专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2022043400A1 NUCLEIC ACIDS ENCODING A POLYPEPTIDE COMPRISING A MODIFIED FC REGION OF A HUMAN IGG1 AND AT LEAST ONE HETEROLOGOUS ANTIGEN 审中-公开
公开(公告)号：WO2022043400A1
公开(公告)日：2022-03-03
申请号：PCT/EP2021/073542
申请日：2021-08-25
申请人： SCANCELL LIMITED
发明人： DURRANT, Linda Gillian , VANKEMMELBEKE, Mireille , BRENTVILLE, Victoria , METHERINGHAM, Rachael
IPC分类号： A61K39/215 , C12N15/62
摘要： The present invention relates to nucleic acids and peptides encoded by those nucleic acids. In particular, the peptides comprise a modified IgG1 Fc region and one or more heterologous epitopes, which may be B- or T-cell epitopes. A nucleic acid of the invention may encode a polypeptide comprising: (i) a modified Fc region of a human IgG1, and (i) at least one heterologous antigen, wherein (a) the modified Fc region comprises at least the part of Fc that is capable of binding to CD64 and/or TRIM21, (b) at least one residue of the Fc region is modified to the corresponding residue from a mouse IgG3 antibody and (c) the modified Fc region has enhanced avidity for Fc- gamma receptor (FcγR) when compared to the corresponding wildtype Fc region.

2. 发明申请

WO2017187185A1 PEPTIDES OF BROMODOMAIN TESTIS-SPECIFIC PROTEIN (BRDT) 审中-公开
标题翻译： BROMODOMAIN睾丸特异性蛋白（BRDT）肽
公开(公告)号：WO2017187185A1
公开(公告)日：2017-11-02
申请号：PCT/GB2017/051192
申请日：2017-04-28
申请人： IMMUNOCORE LIMITED , ADAPTIMMUNE LIMITED
发明人： POWLESLAND, Alex , SUN, Mei
IPC分类号： C07K14/47 , C07K7/06
CPC分类号： C07K14/4748 , A61K38/00 , A61P35/00 , G01N33/574 , G01N33/6878 , G01N33/689 , G01N2333/70539 , G01N2500/02
摘要： The present invention relates to novel peptides derived from Bromodomain testis-specific protein (BRDT), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.
摘要翻译：本发明涉及源自溴色域睾丸特异性蛋白（BRDT）的新型肽，包含与重组MHC分子结合的此类肽的复合物，以及呈递与MHC分子复合的所述肽的细胞。本发明还提供了结合本发明的肽和/或复合物的结合部分。这样的部分可用于开发用于治疗诸如癌症的疾病的免疫治疗剂。

3. 发明申请

WO2017089777A1 PEPTIDES DERIVED FROM LENGSIN (LGSN), COMPLEXES COMPRISING SUCH PEPTIDES BOUND TO MHC MOLECULES 审中-公开
标题翻译：衍生自LENGSIN（LGSN）的肽，包含与MHC分子结合的此类肽的复合物
公开(公告)号：WO2017089777A1
公开(公告)日：2017-06-01
申请号：PCT/GB2016/053659
申请日：2016-11-23
申请人： IMMUNOCORE LIMITED , ADAPTIMMUNE LIMITED
发明人： POWLESLAND, Alex , KLEIJNEN, Maurits
IPC分类号： C07K14/47
CPC分类号： C07K14/4748
摘要： The present invention relates to novel peptides derived from Lengsin (LGSN), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.
摘要翻译：本发明涉及源自Lengsin（LGSN）的新型肽，包含与重组MHC分子结合的此类肽的复合物，以及呈递与MHC分子复合的所述肽的细胞。本发明还提供了结合本发明的肽和/或复合物的结合部分。这样的部分可用于开发用于治疗诸如癌症的疾病的免疫治疗剂。

