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1. 发明申请

WO2012125878A2 WIRELESS GOLF CLUB SHOT COUNT SYSTEM 审中-公开
标题翻译：无线高尔夫俱乐部拍摄计数系统
公开(公告)号：WO2012125878A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029310
申请日：2012-03-15
申请人： BLAST MOTION, INC. , BENTLEY, Michael
发明人： BENTLEY, Michael
IPC分类号： A63B69/36
CPC分类号： A63B69/3623 , A63B24/0006 , A63B24/0021 , A63B60/46 , A63B71/0622 , A63B2024/0031 , A63B2071/0647 , A63B2102/02 , A63B2102/18 , A63B2102/32 , A63B2220/10 , A63B2220/12 , A63B2220/30 , A63B2220/40 , A63B2220/805 , A63B2220/806 , A63B2220/807 , A63B2220/833 , A63B2220/836 , A63B2225/20 , A63B2225/50 , G06K9/00342 , H04M1/7253 , H04M2250/52 , H04W4/80
摘要： Wireless golf club shot count system configured to obtain spatial data from at least one sensor that is coupled with a microcontroller wherein the apparatus fits into a golf club handle or weight port or otherwise couples to a golf club. The apparatus may send a unique identifier and spatial data over a self-contained radio and antenna wirelessly to an external system that may analyze and display the spatial data in a user-friendly manner. The unique identifier and/or radio through use of non-interfering communications mechanisms allows for multiple clubs one or more players to be within range of a wireless receiver and not interfere. Adapters that may be specific to each golf club manufacture allow for coupling the apparatus to any type of golf club.
摘要翻译：无线高尔夫球杆射击计数系统被配置为从至少一个与微控制器耦合的传感器获得空间数据，其中该装置装配到高尔夫球杆手柄或重量端口中，或以其他方式耦合到高尔夫球杆。该装置可以通过无含量的无线电和天线将唯一的标识符和空间数据发送到可以以用户友好的方式分析和显示空间数据的外部系统。通过使用非干扰通信机制的唯一标识符和/或无线电允许多个俱乐部一个或多个玩家在无线接收机的范围内，而不会干扰。可能针对每个高尔夫球杆制造的适配器允许将该装置连接到任何类型的高尔夫球杆。

2. 发明申请

WO2009058387A2 OLIGOMER-NITROIMIDAZOLE ANTI-INFECTIVE CONJUGATES 审中-公开
标题翻译：低分子 - 硝基咪唑抗感染药物
公开(公告)号：WO2009058387A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/012416
申请日：2008-10-31
申请人： NEKTAR THERAPEUTICS AL, CORPORATION , REN, Zhongxu , RIGGS-SAUTHIER, Jennifer , BENTLEY, Michael D.
发明人： REN, Zhongxu , RIGGS-SAUTHIER, Jennifer , BENTLEY, Michael D.
IPC分类号： A61K47/48 , A61P31/00 , A61P31/04
CPC分类号： C07D233/94 , A61K47/48215 , A61K47/60
摘要： The invention provides (among other things) small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer.
摘要翻译：本发明提供了（尤其是）通过共价连接水溶性低聚物化学改性的小分子药物。

3. 发明申请

WO2008112257A1 OLIGOMER-ANTIHISTAMINE CONJUGATES 审中-公开
标题翻译：低分子抗菌素结合物
公开(公告)号：WO2008112257A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/003288
申请日：2008-03-12
申请人： NEKTAR THERAPEUTICS AL, CORPORATION , RIGGS-SAUTHIER, Jennifer , ZHANG, Wen , VIEGAS, Tacey, X. , BENTLEY, Michael, D.
发明人： RIGGS-SAUTHIER, Jennifer , ZHANG, Wen , VIEGAS, Tacey, X. , BENTLEY, Michael, D.
IPC分类号： A61K47/48 , A61P37/08
CPC分类号： A61K47/48215 , A61K31/137 , A61K31/495 , A61K47/60 , C07C217/48 , C07D295/088 , C07D295/15
摘要： The invention provides antihistamine drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the antihistamine drug not attached to the water-soluble oligomer.
摘要翻译：本发明提供通过共价连接水溶性寡聚物进行化学修饰的抗组胺药物。当通过多种施用途径中的任何一种施用时，本发明的缀合物显示出与未附着于水溶性低聚物的抗组胺药物的特征不同的特征。

