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1. 发明申请

WO2014195323A1 PYRIMIDINE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS 审中-公开
标题翻译：吡嗪化合物及其作为GAMMA秘密调节剂的用途
公开(公告)号：WO2014195323A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061503
申请日：2014-06-03
申请人： ACTURUM LIFE SCIENCE AB
发明人： BESIDSKI, Yevgeni , YNGVE, Ulrika , PAULSEN, Kim , LINDE, Christian , MACSÁRI, István , MALMBORG, Jonas , PAPTCHIKHINE, Alexander , ARVIDSSON, Per
IPC分类号： C07D403/12 , A61K31/506 , A61P25/28
CPC分类号： A61K31/506 , A61K45/06 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical compositions comprising these compounds, to processes for making these compounds, and to their use as medicaments for treatment and/or prevention of Aβ-related diseases.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐。本发明还涉及包含这些化合物的药物组合物，制备这些化合物的方法，以及它们作为用于治疗和/或预防与疾病有关的疾病的药物的用途。

2. 发明申请

WO2018033573A1 A URINARY CATHETER CONNECTOR FOR IRRIGATION OF A CATHETERIZED BLADDER 审中-公开
标题翻译：一种导尿管膀胱灌注的尿道导管连接器
公开(公告)号：WO2018033573A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/070769
申请日：2017-08-16
申请人： HÄGGLUND, Susanne
发明人： HÄGGLUND, Susanne , BÄCKÄNG, Andreas , SCHRÖDER, Julia
IPC分类号： A61M39/00 , A61B90/00 , A61M39/26 , A61M39/24 , A61M39/22
CPC分类号： A61B90/05 , A61M3/0262 , A61M25/0017 , A61M25/0097 , A61M39/00 , A61M39/22 , A61M39/24 , A61M39/26 , A61M2039/1033
摘要： The present invention relates to a catheter connector including a body (1) comprising a first end, a second end, an outer and an inner surface extending between the first and second ends, a first port (3) arranged at the first end of the body (1) and configured to receive a syringe (7), a second port (2) for connection to a urinary catheter (8) and arranged at the second end of the body (1), and a channel (4) connecting the first and second ports, whereby the channel (4) consists of two openings at said ports (2, 3). The catheter connector comprises a splash guard (5) extending circumferentially from the outer surface of the body, wherein the first port is configured to receive the syringe on the inner surface of the body and the second port is configured to receive the urinary catheter (8) on the outer surface of the body.
摘要翻译：本发明涉及包括主体（1）的导管连接器，该主体包括第一端，第二端，在第一端和第二端之间延伸的外表面和内表面，第一端口（3 ），其布置在所述主体（1）的所述第一端并且被配置成接收注射器（7）;第二端口（2），其用于连接到导尿管（8）并且被布置在所述主体（1）的所述第二端处; 和连接第一和第二端口的通道（4），由此通道（4）由在所述端口（2,3）处的两个开口组成。导管连接器包括从本体的外表面沿周向延伸的防溅罩（5），其中第一端口构造成在本体的内表面上接收注射器，并且第二端口构造成接收导尿管（8 ）在身体的外表面上。

3. 发明申请

WO2017137419A1 ANTIMICROBIAL AND CLEANSING COMPOSITION CONSISTING OF A POLYMERIC BIGUANIDE AND EDTA 审中-公开
标题翻译：一种聚合双胍和EDTA组成的抗微生物和清洁组合物
公开(公告)号：WO2017137419A1
公开(公告)日：2017-08-17
申请号：PCT/EP2017/052713
申请日：2017-02-08
申请人： SUNMEDIC AB
发明人： KARLADANI, Abbas
IPC分类号： A61K9/00 , A61K47/14 , A61K47/18 , A61K31/14 , A61K31/155 , A61K31/198 , A61P17/02
CPC分类号： A61K31/155 , A61K9/0014 , A61K31/14 , A61K31/198 , A61K47/14 , A61K47/18 , A61K2300/00
摘要： The invention relates to a antimicrobial and cleansing composition consisting of a. a polymeric biguanide, and b. a metal ion chelating agent, and g. a solvent, wherein the ratio of a:b is between 0.75:2.25 and 1.25:2.25, or about 1:2, and optionally one or more of the following ingredients; c. a quaternary ammonium salt, d. at least one surfactant, e. a humectant and f. a gelling agent. The invention further relates to said composition for use in a treatment, prevention or reduction of a disease, disorder or condition related to microbials, or treatment, prevention or reduction of infection, or inflammation, or infected wounds, or inflamed wounds, or treatment, prevention or reduction of biofilms, or removal of necrotic tissue. A liquid flow system may be used for administration of the composition.
摘要翻译：本发明涉及一种抗微生物和清洁组合物，其由以下组分组成：a。一种聚合双胍，和b。金属离子螯合剂，和g。其中a:b的比率在0.75:2.25和1.25:2.25之间，或约为1:2的溶剂，和任选的一种或多种下列成分; C。季铵盐，d。至少一种表面活性剂，保湿剂和f。一种胶凝剂。本发明进一步涉及用于治疗，预防或减少与微生物有关的疾病，病症或病症或治疗，预防或减少感染或炎症，感染伤口或发炎伤口或治疗，预防或减少生物膜或去除坏死组织。液体流动系统可用于施用组合物。

