专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2022187289A1 METHODS AND COMPOSITIONS FOR THE DELIVERY OF RETROVIRAL PARTICLES 审中-公开
公开(公告)号：WO2022187289A1
公开(公告)日：2022-09-09
申请号：PCT/US2022/018404
申请日：2022-03-01
申请人： EXUMA BIOTECH CORP.
发明人： FROST, Gregory Ian , VIGANT, Frederic , KUNDU, Anirban , HENKELMAN, John R., III , KERKAR, Sidharth , SCHREIBER, Gregory
IPC分类号： C12N15/86
摘要： The present disclosure provides methods and compositions for modifying lymphocytes, for example T cells and/or NK cells, for example in vivo. The disclosed compositions can include replication incompetent recombinant retroviral particles (RIPs), formulations thereof, and administration of RIP formulations to a subject. Furthermore, the compositions can include chemokines, including chemokines delivered and/or associated with RIPs.

2. 发明申请

WO2021178701A1 METHODS AND COMPOSITIONS FOR THE DELIVERY OF MODIFIED LYMPHOCYTE AGGREGATES 审中-公开
公开(公告)号：WO2021178701A1
公开(公告)日：2021-09-10
申请号：PCT/US2021/020922
申请日：2021-03-04
申请人： EXUMA BIOTECH CORP.
发明人： FROST, Gregory Ian , VIGANT, Frederic , KUNDU, Anirban , HENKELMAN III, John R. , KERKAR, Sidharth , SCHREIBER, Gregory
IPC分类号： A61K31/522 , A61K35/17 , A61K35/76 , A61K39/00 , A61K47/69 , A61K48/00
摘要： The present disclosure provides methods and compositions for genetically modifying lymphocytes, for example T cells and/or NK cells. In some embodiments, the methods include reaction mixtures, and resulting cell formulations, that are created using whole blood, or a component thereof that is not a PBMC, and additionally comprise T cells and recombinant retroviral particles having polynucleotides that encode a CAR. In some embodiments, modified lymphocytes are reintroduced into a subject subcutaneously. In some embodiments, polynucleotides that provide T cells the ability to regulate cell survival and proliferation in response to binding to a CAR, are provided.

3. 发明申请

WO2020047527A2 METHODS AND COMPOSITIONS FOR GENETICALLY MODIFYING LYMPHOCYTES IN BLOOD OR IN ENRICHED PBMCS 审中-公开
公开(公告)号：WO2020047527A2
公开(公告)日：2020-03-05
申请号：PCT/US2019/049259
申请日：2019-09-02
申请人： F1 BIOVENTURES, LLC , F1 ONCOLOGY, INC.
发明人： FROST, Gregory Ian , ONUFFER, James Joseph , HAERIZADEH, Farzad , VIGANT, Frederic , KUNDU, Anirban
IPC分类号： C12N5/0783 , C12N15/867
摘要： The present disclosure provides methods and compositions for genetically modifying lymphocytes, for example T cells and/or NK cells, in shorter times than previously and/or in whole blood or a component thereof. In some embodiments a lymphodepletion filter assembly is used before or after forming a reaction mixture where lymphocytes are contacted with recombinant retroviral particles in a closed system, to genetically modify the lymphocytes.

4. 发明申请

WO2022047417A1 ANTI-IDIOTYPE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2022047417A1
公开(公告)日：2022-03-03
申请号：PCT/US2021/048532
申请日：2021-08-31
申请人： EXUMA BIOTECH CORP.
发明人： FROST, Gregory Ian , SCHREIBER, Gregory Harold , KUNDU, Anirban
IPC分类号： A61K39/395 , A61K51/00 , C07K16/00 , C07K16/24 , C07K16/28
摘要： The present disclosure provides methods and compositions that include a polynucleotide that includes nucleic acids that encode an anti-idiotype polypeptide, as well as polypeptides that are encoded by the same, and cells that include and express the polypeptide. Disclosed methods include methods that utilize the anti-idiotype polypeptides as safety switches when they are used in combination with antibodies, include approved biologic antibodies, that include the recognized idiotype. Certain embodiments include anti-idiotype polypeptides and nucleotides encoding the same, that include an internal domain. This internal domain in some embodiments has functional domains that can induce proliferation or cell death upon binding of the anti-idiotype polypeptide by its target antibody.

