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1. 发明申请

WO2009145718A1 ISOINDOLINE DERIVATIVES COMPRISING AN ADDITIONAL HETEROCYCLIC GROUP AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS 审中-公开
标题翻译：包含附加杂环组的ISOINDOLINE衍生物及其在治疗疼痛症状中的应用
公开(公告)号：WO2009145718A1
公开(公告)日：2009-12-03
申请号：PCT/SE2009/050615
申请日：2009-05-29
申请人： ASTRAZENECA AB , ARVIDSSON, Per , BESIDSKI, Yevgeni , CSJERNYIK, Gabor , LANGE, Tim , MACSÁRI, István , NILSSON, Linda
发明人： ARVIDSSON, Per , BESIDSKI, Yevgeni , CSJERNYIK, Gabor , LANGE, Tim , MACSÁRI, István , NILSSON, Linda
IPC分类号： C07D401/06 , A61K31/4035 , A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/444 , A61K31/497 , C07D403/06 , C07D413/06 , A61P25/04
CPC分类号： C07D401/06 , C07D209/46 , C07D403/06 , C07D413/06
摘要： Compounds of formula I are claimed, wherein R 1 is hydrogen, C 1 _ 3 alkyl, C 1 _ 3 alkoxy, cyano, hydroxy or halo; wherein C 1-3 alkyl may optionally be substituted by one or more substituents independently selected from hydroxy, C 1-3 alkoxy orfluoro; and wherein Ci^alkoxy may optionally be substituted by one or more fluoro; m is 1 or 2; R 2 and R 3 is each and independently selected from hydrogen, Ci_4haloalkyl, C 1 _ 4 haloalkoxy, halo, C 1 _ 4 alkoxy, C 1 _ 4 alkyl and C 3 _ 7 cycloalkyloxy; and wherein said C 3 _ 7 cycloalkyloxy may optionally be substituted by one or more fluoro; and whereas both R 2 and R 3 can not be hydrogen; Het is selected from any one of pyridinyl, pyrazinyl, isoxazolyl, pyrazolyl, indolyl, triazolyl and pyrimidinyl, wherein each such heteroaryl may optionally be substituted by one or more X 4 ; X 4 is halo, C 1-3 alkyl, C 1-3 alkyl0C 1-3 alkyl, -CH(CH 3 )-O-C(CH 3 ) 3 ,C 1 _ 4 alkoxy, cyano, or hydroxyl, or Ci_2hydroxyalkyl;; and wherein said C 1-3 alkyl, C 1-3 alkylOC 1-3 alkyl, -CH(CH 3 )-O-C(CH 3 ) 3 , or C 1 _ 4 alkoxy may each optionally be substituted by one or more fluoro; L 1 is C 1 _ 4 alkylene, which may optionally be fluorinated or hydroxylated; and L 2 is C 1-3 alkylene; with the exception of the compounds: 2-[1-(1,5-dimethyl-lH-pyrazol-4-yl)ethyl]-5,7-dimethoxy-3-oxo-N-[2-(trifluoromethyl)benzyl]isoindoline-1-carboxamide; N-(4-fluorobenzyl)-3-oxo-2-(-pyridin-4-yletyl)isoindoline-1-carboxamide and N-(2-chlorobenzyl)-2[2-(1H-indol-3-yl)-1-methyletyl]-3-oxoisoindoline-1-carboxamide; The invention further relates to pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译：要求保护的式I化合物，其中R 1为氢，C 1-3烷基，C 1-3烷氧基，氰基，羟基或卤素; 其中C 1-3烷基可以任选被一个或多个独立地选自羟基，C 1-3烷氧基或氟的取代基取代; 并且其中C 1-6烷氧基可任选被一个或多个氟取代; m为1或2; R 2和R 3各自独立地选自氢，C 1-4卤代烷基，C 1-4卤代烷氧基，卤素，C 1-4烷氧基，C 1-4烷基和C 3-7环烷氧基; 并且其中所述C 3-7环烷氧基可任选被一个或多个氟取代; 而R2和R3不能是氢; Het选自吡啶基，吡嗪基，异恶唑基，吡唑基，吲哚基，三唑基和嘧啶基中的任一个，其中每个这样的杂芳基可以任选被一个或多个X 4取代; X 4是卤素，C 1-3烷基，C 1-3烷基C 1-3烷基，-CH（CH 3）-O-C（CH 3）3，C 1-4烷氧基，氰基或羟基或C 1-2羟烷基。并且其中所述C 1-3烷基，C 1-3烷基OC 1-3烷基，-CH（CH 3）-O-C（CH 3）3或C 1-4烷氧基各自任选被一个或多个氟取代; L 1是C 1-4亚烷基，其可以任选被氟化或羟基化; 和L2是C1-3亚烷基; 除了化合物之外：2- [1-（1,5-二甲基-1H-吡唑-4-基）乙基] -5,7-二甲氧基-3-氧代-N- [2-（三氟甲基）苄基] 异吲哚啉-1-甲酰胺; N-（4-氟苄基）-3-氧代-2 - （ - 吡啶-4-基）异吲哚啉-1-甲酰胺和N-（2-氯苄基）-2 [2-（1H-吲哚-3-基） 1-methyletyl] -3- oxoisoindoline -1-甲酰胺; 本发明还涉及含有所述化合物的药物组合物和所述化合物在治疗中的用途。