4. 发明申请

WO2006138463A2 POLYMER-BASED COMPOSITIONS AND CONJUGATES OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：基于聚合物的组合物和非甾体抗炎药物的结合
公开(公告)号：WO2006138463A2
公开(公告)日：2006-12-28
申请号：PCT/US2006/023307
申请日：2006-06-15
申请人： NEKTAR THERAPEUTICS AL, CORPORATION , BURTON, Kevin , ZHAO, Xuan , BENTLEY, Michael D.
发明人： BURTON, Kevin , ZHAO, Xuan , BENTLEY, Michael D.
IPC分类号： A61K47/48
CPC分类号： C08G65/329 , A61K47/60
摘要： Provided herein are water-soluble polymer conjugates and polymer-based compositions of non-steroidal anti-inflammatory drugs. Also provided are methods for synthesizing and administering such conjugates and compositions.
摘要翻译：本文提供的是非甾体抗炎药的水溶性聚合物缀合物和基于聚合物的组合物。还提供了用于合成和施用这种缀合物和组合物的方法。

5. 发明申请

WO2005089805A2 POLYMER-BASED COMPOSITIONS AND CONJUGATES OF HIV ENTRY INHIBITORS 审中-公开
标题翻译：基于聚合物的组合物和HIV入侵抑制剂的结合
公开(公告)号：WO2005089805A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/008632
申请日：2005-03-15
申请人： NEKTAR THERAPEUTICS AL, CORPORATION , BENTLEY, Michael D. , ZHAO, Xuan
发明人： BENTLEY, Michael D. , ZHAO, Xuan
IPC分类号： A61K47/00
CPC分类号： A61K47/48215 , A61K47/60
摘要： Provided herein are water-soluble polymer conjugates and polymer-based compositions of HIV entry inhibitors. Also provided are methods for synthesizing and administering such conjugates and compositions.
摘要翻译：本文提供了HIV入口抑制剂的水溶性聚合物缀合物和基于聚合物的组合物。还提供了用于合成和施用这种缀合物和组合物的方法。

6. 发明申请

WO2005028539A2 MULTI-ARM POLYMER PRODRUGS 审中-公开
标题翻译：多臂聚合物产品
公开(公告)号：WO2005028539A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/030720
申请日：2004-09-17
申请人： NEKTAR THERAPEUTICS AL, CORPORATION , ZHAO, Xuan , BENTLEY, Michael, D. , REN, Zhongxu , VIEGAS, Tacey, X.
发明人： ZHAO, Xuan , BENTLEY, Michael, D. , REN, Zhongxu , VIEGAS, Tacey, X.
IPC分类号： C08G65/00
CPC分类号： C08L71/02 , A61K47/58 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/61
摘要： Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provided an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
摘要翻译：本文提供了水溶性前药。本发明的前药包含具有三个或更多个臂的水溶性聚合物，其中至少三个臂共价连接至活性剂，例如小分子。由于本发明的缀合物具有三种或更多种可释放地连接到多臂水溶性聚合物上的活性剂，因此本发明的缀合物提供了聚合物尺寸和结构的最佳平衡以实现改善的药物负载。与未修饰的母体药物相比，本发明的前体药物在治疗上是有效的，并且体内表现出改善的性质。

7. 发明申请

WO2004060967A1 METHODS FOR THE FORMATION OF HYDROGELS USING THIOSULFONATE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：使用硫代磷酸酯组合物形成水凝胶的方法及其用途
公开(公告)号：WO2004060967A1
公开(公告)日：2004-07-22
申请号：PCT/US2003/041706
申请日：2003-12-31
申请人： NEKTAR THERAPEUTICS AL, CORPORATION , BENTLEY, Michael, D. , FANG, Zhihao
发明人： BENTLEY, Michael, D. , FANG, Zhihao
IPC分类号： C08G65/334
CPC分类号： C08G65/3342 , A61K47/60 , A61L24/0031 , A61L24/046 , C08G65/329 , C08J3/24 , C08J2300/14 , C08J2381/00 , C08L2203/02 , C08L81/08
摘要： The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogels, are also provided.
摘要翻译：本发明提供了两种能够在暴露于水性环境中形成水凝胶的交联聚合物组合物和形成硫代磺酸盐的水凝胶组分。本发明的硫代磺酸盐水凝胶形成组分优选为在不需要存在第二交联剂，氧化还原催化剂或辐射的情况下暴露于碱而形成交联聚合物组合物的多臂硫代磺酸盐聚合物衍生物。还提供了形成水凝胶组合物的方法以及使用水凝胶的方法。

