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1. 发明申请

WO2021216699A1 COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS 审中-公开
公开(公告)号：WO2021216699A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/028385
申请日：2021-04-21
申请人： NED BIOSYSTEMS, INC.
发明人： BENT, Rebecca Lambert , CABECEIRAS, Peter K.
IPC分类号： A61K31/00 , A61K31/05 , A61P31/00 , A61P31/12 , A61P31/14
摘要： The present disclosure is directed to compositions and methods for the treatment or prevention of viral infections and diseases or conditions associated with viral infections. Among other things, the present disclosure encompasses the insight that redundant targeting of multiple pathways essential for viral infection and replication provides effective treatment and prevention of viral infection.

2. 发明申请

WO2018213460A1 LINEAR COVALENTLY CLOSED VECTORS AND RELATED COMPOSITIONS AND METHODS THEREOF 审中-公开
公开(公告)号：WO2018213460A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/032988
申请日：2018-05-16
申请人： HELIX NANOTECHNOLOGIES, INC.
发明人： EROSHENKO, Nikolai , DHAR, Nikhil
IPC分类号： A61K31/7115 , C12N9/12 , C12N15/10 , C12Q1/6853 , C12Q1/6855
摘要： Linear covalently closed vectors, and compositions and methods for making same.

3. 发明申请

WO2022261026A2 METHODS FOR TREATING ALZHEIMER'S DISEASE 审中-公开
公开(公告)号：WO2022261026A2
公开(公告)日：2022-12-15
申请号：PCT/US2022/032397
申请日：2022-06-06
申请人： BIOGEN MA INC.
发明人： SMIRNAKIS, Karen , BURKETT, Patrick Ryland , UMANS, Kimberly
IPC分类号： A61K39/395 , A61B5/055 , A61P25/28 , A61P25/29
摘要： Provided are methods for treating Alzheimer's disease in a human subject in need thereof when the subject develops an Amyloid Related Imaging Abnormality (ARIA) or a hypersensitivity reaction during a treatment regimen comprising administration of multiple doses of an anti -beta-amyloid antibody to the subject.

4. 发明申请

WO2020096992A1 MICROBIAL COMPOSITIONS COMPRISING ELLAGITANNIN AND METHODS OF USE 审中-公开
公开(公告)号：WO2020096992A1
公开(公告)日：2020-05-14
申请号：PCT/US2019/059724
申请日：2019-11-04
申请人： MARVELBIOME, INC.
发明人： JAYAMANI, Elamparithi , GOVINDAN, Jothi Amaranath , CHATTER, Priti H.
IPC分类号： A23L1/30 , C12N1/20 , C12N1/38 , C12N9/16 , C12N9/88 , C12N15/09 , C12P7/22
摘要： A combination is provided comprising an ellagitannin composition, and an enzymatic composition comprising one or more ellagitannin enzymes, where the one or more ellagitannin enzymes comprise a tannin acyl hydrolase enzyme, a gallate decarboxylase enzyme, or a combination thereof. Methods of making and using combinations disclosed herein are also provided.

5. 发明申请

WO2023064612A2 PHARMACEUTICAL COMPOSITIONS FOR DELIVERY OF VIRAL ANTIGENS AND RELATED METHODS 审中-公开
公开(公告)号：WO2023064612A2
公开(公告)日：2023-04-20
申请号：PCT/US2022/046799
申请日：2022-10-14
申请人： BIONTECH SE , GAYNOR, Richard B. , ROONEY, Michael
发明人： GAYNOR, Richard B. , ROONEY, Michael
IPC分类号： C12N7/00 , A61P31/14 , A61P31/22 , C12N15/67 , C12N15/68 , A61K39/12 , A61K39/25 , A61K39/245 , A61K39/125
摘要： The present disclosure provides pharmaceutical compositions for delivery of viral antigens (e.g., a viral vaccine) and related technologies (e.g., components thereof and/or methods relating thereto).

6. 发明申请

WO2021222856A1 COMPOSITIONS AND METHODS FOR RNA SYNTHESIS 审中-公开
公开(公告)号：WO2021222856A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/030332
申请日：2021-04-30
申请人： HELIX NANOTECHNOLOGIES, INC.
发明人： DHAR, Nikhil , EROSHENKO, Nikolai , RAJANIEMI, Hannu
IPC分类号： C12N15/10 , C12N15/52 , C12N15/55 , C12P19/34
摘要： Compositions and methods for synthesizing an RNA product are provided herein. For example, the present disclosure provides a method of producing an RNA product comprising incubating an in vitro transcription mixture, thereby producing an RNA product that comprises a plurality of single-stranded RNA molecules. In some embodiments, an in vitro transcription mixture comprises a DNA template comprising an RNA polymerase promoter sequence operatively linked to a target sequence; at least one RNA polymerase that recognizes the RNA polymerase promoter sequence; a plurality of ribonucleotides comprising at least two different types of ribonucleotides, each type comprising a different nucleoside; and a transcription buffer comprising an osmolyte.

