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1. 发明申请

WO2002064149A1 METHOD FOR THE PREVENTION OF TISSUE ELASTIC FIBER INJURY 审中-公开
标题翻译：防止组织弹性纤维损伤的方法
公开(公告)号：WO2002064149A1
公开(公告)日：2002-08-22
申请号：PCT/US2001/040105
申请日：2001-02-14
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： CANTOR, Jerome, O.
IPC分类号： A61K31/728
CPC分类号： A61K31/728
摘要： The subject invention is directed to the prevention of elastic fiber injury by administering HA or any other polysaccharide or carbohydrate moiety that binds to and coats elastic fibers, thereby preventing enzymes, oxidants, or other injurious agents from contacting and damaging these fibers. The method may be used to prevent elastic fiber damage which occurs to the skin and blood vessels as a consequence of aging, to the uterus during pregnancy, and in diseases such as pulmonary emphysema, aortic aneurysm, and joint disease. The treatment is intended for humans and a variety of other mammals. The polysaccharide or carbohydrate moiety may be administered orally, cutaneously, subcutaneously, intravenously, intracheally, or by any other route deemed efficacious. It may be administered alone or in combination with another polysaccharide or carbohydrate moiety, with or without a carrier such as saline solution, DMSO, alcohol or water. It may be naturally occurring, chemically modified, or artificially synthesized. The effective daily amount of the polysaccharide or carbohydrate moiety is from about 0.1í g/kg to about 1 mg/kg of body weight.
摘要翻译：本发明涉及通过施用HA或结合弹性纤维并涂覆弹性纤维的任何其它多糖或碳水化合物部分来防止弹性纤维损伤，由此防止酶，氧化剂或其它损害剂接触和损坏这些纤维。该方法可以用于防止由于老化，怀孕期间的子宫以及诸如肺气肿，主动脉瘤和关节疾病等疾病而对皮肤和血管发生的弹性纤维损伤。该治疗适用于人类和各种其他哺乳动物。多糖或碳水化合物部分可以口服，皮肤，皮下，静脉内，气管内或任何其他被认为有效的途径给药。其可以单独施用或与另一种多糖或碳水化合物部分组合施用，具有或不具有载体如盐溶液，DMSO，醇或水。它可能是天然存在的，化学修饰的或人工合成的。多糖或碳水化合物部分的有效日剂量为约0.1μg/ kg至约1mg / kg体重。

2. 发明申请

WO2004041189A2 A METHOD FOR INHIBITING CANCER DEVELOPMENT BY FATTY ACID SYNTHASE INHIBITORS 审中-公开
标题翻译：脂肪酸合成酶抑制剂抑制癌症发生的方法
公开(公告)号：WO2004041189A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/034658
申请日：2003-10-31
申请人： FASGEN LLC , THE JOHN HOPKINS UNIVERSITY , KUHAJDA, Francis, Paul, , JAFFEE, Elizabeth, M. , TOWNSEND, Craig, A.
发明人： KUHAJDA, Francis, Paul, , JAFFEE, Elizabeth, M. , TOWNSEND, Craig, A.
IPC分类号： A61K
CPC分类号： A61K31/365 , A61K31/00 , A61K31/34 , A61K31/381
摘要： A method for inhibiting or preventing cancer development by the administration of fatty acid synthase (FAS) inhibitors. In particular, the present invention prohibits or delays the development of invasive cancer from pre-malignant (non-invasive) lesions that express FAS. Compositions containing FAS inhibitors also are provided, as well as methods for administering the FAS inhibitors and compositions to patients in need thereof.
摘要翻译：通过施用脂肪酸合成酶（FAS）抑制剂抑制或预防癌症发展的方法。特别地，本发明禁止或延迟侵入性癌症从表达FAS的恶性（非侵入性）损伤的发展。还提供了含有FAS抑制剂的组合物，以及用于将FAS抑制剂和组合物给予有需要的患者的方法。

