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1. 发明申请

WO2023004411A1 A METHOD FOR IN VIVO GENE THERAPY TO CURE SCD WITHOUT MYELOABLATIVE TOXICITY 审中-公开
公开(公告)号：WO2023004411A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/074043
申请日：2022-07-22
申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人： GLASSBERG, Jeffrey A. , BIEKER, James J.
IPC分类号： C07K14/47 , A61K38/46 , A61P7/00 , C12N9/22 , C12N15/11 , C12N15/90
摘要： Disclosures herein are directed to compositions and methods for increasing gamma globinexpression in a cell or subject by suppressing expression of Klf1. Also described are methods of treating or ameliorating -hemoglobinopathies. The compositions are administered to a subject as a therapeutic amount of a gene editing composition, including an RNA-guided endonuclease and one or more gRNA or sgRNA, or one or more transcription activator-like effector nucleases (TALENs), that targets an intron of a Klf1 gene locus in at least one cell in the subject to effect a deletion in intron, thereby reducing expression of Klf1.

2. 发明申请

WO2022251281A1 INTELLECTUAL PROPERTY AND FINANCIAL DISTRIBUTION MANAGEMENT USING DISTRIBUTED LEDGERS 审中-公开
公开(公告)号：WO2022251281A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/030812
申请日：2022-05-25
申请人： KYODAI TECHNOLOGIES, INC.
发明人： APOLLO, Anthony J. , APOLLO, Frank M. , APOLLO, Nicholas C.
IPC分类号： G06F21/10 , G06Q20/36
摘要： Systems and methods for managing intellectual property and financial distributions associated with digital objects using distributed ledgers are provided. A digital object marketplace receives a request to obtain a license token for a digital object. License tokens for the digital object are generated by a smart contract deployed in a distributed ledger. The digital object is also associated with an owner token generated when the digital object is published to the digital object marketplace, or with a recipient digital wallet. The digital object marketplace, using the smart contract, transfers a payment from a requestor's digital wallet to the holder of the owner token or to the recipient digital wallet and the transfer is recorded in the distributed ledger. A license token for the digital object is provided to the requestor's digital wallet and the transaction associated with the license token is further recorded in the distributed ledger.

3. 发明申请

WO2021252598A1 MOLECULAR SIGNATURE GENERATION 审中-公开
公开(公告)号：WO2021252598A1
公开(公告)日：2021-12-16
申请号：PCT/US2021/036570
申请日：2021-06-09
申请人： OPENNANO INC. , PINSKIY, Vadim , DREXLER, Kim, E. , FAGUET, Serge , GOPINATH, Ashwin , MARKOU, George , BRUNETTE, Tj
发明人： PINSKIY, Vadim , DREXLER, Kim, E. , FAGUET, Serge , GOPINATH, Ashwin , MARKOU, George , BRUNETTE, Tj
IPC分类号： C12N15/10 , C12P19/34 , C12Q1/68 , G01N33/542
摘要： The present invention provides bi-stable functionalized organic molecule and methods of utilizing these bi-stable functionalized organic molecule.

4. 发明申请

WO2020252320A1 DNA METHYLATION BASED HIGH RESOLUTION CHARACTERIZATION OF MICROBIOME USING NANOPORE SEQUENCING 审中-公开
公开(公告)号：WO2020252320A1
公开(公告)日：2020-12-17
申请号：PCT/US2020/037507
申请日：2020-06-12
申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人： FANG, Gang , TOURANCHEAU, Alan
IPC分类号： C12Q1/6869 , G06F19/22 , G06F19/10 , G16B30/10 , G16B10/00
摘要： Disclosed herein are computer- implemented methods of deconvoluting metagenomic assembled contigs from a microbiome sample and methods of using such for therapeutic, diagnostic, and environmental purposes.

