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1. 发明申请

WO2021049992A1 AN INTELLIGENT RESPONSE AND ANALYTICS SYSTEM, COMPUTER PROGRAM AND A COMPUTER READABLE STORAGE MEDIUM 审中-公开
公开(公告)号：WO2021049992A1
公开(公告)日：2021-03-18
申请号：PCT/SE2020/050848
申请日：2020-09-10
申请人： NOURI, Jalal
发明人： NOURI, Jalal
IPC分类号： G06Q50/20 , G09B5/14 , G06N20/00 , G09B5/06 , G09B7/00
摘要： The disclosure relates to an intelligent response system 200 in a communication network comprising at least one guest computing device 232 provided with user interface tools for registering response data in response to a session or activity, and a host computing device 231 to record the session activity. The intelligent response system 200 is capable of processing and synchronizing information data based on the session/activity, the response data and additional multiple source data so the users are provided with data-driven feedback that improves his/her session.

2. 发明申请

WO2020245157A1 METHOD FOR CREATING A cDNA SEQUENCING LIBRARY 审中-公开
公开(公告)号：WO2020245157A1
公开(公告)日：2020-12-10
申请号：PCT/EP2020/065292
申请日：2020-06-03
申请人： WU, Di , KRZYWKOWSKI, Tomasz , NILSSON BERNITZ, Mats
发明人： WU, Di , KRZYWKOWSKI, Tomasz , NILSSON BERNITZ, Mats
IPC分类号： C12N15/09
摘要： The present invention relates to the field of biotechnology and a method for creating a cDNA library. More specifically, the invention refers to a method of forming complementary DNA (cDNA) sequencing libraries from RNA in situ comprising the steps of: (a) fixating cells, immobilized on a solid surface; (b) performing an in situ reverse transcription (RT) inside cells, using RT primers comprising a PCR handle 1, and partially biotinylated dNTPs; (c) releasing single stranded cDNA from the cells using a release mix, wherein the release mix comprises an RNAse, such that the single stranded cDNA is released from intact cells; (d) collecting a supernatant comprising released cDNA into a single larger volume or in separate volumes; and (e) introducing an adapter molecule comprising a PCR handle 2 that will bind 3' of the extended cDNA.

3. 发明申请

WO2020234231A1 METHOD OF PLASTICIZING AND DENSIFYING HYDROPHILIC POLYMERIC BIOMATERIALS AND HYDROPHILIC POLYMERIC BIOMATERIALS 审中-公开
公开(公告)号：WO2020234231A1
公开(公告)日：2020-11-26
申请号：PCT/EP2020/063796
申请日：2020-05-18
申请人： GRENARNA AB
发明人： SANDBERG, Dick , NEYSES, Benedikt
IPC分类号： B32B7/12 , C08B1/00 , C08H8/00 , C08J3/09 , C08L1/02
摘要： The present invention relates to a method of plasticizing and densifying hydrophilic polymeric biomaterial, said hydrophilic polymeric biomaterial having at least one surface, comprising the steps of softening the surface of the hydrophilic polymeric biomaterial to be compressed; compressing the hydrophilic polymeric biomaterial by applying an elevated pressure onto the softened surface of said hydrophilic polymeric biomaterial at an elevated temperature for a predetermined period of time; decreasing the temperature and thereafter the pressure applied to the hydrophilic polymeric biomaterial; wherein a plasticizing liquid is added to said surface of the hydrophilic polymeric biomaterial to be densified, the plasticizing liquid being a non-imidazolium-based ionic liquid (IL), an organic superbase or a Deep Eutectic Solvent (DES).

4. 发明申请

WO2020178005A1 NOVEL COMPOSITIONS AND USE THEREOF 审中-公开
公开(公告)号：WO2020178005A1
公开(公告)日：2020-09-10
申请号：PCT/EP2020/053870
申请日：2020-02-14
申请人： WASSERMAN MEDIC AB
发明人： WASSERMAN, Peter
IPC分类号： A61K8/58 , A61K8/891 , A61Q19/00 , A61K8/02 , A61L26/00
摘要： The present invention relates to a silicone composition comprising the three silicone compounds: stearyl dimethicone, a C30-45 alkyl methicone, and a caprylyl methicone. Said combination provides a unique effect in the treatment of scars, by increasing hydration of stratum corneum and thereby facilitates regulation of fibroblast production and reduction in collagen production, whereby treatment of skin injuries is obtained. Said composition can be applied as a thin transparent silicone film on a desired skin area, does not require any drying time, and has an improved adherence to the patient's skin, thereby improving patient compliance during treatment. Furthermore, said silicone composition can be provided with an SPF of 50 and a relatively high silicone concentration.

5. 发明申请

WO2020171764A1 CRYO-EM SPECIMEN PREPARATION 审中-公开
公开(公告)号：WO2020171764A1
公开(公告)日：2020-08-27
申请号：PCT/SE2020/050191
申请日：2020-02-19
申请人： ZOU, Xiaodong , ZHAO, Jingjing , XU, Hongyi
发明人： ZOU, Xiaodong , ZHAO, Jingjing , XU, Hongyi
IPC分类号： G01N1/28 , G01N1/42
摘要： The present disclosure relates to a method for cryo-electron microscopy (cryo-EM) specimen preparation. The method comprises the steps: a) providing an EM sample grid; b) applying a sample dispersed in a liquid onto a sample face of the EM sample grid; c) providing a pressure gradient through the EM sample grid in order to force a portion of the liquid through the EM sample grid and remove the portion of liquid; and d) immersing the EM sample grid into a cryogenic bath. The disclosure further relates to auxiliary suction modulesand cryo-EM specimenpreparation apparatus for performing such a method.

