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1. 发明申请

WO2021222758A1 METHODS OF TREATING INFECTIONS 审中-公开
公开(公告)号：WO2021222758A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/030184
申请日：2021-04-30
申请人： SIWA CORPORATION
发明人： GRUBER, Lewis S.
IPC分类号： C07K16/44 , A61K39/395 , A61P31/16 , A61K39/385 , A61K2039/505 , A61K2039/6031 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： A method of treating an infection that comprises administering to a subject a composition comprising an anti-AGE antibody. The anti-AGE antibody binds an AGE antigen comprising at least one protein or peptide that exhibits AGE modifications selected from the group consisting of FFI, pyrraline, AFGP, ALI, carboxymethyllysine, carboxyethyllysine and pentosidine. A method of treating an infection that comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

2. 发明申请

WO2021067301A8 DERIVATIVES OF MENTHOL AND USES THEREOF 审中-公开
公开(公告)号：WO2021067301A8
公开(公告)日：2021-04-08
申请号：PCT/US2020/053323
申请日：2020-09-29
申请人： BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY , FONA TECHNOLOGIES, LLC
发明人： KLUMPP, Douglas, A. , KLUMPP, Rachel, A. , LIVERIS, Zachary , STENTZEL, Michael , SOBEL, Robert, M. , KOKKINIDOU, Smaro, G.
IPC分类号： C07C227/18 , C07C229/08 , C07C229/12 , C07C229/46 , C07D211/00 , A61K8/41 , A61Q11/00 , A01N37/44 , A23L2/56 , A23L27/203 , A23V2002/00 , A61K8/37 , A61K8/44 , A61Q17/02 , A61Q19/00 , A61Q9/02 , C07C227/08 , C07C229/28 , C07C67/14 , C07D213/38 , C07D295/15
摘要： A compound that includes a menthol glycinate. The menthol glycinate includes a menthol connected to a glycine or glycine derivative, via an ester linkage. The groups on the N atom are referred to as R1 and R2, and R1 and R2 are independently selected from the group consisting of: H, alkyl and R1 and Ra together with the N atom to which they are attached form a 4-8-member ring. R1 and R2 each contain at most 20 carbon atoms.

3. 发明申请

WO2021050436A8 LIPOPHILLICALLY DISPERSED PHENOLIC POLYMER PARTICLES 审中-公开
公开(公告)号：WO2021050436A8
公开(公告)日：2021-03-18
申请号：PCT/US2020/049742
申请日：2020-09-08
申请人： NANOPHASE TECHNOLOGIES CORPORATION
发明人： SARKAS, Harry, W. , BOFFA, Christopher, C. , CURETON, Kevin
IPC分类号： A61K8/04 , A61K8/30 , A61K8/97 , A61Q17/04 , A61K2800/412 , A61K2800/413 , A61K2800/622 , A61K8/0225 , A61K8/11 , A61K8/34 , A61K8/347 , A61K8/375 , A61K8/463 , A61K8/585 , A61K8/72 , A61K8/84 , A61K8/9789 , A61Q19/00 , C08J2397/00 , C08J3/095 , C08J3/098 , C08J3/126
摘要： A composition comprises phenolic polymer particles and a surfactant, on the phenolic polymer particles. The composition is lipophilic. A dispersion comprises the phenolic polymer particles, the surfactant, and a carrier vehicle. The carrier vehicle may be a cosmetically-acceptable fluid or a wax that is lipophilic.

4. 发明申请

WO2020023532A1 METHODS AND COMPOSITIONS FOR TREATING CHRONIC EFFECTS OF RADIATION AND CHEMICAL EXPOSURE 审中-公开
公开(公告)号：WO2020023532A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/043071
申请日：2019-07-23
申请人： SIWA CORPORATION
发明人： GRUBER, Lewis, S.
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00 , A61P35/04 , C07K14/44 , C07K16/44
摘要： A method of treating a chronic effect of radiation or chemical exposure comprises administering to a subject a composition comprising an anti-AGE antibody. A composition for treating a chronic effect of radiation or chemical exposure comprises a first anti-AGE antibody, a second anti-AGE antibody and a pharmaceutically acceptable carrier. The first anti-AGE antibody is different from the second anti-AGE antibody. A method of treating or preventing the onset of a chronic effect of radiation or chemical exposure comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell.

5. 发明申请

WO2020014648A1 CANTILEVER PROTRACTION DEVICE 审中-公开
公开(公告)号：WO2020014648A1
公开(公告)日：2020-01-16
申请号：PCT/US2019/041667
申请日：2019-07-12
申请人： CRANIOFACIAL TECHNOLOGIES INC. , KAVEH, Cameron , YUSCHAK, Thomas, D. , KAVEH, Kevin
发明人： KAVEH, Cameron , YUSCHAK, Thomas, D. , KAVEH, Kevin
IPC分类号： A61C7/06 , A61B17/60 , A61B17/66 , A61C7/10 , A61F13/12 , A62B18/08 , A61B17/663
摘要： The present invention provides body anchored protraction devices. The protraction devices direct the negative forces of protraction over a large surface area on the chest and abdomen of a patient. The protraction devices employ a cantilever support rod and ultra-low friction joints to enable low compression on the head without restricting free movement.

