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1. 发明申请

WO2018200958A1 COMBINED ADMINISTRATION OF CYSTEINE-ASPARTIC PROTEASE INHIBITORS WITH P2Y12 RECEPTOR ANTAGONISTS PROTECTS THE HEART AGAINST MYOCARDIAL INFARCTION 审中-公开
公开(公告)号：WO2018200958A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/029801
申请日：2018-04-27
申请人： UNIVERSITY OF SOUTH ALABAMA , AUDIA, Jonathon, P. , DOWNEY, James, M. , ALVAREZ, Diego , COHEN, Michael, V.
发明人： AUDIA, Jonathon, P. , DOWNEY, James, M. , ALVAREZ, Diego , COHEN, Michael, V.
IPC分类号： A61K31/197 , A61K38/05 , A61P9/10
摘要： The present disclosure generally pertains to methods of treating myocardial infarct involving administering a platelet anti-aggregate, a cysteine-aspartic protease inhibitor, and reperfusion therapy. In certain embodiments, the platelet anti-aggregate is at least one P2Y 12 receptor antagonist or Glycoprotein Ilb/IIIa inhibitor, the cysteine-aspartic protease inhibitor is selected from the group consisting of Caspase-1, 4, 5, 11 and 12 inhibitors, and reperfusion therapy is percutaneous coronary intervention. In certain embodiments, the at least one P2Y 12 receptor antagonist is selected from the group consisting of cangrelor, ticagrelor, clopidogrel and prasugrel. The disclosed methods provide an improved cardioprotective effect against infarction when compared with the current standard of care.

2. 发明申请

WO2017079625A1 NOVEL PLATFORM DNA VACCINE 审中-公开
标题翻译：新的平台DNA疫苗
公开(公告)号：WO2017079625A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/060631
申请日：2016-11-04
申请人： UNIVERSITY OF SOUTH ALABAMA , SOLODUSHKO, Victor, G. , FOUTY, Brian , BITKO, Vira
发明人： SOLODUSHKO, Victor, G. , FOUTY, Brian , BITKO, Vira
IPC分类号： A61K39/12 , A61K39/145 , C12N7/01
CPC分类号： A61K39/12 , A61K39/015 , A61K2039/53 , A61K2039/6075 , C12N2760/18534
摘要： The present invention relates to novel DNA vaccines, configured to induce a robust and sustained immune response, and methods of use thereof. DNA vaccines proposed herein are configured to achieve this immune response by fusing the extracellular domain of a viral fusion protein to selected antigens or antigen-binding polypeptides. After the expression and secretion of the viral fusion-antigen protein from the initially transfected cells, the natural ability of the viral fusion protein to fuse to cell membranes and actively enter cells will allow for passive delivery of the fused target epitopes into neighboring cells, thus inducing a more robust immune response. The presented method described herein allows for the use of this DNA vaccine against known antigens present in proteins produced by infectious agents or cancer cells within a subject, against unknown antigens produced by infectious agents or cancer cells within a subject, or against naturally-occurring or synthetically-derived antigens delivered by other routes, such as injection.
摘要翻译：本发明涉及新型DNA疫苗，其被配置为诱导稳健和持续的免疫应答，以及其使用方法。通过将病毒融合蛋白的胞外结构域与选择的抗原或抗原结合多肽融合来配置本文提出的DNA疫苗以实现该免疫应答。在从最初转染的细胞表达和分泌病毒融合抗原蛋白后，病毒融合蛋白融合到细胞膜并主动进入细胞的天然能力将允许被融合的靶表位被动递送到相邻细胞中，因此诱导更强大的免疫应答。本文所述的方法允许使用这种DNA疫苗针对存在于受试者体内的感染因子或癌细胞产生的蛋白质中的已知抗原，针对受试者体内的感染因子或癌细胞产生的未知抗原，或针对天然存在的或通过其他途径（如注射）递送的合成衍生抗原。

3. 发明申请

WO2016196323A1 SERODIAGNOSIS OF MELIOIDOSIS AND GLANDERS USING POLYSACCHARIDES 审中-公开
标题翻译：使用多糖的血清纤维化和凝血酶的血清学检测
公开(公告)号：WO2016196323A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/034732
申请日：2016-05-27
申请人： UNIVERSITY OF SOUTH ALABAMA , BRETT, Paul, James , BURTNICK, Mary, Nicole
发明人： BRETT, Paul, James , BURTNICK, Mary, Nicole
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/536 , G01N33/554 , G01N33/569
CPC分类号： G01N33/56911 , G01N2333/21 , G01N2469/20
摘要： The present disclosure generally pertains to methods for the serodiagnosis of melioidosis and glanders in a subject. In one exemplary embodiment, the method for the serodiagnosis of melioidosis and glanders in a subject comprises the steps of: obtaining a sample from a subject; incubating the sample from the subject with at least one Burkholderia polysaccharide; and diagnosing the subject with glanders or melioidosis when the formation of at least one antibody-polysaccharide complex comprising at least one of the purified Burkholderia polysaccharides is detected.The at least one purified Burkholderia polysaccharide may comprise O-polysaccharide, capsular polysaccharide, or any combination thereof.
摘要翻译：本公开内容一般涉及受试者中嗜酸性粒细胞减少症和腺体血清诊断的方法。在一个示例性实施方案中，受试者中的嗜酸性粒细胞减少症和腺体的血清诊断的方法包括以下步骤：从受试者获得样品; 用至少一种伯克霍尔德氏菌多糖孵育受试者的样品; 并且当检测到包含至少一种纯化的伯克霍尔德杆菌多糖的至少一种抗体 - 多糖复合物的形成时，用腺体或霉菌病诊断受试者。至少一种纯化的伯克霍尔德氏菌多糖可以包含O-多糖，荚膜多糖或任何组合它们。

4. 发明申请

WO2019027456A1 TWIN-TAIL HYDROCARBON SURFACTANTS FOR FOAM COMPOSITIONS 审中-公开
公开(公告)号：WO2019027456A1
公开(公告)日：2019-02-07
申请号：PCT/US2017/045147
申请日：2017-08-02
申请人： AMEREX CORPORATION
发明人： CLARK, Timothy , CLARK, Kirtland , KARYDAS, Athanasios
IPC分类号： A61K8/41 , A62D1/02 , A62D1/04 , C07C233/36
摘要： The present disclosure generally pertains to novel water soluble oligomeric and polymeric additives derived from oligomeric and polymeric amines; esters or halides of twin tail alkyl group comprising acids with intervening quaternary ammonium groups; optionally and preferably hydrophilic group comprising compounds capable of reacting with primary, secondary or tertiary amino groups; and optionally hydrophobic group comprising compounds. The compounds of the invention are useful as additives for aqueous film forming foam agents, and can perform as partial or complete replacements for fluorosurfactants and/or fluorinated foam stabilizers in foams.

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