6. 发明申请

WO2019162376A1 BOTULINUM NEUROTOXIN BIOHYBRID 审中-公开
公开(公告)号：WO2019162376A1
公开(公告)日：2019-08-29
申请号：PCT/EP2019/054310
申请日：2019-02-21
申请人： STENMARK, Pål , MASUYER, Geoffrey
发明人： STENMARK, Pål , MASUYER, Geoffrey
IPC分类号： C07K14/33
摘要： The present invention relates to a novel botulinum neurotoxin (BoNT) Heavy Chain Binding domain (H c /TAB) adapted to synergistically bind to a synaptotagmin (Syt) receptor, a synaptic associated vesicle 2 (SV2) receptor and a ganglioside (Gang) receptor, as well as polypeptides comprising said novel H c /TAB, vectors encoding said polypeptides, and uses thereof.

7. 发明申请

WO2019151939A1 NOVEL COMPOSITION AND USE THEREOF 审中-公开
公开(公告)号：WO2019151939A1
公开(公告)日：2019-08-08
申请号：PCT/SE2019/050097
申请日：2019-02-05
申请人： DIAMYD MEDICAL AB
发明人： HANNELIUS, Ulf , ESSEN-MÖLLER, Anders , LINDQVIST, Anton
IPC分类号： A61K39/00 , A61K9/127 , A61K31/197 , A61K31/59 , A61K33/06 , A61K33/242 , A61K38/17
摘要： The present invention relates to the use of at least two autoantigens specific to an autoimmune disease for treatment of said disease.The invention further relates to a method for treatment or prevention of an autoimmune disease, comprising administering to a subject such a pharmaceutical composition or administering to a subject at least two pharmaceutical compositions, each comprising at least one autoantigen which is not present in another such pharmaceutical composition, and which autoantigen is specific to an autoimmune disease.

8. 发明申请

WO2019098923A1 USE OF AN IRRIGATION SYSTEM FOR THE IRRIGATION OF A PLANT 审中-公开
公开(公告)号：WO2019098923A1
公开(公告)日：2019-05-23
申请号：PCT/SE2018/051174
申请日：2018-11-14
申请人： EMAMI, S. Noushin
发明人： EMAMI, S. Noushin
IPC分类号： A01G7/06 , A01G27/00 , A61M5/14
CPC分类号： A01G27/005 , A61M5/162
摘要： The present invention provides for a system and a method that enables a user to control and estimate the amount of water being provided to a plant and that is easy to use, without requiring constant monitoring or any power supplies.Thus the present invention provides for the use of an irrigation system for the irrigation of a plant in a domestic environment or in- door environment, such as an office, wherein said irrigation system comprises at least one liquid container, preferably containing water, and a tubing system, preferably a plastic tubing system, said tubing system comprising a connector for connecting the tubing system to the liquid container, an air vent, a dripping chamber, a first tube being connected to the dripping chamber in the upper end of said first tube, and a flow regulator arranged on the outside of the first tube at a distance from a lower end of the first tube, the tubing system being arranged such that the lower end of the first tube is just above the soil or root system of the plant to be irrigated, wherein said flow regulator controls the flow of liquid droplets per time and space exiting the device from the first tube and into the soil or onto the root system of the plant, such that a controlled watering of the plant is performed.

9. 发明申请

WO2018226150A1 PYRAZOLOPYRIMIDINE AS MALT-1 INHIBITORS 审中-公开
公开(公告)号：WO2018226150A1
公开(公告)日：2018-12-13
申请号：PCT/SE2018/050587
申请日：2018-06-05
申请人： MEDIVIR AKTIEBOLAG
发明人： ERSMARK, Karolina , KARLSTRÖM, Sofia , KLASSON, Björn , LUNDGREN, Stina , ROSENQUIST, Åsa , SALVADOR ODÉN, Lourdes
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： A61P35/00 , C07D487/04
摘要： The invention provides a compound of formula (I): herein R 1 , R 2 and R 3 of series (x), (y) and (z) are as defined in the specification which are potent inhibitors of the enzyme MALT1 and are useful in an immunooncology approach to the treatment of cancer, especially bladder cancer, colon cancer, hepatocellular cancer or small cell or non-small cell lung cancer.

10. 发明申请

WO2018147794A1 METHOD FOR DETERMINING LEVELS OF INTERACTIONS BETWEEN BIOMOLECULES 审中-公开
公开(公告)号：WO2018147794A1
公开(公告)日：2018-08-16
申请号：PCT/SE2018/050121
申请日：2018-02-09
申请人： SÖDERBERG, Ola
发明人： SÖDERBERG, Ola
IPC分类号： C12Q1/6804 , C12N15/10
摘要： The invention relates to a method for determining levels of interactions between biomolecules, such as proteins, in a sample, comprising providing a first and a second information carrying (IC) oligonucleotide, wherein the first and second IC oligonucleotide are attached, covalently or non-covalently, to a first and a second affinity reagent, such as antibodies, that have the capacity to bind to a first and a second biomolecule, wherein the first and second IC oligonucleotide each comprises at least one single-stranded stretch that is complementary to a part of another oligonucleotide, thereby, upon hybridisation of the at least one single-stranded stretch in at least one of the first and second IC oligonucleotides to its complementary part of another oligonucleotide, enabling measurement of the relative proportion of interacting and non-interacting first and second biomolecules in the sample at a single cell or single molecular level. Further, the invention relates to kits including necessary oligonucleotides and reagents to carry out the method of the invention.

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