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1. 发明申请

WO2016133656A1 WET-PACK INTRAOCULAR LENS MATERIALS WITH HIGH REFRACTIVE INDEX 审中-公开
标题翻译：含高折射指数的湿包镜片材料
公开(公告)号：WO2016133656A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/014817
申请日：2016-01-26
申请人： NOVARTIS AG , JIANG, Xuwei , SCHLUETER, Douglas , LAREDO, Walter
发明人： JIANG, Xuwei , SCHLUETER, Douglas , LAREDO, Walter
IPC分类号： A61L27/18 , A61L27/26
CPC分类号： A61L27/16 , A61F2/16 , A61L27/18 , A61L27/26 , A61L27/50 , A61L2430/16 , C08F220/30 , C08F2220/305
摘要： Intraocular lens materials are disclosed. They are are soft and very deformable and have a high refractive index, and a high glistening resistance in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.
摘要翻译：公开了人工晶状体材料。它们是柔软且非常可变形的并且具有高折射率，并且在完全水合状态下具有高闪光性。它们特别适用于制造可通过2.0毫米切口进行输送的湿包装眼内透镜（IOL）。

2. 发明申请

WO2015164630A1 CARBOSILOXANE VINYLIC MONOMERS 审中-公开
标题翻译：碳硅氧烷单体
公开(公告)号：WO2015164630A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/027335
申请日：2015-04-23
申请人： NOVARTIS AG , HUANG, Jinyu , CHANG, Frank
发明人： HUANG, Jinyu , CHANG, Frank
IPC分类号： C07F7/08 , G02B1/04 , C08L83/04
CPC分类号： G02B1/043 , C07F7/0852 , C07F7/0854 , C07F7/1844 , C08F30/08 , C08F230/08 , C08G77/12 , C08G77/26 , C08L83/04 , C08L101/14
摘要： The invention provides a carbosiloxane vinylic monomer which comprises one sole ethylenically unsaturated group, one sole terminal butyl group; and one oligo(carbosiloxane)- containing linkage between the ethylenically unsaturated terminal group and the terminal butyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a carbosiloxane vinylic monomer of the invention.
摘要翻译：本发明提供一种碳硅氧烷乙烯基单体，其包含一个唯一的烯键式不饱和基团，一个唯一的末端丁基基团; 和烯属不饱和端基与末端丁基之间的一个低聚（碳硅氧烷）键。本发明还涉及包含衍生自本发明的碳硅氧烷乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。

3. 发明申请

WO2013086119A2 CONTACT LENSES WITH ENZYMATICALLY DEGRADABLE COATINGS THEREON 审中-公开
标题翻译：接触镜片，含有可降解的涂层
公开(公告)号：WO2013086119A2
公开(公告)日：2013-06-13
申请号：PCT/US2012/068146
申请日：2012-12-06
申请人： NOVARTIS AG , SAMUEL, Newton T.
发明人： SAMUEL, Newton T. , KENKARE, Nirupama
IPC分类号： G02B1/04
CPC分类号： G02B1/043
摘要： The invention is related to a disposable contact lens comprising a top coating which is made of a hydrophilic polymeric material including dangling hydrophilic polymer chains covalently linked to the hydrophilic polymeric material through oligo-caprolactone linkages susceptible to enzymatic degradation in the eyes. The top coating is stable to lens processing/storage and confers lubricity to the lens. However, it slowly is degraded during the lens wear due to the action of enzymes (e.g., Lipase) in tear film. The loss in lubricity will be experienced as a drop in comfort for the lens wearer and thereby serves as the built-in compliance features of the disposable contact lens.
摘要翻译：本发明涉及包含顶部涂层的一次性隐形眼镜，所述顶部涂层由亲水性聚合物材料制成，所述亲水性聚合物材料包括通过对酶降解敏感的寡聚己内酯键与亲水聚合物材料共价连接的悬挂亲水聚合物链在眼里。顶部涂层对镜片加工/存储稳定并赋予镜片润滑性。然而，由于泪液膜中的酶（例如脂肪酶）的作用，其在镜片佩戴过程中缓慢降解。润滑性的损失将作为镜片佩戴者的舒适度下降而经历，并且因此用作一次性隐形眼镜的内置柔顺特征。