3. 发明申请

WO2004005277A1 NOVEL COMPUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME 审中-公开
标题翻译：新型组合物，含有该组合物的药物组合物及其使用方法
公开(公告)号：WO2004005277A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021700
申请日：2003-07-09
申请人： FASGEN, INC. , THE JOHNS HOPKINS UNIVERSITY , KUHAJDA, Francis, P. , MEDGHALCHI, Susan, M. , MCFADDEN, Jill, M. , THUPARI, Jagan , TOWNSEND, Craig, A.
发明人： KUHAJDA, Francis, P. , MEDGHALCHI, Susan, M. , MCFADDEN, Jill, M. , THUPARI, Jagan , TOWNSEND, Craig, A.
IPC分类号： C07D333/32
CPC分类号： C07D409/12 , C07D333/32
摘要： A pharmaceutical composition comprising a phamaceurtical diluent and a compound of formula IV wherein R 21 = H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, -CH 2 OR 25 , -C(O)R 25 , -CO(O)R 25 , -C(O)NR 25 R 26 , -CH 2 C(O)R 25 , or -CH 2 C(O)NHR 25 , where R 25 and R 26 are each independently H, C 1 -C 10 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R 22 = -OH, -OR 27 , -OCH 2 C(O)R 27 , -OCH 2 C(O)NHR 27 , -OC(O)R 27 , -OC(O)OR 27 , -OC(O)NHNH-R 5 , or -OC(O)NR 27 R 28 , where R 27 and R 28 are each independentlyH, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where R 27 and R 28 can each optionally contain halogen atoms; R 23 and R 24 , the same or different from each other, are C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.
摘要翻译：其中R 21 = H，C 1 -C 20烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基，-CH 2 OR 25，-C（O）R 5，（O）R 25，-C（O）NR 25 R 26，-CH 2 C（O）R 25或-CH 2 C（O）NHR 25，其中 R 25和R 26各自独立地为H，C 1 -C 10烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基，任选地含有一个或多个卤素原子。 R 22 = -OH，-OR 27，-OCH 2 C（O）R 27，-OCH 2 C（O）NHR 27，-OC（O）R 27，-OC（O）OR -OC（O）NHNH-R 5或-OC（O）NR 27 R 28，其中R 27和R 28各自独立地为H，C 1 -C 20烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基，其中R 27和R 28各自可以含有卤素原子; R 23和R 24彼此相同或不同，为C 1 -C 20烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基。使用这些制剂治疗癌症，减轻体重，治疗基于微生物的感染，抑制神经肽Y和/或脂肪酸合成酶以及刺激CPT-1的方法。

4. 发明申请

WO2003040271A1 FUEL COMPOSITION CONTAINING HEAVY FRACTION 审中-公开
标题翻译：含有重油的燃料组合物
公开(公告)号：WO2003040271A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/035507
申请日：2002-11-05
申请人： INTERNATIONAL FUEL TECHNOLOGY, INC.
发明人： WILLIAMSON, Ian
IPC分类号： C10L1/18
CPC分类号： C10L1/143 , C10L1/1852 , C10L1/191 , C10L1/1985 , C10L1/2227 , C10L1/224 , C10L1/2286 , C10L1/232 , C10L10/02
摘要： A fuel composition comprising: (a) a hydrocarbon fuel selected from the group consisting of diesel and gasoline; and (b) a synthetic blend, wherein the fuel composition further comprises a fuel additive composition comprising: (1) an ethoxylated alcohol composition having the structure (I): wherein R 1 is a C 6 , C 7 , C 8 , C 9 , C 10 , C 11 , C 12 , C 13 , C 14 ,C 15 ,or C 16 hydrocarbon, R 2 is H or CH 3 , and x is 1-7; (2) a polyethylene glycol ester composition having the structure (II): wherein R 3 is a C 11 , C 12 , C 13 , C 14 , C 15 , or C 16 , C 17 , C 18 , or C 19 hydrocarbon, R 4 is H or CH 3 , y is 1-20, R 5 is H or COR 3 ; and (3) an alkanolamide composition having the following general structure (III): wherein R 6 is a C 12 , C 13 , C 14 ,C 15 , or C 16 , C 17 , or C 18 , hydrocarbon, R 7 is H or CH 2 CH 2 0H.
摘要翻译：一种燃料组合物，包括：（a）选自柴油和汽油的烃燃料; 和（b）合成共混物，其中所述燃料组合物还包含燃料添加剂组合物，其包含：（1）具有结构（I）的乙氧基化醇组合物：其中R 1是C6，C7，C8，C9，C10 ，C11，C12，C13，C14，C15或C16烃，R 2为H或CH3，x为1-7; （2）具有结构（II）的聚乙二醇酯组合物：其中R 3是C 11，C 12，C 13，C 14，C 15或C 16，C 17，C 18或C 19烃，R 4，是H或CH 3，y是1-20，R 5是H或COR 3; 和（3）具有以下一般结构（III）的链烷醇酰胺组合物：其中R 6是C 12，C 13，C 14，C 15或C 16，C 17或C 18烃，R 7是H或CH 2 CH 2 OH 。