2. 发明申请

WO2006011844A1 THE REFLECTOR, AN ANTENNA USING A REFLECTOR AND A MANUFACTURING METHOD FOR A REFLECTOR 审中-公开
标题翻译：反射器，使用反射器的天线和反射器的制造方法
公开(公告)号：WO2006011844A1
公开(公告)日：2006-02-02
申请号：PCT/SE2005/001178
申请日：2005-07-25
申请人： POWERWAVE TECHNOLOGIES SWEDEN AB , LINDBERG, Christofer , UDDIN, Jesper , EDLUND, Johan , ARVIDSSON, Per-Arvid
发明人： LINDBERG, Christofer , UDDIN, Jesper , EDLUND, Johan , ARVIDSSON, Per-Arvid
IPC分类号： H01Q13/02
CPC分类号： H01Q1/246 , H01Q1/48 , H01Q1/52 , H01Q1/521 , H01Q15/141 , H01Q15/18
摘要： The present invention relates to a reflector (20; 30; 40) for use in an antenna (10; 50). The reflector (20; 30; 40) is arranged to be used as an earth plane of the antenna (10) and the reflector is corrugated to form current pockets. The reflector (20; 30; 40) comprises at least two separate parts (21, 22; 21, 22, 31, 32; 41, 42), and the parts are electrically coupled to each other to commonly form the earth plane of the antenna (10; 50). The invention also relates to an antenna including a reflector, and to a method for manufacturing a reflector.
摘要翻译：本发明涉及一种用于天线（10; 50）的反射器（20; 30; 40）。反射器（20; 30; 40）布置成用作天线（10）的接地平面，并且反射器被波纹形成电流凹穴。反射器（20; 30; 40）包括至少两个分开的部分（21,22; 21,22,31,32,31,42），并且这些部分彼此电耦合以共同形成天线（10; 50）。本发明还涉及一种包括反射器的天线以及制造反射器的方法。

