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1. 发明申请

WO2023034646A2 LYSECD7 VARIANTS AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2023034646A2
公开(公告)日：2023-03-09
申请号：PCT/US2022/042667
申请日：2022-09-06
申请人： AANIKA BIOSCIENCES, INC. , ISMAIL, Alexandre , PISAREVA, Vera , SABIO, German , JORGENSEN, Ellen , BHUYAN, Vishaal
发明人： ISMAIL, Alexandre , PISAREVA, Vera , SABIO, German , JORGENSEN, Ellen , BHUYAN, Vishaal
IPC分类号： C07K14/47 , A61K38/16
摘要： The present disclosure relates generally to the field of LysECD7 variants, spores with surface displayed anti-microbial peptides such as the LysECD7 variants, and methods of using the same.

2. 发明申请

WO2005010040A1 EIMERIA TENELLA ANTIGEN FOR IMMUNOTHERAPY OF COCCIDIOSIS 审中-公开
标题翻译： EIMERIA TENELLA抗原用于免疫治疗
公开(公告)号：WO2005010040A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/023113
申请日：2004-07-15
申请人： BARROS RESEARCH INSTITUTE , MICHIGAN STATE UNIVERSITY , AYLSWORTH, Charles
发明人： AYLSWORTH, Charles
IPC分类号： C07K14/455
CPC分类号： A61K39/39 , A61K38/16 , A61K39/012 , A61K2039/55516 , C07K14/455
摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.
摘要翻译：本发明提供了用于预防和治疗原发性和转移性肿瘤疾病和传染病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。特别地，本发明提供具有免疫刺激活性的Apicomlexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。提供了包含ARP的组合。还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法。

3. 发明申请

WO2003070747A3 INSULIN AND IGF-1 RECEPTOR AGONISTS AND ANTAGONISTS 审中-公开
公开(公告)号：WO2003070747A3
公开(公告)日：2003-08-28
申请号：PCT/US2002/030312
申请日：2002-09-24
申请人： NOVO NORDISK A/S , DGI BIOTECHNOLOGIES , PILLUTLA, Renuka , BRISSETTE, Renee , BLUME, Arthur, J. , SCHÄFFER, Lauge , BRANDT, Jakob , GOLDSTEIN, Neil, I. , SPETZLER, Jane , OSTERGAARD, Soren
发明人： PILLUTLA, Renuka , BRISSETTE, Renee , BLUME, Arthur, J. , SCHÄFFER, Lauge , BRANDT, Jakob , GOLDSTEIN, Neil, I. , SPETZLER, Jane , OSTERGAARD, Soren
IPC分类号： A61K38/28
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.

4. 发明申请

WO2003033675A3 IDENTIFICATION OF BINDING PARTNERS FOR SPECIFIC PROTEINS 审中-公开
公开(公告)号：WO2003033675A3
公开(公告)日：2003-04-24
申请号：PCT/US2002/033511
申请日：2002-10-18
申请人： DGI BIO TECHNOLOGIES, INC. , PILLUTLA, Renuka , BLUME, Arthur, J. , GOLDSTEIN, Neil, I.
发明人： PILLUTLA, Renuka , BLUME, Arthur, J. , GOLDSTEIN, Neil, I.
IPC分类号： C07H21/02
摘要： This invention relates to newly characterized protein DGI-3 and peptides ("DGI-3-binders") and polypeptides ("DGI-3-partners") that bind to this protein. Also related are polypeptide complexes comprising DGI-3 and DGI-3-binders or DGI-3 and DGI-3-partners, as well as antibodies that bind to these polypeptide complexes. Additionally, this invention relates to nucleic acids encoding the DGI-3, DGI-3-binder, or DGI-3-partner peptides or polypeptides. The invention also relates to diagnostics and therapeutics employing the disclosed DGI-3, DGI-3-binder, or DGI-3-partner polypeptides, peptides, or polynucletides. In particular, this invention relates to diagnostic and therapeutic applications directed to cancers and similar disorders.

