PCT/US1986001571
申请日：1986-08-01
申请人： BIOGEN, N.V. , HARDY, Kimber , VAN DE POL, Hendrick , GRINDLEY, June , PAYTON, Mark, A.
发明人： BIOGEN, N.V.
IPC分类号： C12N15/00
CPC分类号： C12Y101/01274 , C12N9/0006 , C12P7/60
摘要： An enzyme for conversion of 2,5-diketo-D-gluconate (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) and a genetically modified organism that expresses all the fermentation enzymes needed to convert glucose to 2-KLG (a precursor to ascorbic acid) using the new enzyme. Preferably, the organism is Erwinia citreus, or a mutated strain of Erwinia citreus, unable to use 2,5-DKG or 2-KLG as a sole carbon source, into which the gene for a 2,5-DKG reductase, produced by Corynebacterium sp., SHS 752001, has been inserted. The preferred transformed organism expresses the fermentation enzymes Erwinia citreus normally expresses for fermentation of glucose to 2,5-DKG and, in addition, an enzyme Corynebacterium sp. SHS 752001 expresses for fermentation of 2,5-DKG to 2-KLG.
摘要翻译：用于将2,5-二酮-D-葡萄糖酸盐（2,5-DKG）转化为2-酮-L-古洛糖酸（2-KLG）的酶，以及表达转化葡萄糖所需的所有发酵酶的转基因生物至2-KLG（抗坏血酸的前体）。优选地，生物体是欧文氏菌（Erwinia citreus），或者不能使用2,5-DKG或2-KLG作为唯一碳源的突变的欧文氏菌（Erwinia citreus）菌株，其中由棒状杆菌产生的2,5-DKG还原酶的基因 sp。，SHS 752001，已插入。优选的转化生物表达发酵酶欧文氏菌（Erwinia citreus）通常表达用于将葡萄糖发酵成2,5-DKG，另外还有酶棒杆菌属（Corynebacterium sp。）。 SHS 752001表示2,5-DKG至2-KLG的发酵。

4. 发明申请

WO1986003751A2 PURIFICATION, PRODUCTION AND USE OF TUMOR NECROSIS FACTORS 审中-公开
标题翻译：净化，生产和使用肿瘤坏死因子
公开(公告)号：WO1986003751A2
公开(公告)日：1986-07-03
申请号：PCT/EP1985000721
申请日：1985-12-19
申请人： BIOGEN N.V.
发明人： BIOGEN N.V. , FIERS, Walter, C. , FRANSEN, Lucia, M. , TAVERNIER, Jan, Honoré, Leo , MARMENOUT, Anne, Louis, Marie , VAN DER HEYDEN, José , ALLET, Bernard , KAWASHIMA, Eric, H.
IPC分类号： C07K03/22
CPC分类号： C12N15/70 , A61K38/191 , A61K38/21 , C07K14/525 , Y02A50/411 , A61K38/04 , A61K2300/00
摘要： A process of producing mammalian tumor necrosis factors (TNF) and TNF-like polypeptides by culturing prokaryotic hosts transformed with a recombinant DNA molecule comprising DNA sequences encoding those polypeptides operatively linked to either one of the T4 or the pL-T4 expression control sequences. A process for purifying TNF-like polypeptides using an anion exchanger. The TNFs and TNF-like polypeptides produced by the processes of this invention, and compositions and methods utilizing those TNFs and TNF-like polypeptides, are useful in anticancer, antitumor and antimalarial therapies. They are also useful together with interferon therapy and chemotherapy in anticancer and antitumor therapies, and in combination with actinomycin D in the treatment of tumor-bearing mammals.
摘要翻译：通过培养用包含可操作地连接到T4或pL-T4表达控制序列之一的编码那些多肽的DNA序列的重组DNA分子转化的原核宿主来产生哺乳动物肿瘤坏死因子（TNF）和TNF样多肽的方法。使用阴离子交换剂纯化TNF样多肽的方法。通过本发明方法产生的TNF和TNF样多肽，以及利用这些TNF和TNF样多肽的组合物和方法可用于抗癌，抗肿瘤和抗疟疗法。它们与抗癌和抗肿瘤治疗中的干扰素治疗和化学疗法一起使用，并且与放线菌素D组合用于治疗荷瘤哺乳动物。