7. 发明申请

WO2018035350A1 GLYCAN OXONIUM ION PROFILING OF GLYCOSYLATED PROTEINS 审中-公开
标题翻译：糖基化蛋白质的甘氨酸氧离子特性
公开(公告)号：WO2018035350A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047395
申请日：2017-08-17
申请人： MOMENTA PHARMACEUTICALS, INC.
发明人： MADSEN, James , FARUTIN, Victor
IPC分类号： G01N30/72 , B01D59/44 , C12P21/00
CPC分类号： C12P21/005 , G01N33/6848 , G01N33/6854
摘要： Methods disclosed herein include an improved technique for comparing a glycosylation profile of a first protein (e.g., an innovator protein drug) with a glycosylation profile of a second protein (e.g., a corresponding biogeneric/biosimilar). For example, a method of manufacture can include providing or obtaining a batch of a test glycoprotein drug substance, using mass spectrometry to acquire a test oxonium ion profile from a sample of the test glycoprotein drug substance batch, comparing the test oxonium ion profile to a corresponding target oxonium ion profile of a target glycoprotein drug product, and processing the batch of the test glycoprotein drug substance as a drug product if the difference between the test oxonium ion profile and the corresponding target oxonium ion profile is tolerable, or taking an alternative action if the difference between the test oxonium ion profile and the target oxonium ion profile is not tolerable.
摘要翻译：本文公开的方法包括用于比较第一蛋白（例如，创新蛋白药物）的糖基化分布与第二蛋白（例如，相应的生物基因/生物仿制药）的糖基化分布的改进技术。例如，制造方法可包括提供或获得一批测试糖蛋白药物物质，使用质谱法从测试糖蛋白药物物质批次的样品获得测试氧鎓离子特征，将测试氧鎓离子特征与如果测试氧鎓离子分布图和相应的目标氧鎓离子分布图之间的差异是可容忍的，或者采取替代动作，则将目标糖蛋白药物产品的相应目标氧鎓离子分布图，以及处理该批测试糖蛋白药物物质作为药品如果测试的氧鎓离子分布和目标氧鎓离子分布之间的差异是不可容忍的。

8. 发明申请

WO2023014879A2 SULFATED POLYPEPTIDES FOR SYSTEMIC DELIVERY 审中-公开
公开(公告)号：WO2023014879A2
公开(公告)日：2023-02-09
申请号：PCT/US2022/039413
申请日：2022-08-04
申请人： SUMMATION BIO, INC.
发明人： KOIRALA, Adarsha , DE CEUNYNCK, Karen Ellen Petra
IPC分类号： A61K38/00 , C07K14/705 , A61P35/00 , G08B13/22
摘要： The present disclosure includes, among other things, methods and compositions for systemic (e.g., intravenous) delivery of sulfated polypeptide agents. In various embodiments, the present disclosure includes methods and compositions that reduce toxicity of systemic administration of polypeptide agents. In various embodiments, the present disclosure includes methods and compositions that cause or increase delivery of polypeptide agents to target cells, tissues, or organs (e.g., muscle, e.g., skeletal muscle, cardiac muscle, and/or diaphragm) following systemic (e.g., intravenous) delivery. In various embodiments, the present disclosure provides promoter sequences that achieve advantageous expression of operably linked coding sequences in muscle, e.g., in skeletal muscle, cardiac muscle, and/or diaphragm.

9. 发明申请

WO2023014724A2 SCAFFOLD MATRIX ATTACHMENT REGIONS FOR GENE THERAPY 审中-公开
公开(公告)号：WO2023014724A2
公开(公告)日：2023-02-09
申请号：PCT/US2022/039187
申请日：2022-08-02
申请人： SUMMATION BIO, INC.
发明人： KOIRALA, Adarsha , PACHECO-GARCIA, Almudena , MUSKAVITCH, Marc A. T. , DE CEUNYNCK, Karen Ellen Petra
IPC分类号： C22F1/16
摘要： The present disclosure provides, among other things, methods and compositions in which a nucleic acid sequence includes a mammalian scaffold matrix attachment region (S/MAR) operably linked with a coding sequence. The present disclosure provides S/MARs useful in expression vectors (e.g., for use in gene therapy approaches) to achieve a particular, improved, or target level, duration, and/or tissue specificity of expression of an operably linked coding sequence.

10. 发明申请

WO2022146839A1 COMPOSITIONS AND METHODS FOR TREATING CLRN1-ASSOCIATED HEARING LOSS AND/OR VISION LOSS 审中-公开
公开(公告)号：WO2022146839A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/064924
申请日：2021-12-22
申请人： AKOUOS, INC.
发明人： SIMONS, Emmanuel John , NG, Robert
IPC分类号： A61K48/00 , A61P27/16
摘要： The present disclosure provides constructs comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a clarin 1 protein. Exemplary constructs include AAV constructs. Also provided are methods of using disclosed constructs for the treatment of hearing loss and/or deafness. Also provided are methods of using disclosed constructs for the treatment of vision loss.

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