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1. 发明申请

WO2007144153A2 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS 审中-公开
标题翻译：用于治疗认知障碍的ALPHA-氨基酰胺衍生物
公开(公告)号：WO2007144153A2
公开(公告)日：2007-12-21
申请号：PCT/EP2007/005197
申请日：2007-06-13
申请人： NEWRON PHARMACEUTICALS S.P.A. , SALVATI, Patricia , ROSSETTI, Stefano , BENATTI, Luca
发明人： SALVATI, Patricia , ROSSETTI, Stefano , BENATTI, Luca
CPC分类号： A61K31/404 , A61K31/085 , A61K31/135 , A61K31/165 , A61K31/341 , A61K31/402
摘要： The present invention is in the field of pharmacotherapy of cognitive deficits in learning and memory by administering an α-aminoamide, particularly safinamide. Examples of disturbances in cognition that can be treated with compounds of the invention are the ones associated with disorders such as autism, dyslexia, attention deficit hyperactivity disorder, schizophrenia, obsessive compulsive disorders, psychosis, bipolar disorders, depression, Tourette's syndrome, Mild Cognitive Impairment (MCI) and disorders of learning in children, adolescents and adults, Age Associated Memory Impairment, Age Associated Cognitive Decline, Alzheimer's Disease, Parkinson's Disease, Down's Syndrome, traumatic brain injury Huntington's Disease, Progressive Supranuclear Palsy (PSP), HIV, stroke, vascular diseases, Pick's or Creutzfeldt- Jacob diseases, multiple sclerosis (MS), other white matter disorders and drug-induced cognitive worsening.
摘要翻译：本发明通过给予α-氨基酰胺，特别是safinamide，在学习和记忆中的认知缺陷的药物治疗领域。可以用本发明化合物治疗的认知障碍的例子是与自闭症，阅读困难，注意缺陷多动障碍，精神分裂症，强迫症，精神病，双相情感障碍，抑郁症，Tourette综合征，轻度认知障碍（MCI）和儿童，青少年和成人学习障碍，年龄相关记忆障碍，年龄相关认知衰退，阿尔茨海默病，帕金森病，唐氏综合征，创伤性脑损伤亨廷顿病，进行性核核麻痹（PSP），艾滋病毒，中风，血管疾病，Pick's或Creutzfeldt-Jacob疾病，多发性硬化症（MS），其他白质病症和药物诱导的认知恶化。

2. 发明申请

WO2005018627A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译： α-氨基酰胺衍生物可用作抗炎剂
公开(公告)号：WO2005018627A1
公开(公告)日：2005-03-03
申请号：PCT/IB2004/001574
申请日：2004-04-22
申请人： NEWRON PHARMACEUTICALS, SPA , SALVATI, Patricia , VENERONI, Orietta , BARBANTI, Elena , RUGGERO, Fariello , BENATTI, Luca
发明人： SALVATI, Patricia , VENERONI, Orietta , BARBANTI, Elena , RUGGERO, Fariello , BENATTI, Luca
IPC分类号： A61K31/165
CPC分类号： A61K31/381 , A61K31/165
摘要： Methods of using certain a-aminoamide derivatives as anti-inflammatory agents. The anti-inflammatory agents of the invention are able to reduce or even stop inflammatory s conditions substantially without side effects.
摘要翻译：使用某些α-氨基酰胺衍生物作为抗炎剂的方法。本发明的抗炎剂能够基本上没有副作用地减少甚至停止炎性病症。

