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    • 5. 发明申请
    • INDICATOR SUBSTANCE OF AN OPTICAL FLUORESCENCE MEASURING ARRANGEMENT FOR MEASURING THE pH OF A SAMPLE AND OPTICAL SENSOR WITH SUCH AN INDICATOR SUBSTANCE
    • 用于测量具有这种指示剂物质的样品和光学传感器的pH的光学荧光测量装置的指示剂物质
    • WO1992010739A1
    • 1992-06-25
    • PCT/AT1991000128
    • 1991-12-12
    • AVL MEDICAL INSTRUMENTS AGLIPPITSCH, MaxLEINER, Marco, Jean-PierreKARPF, Hellfried
    • AVL MEDICAL INSTRUMENTS AG
    • G01N21/64
    • G01N31/221G01N21/6408G01N21/6428G01N21/6445
    • An indicator substance for an optical luminescence measuring arrangement for the continuous reversible measurement of the pH of a sample within a measuring range (M) or interest, the luminescence decay time tau depends on the pH of the sample, has the properties below. The pKs of the acid or basic indicator substance in its electronic basic state (S0) lies in the measuring range of interest. The protonation rate kp of the base or the deprotonation rate kdp of the acid in the excited state (S1, X) of the indicator substance is smaller than the decay kA of the excited state and the luminescence decay times DOLLAR (t)S and tau B of the acid (AH*, BH *) and basic (A *, B*) forms of the indicator substance differ. If the pKs* of the indicator substance in its electronically excited state (S1, X) lies in the measuring range of interest, the protonisation rate kp of the base or the deprotonisation rate kdp of the acid in the excited state (S1, X) of the indicator substance is greater than the decay rate kA of the excited state.
    • 用于连续可逆测量测量范围(M)或感兴趣的样品的pH的光学发光测量装置的指示物质,发光衰减时间τ取决于样品的pH,具有以下特性。 其电子基本状态(S0)的酸性或碱性指示剂物质的pK位于感兴趣的测量范围内。 指示物质的激发态(S1,X)中的碱的质子化速率kp或去质子化速率kdp小于激发态的衰变kA,并且发光衰减时间DOLLAR(t)S和τ 指示物质的酸(AH *,BH + *)和碱性(A *,B *)形式的B不同。 如果指示物质的电子激发态(S1,X)的pK *位于感兴趣的测量范围内,则碱的质子化速率kp或激发态的酸的去质子化速率kdp(S1,X) 的指标物质大于激发态的衰减速率kA。
    • 6. 发明申请
    • DYALYSIS PROBE
    • WO1992002270A1
    • 1992-02-20
    • PCT/AT1991000092
    • 1991-07-30
    • AVL MEDICAL INSTRUMENTS AGSKRABAL, FalkoKLEINHAPPL, Erich
    • AVL MEDICAL INSTRUMENTS AG
    • A61M25/00
    • A61M25/0026A61B5/14528A61M25/0032A61M2025/0031
    • The dialysis probe of the invention has an insertion needle (2) sharpened at one end (3), removable after the insertion of the probe if necessary and surrounded by a flexible plastic tube (4). At least part of said plastic tube (4) is surrounded by a hose-like dialysis membrane (5) connected at the distal end (6) to the plastic tube (4) and at the other (7) to a clamp (8) so as to be leakproof. The space between the plastic tube (4) and the dialysis membrane (5) is divided in the longitudinal direction of the dialysis probe providing two spaces (15, 16) of substantially semicircular cross-section, said two spaces (15, 16) having a flow connection (17) in the region of the distal end (6) of the plastic tube (4) and are each connected to one of the separate inlet and outlet lines (9, 10). The space (11) of the plastic tube (4) can be connected to a medicament feed pipe (18). The clamp (8) holds the inlet and outlet lines (9, 10) and any medicament feed pipe for the probe.
    • 本发明的透析探针具有在一端(3)上锐化的插入针(2),如果需要,在插入探头之后可移除,并且被柔性塑料管(4)包围。 所述塑料管(4)的至少一部分由在远端(6)连接到塑料管(4)并且另一个(7)连接到夹具(8)的软管状透析膜(5)围绕, 以防泄漏。 塑料管(4)和透析膜(5)之间的空间在透析探针的纵向方向上分开,提供基本上半圆形横截面的两个空间(15,16),所述两个空间(15,16)具有 在塑料管(4)的远端(6)的区域中的流动连接(17)并且各自连接到单独的入口和出口管线(9,10)中的一个。 塑料管(4)的空间(11)可连接到药物输送管(18)。 夹具(8)保持入口和出口管线(9,10)和用于探针的任何药物进料管。
    • 7. 发明申请
    • DEVICE FOR WITHDRAWING BODY FLUIDS
    • 取出身体液体的装置
    • WO1991018551A1
    • 1991-12-12
    • PCT/AT1991000066
    • 1991-05-21
    • AVL MEDICAL INSTRUMENTS AGSKRABAL, FalkoKLEINHAPPL, ErichLIST, Helmut
    • AVL MEDICAL INSTRUMENTS AG
    • A61B05/14
    • A61B5/155A61B5/15003A61B5/150229G01N35/025G01N35/1079G01N2035/00445
    • A device for withdrawing body fluids with a withdrawal device (1) connected to a hollow needle (6) has a storage system (3) with a plurality of separate sample containers (4) arranged on a mobile holder. The containers are hermetically sealed with a membrane (5) which can be punctured and receive collected fractions of the body fluid at given time-intervals. A device (7) connected to a control device (2) can be positioned above each of the sample containers (4) in succession and can be introduced into the sample container through the membrane (5). The withdrawal device (1) is designed as a double-lumen cannula (18), one lumen (19) being connected through a first connecting line (25) to the hollow needle (6), which can be introduced into the sample containers (4), and the other lumen (20) being connected through a second connecting line (26) to a pump (8'; 21) which can be actuated by the control device (2). The individual unfilled sample containers (4) contain a quantity of gas or mixture of gases whose volume under atmospheric pressure is less than the volume of the body fluid to be withdrawn.
    • 一种用连接到中空针(6)的取出装置(1)取出体液的装置具有一个具有多个分开的样本容器(4)的存储系统(3),该样本容器布置在移动支架上。 容器用膜(5)气密密封,膜(5)可以以给定的时间间隔穿刺并接收体液的收集部分。 连接到控制装置(2)的装置(7)可以连续地定位在每个样本容器(4)上方,并且可以通过膜(5)被引入到样本容器中。 抽出装置(1)被设计为双腔插管(18),一个管腔(19)通过第一连接管线(25)连接到中空针头(6),其可以被引入样品容器 4),另一个管腔(20)通过第二连接管线(26)连接到可由控制装置(2)致动的泵(8'; 21)。 单个未填充的样品容器(4)含有一定量的气体或气体混合物,其体积在大气压下小于要抽出的体液的体积。