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1. 发明申请

WO2008063967A2 ELECTROLYSIS APPARATUS, INTERNAL COMBUSTION ENGINE COMPRISING THE ELECTROLYSIS APPARATUS, AND VEHICLE COMPRISING THE INTERNAL COMBUSTION ENGINE 审中-公开
标题翻译：电解装置，包含电解装置的内燃机，以及包含内燃机的车辆
公开(公告)号：WO2008063967A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/084454
申请日：2007-11-12
申请人： ADVANCED R F DESIGN, LLC , HALLENBECK, John, R.
发明人： HALLENBECK, John, R.
IPC分类号： C25B9/00
CPC分类号： C25B9/00 , B60K6/24 , C25B11/04 , C25B15/00 , F02M25/12 , F02M27/04 , Y02E60/366 , Y02T10/121 , Y02T10/6295
摘要： An electrolysis apparatus comprising an enclosure 110, a first electrode 221disposed within the enclosure, a second electrode 236 disposed within the enclosure, and at least one electromagnetic energy radiator 241 disposed within the enclosure. The apparatus further comprises a power source 210 disposed external to the enclosure, where that power source is interconnected with the first electrode such that the first electrode comprises a cathode, and where the power source is interconnected with the second electrode such that the second electrode comprises an anode. The apparatus further comprises at least one oscillator 254 disposed external to the enclosure, where each oscillator is interconnected to a different electromagnetic energy radiator. An engine system comprising an electrolysis apparatus 100 interconnected to an internal combustion engine 620. The electrolysis apparatus cleaves water into a mixture of hydrogen gas and oxygen gas. The mixture of hydrogen gas and oxygen gas is input into, and fuels, the internal combustion engine. A vehicle 600 comprising the engine system.
摘要翻译：一种电解装置，包括外壳110，布置在外壳内的第一电极221，设置在外壳内的第二电极236和设置在外壳内的至少一个电磁能量辐射器241。该设备还包括设置在外壳外部的电源210，其中电源与第一电极互连，使得第一电极包括阴极，并且其中电源与第二电极互连，使得第二电极包括阳极。该装置还包括设置在外壳外部的至少一个振荡器254，其中每个振荡器互连到不同的电磁能量辐射器。一种发动机系统，包括与内燃机620互连的电解装置100.电解装置将水分解为氢气和氧气的混合物。将氢气和氧气的混合物输入内燃机并燃烧。包括发动机系统的车辆600。

2. 发明申请

WO2004108081A2 OLIGONUCLEOTIDE SYNTHESIS WITH ALTERNATIVE SOLVENTS 审中-公开
标题翻译：具有替代性溶剂的寡核苷酸合成
公开(公告)号：WO2004108081A2
公开(公告)日：2004-12-16
申请号：PCT/US2004/017083
申请日：2004-06-02
申请人： ISIS PHARMACEUTICALS, INC. , MOORE, Max, N. , ANDRADE, Mark , CARTY, Recaldo , SCOZZARI, Anthony , KROTZ, Achim
发明人： MOORE, Max, N. , ANDRADE, Mark , CARTY, Recaldo , SCOZZARI, Anthony , KROTZ, Achim
IPC分类号： A61K
CPC分类号： C07H21/00 , C07H21/02 , C07H21/04
摘要： The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5' blocked-nucleoside, deblocking the 5' blocked-nucleoside to form a 5' OH-nucleoside, coupling the 5' OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.
摘要翻译：本发明提供了制备包含五价磷酸酯三酯的寡核苷酸的方法。特别地，该方法包括提供5'封闭核苷，解封5'封闭核苷以形成5'OH-核苷，将5'OH-核苷与亚磷酰胺偶联以形成含有三价亚磷酸三酯的寡核苷酸; 并将包含三价亚磷酸酯三酯的寡核苷酸氧化成包含五价磷酸酯三酯的寡核苷酸。在一些实施方案中，上述任何步骤之间的洗涤是至少一种包含甲苯的溶剂洗涤液。

3. 发明申请

WO2005000272A1 LONG-CIRCULATING LIPOSOMAL COMPOSITIONS 审中-公开
标题翻译：长循环脂肪组成
公开(公告)号：WO2005000272A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/017699
申请日：2004-06-04
申请人： ISIS PHARMACEUTICALS, INC. , MEHTA, Rahul , HARDEE, Greg , LEAMON, Christopher, P.
发明人： MEHTA, Rahul , HARDEE, Greg , LEAMON, Christopher, P.
IPC分类号： A61K9/127
CPC分类号： A61K48/0025 , A61K9/127 , A61K9/1271
摘要： A liposome comprising about 1-25 mol% of a phosphatidylglycerol component and about 38-62 mol% of a phosphatidylcholine component is provided herein. In some embodiments, the liposomes further comprise a sterol component, for example a cholesterol.
摘要翻译：提供了包含约1-25mol％的磷脂酰甘油组分和约38-62mol％的磷脂酰胆碱组分的脂质体。在一些实施方案中，脂质体还包含固醇组分，例如胆固醇。

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