4. 发明申请

WO2014195322A1 TRIAZOLE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS 审中-公开
标题翻译：三唑化合物及其作为GAMMA秘密调节剂的用途
公开(公告)号：WO2014195322A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061501
申请日：2014-06-03
申请人： ACTURUM LIFE SCIENCE AB
发明人： BESIDSKI, Yevgeni , YNGVE, Ulrika , PAULSEN, Kim , LINDE, Christian , MALMBORG, Jonas
IPC分类号： C07D403/12 , A61K31/496 , A61P25/28
CPC分类号： C07D403/12 , A61K31/4196 , A61K45/06
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical compositions comprising these compounds, to processes for making these compounds, and to their use as medicaments for treatment and/or prevention of Αβ-related diseases.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐。本发明还涉及包含这些化合物的药物组合物，制备这些化合物的方法，以及它们作为用于治疗和/或预防和治疗疾病的药物的用途。

5. 发明申请

WO2014184235A1 BENZAMIDE TRPA1 ANTAGONISTS 审中-公开
公开(公告)号：WO2014184235A1
公开(公告)日：2014-11-20
申请号：PCT/EP2014/059830
申请日：2014-05-14
申请人： ACTURUM LIFE SCIENCE AB
发明人： LINDE, Christian Erik , PAULSEN, Kim , SOHN, Daniel , SVENSSON, Mats A , VALLIN, Karl S A , WEIGELT, Dirk , MINIDIS, Alexander
IPC分类号： C07C255/57 , C07C255/60 , C07D213/81 , C07D213/82 , C07D213/85 , C07D231/14 , C07D233/38 , C07D401/04 , C07D413/12 , C07C323/62 , C07D249/06 , C07C231/20 , A61K31/165 , A61K31/277 , A61P29/00
CPC分类号： C07C233/76 , C07C231/20 , C07C235/46 , C07C255/57 , C07C255/60 , C07C323/62 , C07C2601/02 , C07D207/34 , C07D207/48 , C07D209/42 , C07D213/56 , C07D213/61 , C07D213/81 , C07D213/82 , C07D213/85 , C07D231/14 , C07D233/38 , C07D249/06 , C07D261/18 , C07D261/20 , C07D271/08 , C07D275/03 , C07D277/30 , C07D285/06 , C07D285/14 , C07D307/85 , C07D401/04 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Compounds of formula I, pharmaceutically acceptable salts thereof, diastereomers, enantiomers, or mixtures thereof: wherein R, X, Y, Z, n and A are as defined in the specification, as well as pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译：式I化合物，其药学上可接受的盐，非对映异构体，对映异构体或其混合物：其中R，X，Y，Z，n和A如说明书中所定义，以及包含该化合物的药物组合物。它们可用于治疗，特别是治疗疼痛。

6. 发明申请

WO2014195321A1 TRIAZOLE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS 审中-公开
标题翻译：三唑化合物及其作为GAMMA秘密调节剂的用途
公开(公告)号：WO2014195321A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061498
申请日：2014-06-03
申请人： ACTURUM LIFE SCIENCE AB
发明人： BESIDSKI, Yevgeni , YNGVE, Ulrika , PAULSEN, Kim , LINDE, Christian , NORDVALL, Gunnar , MACSÁRI, István , MALMBORG, Jonas
IPC分类号： C07D403/14 , A61K31/519 , A61P25/28
CPC分类号： C07D403/14 , A61K31/4196 , A61K45/06
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical compositions comprising these compounds, to processes for making these compounds, and to their use as medicaments for treatment and/or prevention of Aβ-related diseases.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐。本发明还涉及包含这些化合物的药物组合物，制备这些化合物的方法，以及它们作为用于治疗和/或预防与疾病有关的疾病的药物的用途。

7. 发明申请

WO2014184248A2 TRPA1 ANTAGONIST COMPOUNDS 审中-公开
标题翻译： TRPA1拮抗剂化合物
公开(公告)号：WO2014184248A2
公开(公告)日：2014-11-20
申请号：PCT/EP2014/059853
申请日：2014-05-14
申请人： ACTURUM LIFE SCIENCE AB
发明人： SVENSSON, Mats A , WEIGELT, Dirk
IPC分类号： C07C275/18
CPC分类号： C07C275/18 , C07D211/34 , C07D217/06 , C07D295/16 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I), pharmaceutically acceptable salts thereof, diastereomers, enantiomers, or mixtures thereof: wherein R 1 , R 2 , R 3 , X, Y n and A are as defined in the specification, as well as pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译：式（I）的化合物，其药学上可接受的盐，非对映异构体，对映异构体或其混合物：其中R 1，R 2，R X，Y，n和A如说明书中所定义，以及制备包括所述化合物的药物组合物。它们在治疗中很有用，特别是在治疗疼痛方面。