3. 发明申请

WO2004048361A1 HALOTHENOYL-CYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：乙烯基环丙烷-1-羧酸衍生物
公开(公告)号：WO2004048361A1
公开(公告)日：2004-06-10
申请号：PCT/EP2003/013244
申请日：2003-11-25
申请人： NEWRON PHARMACEUTICALS S.P.A. , BENATTI, Luca , FARIELLO, Ruggero , SALVATI, Patricia , PELLICCIARI, Roberto , CACCIA, Carla
发明人： BENATTI, Luca , FARIELLO, Ruggero , SALVATI, Patricia , PELLICCIARI, Roberto , CACCIA, Carla
IPC分类号： C07D333/28
CPC分类号： C07D333/28
摘要： Compounds of formula (I) wherein R is hydroxy, linear or branched C 1 -C 6 alkoxy, phenoxy, benzyloxy, a group -N(R 1 R 2 ) wherein R 1 is hydrogen, linear or branched C 1 -C 4 alkyl, benzyl, phenyl and R 2 is hydrogen or linear or branched C 1 -C 4 alkyl, or R is a glycoside residue or a primary alkoxy residue from ascorbic acid, optionally having one or more hydroxy groups alkylated or acylated by linear or branched C 1 -C 4 alkyl or acyl groups; X is a halogen atom and n 1 or 2 are long lasting inhibitors of kynurenine 3-monooxygenase (KMO) and potent glutamate (GLU) release inhibitors.
摘要翻译：其中R是羟基，直链或支链C 1 -C 6烷氧基，苯氧基，苄氧基，基团-N（R 1 R 2）的式（I）化合物，其中R 1是氢，直链或支链C1- C4烷基，苄基，苯基和R 2是氢或直链或支链C 1 -C 4烷基，或R是来自抗坏血酸的糖苷残基或伯烷氧基残基，任选具有一个或多个羟基被烷基化或酰化直链或支链C 1 -C 4烷基或酰基; X是卤素原子，n 1或2是犬尿苷3-单加氧酶（KMO）和强力谷氨酸（GLU）释放抑制剂的长效抑制剂。

4. 发明申请

WO2005070405A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF LOWER URINARY TRACT DISORDERS 审中-公开
标题翻译：用于治疗下尿路感染疾病的ALPHA-氨基酰胺衍生物
公开(公告)号：WO2005070405A1
公开(公告)日：2005-08-04
申请号：PCT/EP2005/000514
申请日：2005-01-20
申请人： NEWRON PHARMACEUTICALS S.P.A. , BARBANTI, Elena , VENERONI, Orietta , THALER, Florian , PELLICCIARI, Roberto , BENATTI, Luca , SALVATI, Patricia
发明人： BARBANTI, Elena , VENERONI, Orietta , THALER, Florian , PELLICCIARI, Roberto , BENATTI, Luca , SALVATI, Patricia
IPC分类号： A61K31/165
CPC分类号： A61K31/4015 , A61K31/165 , A61K31/277 , A61K31/34 , A61K31/353 , A61K31/381 , C07D307/28 , C07D311/58 , C07D313/08 , C07D333/32 , C07D333/58
摘要： Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.
摘要翻译：使用某些α-氨基酰胺衍生物治疗下尿路疾病的方法。本发明的治疗剂能够基本上没有副作用减少甚至阻止下尿路疾病。

5. 发明申请

WO2004089353A3 METHODS FOR TREATMENT OF PARKINSON'S DISEASE 审中-公开
标题翻译：治疗帕金森病的方法
公开(公告)号：WO2004089353A3
公开(公告)日：2004-12-16
申请号：PCT/IB2004001408
申请日：2004-04-08
申请人： NEWRON PHARMACEUTICALS INC , RUGGERO FARIELLO , CATTANEO CARLO , SALVATI PATRICIA , BENATTI LUCA
发明人： RUGGERO FARIELLO , CATTANEO CARLO , SALVATI PATRICIA , BENATTI LUCA
IPC分类号： A61K31/16 , A61K45/06 , A61P25/16
CPC分类号： A61K31/165 , A61K31/137 , A61K31/16 , A61K31/473 , A61K31/4745 , A61K31/475 , A61K31/48 , A61K31/485 , A61K31/498 , A61K31/4985 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： New uses of safinamide, safinamide derivatives and MAO-B inhibitors in novel types of treatment for Parkinson's Disease are described. More specifically, the invention relates to methods for treating Parkinson's Disease through the administration of safinamide, a safinamide derivative, or a MAO-B inhibitor, in combination with other Parkinson's Disease agents or treatments, such as levodopa/PDI or dopamine agonists.
摘要翻译：描述了safinamide，safinamide衍生物和MAO-B抑制剂在新型帕金森病治疗类型中的新用途。更具体地，本发明涉及通过与其他帕金森病药物或治疗如左旋多巴/ PDI或多巴胺激动剂的组合组合施用safinamide，safinamide衍生物或MAO-B抑制剂来治疗帕金森病的方法。

