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1. 发明申请

WO2009022358A1 SUPERABSORBENT POLYMER HYDRO GELS AND A METHOD OF PREPARING THEREOF 审中-公开
标题翻译：超吸收聚合物水凝胶及其制备方法
公开(公告)号：WO2009022358A1
公开(公告)日：2009-02-19
申请号：PCT/IT2007/000584
申请日：2007-08-10
申请人： AMBROSIO, Luigi , NICOLAIS, Luigi , SANNINO, Alessandro
发明人： AMBROSIO, Luigi , NICOLAIS, Luigi , SANNINO, Alessandro
IPC分类号： C08B15/00 , C08B11/20 , C08J3/24
CPC分类号： A61K31/765 , A23L29/262 , A61K9/06 , A61K47/38 , A61L15/225 , A61L15/28 , A61L15/60 , C08B11/20 , C08B15/005 , C08J3/24 , C08J3/246 , C08J2301/28 , Y02E50/343 , Y02W30/47 , C08L1/26
摘要： The invention relates to a method for the preparation of a superabsorbent polymer hydrogel, comprising crosslinking a precursor comprising a carboxymethylcellulose salt optionally in combination with hydroxyethylcellulose, using citric acid as the crosslinking. agent and in the presence of a molecular spacer, subsequently washing the gel in a polar organic solvent and finally drying the gel by phase inversion in a non-solvent for cellulose. The invention further concerns the superabsorbent hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
摘要翻译：本发明涉及一种制备超吸收性聚合物水凝胶的方法，其包括使用柠檬酸作为交联，将包含羧甲基纤维素盐的前体任选与羟乙基纤维素组合交联。在分子间隔物的存在下，随后在极性有机溶剂中洗涤凝胶，最后通过在非纤维素溶剂中相转化干燥凝胶。本发明还涉及通过本发明的方法获得的超吸收性水凝胶及其在许多不同应用中的用途。

2. 发明申请

WO2009021701A2 POLYMER HYDROGELS AND METHODS OF PREPARATION THEREOF 审中-公开
标题翻译：聚合物水凝胶及其制备方法
公开(公告)号：WO2009021701A2
公开(公告)日：2009-02-19
申请号：PCT/EP2008006582
申请日：2008-08-08
申请人： SANNINO ALESSANDRO , AMBROSIO LUIGI , NOCOLAIS LUIGI
发明人： SANNINO ALESSANDRO , AMBROSIO LUIGI , NOCOLAIS LUIGI
IPC分类号： C08B15/10 , A23L29/262 , C08B3/12 , C08J3/24
CPC分类号： A61K31/765 , A23L29/262 , A61K9/06 , A61K47/38 , A61L15/225 , A61L15/28 , A61L15/60 , C08B11/20 , C08B15/005 , C08J3/24 , C08J3/246 , C08J2301/28 , Y02E50/343 , Y02W30/47 , C08L1/26
摘要： The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
摘要翻译：本发明涉及一种制备聚合物水凝胶的方法，该方法包括使用多元羧酸作为交联剂使包含亲水性聚合物的前体任选地与第二亲水性聚合物交联。本发明还涉及通过本发明的方法可获得的聚合物水凝胶及其在许多不同应用中的用途。

3. 发明申请

WO2007007284A2 COMPOSITE BIOMIMETIC TOTAL INTERVERTEBRAL DISC PROSTHESIS 审中-公开
标题翻译：复合生物统计全面椎间盘突出症
公开(公告)号：WO2007007284A2
公开(公告)日：2007-01-18
申请号：PCT/IB2006/052365
申请日：2006-07-12
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE , AMBROSIO, Luigi , CAUSA, Filippo , DE SANTIS, Roberto , NICOLAIS, Luigi
发明人： AMBROSIO, Luigi , CAUSA, Filippo , DE SANTIS, Roberto , NICOLAIS, Luigi
IPC分类号： A61L27/52 , A61L27/48 , A61F2/44
CPC分类号： A61L27/48 , A61F2/3094 , A61F2/30965 , A61F2/442 , A61F2002/30009 , A61F2002/30075 , A61F2002/30563 , A61F2002/30841 , A61F2002/4495 , A61F2210/0061 , A61F2250/0028 , A61F2310/00293 , A61L27/52 , A61L2430/38
摘要： A disc prosthesis, suitable for replacing an intervertebral disc, comprises a pair of endplates (11, 21) , and an intermediate body (31) , interposed or suitable for being interposed between the endplates. The intermediate body- comprises a nucleus (32) made of hydrogel, around which is wound a peripheral structure (35) made of fibre-reinforced hydrogel .
摘要翻译：适合于更换椎间盘的椎间盘假体包括插入或适合插入在终板之间的一对端板（11,21）和中间体（31）。中间体包括由水凝胶制成的细胞核（32），围绕其缠绕由纤维增强的水凝胶制成的周边结构（35）。