3. 发明申请

WO2010120237A1 IMIDAZOLE SUBSTITUTED PYRIMIDINES USEFUL IN THE TREATMENT OF GLYCOGEN SYNTHASE KINASE 3 RELATED DISORDERS SUCH AS ALZHEIMER'S DISEASE 审中-公开
标题翻译：咪达唑替代吡咯啉可用于治疗糖尿病合成酶3相关疾病如阿尔茨海默病
公开(公告)号：WO2010120237A1
公开(公告)日：2010-10-21
申请号：PCT/SE2010/050404
申请日：2010-04-14
申请人： ASTRAZENECA AB , ARVIDSSON, Per, I , BURROWS, Jeremy, Nicholas , YNGVE, Ulrika , TJERNELD, Erica
发明人： ARVIDSSON, Per, I , BURROWS, Jeremy, Nicholas , YNGVE, Ulrika , TJERNELD, Erica
IPC分类号： C07D413/14 , A61K31/5377 , A61P17/14 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/06 , A61P29/00 , A61P3/10 , A61P35/00
CPC分类号： C07D405/14 , A61K31/5377 , C07D413/14
摘要： The present invention relates to a new compound of formula (I) wherein R 1 is hydrogen or fluoro; R 2 and R 3 are independently selected from hydrogen or methyl; or a pharmaceutically acceptable salt thereof, pharmaceutical formulations containing said compound, to the use of said active compound in therapy, to the use for the treatment of conditions associated with glycogen synthase kinase-3 related disorders, such as Alzheimer's disease, as well as for the method of treatment of said disorders, comprising administering to a mammal, including human in need of such treatment, a therapeutically effective amount of said compound.
摘要翻译：本发明涉及新的式（I）化合物，其中R 1是氢或氟; R2和R3独立地选自氢或甲基; 或其药学上可接受的盐，含有所述化合物的药物制剂，以使用所述活性化合物在治疗中，用于治疗与糖原合酶激酶-3相关病症如阿尔茨海默病相关的病症的用途，以及治疗所述疾病的方法，包括向需要这种治疗的哺乳动物，包括给予治疗有效量的所述化合物施用。

4. 发明申请

WO2009145720A1 ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS 审中-公开
标题翻译：包含其他杂环组的ISOINDOLINE衍生物及其在治疗疼痛症状中的应用
公开(公告)号：WO2009145720A1
公开(公告)日：2009-12-03
申请号：PCT/SE2009/050617
申请日：2009-05-29
申请人： ASTRAZENECA AB , ARVIDSSON, Per I , BESIDSKI, Yevgeni , CSJERNYIK, Gabor , SANDBERG, Lars
发明人： ARVIDSSON, Per I , BESIDSKI, Yevgeni , CSJERNYIK, Gabor , SANDBERG, Lars
IPC分类号： C07D401/14 , A61K31/4035 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61P25/02 , A61P25/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
CPC分类号： C07D401/14 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/14 , C07D409/12 , C07D409/14
摘要： Compounds of formula I are claimed wherein R 1 is hydrogen; C 1-3 alkyl, optionally substituted by one or more substituents independently selected from hydroxy, C 1-3 alkoxy andfluoro; C 1-3 alkoxy, optionally substituted by one or morefluoro; cyano; hydroxy or halo; m is 1,2 or 3; Het is C 5-6 heteroaryl substituted by 1 or 2 substituents R 2 ; R 2 is C 1-4 alkyl; C 1-4 haloalkyl;C 1-4 haloalkoxy; halo; C 1-4 alkoxy; or C 3-7 cycloalkyloxy, optionally substituted by one or morefluoro; D is C 5-6 heteroaryl; C 3-7 heterocycloalkyl; or C 3-7 cycloalkyl; wherein each D may optionally be substituted by one or more X4; X 4 is halo; or C 1-3 alkyl, optionally substituted by one or morefluoro; C 1-3 alkyl-O-C 1-3 alkyl, optionally substituted by one or morefluoro; C 1-3 alkoxy, optionally substituted by one or morefluoro; cyano; hydroxy; oxo; R 3 0(C=O); or R 4 (C=O); R 3 is C 1-4 alkyl; C 1-4 alkyl-O-C 1-4 alkyl; C 5-6 cycloalkyl; aryl; or aryl-C 1-2 alkyl; R 4 is C 1-4 alkyl; or C 5-6 heteroaryl; L 1 is C 1-4 alkylene; or a bond; and L 2 is C 1-3 alkylene. Compounds of the invention are useful in therapy, such as pain therapy.
摘要翻译：要求的式I化合物，其中R 1是氢; 任选被一个或多个独立地选自羟基，C 1-3烷氧基和氟的取代基取代的C 1-3烷基; 任选被一个或多个氟取代的C 1-3烷氧基; 氰基; 羟基或卤素; m为1,2或3; Het是被1或2个取代基R2取代的C5-6杂芳基; R2是C1-4烷基; C 1-4卤代烷基; C 1-4卤代烷氧基; 光环; C 1-4烷氧基; 或任选被一个或多个氟取代的C 3-7环烷氧基; D是C 5-6杂芳基; C 3-7杂环烷基; 或C 3-7环烷基; 其中每个D可以任选被一个或多个X 4取代; X4是卤素; 或任选被一个或多个氟取代的C 1-3烷基; 任选被一个或多个氟取代的C 1-3烷基-O-C 1-3烷基; 任选被一个或多个氟取代的C 1-3烷氧基; 氰基; 羟基; 氧; R3 0（C = O）; 或R 4（C = O）; R3是C1-4烷基; C 1-4烷基-O-C 1-4烷基; C5-6环烷基; 芳基; 或芳基-C 1-2烷基; R4是C1-4烷基; 或C5-6杂芳基; L1为C1-4亚烷基; 或债券; 并且L 2是C 1-3亚烷基。本发明的化合物可用于治疗，例如疼痛疗法。