5. 发明申请

WO2004009496A2 PORTABLE/MOBILE WASTEWATER TREATMENT UNIT 审中-公开
标题翻译：便携式/移动式废水处理装置
公开(公告)号：WO2004009496A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022524
申请日：2003-07-17
申请人： AQUA-NOVUS, CORPORATION , BEINE, Bob , FRIEL, John , PESONEN, Mark , SHAFFER, Jon , FERNANDES, Jack
发明人： BEINE, Bob , FRIEL, John , PESONEN, Mark , SHAFFER, Jon , FERNANDES, Jack
IPC分类号： C02F
CPC分类号： C02F3/302 , C02F3/12 , C02F3/348 , C02F2103/20 , C02F2203/008 , C02F2209/02 , C02F2305/06 , Y02W10/15
摘要： The invention is directed to a portable/mobile biological treatment and water-recirculating apparatus for delivering activated microorganisms to an environment to be treated. The unit has at least one biological wastewater treatment unit, aeration unit, biological nitrification unit, and re-circulating pump for circulating the wastewater to be treated and a controller to maintain the conditions of the bioreactor so as to maintain the microorganisms in the exponential phase of growth. The invention also provides a method for the biological treatment of wastes and an organic and inorganic nutrient composition used to feed the microorganisms in the bioreactor.
摘要翻译：本发明涉及用于将活性微生物输送到待处理环境的便携式/移动式生物处理和水再循环装置。该单元具有至少一个生物废水处理单元，曝气单元，生物硝化单元和用于使待处理废水循环的再循环泵和控制器以维持生物反应器的条件以使微生物保持在指数阶段的增长。本发明还提供了用于生物处理废物的方法和用于在生物反应器中供给微生物的有机和无机营养组合物。

6. 发明申请

WO2003038365A1 INTERRUPTIBLE THERMAL BRIDGE SYSTEM 审中-公开
标题翻译：中断热桥系统
公开(公告)号：WO2003038365A1
公开(公告)日：2003-05-08
申请号：PCT/US2002/033606
申请日：2002-10-21
申请人： ITB SOLUTIONS LLC.
发明人： BAKER, Rex, III
IPC分类号： F28F27/00
CPC分类号： F25B21/04 , F25B21/02 , F25D19/006 , F28F13/00 , F28F2013/008
摘要： An interruptible thermal bridge system (50) including: a first thermally conductive surface (54) positioned proximate an object (56) which absorbs energy (58); a second thermally conductive surface (62) thermally connected to the first conductive surface (54) positioned proximate to an object (66) which dissipates energy (68), a thermal switch (70) positioned between the first and second conductive surfaces for regulating a thermal connection between the first and second surfaces by alternatively switching between a first position, blocking the conductive path and thermally insulating the first conductive surface from the second conductive surface, and a second position, opening the conductive surface with the second conductive surface.
摘要翻译：可中断热桥系统（50），包括：靠近吸收能量（58）的物体（56）定位的第一导热表面（54）; 热连接到第一导电表面（54）的第二导热表面（62），所述第一导电表面位于靠近物体（66）附近，所述物体（66）消散能量（68）;热开关（70），其定位在所述第一和第二导电表面之间，在第一和第二表面之间通过交替切换第一位置，阻挡导电路径并将第一导电表面与第二导电表面热绝缘的第一和第二表面之间的热连接，以及第二位置，用第二导电表面打开导电表面。

