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1. 发明申请

WO2019135074A8 IMPROVEMENTS IN OR RELATING TO AMPLIFICATION OF NUCLEIC ACIDS 审中-公开
公开(公告)号：WO2019135074A8
公开(公告)日：2019-07-11
申请号：PCT/GB2019/050005
申请日：2019-01-02
申请人： LUMIRADX UK LTD
发明人： SHEN, Daiwei , KRAYNACK, Bryan , PEREZ, Victor , PROVINS, Jarrod
IPC分类号： C12Q1/6848
摘要： Disclosed is a method of performing a non-isothermal nucleic acid amplification reaction, the method comprising the steps of: (a)mixing a target sequence with one or more complementary single stranded primers in conditions which permit a hybridisation event in which the primers hybridise to the target, which hybridisation event, directly or indirectly, leads to the formation of a duplex structure comprising two nicking sites disposed at or near opposite ends of the duplex; and performing an amplification process by; (b)using a nicking enzyme to cause a nick at each of said nicking sites in the strands of the duplex; (c)using a polymerase to extend the nicked strands to as to form newly synthesised nucleic acid, which extension with the polymerase recreates nicking sites; (d)repeating steps (b) and (c) as desired so as to cause the production of multiple copies of the newly synthesised nucleic acid; characterised in that the temperature at which the method is performed is non-isothermal, and subject to shuttling, a plurality of times, between an upper temperature and a lower temperature during the amplification process of steps (b)-(d), wherein at the upper temperature, one of said polymerase or nicking enzyme is more active than the other of said enzymes, such that there is a disparity in the activity of the enzymes, and at the lower temperature the disparity in the activity of the enzymes is reduced or reversed.

2. 发明申请

WO2016132102A1 IMPROVEMENTS IN OR RELATING TO LIGHTING PANELS 审中-公开
标题翻译：照明面板或照明面板的改进
公开(公告)号：WO2016132102A1
公开(公告)日：2016-08-25
申请号：PCT/GB2016/050338
申请日：2016-02-12
申请人： MANGO ELECTRONICS LTD.
发明人： LEAK, Peter
IPC分类号： G02F1/1335
CPC分类号： G02F1/133604 , G02F1/133605 , G02F1/133611
摘要： Disclosed is a lighting panel comprising a substrate with a reflective surface, the substrate being formed of, or comprising a plurality of channel sections, each channel section comprising a major light source and a minor light source, the light sources being disposed in a corresponding respective major and minor groove formed in the channel sections, the major and minor light sources within the same channel section being at least partially separated by an opaque projection therebetween, such that light output from one of the light sources is substantially prevented from being incident on the other light source in the same channel.
摘要翻译：公开了一种照明面板，其包括具有反射表面的基板，所述基板由多个通道部分形成或包括多个通道部分，每个通道部分包括主光源和次光源，所述光源设置在相应的相应的形成在通道部分中的主槽和小槽，同一通道部分内的主光源和次光源至少部分地由其间的不透明突起部分地分开，从而基本上防止从其中一个光源输出的光入射到其他光源在同一通道。

3. 发明申请

WO2009144507A1 ASSAY DEVICE 审中-公开
标题翻译：测定装置
公开(公告)号：WO2009144507A1
公开(公告)日：2009-12-03
申请号：PCT/GB2009/050590
申请日：2009-05-29
申请人： SPD SWISS PRECISION DIAGNOSTICS GMBH , SHARROCK, Paul
发明人： SHARROCK, Paul
IPC分类号： G01N33/487 , G01N33/52 , G01N33/543 , G01N33/68
CPC分类号： G01N33/558 , G01N21/8483 , G01N2333/59
摘要： Disclosed is an assay result reading apparatus, for reading the result of an assay, comprising: a)first and second control thresholds; b)a data processing means for processing an analyte measurement signal indicative of the presence and/or amount of an analyte; and for processing a control signal indicative of whether the assay has been carried out satisfactorily; to: up until a time t 1 after commencement of the assay measurement, to compare the control signal with the first control threshold and determine that the assay has been carried out satisfactorily if the control signal exceeds or is equal to the first control threshold, and if the control signal is less than the first control threshold to continue the assay measurement; and at a time t > t 1 to compare the control signal with a second control threshold and provide an assay result if the control signal exceeds or is equal to the second control threshold.
摘要翻译：公开了一种用于读取测定结果的测定结果读取装置，包括：a）第一和第二控制阈值; b）数据处理装置，用于处理指示分析物的存在和/或量的分析物测量信号; 并且用于处理指示该测定是否已经令人满意地进行的控制信号; 以：直到测定测量开始后的时间t1，将对照信号与第一对照阈值进行比较，并确定如果控制信号超过或等于第一对照阈值，则该测定已经令人满意地进行，并且如果控制信号小于第一控制阈值以继续测定测量; 并且在时间t> t1以将控制信号与第二控制阈值进行比较，并且如果控制信号超过或等于第二控制阈值，则提供测定结果。