5. 发明申请

WO2021151119A1 CHIMERIC ANTIGEN RECEPTORS TO HER2 AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021151119A1
公开(公告)日：2021-07-29
申请号：PCT/US2021/070073
申请日：2021-01-23
申请人： EXUMA BIOTECH CORP. , BIOATLA, LLC
发明人： FROST, Gregory Ian , ONUFFER,, James Joseph , KUNDU, Anirban , SHORT, Jay M , FREY, Gerhard , CHANG, Hwai Wen
IPC分类号： C07K14/705 , C07K16/28 , C12N5/00
摘要： The present disclosure provides chimeric antigen receptors (CARs), and nucleic acids comprising nucleotide sequences encoding the CARs, that bind to HER2, and conditionally active biologic (CAB) CARs that bind to HER2. The present disclosure provides cells genetically modified to produce the CARs, delivery suspensions comprising these genetically modified cells, and methods for making such cells. The CARs of the present disclosure can be used in various methods, which are also provided, including methods for activating immune cells under certain conditions, and methods for performing adoptive cell therapy such as CAR therapy, for example CAR therapy against cancer.

6. 发明申请

WO2020092982A1 MICROFLUIDIC VISCOMETER AND ASSEMBLY, AND METHODS USING THE SAME 审中-公开
公开(公告)号：WO2020092982A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/059504
申请日：2019-11-01
申请人： NEOFLUIDICS, LLC
发明人： SOLOMON, Deepak
IPC分类号： B01L3/00 , F16K7/07 , F16K99/00 , G01N11/02 , G01N11/04 , G01N11/08
摘要： Provided herein are microfluidic viscometer assemblies and methods using the same, that include a microfluidic cartridge having microfluidic circuits that have channels adapted for viscosity determination without the need of a control fluid or oil. The viscometer assemblies also include an image recording system and a pressure control unit. In some embodiments, a temperature control unit is included as well. During methods using the viscometers provided herein, microfluidic cartridges can be loaded and removed from a viscometer, and disposed of.

7. 发明申请

WO2018161064A1 METHODS AND COMPOSITIONS FOR TRANSDUCING AND EXPANDING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF 审中-公开
公开(公告)号：WO2018161064A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020818
申请日：2018-03-03
申请人： F1 ONCOLOGY, INC.
发明人： FROST, Gregory Ian , ONUFFER, James Joseph , GUIBINGA, Ghiabe H. , HAERIZADEH, Farzad
IPC分类号： C12N15/10 , C12N15/867 , C12N5/0783 , C12N5/10 , C07K14/725 , C07K14/705 , C07K14/715 , A61K48/00 , C12N15/86
摘要： The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/or engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted biologic CAR (MRB-CAR). Additional elements of such engineered signaling polypeptides are provided herein, such as those that drive proliferation and regulatory elements therefor, as well as replication incompetent recombinant retroviral particles and packaging cell lines and methods of making the same. Numerous elements and methods for regulating transduced and/or genetically modified T cells and/or NK cells are provided, such as, for example, those including riboswitches, MRB-CARs, recognition domains, and/or pH-modulating agents.