6. 发明申请

WO2009109334A1 (S)-(+)-2-[4-FLUORBENZYLOXY)BENZYLAMINO]PROPANAMIDE FOR USE IN THE TREATMENT OF MIXED OR COMBINED PAIN 审中-公开
标题翻译：（S） - （+） - 2- [4-氟苄氧基]苯甲酰胺]丙酰胺用于治疗混合或组合的疼痛
公开(公告)号：WO2009109334A1
公开(公告)日：2009-09-11
申请号：PCT/EP2009/001407
申请日：2009-02-27
申请人： NEWRON PHARMACEUTICALS S.P.A. , FARAVELLI, Laura , MARCHETTINI, Paolo , GIULIANI, Rodolfo , ROSSETTI, Stefano , BENATTI, Luca
发明人： FARAVELLI, Laura , MARCHETTINI, Paolo , GIULIANI, Rodolfo , ROSSETTI, Stefano , BENATTI, Luca
IPC分类号： A61K31/165 , A61P25/02 , A61P29/02 , A61K45/06
CPC分类号： A61K45/06 , A61K31/165 , A61K2300/00
摘要： (S)-(+)-2-[4-(2-Fluorobenzyloxy) benzylamino] propanamide (ralfϊnamide) and the salts thereof with pharmaceutically acceptable acids for use in the treatment of mixed or combined pain where a nociceptive component is combined with a neuropathic component, such as nerve compression and/or nerve entrapment syndromes, in particular, neuropathic low back pain (NLBP) or radicular low back pain (RLBP), alone or in combination with other therapeutic agents.
摘要翻译：（S） - （+） - 2- [4-（2-氟苄氧基）苄基氨基]丙酰胺（ralf？namide）及其与药学上可接受的酸的盐，用于治疗混合或组合的疼痛，其中伤害性成分组合具有神经性成分，例如神经压迫和/或神经阻滞综合征，特别是神经性下腰痛（NLBP）或根性背痛（RLBP），单独或与其它治疗剂组合。

7. 发明申请

WO2005018627A8 ALPHA-AMINOAMIDE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：可用作抗炎药物的ALPHA-氨基脲衍生物
公开(公告)号：WO2005018627A8
公开(公告)日：2005-09-01
申请号：PCT/IB2004001574
申请日：2004-04-22
申请人： NEWRON PHARM SPA , SALVATI PATRICIA , VENERONI ORIETTA , BARBANTI ELENA , RUGGERO FARIELLO , BENATTI LUCA
发明人： SALVATI PATRICIA , VENERONI ORIETTA , BARBANTI ELENA , RUGGERO FARIELLO , BENATTI LUCA
IPC分类号： A61K31/165 , A61K31/381 , A61P1/04 , A61P13/10 , A61P19/02
CPC分类号： A61K31/381 , A61K31/165
摘要： Methods of using certain a-aminoamide derivatives as anti-inflammatory agents. The anti-inflammatory agents of the invention are able to reduce or even stop inflammatory s conditions substantially without side effects.
摘要翻译：使用某些α-氨基酰胺衍生物作为抗炎剂的方法。本发明的抗炎剂能够基本上没有副作用减少甚至阻止炎性病症。