4. 发明申请

WO2006070337A2 BIODEGRADABLE, SUPER ABSORBENT POLYMER HYDROGELS AND A METHOD FOR THEIR PREPARATION 审中-公开
标题翻译：可生物降解的超吸收聚合物氢化物及其制备方法
公开(公告)号：WO2006070337A2
公开(公告)日：2006-07-06
申请号：PCT/IB2005054412
申请日：2005-12-28
申请人： AMBROSIO LUIGI , NICOLAIS LUIGI , SANNINO ALESSANDRO
发明人： AMBROSIO LUIGI , NICOLAIS LUIGI , SANNINO ALESSANDRO
CPC分类号： C08J3/246 , C08B11/20 , C08B15/00 , C08J3/075 , C08J2301/28 , C08L1/28 , C08L2666/26
摘要： The invention relates to a method for the preparation of a superabsorbent polymer hydrogel, comprising the steps of (i) crosslinking a 3% overall aqueous solution of carboxymethylcellulose sodium salt and hydroxyethylcellulose with 5% carbodiimide, in the presence of an acid catalyst; (ii) washing the gel obtained at least once by swelling in a polar organic solvent; and (iii) drying the gel by phase inversion in a non-solvent for cellulose. The invention further concerns the superabsorbent hydrogels obtainable by said method and the uses thereof .
摘要翻译：本发明涉及一种制备超吸收聚合物水凝胶的方法，包括以下步骤：（i）在酸催化剂存在下，将3％总羧甲基纤维素钠盐和羟乙基纤维素水溶液与5％碳二亚胺交联; （ii）通过在极性有机溶剂中溶胀洗涤至少一次获得的凝胶; 和（iii）通过纤维素的非溶剂中的相转化干燥凝胶。本发明还涉及通过所述方法获得的超吸收剂水凝胶及其用途。

5. 发明申请

WO2020049475A1 USE OF EXFOLIATED BLACK PHOSPHORUS FOR THE TREATMENT OF BONE CANCERS 审中-公开
公开(公告)号：WO2020049475A1
公开(公告)日：2020-03-12
申请号：PCT/IB2019/057444
申请日：2019-09-04
申请人： MATERIAS S.R.L. , RAUCCI, Maria Grazia , AMBROSIO, Luigi , FASOLINO, Ines , CAPORALI, Maria , SERRANO RUIZ, Manuel , PERUZZINI, Maurizio
发明人： RAUCCI, Maria Grazia , AMBROSIO, Luigi , FASOLINO, Ines , CAPORALI, Maria , SERRANO RUIZ, Manuel , PERUZZINI, Maurizio
IPC分类号： A61K33/42 , A61K47/00 , A61P35/00 , A61P35/04
摘要： The present invention relates to exfoliated black phosphorus for use in the treatment of bone cancer, in particular osteosarcoma, without any irradiation by photothermal or photodynamic therapy, and to a pharmaceutical composition for parenteral administration comprising exfoliated black phosphorus.