4. 发明申请

WO2013074535A1 A SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 审中-公开
标题翻译：具有交联水解涂层的硅胶水镜
公开(公告)号：WO2013074535A1
公开(公告)日：2013-05-23
申请号：PCT/US2012/064853
申请日：2012-11-13
申请人： NOVARTIS AG , KOLLURU, Chandana
发明人： KOLLURU, Chandana , QUINTER, Bradley
IPC分类号： G02B1/04 , G02B1/10
CPC分类号： G02B1/043 , B29C35/0805 , B29C2035/0827 , B29D11/00038 , B29D11/00134 , B29D11/00865 , B29K2083/00 , B29K2105/0061 , B29K2833/12 , B29K2909/08 , B29K2995/0027 , B29K2995/0092 , B65B5/04 , G02C7/049 , G02C2202/16 , C08L101/14 , C08L101/02
摘要： Method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. The methodinvolves autoclav- ing, in a sealed lens package, a silicone hydrogel contact lens having a base coating of polyacrylic acid thereon in an aqueous solution in the presence of a watersoluble, crosslinkable hydrophilic polymeric material having epoxide groups, especially multi-arm polyethyleneg- lycol, for a period of time sufficient to covalently attach the crosslink- able hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one epoxide group and one of the carboxyl groups on and/or near the surface of the silicone hydrogel contact lens.
摘要翻译：制备其上具有交联亲水涂层的硅酮水凝胶隐形眼镜的方法。该方法在密封的镜片包装中，在具有环氧基团的水溶性可交联的亲水性聚合物材料的存在下，在其中在水溶液中具有聚丙烯酸基底涂层的硅氧烷水凝胶隐形眼镜进行高压灭菌，特别是多臂聚乙烯 - 在一段时间内足以通过共价键将可交联的亲水性聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，所述共价键各自在一个环氧基团与一个环氧化物基团之间和/或表面附近的羧基之间形成硅酮水凝胶隐形眼镜。

5. 发明申请

WO2012078457A1 METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES 审中-公开
标题翻译：制造硅胶水凝胶接触透镜的方法
公开(公告)号：WO2012078457A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/062986
申请日：2011-12-02
申请人： NOVARTIS AG , SAMUEL, Newton, T. , HUANG, Horngyih , WU, Daqing , HAKEN, Uwe , PRUITT, John, Dallas , DOMSCHKE, Angelika, Maria , MATSUZAWA, Yasuo
发明人： SAMUEL, Newton, T. , HUANG, Horngyih , WU, Daqing , HAKEN, Uwe , PRUITT, John, Dallas , DOMSCHKE, Angelika, Maria , MATSUZAWA, Yasuo
IPC分类号： B29D11/00
CPC分类号： B29D11/00153 , B08B9/00 , G02B1/043 , C08L83/04 , C08L101/14
摘要： The invention provides a method for washing, with a water-based system, reusable molds for making silicone hydrogel contact lenses. The water-based washing system comprises an ethoxylated silicone polyether surfactant. The water-based system of the invention can effectively wash away silicone-containing components and other components of a lens formulation left behind on the molding surfaces of a reusable mold, after removing a silicone hydrogel contact lens cast molded in the reusable mold.
摘要翻译：本发明提供了一种用水洗系统清洗可重复使用的模具以制造硅酮水凝胶隐形眼镜的方法。水基洗涤系统包括乙氧基化硅氧烷聚醚表面活性剂。在去除在可重复使用的模具中铸造的硅酮水凝胶隐形眼镜之后，本发明的水基系统可以有效地洗掉留在可重复使用的模具的模制表面上的透镜制剂的含硅酮组分和其它组分。

6. 发明申请

WO2012016098A1 A SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 审中-公开
标题翻译：具有交联水解涂层的硅胶水镜
公开(公告)号：WO2012016098A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045810
申请日：2011-07-29
申请人： NOVARTIS AG , QIU, Yongxing , SAMUEL, Newton, T. , PRUITT, John, Dallas , KOLLURU, Chandana , MEDINA, Arturo, N. , WINTERTON, Lynn, Cook , WU, Daqing , QIAN, Xinming , NELSON, Jared
发明人： QIU, Yongxing , SAMUEL, Newton, T. , PRUITT, John, Dallas , KOLLURU, Chandana , MEDINA, Arturo, N. , WINTERTON, Lynn, Cook , WU, Daqing , QIAN, Xinming , NELSON, Jared
IPC分类号： G02C7/04 , B05D5/06 , B29D11/00
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： A cost-effective method for making a silicone hydrogel contact lens has a crosslinked hydrophilic coating applied thereon. The method involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally- crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, and at a temperature from 40 Centigrade to 140 Centigrade for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
摘要翻译：制造硅酮水凝胶隐形眼镜的成本有效的方法具有涂覆在其上的交联的亲水涂层。该方法包括在具有带正电的氮杂环丁烷基团的水溶性，高度支化，可热交联的亲水性聚合物材料的存在下，在40℃至140℃的温度存在下，在水溶液中加热硅氧烷水凝胶隐形眼镜，用于足以将热交联亲水性聚合物材料共价连接到硅酮水凝胶隐形眼镜的表面上的共价键，每个共价键在硅氧烷水凝胶的表面上和/或附近的一个氮杂环丁烷基与一个反应性官能团之间形成接触透镜，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