5. 发明申请

WO2006094193A2 COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL DELIVERY OF AN OLIGOPEPTIDE 审中-公开
标题翻译：用于局部应用和寡核苷酸转运的组合物和方法
公开(公告)号：WO2006094193A2
公开(公告)日：2006-09-08
申请号：PCT/US2006/007600
申请日：2006-03-03
申请人： REVANCE THERAPEUTICS, INC. , DAKE, Michael, D. , WAUGH, Jacob, M.
发明人： DAKE, Michael, D. , WAUGH, Jacob, M.
CPC分类号： A61K9/7023 , A61K8/64 , A61K38/08 , A61Q7/00 , A61Q15/00 , C07K14/33
摘要： The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an oligopeptide and optionally a carrier comprising a positively charged "backbone" having positively charged branching or "efficiency" groups, as described herein. Most preferably the positively charged carrier is a long-chain positively charged polypeptide or a positively charged nonpeptidyl polymer, for example, a polyalkyleneimine. The invention further relates methods for producing a biologic effect of reducing synaptic transmission in a tissue by topically applying an effective amount of such a composition, preferably to the skin, of a subject or patient in need of such treatment. This invention also provides kits for preparing or formulating a composition that comprises the oligopeptide and optionally a carrier, as well as such additional items that are needed to produce a usable formulation, or a premix that may in turn be used to produce such a formulation.
摘要翻译：本发明涉及用于减少动物组织中突触传递的寡肽的透皮应用。一方面，本发明涉及包含寡肽和任选的载体的组合物，其包含具有带正电荷的支链或“效率”基团的带正电荷的“骨架”，如本文所述。最优选地，带正电荷的载体是长链带正电荷的多肽或带正电荷的非肽基聚合物，例如聚亚烷基亚胺。本发明还涉及用于通过局部施用有效量的这种组合物，优选给予需要这种治疗的受试者或患者的皮肤来产生减少组织中突触传递的生物学效应的方法。本发明还提供用于制备或配制包含寡肽和任选的载体的组合物的试剂盒，以及产生可用制剂所需的其它物质，或可以依次用于制备这种制剂的预混物。

6. 发明申请

WO2005032485A2 COMPOUNDS AND METHODS FOR THE TREATMENT OF ATTENTION-DEFICIT HYPERACTIVITY DISORDER 审中-公开
标题翻译：治疗缺血性高血压疾病的化合物和方法
公开(公告)号：WO2005032485A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/032632
申请日：2004-10-01
申请人： PSYCHOGENICS, INC. , LEAHY, Emer
发明人： LEAHY, Emer
IPC分类号： A61K
CPC分类号： C07D311/58 , C07D491/052
摘要： A method for treating Attention Deficit/Hyperactivity Disorder (ADHD) using a compound of Formula (I) and related compounds is provided.
摘要翻译：提供了使用式（I）化合物和相关化合物治疗注意力缺陷/多动障碍（ADHD）的方法。

7. 发明申请

WO2005001768A1 SYSTEM AND METHOD FOR ASSESSING MOTOR AND LOCOMOTOR DEFICITS AND RECOVERY THEREFROM 审中-公开
标题翻译：用于评估电动机和定位器缺陷并恢复其的系统和方法
公开(公告)号：WO2005001768A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/018046
申请日：2004-06-04
申请人： PSYCHOGENICS, INC. , BRUNNER, Daniela , ROSS, William, P. , LAROSE, David
发明人： BRUNNER, Daniela , ROSS, William, P. , LAROSE, David
IPC分类号： G06T7/20
CPC分类号： G06T7/20 , A01K1/031 , A61B5/1038 , A61B5/1104 , A61B5/1118 , A61B5/4833 , A61B2503/40 , A61B2503/42
摘要： An automated intelligent computer system for analyzing motor or locomotor behavior and method of use is provided. The system comprises an automatic, objective, fast and consistent assessment of the level of injury and course of recovery in animal models of spinal cord injury and other gait and motor coordination disorders. The system also is useful for analyzing other types of motor or neurologic dysfunction.
摘要翻译：提供了一种用于分析马达或运动行为的自动智能计算机系统及其使用方法。该系统包括对脊髓损伤和其他步态和运动协调障碍动物模型中的损伤水平和恢复过程的自动，客观，快速和一致的评估。该系统还可用于分析其他类型的运动或神经功能障碍。

