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1. 发明申请

WO2021226330A1 AGENTS TO PREVENT TISSUE DAMAGE FROM CLOSTRIDIUM DIFFICILE INFECTIONS BY INHIBITION OF THE GUT-DAMAGING BACTERIAL TOXINS TCDA AND TCDB 审中-公开
公开(公告)号：WO2021226330A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/031072
申请日：2021-05-06
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE , VICTORIA LINK LIMITED
发明人： SCHRAMM, Vern, L. , PAPARELLA, Ashleigh, S. , TYLER, Peter, Charles
IPC分类号： A61K31/4164 , A61K31/4709 , A61K31/65
摘要： Methods for treating or preventing diseases and conditions associated with Clostridium difficile infection are provided. The methods effectively inhibit bacterial pathogens induced UDP-glucose hydrolysis activity with minimized damage to host tissue.

2. 发明申请

WO2019217516A1 MODULE AND METHODS OF ASSEMBLY FOR LARGE AREA FLAT PANEL DETECTORS 审中-公开
公开(公告)号：WO2019217516A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031259
申请日：2019-05-08
申请人： EASTERN BLUE TECHNOLOGIES, INC.
发明人： GUO, Jianjun , QIAN, Yin
IPC分类号： H01L27/146 , H01L23/52 , H01L23/522 , H01L27/14 , H01L31/02
摘要： An image sensor unit is disclosed that includes an array of image sensing pixels, arranged in a plurality of rows and a plurality of columns, wherein each pixel is individually addressable. Each row of pixels is controlled via a row control in communication with the row of pixels in the array via a row addressing line, and capable of selectively addressing one or more of the plurality of rows. Each column of pixels is controlled by a column control in communication with each column of pixels in the array via a column addressing line, and capable of selectively addressing one or more of the plurality of columns. A unit controller is configured to specify selective readout of one or more pixel readout signals by instructing the row and column control to address one or more specific rows and columns of the array. A flat panel image sensor may include image sensor chips mounted on a substrate, the substrate may include a plurality of openings, and each of the plurality of openings enables access to at least one image sensor unit of the image sensor units. Each image sensor chip may include at least one chip contact array where at least one contact of each image sensor unit is accessible through at least one opening. The flat panel image sensor also may include a printed circuit board ("PCB") attached to the substrate, which includes PCB contact arrays and each PCB contact array may be in alignment with and in electrical connection with a corresponding chip contact array using electrically adhesive paste. The substrate and the PCB may be aligned so that each ball of electrically conductive adhesive paste is in contact with one electrical contact pad to form an image sensor assembly.

3. 发明申请

WO2019156949A1 HYDROPHILIC POLYARYLENE ETHER KETONE POLYMER AND METHODS OF FORMING SAME 审中-公开
公开(公告)号：WO2019156949A1
公开(公告)日：2019-08-15
申请号：PCT/US2019/016588
申请日：2019-02-05
申请人： ALLEGHENY SINGER RESEARCH INSTITUTE
发明人： AVERICK, Saadyah , CHENG, Boyle , KASSICK, Andrew , OH, Michael
IPC分类号： A61L27/00 , A61L27/14 , A61L27/18 , C08L71/12 , C08L79/04 , C08L79/06
摘要： This patent document discloses a modified polymer having increased hydrophilicity and a method of preparing the same. A polyarylene ether ketone polymer having a plurality of repeating units, wherein one or more units of the plurality of repeating units contains a hydrophilic N-substituted imine, which is derived from a ketone in the one or more units.

4. 发明申请

WO2018071654A1 SUSTAINED RELEASE PHARMACEUTICAL DOSAGE FORM OF ENTECAVIR 审中-公开
标题翻译： ENTECAVIR的持续释放药物剂型
公开(公告)号：WO2018071654A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/056318
申请日：2017-10-12
申请人： AUCTA PHARMACEUTICALS
发明人： LU, Enxian , LI, Shoufeng , LYU, Shaoqiong
IPC分类号： A61K31/522 , A61K47/26 , A61K9/20 , A61K9/48
CPC分类号： A61K9/0004 , A61K9/0053 , A61K9/2009 , A61K31/522 , A61K31/708 , A61K47/26 , A61K47/38 , A61P1/16 , A61P31/20
摘要： This document discloses a sustained release dosage form for oral administration of entecavir in a subject. Also disclosed is a method of treating hepatitis virus B infection.
摘要翻译：本文件公开了用于在受试者中口服施用恩替卡韦的持续释放剂型。还公开了一种治疗乙型肝炎病毒感染的方法。

5. 发明申请

WO2018071547A1 POWDER FOR ORAL SUSPENSION CONTAINING LAMOTRIGINE 审中-公开
标题翻译：含有LAMOTRIGINE的口服悬浮液粉末
公开(公告)号：WO2018071547A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/056146
申请日：2017-10-11
申请人： AUCTA PHARMACEUTICALS
发明人： LU, Enxian , LI, Shoufeng , ZHANG, Wei , WANG, Yong , WANG, Zhongqin
IPC分类号： A61K31/53 , C07D253/075 , A61K9/14
摘要： This document discloses a powder formulation of lamotrigine for oral administration. Also disclosed is a suspension of lamotrigine and a method of treating diseases.
摘要翻译：该文献公开了口服拉莫三嗪的粉末制剂。还公开了拉莫三嗪的悬浮液和治疗疾病的方法。