6. 发明申请

WO2010116321A2 BIOPOLYMER-CONTAINING CALCIUM PHOSPHATE FOAM, PROCESS FOR OBTAINING THEREOF AND USE FOR BONE REGENERATION 审中-公开
标题翻译：含有聚磷酸钙的磷酸钙泡沫，其获得的方法和用于骨再生
公开(公告)号：WO2010116321A2
公开(公告)日：2010-10-14
申请号：PCT/IB2010/051475
申请日：2010-04-06
申请人： UNIVERSITAT POLITECNICA DE CATALUNYA , UNIVERSITY OF BRIGHTON , GINEBRA MOLINS, Maria Pau , PLANELL ESTANY, Josep-Antón , GIOVANNI SANTIN, Matteo Alfredo , AMBROSIO, Luigi
发明人： GINEBRA MOLINS, Maria Pau , PLANELL ESTANY, Josep-Antón , GIOVANNI SANTIN, Matteo Alfredo , AMBROSIO, Luigi
IPC分类号： A61L24/00
CPC分类号： A61L24/0084
摘要： The present invention relates to a process for obtaining a composite calcium phosphate foam comprising the steps of : a) forming a biopolymer foam by agitating or gas blowing a polymer aqueous solution comprising gelatin, sodium alginate, soybean derived polymer or combinations thereof; and b) mixing the biopolymer foam obtained in a) with calcium phosphate cement powder. The invention also relates to the composite calcium phosphate foam obtainable by the process of the present invention and its use as a biomaterial in bone regeneration and/or scaffold for bone tissue engineering.
摘要翻译：本发明涉及一种获得复合磷酸钙泡沫的方法，包括以下步骤：a）通过搅拌或气吹聚合物包含明胶，藻酸钠，大豆衍生的聚合物或其组合的水溶液形成生物聚合物泡沫; 和b）将a）中得到的生物聚合物泡沫与磷酸钙水泥粉混合。本发明还涉及通过本发明的方法获得的复合磷酸钙泡沫及其在骨再生和/或骨组织工程支架中作为生物材料的用途。

7. 发明申请

WO2007007284A3 COMPOSITE BIOMIMETIC TOTAL INTERVERTEBRAL DISC PROSTHESIS 审中-公开
标题翻译：复合生物美观全椎间盘假体
公开(公告)号：WO2007007284A3
公开(公告)日：2007-10-11
申请号：PCT/IB2006052365
申请日：2006-07-12
申请人： CONSIGLIO NAZIONALE RICERCHE , AMBROSIO LUIGI , CAUSA FILIPPO , DE SANTIS ROBERTO , NICOLAIS LUIGI
发明人： AMBROSIO LUIGI , CAUSA FILIPPO , DE SANTIS ROBERTO , NICOLAIS LUIGI
IPC分类号： A61L27/44 , A61F2/44
CPC分类号： A61L27/48 , A61F2/3094 , A61F2/30965 , A61F2/442 , A61F2002/30009 , A61F2002/30075 , A61F2002/30563 , A61F2002/30841 , A61F2002/4495 , A61F2210/0061 , A61F2250/0028 , A61F2310/00293 , A61L27/52 , A61L2430/38
摘要： A disc prosthesis, suitable for replacing an intervertebral disc, comprises a pair of endplates (11, 21) , and an intermediate body (31) , interposed or suitable for being interposed between the endplates. The intermediate body- comprises a nucleus (32) made of hydrogel, around which is wound a peripheral structure (35) made of fibre-reinforced hydrogel .
摘要翻译：适用于替换椎间盘的椎间盘假体包括一对端板（11,21）和中间体（31），中间体（31）插入或适合插入在端板之间。中间体包括由水凝胶制成的核（32），其周围缠绕由纤维增强水凝胶制成的外围结构（35）。