8. 发明申请

WO2017091818A1 COMT INHIBITING METHODS AND COMPOSITIONS 审中-公开
标题翻译： COMT抑制方法和组合物
公开(公告)号：WO2017091818A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063779
申请日：2016-11-25
申请人： LIEBER INSTITUTE FOR BRAIN DEVELOPMENT
发明人： BARROW, James , ERNST, Glen , SWINNEN, Dominique , MONTEL, Florian , DEFAYS, Sabine
IPC分类号： C07D471/04 , C07F9/6561
CPC分类号： C07D471/04
摘要： Compounds that inhibit COMT enzyme and pharmaceutical compositions comprising the same are provided herein. Methods of treating various psychiatric and neurological disorders with the compounds and pharmaceutical compositions described herein are also provided.
摘要翻译：本文提供了抑制COMT酶的化合物和包含其的药物组合物。还提供了用本文所述的化合物和药物组合物治疗各种精神病和神经病症的方法。

9. 发明申请

WO2009102747A2 ALTERNATIVELY TRANSCRIBED GENES ASSOCIATED WITH MEMORY CONSOLIDATION 审中-公开
标题翻译：与记忆综合相关的替代基因
公开(公告)号：WO2009102747A2
公开(公告)日：2009-08-20
申请号：PCT/US2009/033732
申请日：2009-02-11
申请人： UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN , MURPHY, Keith J. , REGAN, Ciaran M. , RING, Robert H. , VON SCHACK, David
发明人： MURPHY, Keith J. , REGAN, Ciaran M. , RING, Robert H. , VON SCHACK, David
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6876 , C12Q2600/136
摘要： Methods of identifying gene targets associated with learning and memory and with memory consolidation, as well as to specific nucleic acid molecules that have been discovered to be associated with memory consolidation are provided. Accordingly, the invention also relates to methods of modulating learning and memory function, methods of diagnosing learning and memory disorders, and methods of identifying compounds that modulate learning and memory function via manipulations of the nucleic acid molecules and their products.
摘要翻译：提供了识别与学习和记忆以及记忆巩固相关的基因靶标以及被发现与记忆合并相关联的特定核酸分子的方法。因此，本发明还涉及调节学习和记忆功能的方法，诊断学习和记忆障碍的方法，以及通过操纵核酸分子及其产物来鉴定调节学习和记忆功能的化合物的方法。

10. 发明申请

WO2007030300A1 APPARATUS AND METHOD FOR USING A SURGICAL INSTRUMENT WITH AN EXPANDABLE SPONGE 审中-公开
标题翻译：使用具有可膨胀海绵的手术仪器的装置和方法
公开(公告)号：WO2007030300A1
公开(公告)日：2007-03-15
申请号：PCT/US2006/032477
申请日：2006-08-18
申请人： SEMINARA, Robert
发明人： SEMINARA, Robert
IPC分类号： A61B17/00 , A61B17/32 , A61F13/36
CPC分类号： A61B17/00234 , A61B17/32 , A61B2017/00473 , A61B2017/320044 , A61F13/36 , A61F13/38
摘要： An apparatus and method for using a surgical instrument to quickly, safely and effectively clear tissue, procure dissection and contain bleeding during surgery. The instrument comprises an expandable sponge suitable for insertion into a body cavity. The sponge comprises a material having a first unexpanded state and a second expanded state. The expandable sponge may be attached to the distal end of a handle. The expandable sponge may have slots or filet cuts which, when the sponge expands, become a network of ridges and grooves to increase the surface area of the sponge and entrap tissue for dissection. The expandable sponge may also have an indented neck region adapted to engage blood vessels and ductal structures encountered in most surgical procedures. The sponge may have taper angles at the proximal end of the sponge and at the distal end region to facilitate insertion into and removal from a trocar, introducer or cannula.
摘要翻译：一种使用手术器械快速，安全和有效地清除组织，采取解剖并在手术期间容纳出血的装置和方法。仪器包括适于插入体腔的可膨胀海绵体。海绵包括具有第一未膨胀状态和第二扩张状态的材料。可膨胀海绵可以附接到手柄的远端。可膨胀海绵可以具有狭槽或扒口切口，当海绵膨胀时，它们变成脊和凹槽的网络，以增加海绵的表面积并捕获组织以进行解剖。可膨胀海绵还可以具有适于接合大多数手术过程中遇到的血管和导管结构的凹陷颈部区域。海绵可以在海绵的近端处和在远端区域处具有锥角，以便于插入套管针，导引器或插管中并从套管针或插管中取出。

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