7. 发明申请

WO2011075377A1 METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS 审中-公开
标题翻译：从水基镜片配方制造硅胶水镜的方法
公开(公告)号：WO2011075377A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/059616
申请日：2010-12-09
申请人： NOVARTIS AG , CHANG, Frank , WINTERTON, Lynn, Cook
发明人： CHANG, Frank , WINTERTON, Lynn, Cook
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , B29D11/00038 , B29D11/00048 , C08L83/04 , C08L101/14
摘要： Described herein are methods for producing silicone hydrogel lenses. The methods involve introducing into a mold a water-based lens-forming composition, curing the lens- forming composition in a mold to form the lens, and removing the lens from the mold. The lens-forming composition comprises (i) a polysiloxane-containing vinylic monomer or macromer, (ii) at least one hydrophilic vinylic monomer, (iii) a surfactant, and, and (iv) water. The surfactant is polysiloxane-containing surfactant that is free of actinically- polymerizable groups and is a copolymer having from about 10% to about 40% by weight of one or more polysiloxane segments and from about 90% to about 60% by weight hydrophilic units and/or segments. The methods permit the use of water as a solvent and reduce the need for organic solvents. Additionally, the lenses produced by the methods can have improved properties such oxygen permeability.
摘要翻译：本文描述了生产硅酮水凝胶透镜的方法。所述方法包括向模具中引入基于水的透镜形成组合物，在模具中固化透镜形成组合物以形成透镜，以及从模具中去除透镜。透镜形成组合物包含（i）含聚硅氧烷的乙烯基单体或大分子单体，（ii）至少一种亲水乙烯基单体，（iii）表面活性剂和（iv）水。表面活性剂是不含可光化聚合基团的含聚硅氧烷的表面活性剂，并且是具有约10％至约40％重量的一种或多种聚硅氧烷链段和约90％至约60％重量的亲水单元的共聚物，以及 /或段。该方法允许使用水作为溶剂并减少对有机溶剂的需要。另外，通过该方法制造的镜片可以具有改善的这种透氧性。

8. 发明申请

WO2011071790A1 METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES 审中-公开
标题翻译：增加接触镜的离子渗透性的方法
公开(公告)号：WO2011071790A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059021
申请日：2010-12-06
申请人： NOVARTIS AG , QIU, Yongxing , QIAN, Xinming
发明人： QIU, Yongxing , QIAN, Xinming
IPC分类号： C08L43/02 , G02C7/04
CPC分类号： G02B1/043 , C08L101/14
摘要： Described herein are methods for increasing the ion permeability of a silicone hydrogel contact lens by adding a small amount of an ion-permeability-enhancing ("IP-enhancing") hydrophilic vinylic monomer or macromer into a lens-forming material for cast-molding silicone hydrogel contact lenses, while not altering significantly the water content and/or the oxygen permeability of resultant lenses from the lens-forming material.
摘要翻译：本文描述的是通过将少量的离子渗透性增强（“IP增强”）亲水乙烯基单体或大分子单体添加到用于铸塑硅胶的透镜形成材料中来增加硅酮水凝胶隐形眼镜的离子渗透性的方法水凝胶隐形眼镜，同时不会显着改变所得透镜从透镜形成材料中的含水量和/或透氧性。

9. 发明申请

WO2010078001A1 TRI-FUNCTIONAL UV-ABSORBING COMPOUNDS AND USE THEREOF 审中-公开
标题翻译：三功能紫外线吸收化合物及其用途
公开(公告)号：WO2010078001A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/068347
申请日：2009-12-17
申请人： NOVARTIS AG , DOMSCHKE, Angelika, Maria , WINTERTON, Lynn, Cook , HOLLAND, Troy, Vernon , TUREK, Richard, Charles
发明人： DOMSCHKE, Angelika, Maria , WINTERTON, Lynn, Cook , HOLLAND, Troy, Vernon , TUREK, Richard, Charles
IPC分类号： C07D249/20 , G02C7/04
CPC分类号： C07D249/20 , G02B1/043
摘要： Described herein are tri-functional compounds useful in the production of ophthalmic lenses. The compounds are composed of UV absorber having a polymerization initiator directly or indirectly bonded to the ultraviolet absorber, and an olefinic group directly or indirectly bonded to the ultraviolet absorber. Also described herein are polymers and ophthalmic lenses produced from the tri-functional compounds described herein.
摘要翻译：本文描述了可用于制造眼科镜片的三官能化合物。该化合物由具有与紫外线吸收剂直接或间接结合的聚合引发剂的紫外线吸收剂以及与紫外线吸收剂直接或间接接合的烯属基团构成。本文还描述了由本文所述的三官能化合物制备的聚合物和眼用透镜。

10. 发明申请

WO2010056687A3 SILICONE HYDROGEL MATERIALS WITH CHEMICALLY BOUND WETTING AGENTS 审中-公开
公开(公告)号：WO2010056687A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/063945
申请日：2009-11-11
申请人： NOVARTIS AG , PHELAN, John, Christopher
发明人： PHELAN, John, Christopher
IPC分类号： G02B1/04 , C08F220/00
摘要： Silicone-containing prepolymers containing ehtylenically unsaturated groups and latent UV-activated free radical generating moieties. This class of silicone-containing prepolymer is capable of being actinically crosslinked in the presence of one or more hydrophilic vinylic monomers to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and a vinylic monomer having a latent UV-activated free radical generating moiety.

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