4. 发明申请

WO2016166600A1 DELIVERY OF MICRORNA USING MESENCHYMAL STEM CELL MICROPARTICLES 审中-公开
标题翻译：使用MESENCHYMAL STEM CELL MICROPARTICLES递送MICRORNA
公开(公告)号：WO2016166600A1
公开(公告)日：2016-10-20
申请号：PCT/IB2016/000563
申请日：2016-04-15
申请人： TROJANTEC TECHNOLOGIES LTD
发明人： EPENETOS, Agamemnon , PROKOPI, Marianna
IPC分类号： C12N15/11 , A61P35/00 , A61K9/50 , A61K47/48
CPC分类号： C12N15/111 , A61K9/5068 , A61K47/6901 , C12N2310/141 , C12N2330/10
摘要： MIRNAs have been implicated in the development of some if not all cancer types and have been identified as attractive targets for therapy. However, systemic delivery of miRNAs faces its own set of limitations because of degradation by RNases and filtration and excretion by the kidneys. In this work we propose a new class of therapeutic agents, based on microparticles (MPs) derived from mesenchymal stem cells (MSCs) that can selectively target tumors in vivo, containing and delivering miRNAs that affect the action of genes associated with cancer growth, neovascularization and metastasis applicable to both local and systemic administration.
摘要翻译： MIRNA已经涉及一些（如果不是全部）癌症类型的发展，并且已被确定为治疗的有吸引力的靶标。然而，由于RNA酶的降解和肾的排泄，miRNA的系统传递面临着自己的限制。在这项工作中，我们提出了一类新的治疗剂，基于源自间充质干细胞（MSCs）的微粒（MP），其可以选择性靶向体内肿瘤，含有和递送影响与癌症生长，新生血管形成相关基因的作用的miRNA 和转移适用于局部和全身给药。

5. 发明申请

WO2013041865A1 T CELL RECEPTORS 审中-公开
标题翻译：细胞受体
公开(公告)号：WO2013041865A1
公开(公告)日：2013-03-28
申请号：PCT/GB2012/052322
申请日：2012-09-20
申请人： IMMUNOCORE LIMITED , JAKOBSEN, Bent Karsten , LIDDY, Nathaniel Ross , VUIDEPOT, Annelise Brigitte , MOLLOY, Peter Eamon
发明人： JAKOBSEN, Bent Karsten , LIDDY, Nathaniel Ross , VUIDEPOT, Annelise Brigitte , MOLLOY, Peter Eamon
IPC分类号： C07K14/705
CPC分类号： C07K14/7051 , C07K2319/30
摘要： The present invention relates to T cell receptors (TCRs) that the property of binding to EVDPIGHLY (SEQ ID No: 1) HLA-A1 complex and comprise a TCR alpha chain variable domain and a TCR beta chain variable domain. The EVDPIGHLY peptide is derived from the MAGE-3 protein which is expressed in many tumour types, including melanomas, and other solid tumours such as Head and Neck Squamous Cell, lung, bladder, gastric, prostate, colorectal and esophageal carcimomas. Also provided are nucleic acids encoding such TCRs, cells presenting such TCRs and pharmaceutical compositions comprising such TCRs.
摘要翻译：本发明涉及结合EVDPIGHLY（SEQ ID No：1）HLA-A1复合物并包含TCRα链可变结构域和TCRβ可变结构域的特性的T细胞受体（TCR）。 EVDPIGHLY肽衍生自MAGE-3蛋白，其在许多肿瘤类型中表达，包括黑素瘤和其他实体瘤如头颈部鳞状细胞，肺，膀胱，胃，前列腺，结肠直肠和食管癌。还提供了编码这种TCR的核酸，呈现这种TCR的细胞和包含这种TCR的药物组合物。