4. 发明申请

WO2020183153A1 APPARATUS AND METHOD FOR INSTALLATION OF SUPPORT POSTS FOR A VEHICLE RESTRAINT SYSTEM 审中-公开
公开(公告)号：WO2020183153A1
公开(公告)日：2020-09-17
申请号：PCT/GB2020/050580
申请日：2020-03-11
申请人： PETTERS, Karl
发明人： PETTERS, Karl
IPC分类号： E01F15/04
摘要： Disclosed is apparatus for installing a vehicle restraint at a desired location, the apparatus comprising a length of pre-fabricated a base unit locatable in or on the ground at the desired location, the base unit having a plurality of attachment positions at intervals for attachment thereto of at least one substantially vertical support post for supporting the vehicle restraint.

5. 发明申请

WO2019145678A1 APPARATUS AND METHOD FOR OBTAINING A BREATH SAMPLE 审中-公开
公开(公告)号：WO2019145678A1
公开(公告)日：2019-08-01
申请号：PCT/GB2019/050112
申请日：2019-01-16
申请人： OWLSTONE MEDICAL LIMITED
发明人： ALLSWORTH, Max , APTHORP, Duncan , BICKERSTAFFE, Jeremy , COX, Michael , GORDON, Patrick , KARECLA, Georgina , KITCHEN, Simon , SPINKS, Jeremy , TAYLOR, Alastair
IPC分类号： A61B5/097 , A61B5/083 , A61B5/087 , A61B5/11 , A61B5/00
CPC分类号： A61B5/097 , A61B5/0836 , A61B5/087 , A61B5/1116 , A61B5/746 , A61B2562/24
摘要： Disclosed is apparatus for use in obtaining a breath sample from a mammalian, preferably human, subject, the apparatus comprising: a headset which is attachable to the subject; a separate suction pump; and an umbilical connecting the suction pump to the headset so as to allow the suction pump to create a lower than ambient pressure within the headset; wherein the headset comprises: a mask piece which fits over the nostrils and mouth of the subject; at least one breath sample capture device, and at least one valve to regulate the passage of gas into the sample capture device.

6. 发明申请

WO2017194934A1 NON-LINEAR LIGHTING UNITS 审中-公开
标题翻译：非线性照明设备
公开(公告)号：WO2017194934A1
公开(公告)日：2017-11-16
申请号：PCT/GB2017/051294
申请日：2017-05-10
申请人： LUXTEC GLOBAL LIMITED
发明人： LEAK, Peter
IPC分类号： F21V7/00 , F21S2/00 , F21V7/09 , F21Y103/30 , F21Y113/00 , F21Y115/20 , F21S8/04 , F21L13/06
CPC分类号： F21V7/0083 , F21K9/232 , F21L13/06 , F21S8/04 , F21V7/005 , F21V7/09 , F21Y2103/30 , F21Y2113/00 , F21Y2115/20
摘要： Disclosed is a lighting unit comprising a substrate (2) with a reflective surface, the substrate being formed of, or comprising one or more channel sections (4), the or each channel section comprising a major light source (7) and a minor light source (8), the light sources being electroluminescent tubes disposed in a corresponding respective major groove (6) and minor groove (8) formed in the channel section (4), the major and minor light sources within the same channel section (4) being at least partially separated by an opaque projection (10) therebetween, such that light output from one of the light sources is substantially prevented from being incident on the other light source in the same channel,characterised in that the channel section (4) and the electroluminescent light tubes are substantially non-linear along their length.
摘要翻译：公开了一种照明单元，其包括具有反射表面的衬底（2），所述衬底由一个或多个通道部分（4）形成或包括一个或多个通道部分（4），所述通道部分或每个通道部分包括主光（7）和次要光源（8），所述光源是设置在形成于所述通道部分（4）中的相应的主要凹槽（6）和次要凹槽（8）中的电致发光管，所述主要和次要光源在相同的通道部分（4）内至少部分地被其间的不透明的突起（10）分开，使得从一个光源输出的光基本上被防止入射到同一通道中的另一个光源上，其特征在于：通道部分（4）和电致发光灯管沿其长度基本上是非线性的。

7. 发明申请

WO2016151281A1 IMPROVEMENTS IN OR RELATING TO MEASUREMENT OF BLOOD PRESSURE 审中-公开
标题翻译：改善或相关血压测量
公开(公告)号：WO2016151281A1
公开(公告)日：2016-09-29
申请号：PCT/GB2016/050644
申请日：2016-03-09
申请人： EPITHERM LIMITED
发明人： BAUMBACH, Per
IPC分类号： A61B5/00 , A61B5/022 , A61B5/026 , A61B5/1491 , A61B5/1477 , G01K1/16
CPC分类号： A61B5/02233 , A61B5/022 , A61B5/02208 , A61B5/026 , A61B5/1477 , A61B5/1491
摘要： Disclosed is a blood pressure measurement device comprising a heat flow perfusion sensor in combination with occlusion means for restricting the flow of blood in a portion of a human or animal body.
摘要翻译：公开了一种血压测量装置，其包括与用于限制人体或动物身体的一部分中的血液流动的阻塞装置的热流灌注传感器。