6. 发明申请

WO2019217933A1 INHIBITORS OF THE RAS ONCOPROTEIN, METHODS OF MAKING AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2019217933A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031885
申请日：2019-05-10
申请人： THE UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： CLARK, Geoffrey, J. , TRENT, John, O. , BURLSON, Joseph, A.
IPC分类号： A61K31/167 , A61K31/18 , A61K31/55 , A61P35/00 , C07D223/04
摘要： A compound for use in treating a disease associated with activating mutations in RAS, or for use in treating a disease treatable by a reduction in RAS activity, is selected from a compound of Formula (I), salts and esters thereof. The compounds are particularly useful in treating cancer.

7. 发明申请

WO2019195459A1 FINGERMARK LIFTING AND VISUALIZATION DEVICE AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2019195459A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/025630
申请日：2019-04-03
申请人： HOFSTETTER, Oliver, D. , MLAKAR, Andrei , ROUX, Claude , LENNARD, Chris , SPINDLER, Xanthe , BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY , UNIVERSITY OF TECHNOLOGY SYDNEY , WESTERN SYDNEY UNIVERSITY
发明人： HOFSTETTER, Oliver, D. , MLAKAR, Andrei , ROUX, Claude , LENNARD, Chris , SPINDLER, Xanthe
IPC分类号： G01N31/22
摘要： A fingermark lifting and visualization device includes a carrier and an indicator. The carrier has a lifting surface. The indicator is immobilized on the lifting surface. The indicator changes color or changes in fluorescence in the visible spectrum in response to contact with a glandular secretion.

8. 发明申请

WO2018191245A1 COATED POWDERS HAVING HIGH PHOTOSTABILITY 审中-公开
公开(公告)号：WO2018191245A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/026855
申请日：2018-04-10
申请人： SARKAS, Harry, W. , HOOPER, Abigail, R. , HOFFMANN, Nathan, H.
发明人： SARKAS, Harry, W. , HOOPER, Abigail, R. , HOFFMANN, Nathan, H.
IPC分类号： B01J13/14 , A61Q17/04 , B01J13/22 , A61K8/89 , C09C3/00
摘要： A coated powder comprises (a) particles, and (b) a coating on the surface of the particles including (1) silica moieties, (2) organo oxysilane moieties selected from the group consisting of mono-organo oxysilane moieties, bi-organo oxysilane moieties and tri-organo oxysilane moieties, and (3) poly(dialkyl)siloxane moieties. The amount by weight in SiO 2 equivalents of the organo oxysilane moieties and the silica moieties is at least 0.0625% of the total coated powder weight per m 2 /g of the specific surface area of the particle to be coated.

9. 发明申请

WO2018093612A1 COMPRESSION TORQUE DEVICE 审中-公开
公开(公告)号：WO2018093612A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/060414
申请日：2017-11-07
申请人： VASCUGENIX LLC
发明人： CHRISMAN, Freddy, Dwight
IPC分类号： A61M25/09 , A61M39/28
摘要： A compression torque device comprises a housing, an actuator, a flexible clamping member and a linear lumen. The housing comprises a body, a handle, a leading portion and an actuator opening. The actuator is operably coupled to the housing at the actuator opening. The linear lumen passes through the housing and is contiguous with the actuator opening. The actuator pivots between a first position and a second position, such that the flexible clamping member extends into the lumen when the actuator is in the first position and does not extend into the lumen when the actuator is in the second position. The actuator and the flexible clamping member may be monolithic. A kit for catheter-based intervention comprises a compression torque device and an adaptor.

10. 发明申请

WO2018026958A1 TARGETED NANODROPLET EMULSIONS FOR TREATING CANCER 审中-公开
标题翻译：靶向纳米颗粒乳剂治疗癌症
公开(公告)号：WO2018026958A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/045169
申请日：2017-08-02
申请人： THE UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： MALIK, Mohammad, Tariq , KOPECHEK, Jonathan, A. , BATES, Paula
IPC分类号： A61K47/54 , A61K47/69 , A61P35/00
摘要： A micelle, comprises a first phospholipid, a second phospholipid, a targeting agent, conjugated to the first phospholipid, a perfluorocarbon, and a therapeutically active compound. The first phospholipid and the second phospholipid form a shell enclosing the perfluorocarbon and the therapeutically active compound. The targeting agent comprises an anti-nucleolin agent, and the therapeutically active compound comprises a chemotherapeutic agent and/or a cytotoxic agent. An emulsion may be formed, comprising a plurality of the micelles, and continuous aqueous phase. A pharmaceutical composition for treating cancer may be prepared, comprising the emulsion, and a pharmaceutically acceptable carrier. A method of treating cancer includes administering an effective amount of the pharmaceutical composition to a patient in need thereof.
摘要翻译：胶束包含第一磷脂，第二磷脂，与第一磷脂缀合的靶向剂，全氟化碳和治疗活性化合物。第一种磷脂和第二种磷脂形成包封全氟化碳和治疗活性化合物的壳。靶向剂包含抗核素剂，并且治疗活性化合物包含化学治疗剂和/或细胞毒性剂。可形成包含多个胶束和连续水相的乳液。可以制备用于治疗癌症的药物组合物，其包含乳剂和药学上可接受的载体。治疗癌症的方法包括给有此需要的患者施用有效量的药物组合物。

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