8. 发明申请

WO2002059179A3 SYNTHESIS OF HIGH MOLECULAR WEIGHT NON-PEPTIDIC POLYMER DERIVATIVES 审中-公开
公开(公告)号：WO2002059179A3
公开(公告)日：2002-08-01
申请号：PCT/US2001/049081
申请日：2001-12-18
申请人： SHEARWATER CORPORATION , KOZLOWSKI, Antoni , SHEN, Xioaming , BENTLEY, Michael, David , FANG, Zhihao
发明人： KOZLOWSKI, Antoni , SHEN, Xioaming , BENTLEY, Michael, David , FANG, Zhihao
IPC分类号： C08G65/329
摘要： High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the reaction steps can be accomplished on the more readily purified small molecule to avoid laborious purification of the high molecular weight derivatives.

9. 发明申请

WO2001024831A3 POLYMER STABILIZED NEUROPEPTIDES 审中-公开
公开(公告)号：WO2001024831A3
公开(公告)日：2001-04-12
申请号：PCT/US2000/041070
申请日：2000-10-04
申请人： SHEARWATER CORPORATION , BENTLEY, Michael, David , ROBERTS, Michael, James
发明人： BENTLEY, Michael, David , ROBERTS, Michael, James
IPC分类号： A61K47/48
摘要： A substantially hydrophilic conjugate is provided having a peptide that is capable of passing the blood-brain barrier covalently linked to a water-soluble nonpeptidic polymer such as polyethylene glycol. The conjugate exhibits improved solubility and in vivo stability and is capable of passing the blood-brain barrier of an animal.

10. 发明申请

WO9721011A2 PORTABLE FLOOR 审中-公开
标题翻译：便利地板
公开(公告)号：WO9721011A2
公开(公告)日：1997-06-12
申请号：PCT/US9619282
申请日：1996-12-05
申请人： SICO INC , BENTLEY MICHAEL JOHN , CLOVER ADRIAN ALLEN RONALD , PEPPER ANTONY JOHN RICHARD
发明人： BENTLEY MICHAEL JOHN , CLOVER ADRIAN ALLEN RONALD , PEPPER ANTONY JOHN RICHARD
IPC分类号： E04F15/02 , E04F15/04 , E04F19/06 , E04F15/024
CPC分类号： E04F15/02033 , E04F15/04 , E04F19/061 , E04F2201/0153
摘要： A portable floor system (20) including individual floor sections (22, 24) joined by interlocking tongue elements (40) and receiver elements (50, 70). Each floor section (22, 24) is substantially planar and rectangular, and includes tongue elements on two sides and receiver elements on two sides. The tongue elements (40) have an upwardly-turned portion (44) which engages a downwardly projecting inner member (58, 78) of the receiver elements (50, 70). The receiver elements include a first embodiment (50) having an opening (56) which can be entered by a tongue element from the side of the panel, and a second embodiment (70) having an opening (76) which can be entered by a tongue element from either the side or the bottom of the panel. The portable floor system further includes edge sections (26, 28) which create a smooth transition from the portable floor sections to the permanent floor surface.
摘要翻译：一种便携式地板系统（20），包括通过互锁的舌形元件（40）和接收元件（50,70）连接的各个地板部分（22,24）。每个地板部分（22,24）基本上是平面的和矩形的，并且包括两侧的舌元件和两侧的接收器元件。舌元件（40）具有与接收器元件（50,70）的向下突出的内部构件（58,78）接合的向上转动部分（44）。接收器元件包括具有开口（56）的第一实施例（50），该开口可由面板的侧面通过舌形元件进入;以及具有开口（76）的第二实施例（70），该开口可由舌片从面板的侧面或底部。便携式地板系统还包括边缘部分（26,28），其形成从便携式地板部分到永久地板表面的平滑过渡。

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