5. 发明申请

WO2020150425A1 PROCESSES FOR PREPARING METAL OXIDE SEMICONDUCTOR NANOMATERIALS 审中-公开
公开(公告)号：WO2020150425A1
公开(公告)日：2020-07-23
申请号：PCT/US2020/013800
申请日：2020-01-16
申请人： NANO SONO COOPERATION LTD
发明人： FRANCO, Ariel, Antonio , SARUSI, Ronen
IPC分类号： B82Y30/00 , B82Y40/00 , C01G49/02
摘要： The present invention provides processes for preparing metal oxide semiconductor nanomaterials.

6. 发明申请

WO2020076591A1 MACRO INSPECTION SYSTEMS, APPARATUS AND METHODS 审中-公开
公开(公告)号：WO2020076591A1
公开(公告)日：2020-04-16
申请号：PCT/US2019/054386
申请日：2019-10-03
申请人： NANOTRONICS IMAGING, INC.
发明人： PUTMAN, Matthew C. , PUTMAN, John B. , MOFFITT, John , ANDRESEN, Jeffrey , POZZI-LOYOLA, Scott , ORLANDO, Julie , MOSKIE, Michael
IPC分类号： G06K9/20 , G06K9/36 , G06K9/60 , G02B21/00 , G02B21/06 , G02B21/26 , G01B11/00
摘要： The disclosed technology relates to an inspection apparatus that includes a stage configured to retain a specimen for inspection, an imaging device having a field of view encompassing at least a portion of the stage to view a specimen retained on the stage, a lens having a view encompassing the specimen retained on the stage, and a plurality of lights disposed on a moveable platform. The inspection apparatus can further include a control module configured to control a position of the stage, an elevation of the moveable platform, and a focus of the lens. In some implementations, the inspection apparatus includes an image processing system configured for receiving image data from the imaging device, analyzing the image data to determine a specimen classification, and automatically selecting an illumination profile based on the specimen classification. Methods and machine-readable media are also contemplated.

7. 发明申请

WO2014201328A1 PAD OF LABELS AND LABELS FOR USE ON STORE SHELVES IN A RETAIL ENVIRONMENT 审中-公开
标题翻译：标签和标签用于零售环境中的商店店铺
公开(公告)号：WO2014201328A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/042271
申请日：2014-06-13
申请人： ELECTRONIC IMAGING SERVICES, INC.
发明人： WEIDAUER, Jeffrey , WILKINSON, Michael , BLACKWELL, Jeffrey , ATEN, Scott , ADLER, David , BETHARDS, Gene
IPC分类号： G09F3/00 , G09F3/02
CPC分类号： G09F3/10 , B31D1/021 , B31D1/026 , B31D1/027 , B32B3/266 , B32B7/06 , B32B7/12 , B32B27/10 , B32B27/32 , B32B27/36 , B32B37/12 , B32B37/1292 , B32B38/0004 , B32B38/1825 , B32B2255/26 , B32B2307/732 , B32B2307/748 , B32B2317/12 , B32B2323/10 , B32B2367/00 , B32B2383/00 , B32B2519/00 , G06K19/06028 , G06K19/06046 , G09F3/02 , G09F3/0297 , G09F2003/0208 , G09F2003/0214 , G09F2003/0225 , G09F2003/023 , G09F2003/0257 , Y10T156/10 , Y10T156/1052 , Y10T156/1057
摘要： A pad of labels and labels for use on store shelves in a retail environment. The pad of labels include labels with adhesive strips applied to a bottom surface of each label and a top laminate layer with a release coating applied to the top surface of each label. The labels in the pad are sequenced according to a store's planogram.
摘要翻译：在零售环境中用于商店货架上的标签和标签垫。标签垫包括具有施加到每个标签的底表面的粘合带的标签和具有施加到每个标签的顶表面上的剥离涂层的顶层叠层。垫中的标签根据商店的平面图进行排序。