6. 发明申请

WO2012131311A2 APPLICATOR FOR AN ENDOSCOPE 审中-公开
标题翻译：内镜应征者
公开(公告)号：WO2012131311A2
公开(公告)日：2012-10-04
申请号：PCT/GB2012/000299
申请日：2012-03-30
申请人： ENDOGUARD LIMITED , WILLS, Anthony, Arthur
发明人： WILLS, Anthony, Arthur
IPC分类号： A61B1/313
CPC分类号： A61B1/00154 , A61B1/00105 , A61B1/0011 , A61B1/00135 , A61B1/128 , A61B1/3132 , A61B17/00234 , A61F7/007 , A61F7/12
摘要： A device for applying an attachment to an endoscope is disclosed. The device comprises an applicator supporting the attachment, an end of the attachment being accessible such that the endoscope is insertable into the attachment in a longitudinal direction. The attachment is removably secured to the applicator to enable the attachment to be withdrawn from the applicator together with the endoscope.
摘要翻译：公开了一种用于向内窥镜施加附件的装置。所述装置包括支撑所述附件的施加器，所述附件的端部是可接近的，使得所述内窥镜沿纵向方向可插入所述附件中。附件可拆卸地固定到施加器上，以使连接件能够与内窥镜一起从施用器中取出。

7. 发明申请

WO2011092449A1 TREATMENT PATCH ELECTRODE FOR APPLYING ELECTRICAL IMPULSES TO THE BODY OF A PATIENT 审中-公开
标题翻译：用于将电刺激应用于患者身体的治疗电极
公开(公告)号：WO2011092449A1
公开(公告)日：2011-08-04
申请号：PCT/GB2010/002280
申请日：2010-12-15
申请人： FENZIAN LIMITED , COLTHURST, James
发明人： COLTHURST, James
IPC分类号： A61N1/32 , A61N1/04
CPC分类号： A61N1/32 , A61N1/0468 , A61N1/0492
摘要： The invention provides a handheld treatment device (10) for applying electrical impulses to a living body through the surface of the body, for treating a variety of clinical conditions. The device comprises first and second electrodes (54) for contact with the skin; a waveform generator (146) for repeatedly generating an AC waveform for applying electrical impulses through the electrodes to the skin; a detector (150) for detecting changes in the skin impedance and for generating output signals representing the skin impedance; means (142) responsive to the output signals from the detector for monitoring the responsivity of the skin; and indicator means (158) for generating a first indication when a predetermined level of responsivity is reached and a second indication when a pre-determined treatment has been administered. The device is characterised by a treatment patch (50) comprising a flexible sheet (52) having on one surface said first and second electrodes (54) separated by insulation (60); a pair of leads (56) connected respectively to said first and second electrodes; and a connection arrangement (58) attached to the first and second leads for connecting the electrodes with said waveform generator. Each electrode comprises at least one elongate strip, with the, or each, strip of the first electrode being separated from the, or each adjacent, strip of the second electrode by a, or a respective, line of said insulation.
摘要翻译：本发明提供了一种用于通过身体表面向活体施加电脉冲以用于治疗各种临床状况的手持式治疗装置（10）。该装置包括用于与皮肤接触的第一和第二电极（54）波形发生器（146），用于重复地产生用于通过电极将电脉冲施加到皮肤的AC波形; 检测器（150），用于检测皮肤阻抗的变化并产生表示皮肤阻抗的输出信号; 响应于来自检测器的输出信号的装置（142），用于监测皮肤的响应度; 以及用于当达到预定的响应度水平时产生第一指示的指示装置（158），以及当已经施加了预定治疗时的第二指示。该装置的特征在于包括柔性片（52）的处理片（50），所述柔性片（52）在一个表面上具有由绝缘体（60）分开的所述第一和第二电极（54）。分别连接到所述第一和第二电极的一对引线（56）以及附接到第一和第二引线的连接装置（58），用于将电极与所述波形发生器连接。每个电极包括至少一个细长带，其中第一电极的每个或每个条带通过所述绝缘体的一个或相应的线与第二电极的每个相邻条带分离。

8. 发明申请

WO2011036459A1 DIFFUSER 审中-公开
标题翻译：扩散器
公开(公告)号：WO2011036459A1
公开(公告)日：2011-03-31
申请号：PCT/GB2010/001801
申请日：2010-09-24
申请人： DYNAMIC BOOSTING SYSTEMS LIMITED , VINE, Andrew
发明人： VINE, Andrew
IPC分类号： F04D29/44
CPC分类号： F04D29/444 , F04D17/122 , F05D2250/52
摘要： A diffuser having a flow path including generally annular regions arranged to direct a flow of fluid with both tangential and axial velocity components.
摘要翻译：一种扩散器，其具有包括大致环形区域的流动路径，其布置成用切向和轴向速度分量引导流体流动。