8. 发明申请

WO2013007982A1 VEHICLE-MOUNTED DEHUMIDIFIER 审中-公开
标题翻译：车用安全除湿器
公开(公告)号：WO2013007982A1
公开(公告)日：2013-01-17
申请号：PCT/GB2012/051531
申请日：2012-06-29
申请人： MUNTERS EUROPE AB , BESSANT, Alan
发明人： BESSANT, Alan
IPC分类号： B60H1/00 , B60H3/02 , B65D88/74
CPC分类号： B60H3/024
摘要： Disclosed is a dehumidifying apparatus, adapted and configured to be mounted on a road-going vehicle having at least one battery and a cargo storage compartment, the dehumidifying apparatus, in use, supplying a flow of dehumidified air to the interior of the cargo storage compartment, wherein the dehumidifying apparatus is capable of running using, as a sole power source, an electrical power supply taken from the battery of the road-going vehicle.
摘要翻译：公开了一种除湿装置，其适于并构造成安装在具有至少一个电池和货物储存室的道路车辆上，所述除湿装置在使用中将除湿空气流供应到货物储存室的内部其中，所述除湿装置能够使用从所述道路车辆的电池取出的电力供给，作为唯一的动力源。

9. 发明申请

WO2009147437A1 ASSAY READER, DEVICE AND METHOD FOR MEASURING HCG 审中-公开
标题翻译：测定读数器，测量HCG的装置和方法
公开(公告)号：WO2009147437A1
公开(公告)日：2009-12-10
申请号：PCT/GB2009/050619
申请日：2009-06-03
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , ELLIS, Jayne , MARSHALL, Jayne
发明人： ELLIS, Jayne , MARSHALL, Jayne
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/689 , G01N21/8483 , G01N33/54386 , G01N33/558 , G01N33/76 , G01N2021/8488 , G01N2333/59
摘要： Disclosed is a method for determining a quantitative estimate of the length of time since conception in a female mammalian subject, the method comprising: a)providing a liquid sample suspected of containing hCG; b)measuring, by means of an assay or assay device, an analyte measurement signal, whose value is dependent upon the level of hCG; c)comparing the measured signal value to an analyte threshold, wherein said analyte threshold corresponds to a time since conception; d)providing an quantitative estimate of the length of time since conception based upon the comparison in step (c).
摘要翻译：公开了一种用于确定雌性哺乳动物受试者自受孕以来的时间长度的定量估计的方法，所述方法包括：a）提供疑似含有hCG的液体样品; b）通过测定或测定装置测量其值取决于hCG水平的分析物测量信号; c）将测量的信号值与分析物阈值进行比较，其中所述分析物阈值对应于受孕后的时间; d）基于步骤（c）中的比较，提供自受孕以来时间长度的定量估计。

10. 发明申请

WO2016156769A1 IMPROVEMENTS IN OR RELATING TO DETECTION OF PARASITE INFESTATIONS 审中-公开
标题翻译：改善或相关于检测PARASITE INFESTATIONS
公开(公告)号：WO2016156769A1
公开(公告)日：2016-10-06
申请号：PCT/GB2015/052985
申请日：2015-10-12
申请人： AUSTIN DAVIS BIOLOGICS LIMITED
发明人： AUSTIN, Corrine , LIGHTBODY, Kirsty , DAVIS, Paul
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/6854 , G01N2333/43539 , G01N2469/20 , G01N2800/06
摘要： Title: Improvements in or Relating to Detection of Equine Disease Disclosed is a method of detecting a tapeworm infestation in an equid animal subject, the method comprising the step of performing, in vitro, (a) an assay on a saliva sample, obtained from the subject, to detect the presence and/or amount in the sample of a first analyte which is or comprises antibody specific to antigen/s from the tapeworm; and (b) an assay on a saliva sample, obtained from the subject, to measure the amount and/or concentration of a second analyte, the result of which assay gives a measure of the dilution of the sample.
摘要翻译：标题：马氏体检测的改进或涉及检测马氏病是一种检测等体动物受试者的绦虫侵袭的方法，该方法包括以下步骤：在体外进行（a）从唾液样品获得的测定检测第一分析物的样品中存在和/或量，该第一分析物是或包含来自绦虫的抗原特异性抗体; 和（b）从受试者获得的唾液样品的测定来测量第二分析物的量和/或浓度，其结果是测定样品的稀释度。

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