5. 发明申请

WO1986001538A1 MODIFIED TISSUE PLASMINOGEN ACTIVATORS 审中-公开
标题翻译：改良组织培养基激活剂
公开(公告)号：WO1986001538A1
公开(公告)日：1986-03-13
申请号：PCT/US1985001613
申请日：1985-08-26
申请人： BIOGEN N.V. , ROSA, Joseph, John , ROSA, Margaret, Dorethy
发明人： BIOGEN N.V.
IPC分类号： C12P21/00
CPC分类号： C12N9/6459 , A61K38/00 , C12Y304/21069
摘要： Modified human tissue plasminogen activators, the DNA sequences coding on expression for them and methods of making them in hosts transformed with those DNA sequences. The single chain form of these modified human t-PAs, t-PA (Lys 277$(1,4)$X), has a longer half life than the single chain form of native, or recombinant, t-PA, yet, in the two chain form these modified t-PAs have substantially the same affinity for fibrin and substantially the same activity as the two chain form of native, or recombinant, t-PA.

6. 发明申请

WO1988009820A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN-3 审中-公开
标题翻译： DNA序列，重组DNA分子和产生淋巴细胞功能相关抗原3的方法
公开(公告)号：WO1988009820A1
公开(公告)日：1988-12-15
申请号：PCT/US1988001924
申请日：1988-06-03
申请人： BIOGEN N.V. , DANA-FARBER CANCER INSTITUTE, INC. , WALLNER, Barbara, P. , SPRINGER, Timothy, A. , HESSION, Catherine , TIZARD, Richard , MATTALIANO, Robert , DUSTIN, Michael, L.
发明人： BIOGEN N.V. , DANA-FARBER CANCER INSTITUTE, INC.
IPC分类号： C12P21/00
CPC分类号： C07K14/70528 , A61K38/00 , G01N33/56972
摘要： Polypeptides that bind to CD2, the receptor on the surface of T-lymphocytes. Most preferably, the polypeptides bind to CD2 on the surface of T-lymphocytes and inhibit adhesion between T-lymphocytes and target cells. DNA sequences that code on expression in appropriate unicellular hosts for those polypeptides. Methods of making and using those polypeptides in therapy and diagnosis.

7. 发明申请

WO1988009674A1 STABILIZED FORMULATIONS OF GAMMA INTERFERONS 审中-公开
标题翻译：稳定的制糖剂
公开(公告)号：WO1988009674A1
公开(公告)日：1988-12-15
申请号：PCT/US1988001895
申请日：1988-06-09
申请人： BIOGEN N.V. , GOLDSTEIN, Joel, D.
发明人： BIOGEN N.V. , THATCHER, David, R.
IPC分类号： A61K45/02
CPC分类号： A61K47/26 , A61K38/217 , A61K47/12 , A61K47/183 , A61K31/7004 , A61K2300/00
摘要： This invention relates to compositions and methods useful for the stabilization of interferons. More particularly, this invention relates to the formulation of gamma interferons with lactobionic acid in an acetate/glycine buffer.