9. 发明申请

WO2010067084A1 TEXTURE CHARACTERISATION 审中-公开
标题翻译：纹理特征
公开(公告)号：WO2010067084A1
公开(公告)日：2010-06-17
申请号：PCT/GB2009/002872
申请日：2009-12-11
申请人： ONCOMORPH ANALYSIS LTD , ZWIGGELAAR, Reyer
发明人： ZWIGGELAAR, Reyer
IPC分类号： G06T7/40 , G06T7/00
CPC分类号： G06T7/41 , G06T2207/10088 , G06T2207/30004
摘要： A method for creating an electronic library for characterising texture types of portions of digital images, a portion of a digital image comprising a plurality of pixels, each pixel having a texture value which is representative of texture at a respective position, wherein a portion of the digital image represents a particular texture type and a texture profile for a portion identifies pixels of the portion having texture values within a particular range of texture values, the method comprising: combining a plurality of texture profiles for portions of a particular texture type to create a composite texture profile for a representative portion of the digital image having the particular texture type, wherein the composite texture profile characterises the distribution, across the pixels of the representative portion, of texture values within the particular range; and storing in the electronic library the composite texture profile and an associated indication of the particular texture type.
摘要翻译：一种用于创建用于表征数字图像的部分的纹理类型的电子库的方法，包括多个像素的数字图像的一部分，每个像素具有代表各个位置处的纹理的纹理值，其中，数字图像表示特定纹理类型，并且用于部分的纹理轮廓标识具有特定纹理值范围内的纹理值的部分的像素，该方法包括：将特定纹理类型的部分的多个纹理轮廓组合以创建用于具有特定纹理类型的数字图像的代表性部分的复合纹理轮廓，其中所述复合纹理轮廓表征所述代表部分的所述像素在所述特定范围内的纹理值的分布; 并在电子图书馆中存储复合纹理轮廓和特定纹理类型的相关指示。

10. 发明申请

WO2010032023A1 TUNEABLE PLANAR DIELECTRIC RESONATOR 审中-公开
标题翻译：可调平面电介质谐振器
公开(公告)号：WO2010032023A1
公开(公告)日：2010-03-25
申请号：PCT/GB2009/002252
申请日：2009-09-18
申请人： IMPERIAL INNOVATIONS LIMITED , BUSLOV, Oleg, Yurevich , KEIS, Vladimir, Nikolayevich , KOZYREV, Andrei, Borisovich , SHIMKO, Aleksei, Yurevich , ALFORD, Neil, McNeill , PETROV, Peter, Krastev
发明人： BUSLOV, Oleg, Yurevich , KEIS, Vladimir, Nikolayevich , KOZYREV, Andrei, Borisovich , SHIMKO, Aleksei, Yurevich , ALFORD, Neil, McNeill , PETROV, Peter, Krastev
IPC分类号： H01P1/203 , H01P7/08
CPC分类号： H01P1/20318 , H01P7/08
摘要： The invention relates to a planar dielectric resonator (50) for use in high frequency electromagnetic wave devices. Apparatus and methods are provided for a tuneable planar dielectric resonator having a single substrate (120), a tuneable planar dielectric resonator having a single metallized layer (100) and a tuneable planar dielectric resonator comprising a tuning conductor (520) disposed in the hole (110) of the resonator and coupled to the conductive layer (100) of the resonator by a tuning element (510).
摘要翻译：本发明涉及一种用于高频电磁波器件的平面介质谐振器（50）。提供了用于可调平面介质谐振器的装置和方法，该谐振器具有单个基板（120），具有单个金属化层（100）的可调谐平面介质谐振器和包括布置在孔中的调谐导体（520）的可调平面介质谐振器 110），并通过调谐元件（510）耦合到谐振器的导电层（100）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式