8. 发明申请

WO2018136566A1 METHODS OF TRANSDUCING AND EXPANDING IMMUNE CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2018136566A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014116
申请日：2018-01-17
申请人： F1 ONCOLOGY, INC.
发明人： FROST, Gregory Ian , ONUFFER, James Joseph
IPC分类号： C12N5/0783
摘要： The present disclosure provides methods for genetically modifying and expanding immune cells ex vivo, especially for use in cell-based adoptive immunotherapy. As such, method embodiments are provided for transducing immune cells (e.g. T cells and/or NK cells) that include a step of activating the cells and genetically modifying the activated cells, for example by transducing the cells with recombinant retroviral particles, such as lentiviral particles. Genetically modified cells produced by these methods are also provided. Such methods are typically performed within a closed system, and in illustrative embodiments within a single chamber of a closed system. The methods typically include expanding the genetically modified immune cells in cell expansion media within the closed system, in illustrative embodiments within the single chamber of the closed system. As such, provided herein in illustrative embodiments, are fed-batch, single-reactor method systems.

9. 发明申请

WO2008106660A2 ISOLATED PHOSPHOLIPID-PROTEIN PARTICLES 审中-公开
标题翻译：分离的磷脂 - 蛋白质颗粒
公开(公告)号：WO2008106660A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/055567
申请日：2008-02-29
申请人： INVITROGEN CORPORATION , KATZEN, Federico , FLETCHER, Julia , KUDLICKI, Wieslaw , BEECHEM, Joseph , WANG, Lilin
发明人： KATZEN, Federico , FLETCHER, Julia , KUDLICKI, Wieslaw , BEECHEM, Joseph , WANG, Lilin
IPC分类号： C07K14/47 , C07K1/00 , C12Q1/68 , C12P21/06
CPC分类号： C12P21/02 , C07K1/02
摘要： Systems and methods are provided for producing a protein of interest that is typically not amenable to expression in soluble form in in vitro expression systems. In some aspects, the invention provides methods of synthesizing proteins using in vitro protein synthesis systems that include a scaffold protein such as apolipoprotein or an amphipathic alpha helix containing ("AAHC") protein, in which higher yields of soluble protein are produced than in the absence of the scaffold protein. The scaffold proteins may be provided in an in vitro protein synthesis system associated with lipid or not associated with lipid. The scaffold protein may be provided as a protein per se or may be encoded by a nucleic acid template and co-expressed with the protein of interest. The invention also provides compositions and kits for synthesis of proteins in soluble form, in which the compositions and kits include cell extracts for protein expression and isolation.
摘要翻译：提供的系统和方法用于产生通常不适于在体外表达系统中以可溶形式表达的目标蛋白质。在一些方面，本发明提供使用体外蛋白质合成系统合成蛋白质的方法，所述体外蛋白质合成系统包括支架蛋白如载脂蛋白或含有（“AAHC”）蛋白的两亲性α螺旋，其中产生比在没有支架蛋白。支架蛋白质可以提供在与脂质相关的体外蛋白质合成系统中或与脂质不相关。支架蛋白质可以作为蛋白质本身提供，或者可以由核酸模板编码并与感兴趣的蛋白质共表达。本发明还提供用于合成可溶形式的蛋白质的组合物和试剂盒，其中组合物和试剂盒包括用于蛋白质表达和分离的细胞提取物。

10. 发明申请

WO2023081804A1 PLATELET DERIVATIVE COMPOSITIONS, AND METHODS OF MAKING AND USING SUCH COMPOSITIONS 审中-公开
公开(公告)号：WO2023081804A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/079280
申请日：2022-11-04
申请人： CELLPHIRE, INC.
发明人： MONTGOMERY, Joshua Donald , ISHLER, Braden Carl , AMOS, Stephen Edward , MOSKOWITZ, Keith Andrew , LEE, Amber Nicole , JORDA, Rafael , FITZPATRICK, Glen Michael , MATHEWS, Michael Alexander
IPC分类号： A61K35/19 , A61P7/02
摘要： Provided herein are materials and methods for the preparation of blood products. In some aspects, provided herein are compositions that include populations of platelet derivatives, including freeze-dried platelet derivatives, methods of producing the same, as well as methods of using the same to treat a subject. Such platelet derivatives have improved properties, as disclosed herein.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式