5. 发明申请

WO2007145589A8 PEPTIDES THAT ARE CAPABLE OF BINDING TO AMYLOID-BETA PEPTIDE. 审中-公开
标题翻译：能够与淀粉样蛋白肽结合的肽。
公开(公告)号：WO2007145589A8
公开(公告)日：2009-07-23
申请号：PCT/SE2007050424
申请日：2007-06-15
申请人： ARVIDSSON PER , JOHANSSON JAN
发明人： ARVIDSSON PER , JOHANSSON JAN
IPC分类号： C07K7/06 , A61K38/08 , A61P25/28
CPC分类号： C07K14/4711 , A61K38/00
摘要： The present invention relates to novel peptides capable of binding to amyloid- ß peptide, wherein the Na-atom of at least one amino acid residue is substituted with a substituent sterically hindering further binding of amyloid-ß peptide. The invention further relates to use of such peptides in medicine and to pharmaceutical compositions for treatment of Alzheimer's disease.
摘要翻译：本发明涉及能够结合淀粉样蛋白肽的新型肽，其中至少一个氨基酸残基的Na原子被空间位阻取代淀粉样蛋白-β肽的进一步结合的取代基取代。本发明还涉及这种肽在医学中的应用和用于治疗阿尔茨海默氏病的药物组合物。

6. 发明申请

WO2008121063A1 NEW IMIDAZO[ 4,5-B]PYRIDINE-7-CARBOXAMIDES 704 审中-公开
标题翻译：新的咪唑并[4,5-B]吡啶-7-羧酸酯704
公开(公告)号：WO2008121063A1
公开(公告)日：2008-10-09
申请号：PCT/SE2008/050356
申请日：2008-03-28
申请人： ASTRAZENECA AB , ARVIDSSON, Per , BURROWS, Jeremy , SÖDERMAN, Peter , YNGVE, Ulrika
发明人： ARVIDSSON, Per , BURROWS, Jeremy , SÖDERMAN, Peter , YNGVE, Ulrika
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5375 , A61P19/08 , A61P25/00 , A61P25/28 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to new compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明涉及作为其盐的游离碱或其药学上可接受的盐，溶剂化物或溶剂化物的新的式（I）化合物，其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。

7. 发明申请

WO2007040438A3 NOVEL IMIDAZO [4,5 -B] PYRIDINE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 FOR USE IN THE TREATMENT OF DEMENTIA AND NEURODEGENERATIVE DISORDERS 审中-公开
公开(公告)号：WO2007040438A3
公开(公告)日：2007-04-12
申请号：PCT/SE2006/001114
申请日：2006-10-02
申请人： ASTRAZENECA AB , ARVIDSSON, Per I , ARZEL, Erwan , BURROWS, Jeremy , CLAESSON, Martina , RAY, Colin , REIN, Tobias , ROTTICCI, Didier , SÖDERMAN, Peter
发明人： ARVIDSSON, Per I , ARZEL, Erwan , BURROWS, Jeremy , CLAESSON, Martina , RAY, Colin , REIN, Tobias , ROTTICCI, Didier , SÖDERMAN, Peter
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/501 , A61K31/551 , A61P19/08 , A61P25/00 , A61P25/28 , A61P3/10
摘要： The present invention relates to new compounds of formula (I) Wherein X is or Y; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.