8. 发明申请

WO2018162625A1 PRODRUGS OF SULFASALAZINE, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE DISEASE 审中-公开
公开(公告)号：WO2018162625A1
公开(公告)日：2018-09-13
申请号：PCT/EP2018/055720
申请日：2018-03-08
申请人： TRULY TRANSLATIONAL SWEDEN AB
发明人： MASCHA MENSONIDES-HARSEMA, Marguérite , BRUNMARK, Charlott , VON WACHENFELDT, Karin
IPC分类号： C07D213/76 , A61K31/4402 , A61P37/00
摘要： The present invention relates to new compounds of formula (I) and pharmaceutically acceptable salts and/or co-crystals thereof. The present invention also relates to pharmaceutical compositions comprising these compounds and to their use as medicaments for the prevention, prophylaxis of progression, and/or treatment of a disease in which modulation of extracellular (chemotactic) cytokines and/or TNF-alpha and or nuclear factor kappa B (NFKB) and/or inflammatory cells is beneficial, such as autoimmune diseases, like rheumatoid arthritis, oligoarthritis, spondyloarthropathy, psoriatic arthritis, psoriasis and inflammatory bowel diseases, such as Crohns' disease and ulcerative colitis.

9. 发明申请

WO2016024897A1 A METHOD AND A SYSTEM FOR PRODUCING A TAPE FOR CORRECTION OF A MOTION PATTERN 审中-公开
标题翻译：一种用于生产用于校正运动图案的胶带的方法和系统
公开(公告)号：WO2016024897A1
公开(公告)日：2016-02-18
申请号：PCT/SE2015/050834
申请日：2015-07-28
申请人： BABOTA, BALANCE BODY TAPE AB
发明人： ANGEL, Krister , BLOMQVIST, Erik
IPC分类号： A61F13/02 , A61F5/40
CPC分类号： A61F13/02
摘要： The present invention relates to a method and a system for producing a tape for correction of a motion pattern of a part of a body comprising a machine(1) for producing the tape, a memory location (5) for storing a plurality of predefined motion patterns associated with a part of the body, a memory location (6) for storing tape templates defining a contour of a tape for correcting a motion pattern, a display unit (12) for providing information about said motion patterns, and allowing a user to choose the motion patterns, an image device (14) for capturing an image of a part of the body,an image processing module (7), and a tape production module (8) adapted receiving information about a chosen motion pattern, to select templates, determine the contour, generate instructions for producing the tape based on the determined contour, and transfer instructions to the machine for production.
摘要翻译：本发明涉及一种用于制造用于校正身体的一部分的运动模式的带的方法和系统，包括用于生产带的机器（1），用于存储多个预定运动的存储器位置（5）与身体的一部分相关联的模式，用于存储限定用于校正运动模式的磁带轮廓的磁带模板的存储器位置（6），用于提供关于所述运动模式的信息的显示单元（12）选择运动图案，用于捕获身体的一部分的图像的图像装置（14），图像处理模块（7）和适于接收关于所选择的运动模式的信息的胶片制作模块（8），以选择模板确定轮廓，生成基于所确定的轮廓产生胶带的指令，并将指令传送到机器进行生产。

10. 发明申请

WO2015135664A1 A DEVICE FOR IMPROVING MIXING OF A LIQUID AND A POWDERED SUBSTANCE AND A BABY BOTTLE COMPRISING THE DEVICE 审中-公开
标题翻译：一种用于改善液体和粉末物质的混合的装置和包含装置的婴儿手套
公开(公告)号：WO2015135664A1
公开(公告)日：2015-09-17
申请号：PCT/EP2015/025010
申请日：2015-03-03
申请人： ROAKS, Vienar
发明人： ROAKS, Vienar
IPC分类号： A47J43/27
CPC分类号： B01F5/0688 , A47J43/27 , A61J9/00 , A61J11/04 , B01F3/12 , B01F15/00512 , B01F2215/0022
摘要： The present invention relates to a device (1) for mixing of a liquid and a powdered substance in a bottle. The device comprises a body (2) including a grid (3) having a plurality of openings (4) and a rim (6) surrounding the grid. The device comprises at least two elongated apertures (8) arranged in different radial directions in relation to a central part (9) of the body, to allow a part of the liquid to pass through the device without passing through the openings of the grid, and each of the apertures has a cross-sectional area which is more than twice as large as the cross-sectional area of the openings of the grid.
摘要翻译：本发明涉及一种用于在瓶子中混合液体和粉末状物质的装置（1）。该装置包括主体（2），其包括具有多个开口（4）的格栅（3）和围绕网格的边缘（6）。所述装置包括相对于所述主体的中心部分（9）以不同的径向方向布置的至少两个细长的孔（8），以允许所述液体的一部分穿过所述装置而不穿过所述栅格的开口，并且每个孔的横截面面积是栅格开口的横截面面积的两倍以上。

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