6. 发明申请

WO2017210436A1 ULTRA LOW THERMO FUSION PVC ALTERNATIVE PLASTISOL COATING AND TEXTILE PRINTING INK 审中-公开
标题翻译：超低热熔聚氯乙烯替代涂层和纺织印刷油墨
公开(公告)号：WO2017210436A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035465
申请日：2017-06-01
申请人： KANG, Hack, S.
发明人： KANG, Hack, S.
IPC分类号： A61L2/08
摘要： The present invention relates to a novel PVC-free plastisol composition that cures at a temperature much lower than conventional plastisols. Also disclosed is a method of applying the composition.
摘要翻译：本发明涉及一种在比常规增塑溶胶低得多的温度下固化的新型不含PVC的增塑溶胶组合物。还公开了施用组合物的方法。

7. 发明申请

WO2016106135A1 COMPOUNDS, COMPOSITIONS AND METHODS 审中-公开
标题翻译：化合物，组合物和方法
公开(公告)号：WO2016106135A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/066741
申请日：2015-12-18
申请人： CERECOR, INC. , MERCK SHARP DOHME & CORP.
发明人： MAZHARI, Reza , MEZAACHE, Djelila , PATERSON, Blake, M. , VORNOV, James , GARNER, Rachel, M. , NELSON, Todd
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The disclosed subject matter provides certain polymorphic forms of Compound (I) as well as pharmaceutical compositions comprising Compound (I) or such polymorphic forms, and methods of using or making such compounds and pharmaceutical compositions. It has now been discovered that Compound (I) can exist in multiple crystalline forms (polymorphs). One particular crystalline form, Form II, has been found to be more thermodynamically stable and, thus, likely more suitable for bulk preparation and handling than other polymorphic forms. Efficient and economic methods have been developed to prepare Compound (I) and Form II in high purity on a large scale. In animal studies, Form II has demonstrated safety and efficacy in treating depressive disorders and, when micronized, improved absorption compared to non-micronized Form II.
摘要翻译：所公开的主题提供了化合物（I）的某些多晶形式以及包含化合物（I）或这些多晶形式的药物组合物，以及使用或制备这些化合物和药物组合物的方法。现已发现化合物（I）可以多晶型（多晶型物）存在。已经发现一种特定的结晶形式II形式比其他多晶形式更具有热力学稳定性，因此可能更适合于大量制备和处理。已经开发了高效和经济的方法来大量制备高纯度的化合物（I）和形式II。在动物研究中，II型已经证明了治疗抑郁障碍的安全性和有效性，并且当微粉化时，与非微粉化形式II相比，改善了吸收。

8. 发明申请

WO2023023316A1 COMPOSITIONS FOR ORGAN AND TISSUE PRESERVATION 审中-公开
公开(公告)号：WO2023023316A1
公开(公告)日：2023-02-23
申请号：PCT/US2022/040874
申请日：2022-08-19
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE , YALE UNIVERSITY
发明人： GAVATHIOTIS, Evripidis , KITSIS, Richard N. , TIETJEN, Gregory , DIRITO, Jenna
IPC分类号： A01N1/02 , A61K31/137 , C07D209/88 , C07D295/13 , A61P39/00
摘要： Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the compositions and methods permit mammalian cells, tissues, and organs to be recovered from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.

9. 发明申请

WO2019213656A1 PRISTINE GRAPHENE AND COMPOSITIONS WITH NATURAL PRESSURE SENSITIVE ADHESIVE (PSA) METHOD FOR OVER SKIN APPLICATIONS 审中-公开
公开(公告)号：WO2019213656A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030898
申请日：2019-05-06
申请人： BIO-NATURE LABORATORIES LLC
发明人： KRUEL, Michael , KRUEL, Lily
IPC分类号： A61K8/00 , A61K8/18 , A61Q19/08
摘要： This patent document discloses a kit containing a base component and an activating component for cosmetics, therapeutic and aesthetic application purposes. The kit, comprised innovative technology, ingredients, and formulations that overcome the drawbacks of unviable, unpractical, unwearable and unmarketable products, enables a film-formed "young-looking skin" to cling onto the real skin for much longer period of time, and is truly wearable and viable to the consumers for achieving the benefits of dramatically reducing or diminishing eye bags, dark circles, enlarged pores, wrinkles, age spots, and so on with desired and rapid results. The film is comfortable, invisible, safe, non- invasive and easy to wear.

10. 发明申请

WO2017210431A1 ULTRA LOW THERMO FUSION PVC PLASTISOL COATING AND TEXTILE PRINTING INK 审中-公开
标题翻译：超低热熔聚氯乙烯塑料涂层和纺织品印刷油墨
公开(公告)号：WO2017210431A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035457
申请日：2017-06-01
申请人： KANG, Hack, S.
发明人： KANG, Hack, S.
IPC分类号： A61L2/08
CPC分类号： C09D127/06 , A61L2/08 , C08K5/0016 , C08K5/10 , C09D5/00 , C09D7/61 , C09D7/63 , C09D7/65 , C09D11/03 , C09D11/106 , C08L27/06
摘要： The present invention relates to a novel plastisol composition that cures at a temperature much lower than conventional plastisols. Also disclosed is a method of applying the composition.
摘要翻译：本发明涉及在比常规增塑溶胶低得多的温度下固化的新型增塑溶胶组合物。还公开了施用组合物的方法。

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