7. 发明申请

WO2002091197A1 SYSTEM AND METHOD FOR GENERATING DYNAMICALLY UPDATED GRAPHICAL USER INTERFACES 审中-公开
标题翻译：用于生成动态更新的图形用户界面的系统和方法
公开(公告)号：WO2002091197A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/013642
申请日：2002-04-30
申请人： BELKIN COMPONENTS
发明人： LOW, Michael
IPC分类号： G06F15/00
CPC分类号： G06Q30/02 , G06F17/30899
摘要： A system and method for generating dynamically updated graphical user interfaces over a distributed computer network is disclosed. The system and method use existing hypertext transfer protocols (2) and existing Java Script and Active Server Pages to generate a dynamic graphical user interface based on a database of records identifying goods or services. The consumer is provided a range of predetermined choices and in accordance with replies to the predetermined choices, the graphical user interface is dynamically updated with icons and other graphic symbols representing the consumer choices. Importantly, the graphical user interface (4) does not need to refresh the browser application and therefore, minimizes data transmission delays over the distributed computer network.
摘要翻译：公开了一种用于在分布式计算机网络上生成动态更新的图形用户界面的系统和方法。系统和方法使用现有的超文本传输协议（2）和现有的Java脚本和活动服务器页面，以基于识别商品或服务的记录数据库生成动态图形用户界面。向消费者提供一系列预定的选择，并且根据对预定选择的回复，图形用户界面被动态地更新为表示消费者选择的图标和其他图形符号。重要的是，图形用户界面（4）不需要刷新浏览器应用，并且因此最小化分布式计算机网络上的数据传输延迟。

8. 发明申请

WO2004006835A2 NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME 审中-公开
标题翻译：新化合物，含有该化合物的药物组合物及其使用方法
公开(公告)号：WO2004006835A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/020960
申请日：2003-07-01
申请人： FASGEN, LLC. , THE JOHNS HOPKINS UNIVERSITY , KUHADJA, Francis, P. , MEDGHALCHI, Susan, M. , THUPARI, Jagan, N. , TOWNSEND, Craig, A. , McFADDEN, Jill, M.
发明人： KUHADJA, Francis, P. , MEDGHALCHI, Susan, M. , THUPARI, Jagan, N. , TOWNSEND, Craig, A. , McFADDEN, Jill, M.
IPC分类号： A61K
CPC分类号： C07D307/33 , C07D307/58 , C07D307/68
摘要： Pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IX: R 29 = H, or C I -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, =CHR 31 , -C(O)OR 31 , - C(O)R 31 , -CH 2 C(O)OR 31 , CH 2 C(O)NHR 31 , where R 31 is H or C 1 -C 10 alkyl, cycloalkyl, or alkenyl; R 30 = C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl; X 5 = -OR 32 , or NHR 32 , Where R 32 is H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, the R 32 group optionally containing a carbonyl group, a carboxyl group, a carboxyamide group, an alcohol group, or an ether group, the R 32 group further optionally containing one or more halogen atoms; with the proviso that when R 29 is =CH 2 , then X 5 is not OH. Also disclosed are compounds within the scope of the formula IX, as well as uses of the pharmaceutical compositions for weight loss, anti-microbial and anti-cancer applications, inhibition of fatty acid synthase and neuropeptide-Y, and the stimulation of the activity of carnitine palmitoyl transferase-1.
摘要翻译： R 29 = H或C 1 -C 20烷基，环烷基，烯基，芳基，芳基烷基或烷芳基，= CHR 31，-C（O）OR 3，（O）R 31，-CH 2 C（O）OR 31，CH 2 C（O）NHR 31，其中R 31是H或C 1 -C 10烷基，环烷基或链烯基; R 30 = C 1 -C 20烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基; X 5 = -OR 32或NHR 32，其中R 32是H，C 1 -C 20烷基，环烷基，烯基，芳基，芳烷基或烷芳基，R 32基任选地含有羰基，羧基，羧酰胺基，醇基或醚基，R 32基团还任选地含有一个或多个卤原子; 条件是当R 29是= CH 2时，则X 5不是OH。还公开了式IX范围内的化合物，以及药物组合物用于体重减轻，抗微生物和抗癌应用，抑制脂肪酸合酶和神经肽Y的用途以及刺激活性肉碱棕榈酰转移酶-1。