8. 发明申请

WO2004089353A8 METHODS FOR TREATMENT OF PARKINSON'S DISEASE 审中-公开
标题翻译：治疗帕金森病的方法
公开(公告)号：WO2004089353A8
公开(公告)日：2005-09-01
申请号：PCT/IB2004001408
申请日：2004-04-08
申请人： NEWRON PHARMACEUTICALS INC , RUGGERO FARIELLO , CATTANEO CARLO , SALVATI PATRICIA , BENATTI LUCA
发明人： RUGGERO FARIELLO , CATTANEO CARLO , SALVATI PATRICIA , BENATTI LUCA
IPC分类号： A61K31/16 , A61K45/06 , A61P25/16
CPC分类号： A61K31/165 , A61K31/137 , A61K31/16 , A61K31/473 , A61K31/4745 , A61K31/475 , A61K31/48 , A61K31/485 , A61K31/498 , A61K31/4985 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： New uses of safinamide, safinamide derivatives and MAO-B inhibitors in novel types of treatment for Parkinson's Disease are described. More specifically, the invention relates to methods for treating Parkinson's Disease through the administration of safinamide, a safinamide derivative, or a MAO-B inhibitor, in combination with other Parkinson's Disease agents or treatments, such as levodopa/PDI or dopamine agonists.
摘要翻译：描述了safinamide，safinamide衍生物和MAO-B抑制剂在新型帕金森病治疗类型中的新用途。更具体地，本发明涉及通过与其他帕金森病药物或治疗如左旋多巴/ PDI或多巴胺激动剂的组合组合施用safinamide，safinamide衍生物或MAO-B抑制剂来治疗帕金森病的方法。

9. 发明申请

WO2003020273A2 PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN $G(A)-AMINOAMIDE AND ITS ANALGESIC USE 审中-公开
标题翻译：包含GABAPENTIN或其类似物和ANG（A） - 氨基酰胺的药物组合物及其镇痛用途
公开(公告)号：WO2003020273A2
公开(公告)日：2003-03-13
申请号：PCT/EP2002/008910
申请日：2002-08-09
申请人： NEWRON PHARMACEUTICALS SPA , SALVATI, Patricia , VENERONI, Orietta , MAJ, Roberto , FARIELLO, Ruggero , BENATTI, Luca
发明人： SALVATI, Patricia , VENERONI, Orietta , MAJ, Roberto , FARIELLO, Ruggero , BENATTI, Luca
IPC分类号： A61K31/445
CPC分类号： A61K31/16 , A61K31/445 , A61K2300/00
摘要： There is disclosed a pharmaceutical composition comprising gabapentin or an analogue thereof (pregabalin or tiagabine) and an α-aminoamide and its analgesic use. A synergistic effect of the respective analgesic activities without concomitant increase of side effects was observed.
摘要翻译：公开了包含加巴喷丁或其类似物（普瑞巴林或噻加宾）和α-氨基酰胺及其镇痛用途的药物组合物。观察到各自镇痛活性的协同作用，但没有伴随副作用的增加。

10. 发明申请

WO1998002553A1 RECOMBINANT KYNURENINE-3-HYDROXYLASE ENZYME AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：重组鸟嘌呤-3-羟基酶及其制备方法
公开(公告)号：WO1998002553A1
公开(公告)日：1998-01-22
申请号：PCT/EP1997003589
申请日：1997-07-03
申请人： PHARMACIA & UPJOHN S.P.A. , MAGAGNIN, Simona , BENATTI, Luca , CINI, Massimo , SPECIALE, Carmela , COVINI, Nevie
发明人： PHARMACIA & UPJOHN S.P.A.
IPC分类号： C12N15/53
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2267/03 , A61K48/00 , C07K14/5759 , C07K14/72 , C12N9/0073 , C12N2799/022
摘要： Disclosed are isolated DNA sequences encoding kyn-3-OHase enzymes. Vectors and host cells containing the DNA sequences above, Xenopus laevis oocytes transiently expressing the rat kyn-3-OHase enzyme and E. coli cells stably producing human kyn-3-OHase enzyme, are also disclosed.
摘要翻译：公开了编码kyn-3-OHase酶的分离的DNA序列。还公开了含有上述DNA序列的载体和宿主细胞，瞬时表达大鼠kyn-3-OH酶的非洲爪蟾卵母细胞和稳定产生人类kyn-3-OH酶的大肠杆菌细胞。

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