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1. 发明申请

WO2022076979A1 FUSION PROTEIN USEFUL FOR VACCINATION AGAINST ROTAVIRUS 审中-公开
公开(公告)号：WO2022076979A1
公开(公告)日：2022-04-14
申请号：PCT/US2021/071701
申请日：2021-10-04
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人： ANSTROM, David , PATTERSON, Abby, Rae , HAIWICK, Gregory, Brian , JOHNSON, Wesley, Scott , NICHOLSON, Bryon , VAUGHN, Eric, Martin
IPC分类号： C07K14/005 , C07K14/47 , A61K39/12 , C07K16/00 , A61P31/14 , A61K39/00
摘要： The present invention relates to recombinantly constructed polypeptides useful for preparing vaccines, in particular for reducing one or more clinical signs caused by a rotavirus infection. More particular, the present invention is directed to a fusion protein comprising in N- to C- terminal direction (i) an immunogenic fragment of a rotavirus VP8 protein and (ii) an immunoglobulin Fc fragment such as, for example, an IgG Fc fragment, wherein said fusion protein is usable in a method of reducing one or more clinical signs, mortality or fecal shedding caused by a rotavirus infection in swine.

2. 发明申请

WO2022076977A1 FUSION PROTEIN COMPRISING CIRCOVIRIDAE CAPSID PROTEIN, AND CHIMERIC VIRUS-LIKE PARTICLES COMPOSED THEREOF 审中-公开
公开(公告)号：WO2022076977A1
公开(公告)日：2022-04-14
申请号：PCT/US2021/071697
申请日：2021-10-04
申请人： BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
发明人： ANSTROM, David , PATTERSON, Abby Rae , HAIWICK, Gregory Brian , JOHNSON, Wesley Scott , NICHOLSON, Bryon , VAUGHN, Eric Marin
IPC分类号： A61K39/12 , A61P31/14 , A61P31/20 , A61K39/00
摘要： The present invention relates to recombinantly constructed polypeptides useful for preparing vaccines, in particular for reducing one or more clinical signs caused by an infection with at least one pathogen, such as clinical signs caused by a viral infection. More particular, the present invention is directed to a polypeptide comprising a Circoviridae capsid protein linked to a heterologous protein or fragment thereof, and to chimeric virus-like particles composed of such polypeptides. In one example, a fusion protein is provided which comprises PCV2 ORF2 protein linked to an immunogenic fragment of rotavirus VP8 protein, and which is usable for reducing one or more clinical signs, mortality or fecal shedding caused by a rotavirus infection in swine.

3. 发明申请

WO2002042319A3 2-SUBSTITUTED ESTROGENS AS ANTIANGIOGENIC AGENTS 审中-公开
公开(公告)号：WO2002042319A3
公开(公告)日：2002-05-30
申请号：PCT/US2001/026490
申请日：2001-08-24
申请人： ENTREMED, INC. , AGOSTON, Gregory , SHAH, Jamshed, H. , HUNSUCKER, Kimberly, A. , PRIBLUDA, Victor , LAVALLEE, Theresa, M. , GREEN, Shawn, J. , HERBSTRITT, Christopher, J. , ZHAN, Xiaoguo, H. , TRESTON, Anthony
发明人： AGOSTON, Gregory , SHAH, Jamshed, H. , HUNSUCKER, Kimberly, A. , PRIBLUDA, Victor , LAVALLEE, Theresa, M. , GREEN, Shawn, J. , HERBSTRITT, Christopher, J. , ZHAN, Xiaoguo, H. , TRESTON, Anthony
IPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula (I), wherein the variables are defined in the specification.

4. 发明申请

WO2000060362A1 APPARATUS FOR FAST PREPARATION AND ANALYSIS OF NUCLEIC ACIDS 审中-公开
标题翻译：用于快速准备和分析核酸的装置
公开(公告)号：WO2000060362A1
公开(公告)日：2000-10-12
申请号：PCT/US2000/009588
申请日：2000-04-10
申请人： YOUNG, Chung, Chang , CHAN, Joseph, L.
发明人： YOUNG, Chung, Chang , CHAN, Joseph, L.
IPC分类号： G01N35/02
CPC分类号： B01L7/52 , G01N27/44782 , G01N35/0099 , G01N35/028 , G01N2035/00326 , G01N2035/00495
摘要： The analyzers of the present invention can be used for diagnostic applications of gene analysis by allowing flexible programming of thermal cycling, robotics, electrophoresis and reagents modules. The instrument is designed as three independent sub-systems, the nucleic acid sample preparation module, the nucleic acid manipulation module and the gel electrophoresis module. The system can be customized by removing any of these sub-systems, thus allowing for modification and future expansion. The system is fully automatic, including pre-analysis sample preparation (extracting nucleic acid from blood or tissue samples), manipulation of the nucleic acid (employing programmable incubators if needed), separation of the nucleic acid fractions using gel electrophoresis, analysis of the processed gels by an optical reader connected to the laboratory computer system having gel analysis software, and continuous sample identification from primary tube to result with a barcode reader.
摘要翻译：本发明的分析仪可用于通过热循环，机器人，电泳和试剂模块的灵活编程来进行基因分析的诊断应用。仪器设计为三个独立的子系统，核酸样品制备模块，核酸操纵模块和凝胶电泳模块。可以通过删除任何这些子系统来定制系统，从而允许修改和将来扩展。该系统是全自动的，包括预分析样品制备（从血液或组织样品中提取核酸），操纵核酸（如果需要，使用可编程培养箱），使用凝胶电泳分离核酸部分，分析加工的通过连接到具有凝胶分析软件的实验室计算机系统的光学读取器的凝胶，以及从初级管连续样品鉴定得到条形码读取器。

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