9. 发明申请

WO2004004712A1 METHODS OF TREATING MICROBIAL INFECTIONS IN HUMANS AND ANIMALS 审中-公开
标题翻译：人类和动物微生物感染的治疗方法
公开(公告)号：WO2004004712A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021469
申请日：2003-07-09
申请人： FASGEN, LLC , THE JOHNS HOPKINS UNIVERSITY , TOWNSEND, Craig, A. , DICK, James, D. , PARRISH, Nicole, M. , HUGHES, Minerva, Amorette
发明人： TOWNSEND, Craig, A. , DICK, James, D. , PARRISH, Nicole, M. , HUGHES, Minerva, Amorette
IPC分类号： A61K31/435
CPC分类号： A61K31/4409 , A61K31/16 , A61K31/165 , A61K31/22 , A61K31/221 , A61K31/341 , A61K31/365 , A61K31/381 , A61K31/421 , A61K31/455
摘要： A method of treating a subject with a microbially-based infection, comprising the administration of a compound to the subject. The compound is able to decrease ATP levels in the microbe by at least 10% compared to controls after 24 hours in an in vitro test, without killing mammalian cells during the same time period. The decrease in ATP levels is measured by: (1) removing the cells from the testing location and putting them on ice; (2) harvesting the cells at 4 degrees C by centrifugation and disrupting it with bead-beating in an ATP extraction buffer; (3) removing cellular debris by centrifugation at 4 degrees C, leaving an ATP-containing supernatant; (4) measuring the amount of ATP present in the supernatant by a bioluminescence assay at 4 degrees C.
摘要翻译：一种用基于微生物的感染治疗受试者的方法，包括向受试者施用化合物。该化合物能够在体外试验中在24小时后将微生物中的ATP水平降低至少10％，而不会在同一时间段内杀死哺乳动物细胞。 ATP水平的降低通过以下方法测量：（1）从测试位置移除细胞并将其放在冰上; （2）通过离心在4℃下收获细胞，并在ATP提取缓冲液中用珠子打浆破坏细胞; （3）通过在4℃离心除去细胞碎片，留下含ATP的上清液; （4）通过4℃下的生物发光测定法测定上清液中存在的ATP的量。

10. 发明申请

WO2003061053A1 CHARGING STATION FOR HYBRID POWERED VEHICLES 审中-公开
标题翻译：混合动力车辆充电站
公开(公告)号：WO2003061053A1
公开(公告)日：2003-07-24
申请号：PCT/US2002/040886
申请日：2002-12-20
申请人： PELLEGRINO, Nicholas, J. , FARRELL, Edward
发明人： PELLEGRINO, Nicholas, J. , FARRELL, Edward
IPC分类号： H01M10/44
CPC分类号： G07F15/005 , B60L11/1816 , B60L11/1825 , B60L11/1838 , B60L2230/16 , Y02T10/7005 , Y02T10/7088 , Y02T90/121 , Y02T90/128 , Y02T90/14 , Y02T90/16 , Y02T90/163
摘要： A charging station for a hybrid energy vehicle includes a housing, a controlled access power receptacle coupled to the housing, the power receptacle having a connector coupled to a power source, the connector for receiving a connection to supply an electrical charge to a vehicle, logic circuitry contained within the housing coupled to the power receptacle for controlling access by a user to one of the connector and the power receptacle, and an optical reader coupled to the logic circuitry for reading data associated with the vehicle from a data source remote from the optical scanner unit, where said data to the logic circuitry. A method of charging a vehicle includes the steps of providing a machine readable coded element associated with a vehicle, locating the vehicle sufficiently proximate to a charging station having an optical reader unit to allow the vehicle to be connected thereto, connecting the vehicle to the charging station, and displaying the coded element to the charging station optical reader unit so as to initiate flow of power from a power supply to charge the vehicle. Additionally, a method of charging a vehicle includes reading machine readable data associated with a vehicle, communicating the machine readable data to a central processing location, processing the machine readable to receive an approval signal or a disapproval signal, in response to receiving an approval signal of the data, instructing the charging station to open a power recptacle for receiving a connector allowing an electrical power connection between a power source and the vehicle, and charging the vehicle.
摘要翻译：一种用于混合动力能源车辆的充电站包括壳体，耦合到壳体的受控进入电力插座，电源插座具有耦合到电源的连接器，用于接收连接以向车辆提供电荷的连接器，逻辑包含在耦合到电源插座的壳体内的电路，用于控制用户对连接器和电源插座之一的访问;以及耦合到逻辑电路的光学读取器，用于从远离光学器件的数据源读取与车辆相关联的数据扫描仪单元，其中所述数据到逻辑电路。一种对车辆充电的方法包括以下步骤：提供与车辆相关联的机器可读编码元件，将车辆充分靠近具有光学读取器单元的充电站定位，以允许车辆与其连接，将车辆连接到充电站，并且将编码元件显示给充电站光学读取器单元，以便启动来自电源的电力流向车辆充电。另外，对车辆充电的方法包括读取与车辆相关联的机器可读数据，将机器可读数据传送到中央处理位置，响应于接收到批准信号，处理机器可读以接收批准信号或拒绝信号的数据，指示充电站打开用于接收允许电源和车辆之间的电力连接的连接器的充电座椅，并为车辆充电。

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