8. 发明申请

WO2007023399A8 A NOVEL INTERVERTEBRAL DISC PROSTHESIS 审中-公开
标题翻译：一个新的跨地区的DISC PROSTHISISIS
公开(公告)号：WO2007023399A8
公开(公告)日：2007-05-18
申请号：PCT/IB2006052359
申请日：2006-07-12
申请人： CONSIGLIO NAZIONALE RICERCHE , AMBROSIO LUIGI , TANNER ELIZABETH K
发明人： AMBROSIO LUIGI , TANNER ELIZABETH K
IPC分类号： A61F2/44 , A61L27/46
CPC分类号： A61F2/4425 , A61F2/30965 , A61F2002/30004 , A61F2002/30649 , A61F2002/30685 , A61F2002/30841 , A61F2250/0014 , A61F2310/00293 , A61L27/46 , A61L2430/38 , C08L23/06
摘要： A disc prosthesis, suitable for replacing an intervertebral disc, includes a first (1; 1') and a second (2; 2') articulation component. The components comprise respective endplates (11, 21; 11', 21') suitable for being anchored to respective vertebrae. . The first articulation component further comprises a spacer member (13; 13') suitable for being interposed between the endplates, and which is disposed on the endplate (11; 11') of the first component (1; 1') and has a convex articulation surface (19; 19') suitable for being placed in contact with a corresponding concave articulation surface (29; 29') disposed on the endplate of- the second component. The articulation -components are made at least partially of polyethylene reinforced with calcium phosphate, one of same further having a part (17; 27'), facing towards the other articulation component, which is made of ultra-high molecular weight polyethylene, and on which one of the articulation surfaces is provided.
摘要翻译：适合于更换椎间盘的椎间盘假体包括第一（1; 1'）和第二（2; 2'）铰接部件。这些部件包括适于锚定到相应椎骨的相应端板（11,21; 11'，21'）。。所述第一关节部件还包括适于插入在所述端板之间并且设置在所述第一部件（1; 1'）的所述端板（11; 11'）上并具有凸起的间隔件（13; 13'）铰接表面（19; 19'）适于与设置在第二部件的端板上的对应的凹形铰接表面（29; 29'）放置接触。关节 - 组件至少部分地由磷酸钙增强的聚乙烯制成，其中一个还具有面向另一个铰接部件的部分（17; 27'），该部分由超高分子量聚乙烯制成，并且在提供哪一个关节表面。

9. 发明申请

WO2007029278A1 AN APPARATUS FOR THE PHOTO-POLYMERISATION OF COMPOSITE MATERIALS, IN PARTICULAR FOR DENTAL APPLICATIONS 审中-公开
标题翻译：用于复合材料的光聚合的装置，特别是用于牙科应用
公开(公告)号：WO2007029278A1
公开(公告)日：2007-03-15
申请号：PCT/IT2006/000646
申请日：2006-09-07
申请人： CNR CONSIGLIO NAZIONALE DELLE RICERCHE , DE SANTIS, Roberto , AMBROSIO, Luigi , NICOLAIS, Luigi
发明人： DE SANTIS, Roberto , AMBROSIO, Luigi , NICOLAIS, Luigi
IPC分类号： A61C13/15
CPC分类号： A61C19/004
摘要： An apparatus for the photo-polymerisation of composite materials, in particular for dental applications, comprising emitter means (10) for generating at least one electromagnetic radiation (20) and irradiating a material to be polymerised, and a control unit (30) for regulating the power irradiated by the emitter means (10), in such a way that said irradiated power has a profile comprising a first segment (2) of polymerisation that is substantially growing or constant over time, and a second segment (3) of thermal control, subsequent in time and contiguous to the first, and having at least one portion (3a) decreasing over time with finite derivative.
摘要翻译：一种用于复合材料，特别是牙科用途的光聚合的装置，包括用于产生至少一个电磁辐射（20）并照射待聚合的材料的发射器装置（10）和用于调节的控制单元（30）由发射装置（10）照射的功率，使得所述照射的功率具有包括随时间基本上增长或恒定的聚合的第一段（2）和热控制的第二区段（3）的轮廓，随后在时间上并与第一个相邻，并且具有至少一个部分（3a）随着时间的推移而随着有限导数而减小。

10. 发明申请

WO2021084361A1 USE OF EXFOLIATED BLACK PHOSPHORUS FOR THE TREATMENT OF PROSTATE CANCERS 审中-公开
公开(公告)号：WO2021084361A1
公开(公告)日：2021-05-06
申请号：PCT/IB2020/059686
申请日：2020-10-15
申请人： MATERIAS S.R.L. , RAUCCI, Maria Grazia , AMBROSIO, Luigi , FASOLINO, Ines , CAPORALI, Maria , SERRANO RUIZ, Manuel , PERUZZINI, Maurizio
发明人： RAUCCI, Maria Grazia , AMBROSIO, Luigi , FASOLINO, Ines , CAPORALI, Maria , SERRANO RUIZ, Manuel , PERUZZINI, Maurizio
IPC分类号： A61K33/42 , A61K41/00 , A61P35/00
摘要： The present invention relates to exfoliated black phosphorus for use in the treatment of prostate cancer with or without irradiation by photothermal or photodynamic therapy.

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