8. 发明申请

WO2007040439A1 NEW COMPOUNDS II 审中-公开
标题翻译：新化合物II
公开(公告)号：WO2007040439A1
公开(公告)日：2007-04-12
申请号：PCT/SE2006/001115
申请日：2006-10-02
申请人： ASTRAZENECA AB , ARVIDSSON, Per I , ARZEL, Erwan , BURROWS, Jeremy , GYBÄCK, Helena , REIN, Tobias , ROTTICCI, Didier , SÖDERMAN, Peter
发明人： ARVIDSSON, Per I , ARZEL, Erwan , BURROWS, Jeremy , GYBÄCK, Helena , REIN, Tobias , ROTTICCI, Didier , SÖDERMAN, Peter
IPC分类号： C07D471/04 , A61K31/437 , A61P19/08 , A61P25/00 , A61P25/28 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to new compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明涉及作为其盐的游离碱或其药学上可接受的盐，溶剂化物或溶剂化物的新的式（I）化合物，其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。

9. 发明申请

WO2007040438A2 NEW COMPOUNDS I 审中-公开
标题翻译：新化合物
公开(公告)号：WO2007040438A2
公开(公告)日：2007-04-12
申请号：PCT/SE2006001114
申请日：2006-10-02
申请人： ASTRAZENECA AB , ARVIDSSON PER I , ARZEL ERWAN , BURROWS JEREMY , CLAESSON MARTINA , RAY COLIN , REIN TOBIAS , ROTTICCI DIDIER , SOEDERMAN PETER
发明人： ARVIDSSON PER I , ARZEL ERWAN , BURROWS JEREMY , CLAESSON MARTINA , RAY COLIN , REIN TOBIAS , ROTTICCI DIDIER , SOEDERMAN PETER
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/501 , A61K31/551 , A61P3/10 , A61P19/08 , A61P25/00 , A61P25/28
CPC分类号： C07D471/04
摘要： The present invention relates to new compounds of formula (I) Wherein X is or Y; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明涉及新的式（I）化合物，其中X是或Y; 作为其盐的游离碱或其药学上可接受的盐，溶剂合物或溶剂合物，其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。

10. 发明申请

WO2006057613A1 ANTENNA CONTROL SYSTEM 审中-公开
标题翻译：天线控制系统
公开(公告)号：WO2006057613A1
公开(公告)日：2006-06-01
申请号：PCT/SE2005/001777
申请日：2005-11-25
申请人： POWERWAVE TECHNOLOGIES SWEDEN AB , ARVIDSSON, Per-Anders , EKERVIK, Olov , LINDH, Torbjörn , LILJEVIK, Tord
发明人： ARVIDSSON, Per-Anders , EKERVIK, Olov , LINDH, Torbjörn , LILJEVIK, Tord
IPC分类号： H01Q3/32
CPC分类号： H01Q3/005 , H01Q1/246 , H01Q3/32
摘要： An antenna control system in which various antenna elements in a vertical row are coupled by fixed transmission lines to a central feeding point for a common signal. Adjustment of the phase of the common signal is achieved by means of a linearly movable slide having dielectric body portions influencing the signal velocity along said fixed transmission lines. Further, an electrical motor is used for linearly displacing said movable slide with said dielectric body portions.
摘要翻译：一种天线控制系统，其中垂直行中的各种天线元件通过固定传输线耦合到用于公共信号的中央馈电点。通过具有影响沿着所述固定传输线的信号速度的介电体部分的线性移动滑块来实现公共信号的相位的调整。此外，电动马达用于使所述可动滑动件与所述介电体部分直线移位。

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