8. 发明申请

WO2014110364A2 FANTASY LEAGUE ACROSS MULTIPLE SPORTS 审中-公开
标题翻译：幻想联盟多项运动
公开(公告)号：WO2014110364A2
公开(公告)日：2014-07-17
申请号：PCT/US2014/011037
申请日：2014-01-10
申请人： POOL OF AGES, LTD.
发明人： KOTT, Paul, Geoffrey Daniel , COELEN, Nathan, Mathis
IPC分类号： A63F13/12
CPC分类号： A63F13/828 , A63F13/65
摘要： The fantasy league across multiple sports includes a plurality of fantasy teams owned by fantasy owners, a fantasy draft that allows the fantasy owners to select their fantasy team, and a plurality of fantasy players that make up a roster of the fantasy team, where the fantasy players include individual athletes and sports franchises across multiple sports. The fantasy league across multiple sports further includes a designated number of slots on each fantasy team, where each slot is assigned a specific category that includes either athletes, positions of athletes on sports teams, or sports franchises. The fantasy draft includes the fantasy owners selecting individual athletes and sports franchises across multiple sports.
摘要翻译：跨越多个运动的幻想联盟包括由幻想所有者拥有的多个幻想团队，一个幻想草案，允许幻想所有者选择他们的幻想团队，以及组成幻想团队名单的多个幻想球员，其中幻想球员包括个人运动员和多项运动的运动专长。跨越多个运动的幻想联盟还包括每个幻想团队的指定数量的插槽，其中每个插槽被分配一个特定的类别，包括运动员，运动员在运动队的位置或运动专长。幻想草案包括幻想主人选择个人运动员和运动专长多个运动。

9. 发明申请

WO2013085995A1 SYSTEM AND METHOD FOR PRODUCING HOMOGENIZED OILFIELD GELS 审中-公开
标题翻译：用于生产均质油田凝胶的系统和方法
公开(公告)号：WO2013085995A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/067948
申请日：2012-12-05
申请人： SAFFIOTI, Stephen, M.
发明人： SAFFIOTI, Stephen, M.
IPC分类号： B01F3/12 , C08J3/05 , E21B43/22
CPC分类号： B29B7/60 , B01F3/1228 , B01F5/0415 , B01F5/0606 , B01F5/106 , B01F13/004 , B01F15/0251 , B01F2215/0081
摘要： A system for producing homogenized oil field gel including a power unit, a control system, a feed tank, a hopper, and a piping assembly that includes inlet and outlet manifolds, centrifugal pumps, and metering devices for filling the feed tank and handling a discharge of oilfield gel. The system further includes a powder hydration component and liquid chemical equipment. The method for producing homogenized oil field gel includes a guar powder procedure including a controlled sequence for starting and stopping a venturi mixer in a hydration unit. The method for producing homogenized oil field gel further includes a liquefied gel concentrate procedure including a metering and chemical injection procedure for mixing a liquefied gel concentrate.
摘要翻译：一种用于生产均质油田凝胶的系统，包括动力单元，控制系统，进料罐，料斗和管道组件，其包括入口和出口歧管，离心泵和用于填充进料罐的处理排放物的计量装置的油田凝胶。该系统还包括粉末水合组分和液体化学设备。用于生产均质油田凝胶的方法包括瓜尔胶法，其包括在水合单元中启动和停止文丘里搅拌器的受控顺序。用于生产均质油田凝胶的方法还包括液化凝胶浓缩程序，其包括用于混合液化凝胶浓缩物的计量和化学注入程序。

10. 发明申请

WO2021226346A1 SYNTHETIC TUMOR MODELS FOR USE IN THEPAREUTIC RESPONSE PREDICTION 审中-公开
公开(公告)号：WO2021226346A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/031108
申请日：2021-05-06
申请人： QUANTITATIVE IMAGING SOLUTIONS, LLC , KINSEY, Charles Matthew , ESTEPAR, Raul San Jose , WASHKO, George
发明人： KINSEY, Charles Matthew , ESTEPAR, Raul San Jose , WASHKO, George
IPC分类号： G06T11/00
摘要： Systems and methods for creating therapeutic response predictions based on a synthetic tumor model generated based on micro-scale data associated with one or more parameters representative of one or more biological characteristics of tumors, where synthetic CT images constructed via back projection of the synthetic tumor model and distribution/response of one or more therapeutic therapies predicted for the synthetic tumor model are used to train an unsupervised learning model for determining a personalized treatment plan for a patient's tumor.

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