8. 发明申请

WO1988002632A1 COMBINATIONS OF TUMOR NECROSIS FACTORS AND ANTI-INFLAMMATORY AGENTS AND METHODS FOR TREATING MALIGNANT AND NON-MALIGNANT DISEASES 审中-公开
标题翻译：肿瘤坏死因子和抗炎药物的组合和治疗恶性和非恶性疾病的方法
公开(公告)号：WO1988002632A1
公开(公告)日：1988-04-21
申请号：PCT/US1987002602
申请日：1987-10-14
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BIOGEN N.V.
发明人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BIOGEN N.V. , GOLDBERG, Alfred, L. , FIERS, Walter, C. , KETTELHUT, Isis, C.
IPC分类号： A61K37/02
CPC分类号： A61K38/191 , A61K31/60 , A61K31/19 , A61K31/415 , A61K2300/00
摘要： Combinations and methods for the treatment of malignant and non-malignant diseases. More particularly, this invention relates to combinations of natural or recombinant tumor necrosis factors (''TNF'') and non-steroidal anti-inflammatory agents, such as indomethacin and ibuprofen, useful for the growth inhibition or killing of transformed cells. According to this invention, the non-steroidal anti-inflammatory agents are used to reduce or eliminate the toxic side effects of high doses of TNFs employed in the treatment of malignant and non-malignant neoplastic diseases. Advantageously, the combinations and methods of this invention allow the administration of higher doses of TNF than those tolerated in conventional treatment regimens based upon TNF alone.
摘要翻译：用于治疗恶性和非恶性疾病的组合和方法。更具体地说，本发明涉及可用于生长抑制或杀死转化细胞的天然或重组肿瘤坏死因子（“TNF”）和非甾体抗炎药物如吲哚美辛和布洛芬的组合。根据本发明，非甾体抗炎剂用于减少或消除用于治疗恶性和非恶性肿瘤疾病的高剂量TNF的毒副作用。有利地，本发明的组合和方法允许施用比基于单独TNF的常规治疗方案中耐受的那些更高剂量的TNF。

9. 发明申请

WO1987005629A1 PLANT CELLS RESISTANT TO GLUTAMINE-SYNTHETASE INHIBITORS, MADE BY GENETIC ENGINEERING 审中-公开
标题翻译：植物细胞抗谷氨酰胺合成酶抑制剂，通过遗传工程制造
公开(公告)号：WO1987005629A1
公开(公告)日：1987-09-24
申请号：PCT/EP1987000141
申请日：1987-03-11
申请人： PLANT GENETIC SYSTEMS N.V. , BIOGEN N.V. , LEEMANS, Jan , ROTTERMAN, Johan , DE BLOCK, Marc , THOMPSON, Charles , MOUVA, Rao
发明人： PLANT GENETIC SYSTEMS N.V. , BIOGEN N.V.
IPC分类号： C12N15/00
CPC分类号： A01H1/00 , C07K2319/00 , C12N9/1029 , C12N15/63 , C12N15/70 , C12N15/76 , C12N15/8277 , Y10S47/01
摘要： DNA fragment containing a determined gene, the expression of which inhibits the antibiotic and herbicidal effects of Bialaphos and related products. It also relates to recombinant vectors, containing such DNA fragment, which enable this protective gene to be introduced and expressed into cells and plant cells.

10. 发明申请

WO1987003489A1 COMBINATIONS OF TUMOR NECROSIS FACTORS AND ANTIBIOTICS AND METHODS FOR TREATING TUMORS 审中-公开
标题翻译：肿瘤坏死因子和抗肿瘤药物的组合及治疗肿瘤的方法
公开(公告)号：WO1987003489A1
公开(公告)日：1987-06-18
申请号：PCT/EP1986000710
申请日：1986-12-05
申请人： BIOGEN N.V.
发明人： BIOGEN N.V. , FIERS, Walter, Charles , FRANSEN, Lucia, Marie , VAN DER HEYDEN, Jose
IPC分类号： A61K45/06
CPC分类号： A61K38/191 , A61K31/65 , A61K31/165 , A61K31/70 , A61K2300/00
摘要： Combinations of TNF and antibiotics, such as the broad spectrum antibiotics chloramphenicol or tetracycline, which impede or inhibit protein synthesis, and methods of treatment of tumors by administering pharmaceutically effective amounts of TNF and those antibiotics to a tumor-bearing mammal.
摘要翻译：阻止或抑制蛋白质合成的TNF和抗生素如广谱抗生素氯霉素或四环素的组合以及通过向含肿瘤的哺乳动物施用药物有效量的TNF和那些抗生素来治疗肿瘤的方法。

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