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1. 发明申请

WO2022043400A1 NUCLEIC ACIDS ENCODING A POLYPEPTIDE COMPRISING A MODIFIED FC REGION OF A HUMAN IGG1 AND AT LEAST ONE HETEROLOGOUS ANTIGEN 审中-公开
公开(公告)号：WO2022043400A1
公开(公告)日：2022-03-03
申请号：PCT/EP2021/073542
申请日：2021-08-25
申请人： SCANCELL LIMITED
发明人： DURRANT, Linda Gillian , VANKEMMELBEKE, Mireille , BRENTVILLE, Victoria , METHERINGHAM, Rachael
IPC分类号： A61K39/215 , C12N15/62
摘要： The present invention relates to nucleic acids and peptides encoded by those nucleic acids. In particular, the peptides comprise a modified IgG1 Fc region and one or more heterologous epitopes, which may be B- or T-cell epitopes. A nucleic acid of the invention may encode a polypeptide comprising: (i) a modified Fc region of a human IgG1, and (i) at least one heterologous antigen, wherein (a) the modified Fc region comprises at least the part of Fc that is capable of binding to CD64 and/or TRIM21, (b) at least one residue of the Fc region is modified to the corresponding residue from a mouse IgG3 antibody and (c) the modified Fc region has enhanced avidity for Fc- gamma receptor (FcγR) when compared to the corresponding wildtype Fc region.

2. 发明申请

WO2021078774A1 SPECIFIC BINDING MOLECULES 审中-公开
公开(公告)号：WO2021078774A1
公开(公告)日：2021-04-29
申请号：PCT/EP2020/079573
申请日：2020-10-21
申请人： IMMUNOCORE LIMITED
发明人： CHILLAKURI, Chandramouli , DIAS DO NASCIMENTO, Jorge , HAYES, Conor , PARKER, James , JAMES, Peter , O'DWYER, Ronan , POOLE, Andrew
IPC分类号： C07K14/47 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725
摘要： The present invention relates to specific binding molecules, such as T cell receptors (TCRs), that bind the HLA-A*02 restricted peptide KVLEYVIKV (SEQ ID NO: 1) derived from the germline cancer antigen MAGEA1. The specific binding molecules may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native MAGEA1 TCR. The specific binding molecules of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

3. 发明申请

WO2021069729A1 PULSE OXIMETRY METHODS, DEVICES AND SYSTEMS 审中-公开
公开(公告)号：WO2021069729A1
公开(公告)日：2021-04-15
申请号：PCT/EP2020/078516
申请日：2020-10-09
申请人： LIFE METER SRL
发明人： DE BENEDETTO, Fernando , AVENTAGGIATO, Matteo , RAIMONDI, Marco , VISCONTI, Alberto
IPC分类号： A61B5/1455
摘要： There is provided a method of taking pulse oximetry measurements, the method comprising: providing a calibration pulse-oximeter adapted to estimate one or more first, reference SpO2 values from a first, reference PPG signal measured by the pulse-oximeter on a first, reference area of the human body; and, using the same or a different calibration pulse-oximeter, estimating one or more second SpO2 values from a second PPG signal measured by said same or different calibration pulse-oximeter on a second, target area of the human body. At this point, a calibration parameter or calibration function is calculated on the basis of the one or more first, reference SpO2 values and the second SpO2 values. Then, using a measurement pulse-oximeter, a plurality of third SpO2 values is measured from the second PPG signal on the second, target area of the human body and the resulting values are calibrated using said calibration parameter or function. In this manner, measurements taken for example with a bracelet-type pulse oximeter on an area relatively poorly perfused with blood can be improved on the basis of calibration measurements taken on an area better perfused with blood. A manner of further improving such measurements is by providing multiple sensing units on the measurement pulse oximeter, which can each be calibrated against the reference pulse oximeter.

4. 发明申请

WO2021064010A1 HYBRID HYDROGEN POWER MODULE 审中-公开
公开(公告)号：WO2021064010A1
公开(公告)日：2021-04-08
申请号：PCT/EP2020/077348
申请日：2020-09-30
申请人： ANGLO AMERICAN TECHNICAL & SUSTAINABILITY SERVICES LIMITED
发明人： SOLES, Julian, Jeremy , VOORHEES, Christopher, Jason
IPC分类号： C25B1/04 , B60L50/75 , H01M16/00 , H01M8/0656 , H01M8/249
摘要： Apparatus for powering trucks, the apparatus including a power module skid and supporting structure for fitting on a truck, the skid housing one or more hydrogen fuel cell modules, one or more battery sub packs, cooling means and cooling management, and integrated power electronics, to provide an electrical drive train of the truck with a constant high voltage DC power supply. Also an integrated system for using renewable energy in a mine environment to reduce the emission of greenhouse gases, in which environment, mined material is transported around the mine using one or more trucks, in which integrated system there are: means for providing renewable energy; means for using the renewable energy to synthesise hydrogen; means for storing the synthesised hydrogen; wherein, the integrated system further includes hybrid hydrogen power modules fitted to each truck, said power modules including hydrogen fuel cell modules and battery sub packs, whereby the stored hydrogen is loaded on to the truck to feed the hydrogen fuel cell modules so that the truck is entirely powered by the combination of the hydrogen fuel cells and the battery sub packs and the battery sub packs are recharged by the hydrogen fuel cells during use such that they do not need to be removed or remotely charged.

5. 发明申请

WO2021023797A1 METHOD FOR USE WITH A RADIOTHERAPY DEVICE 审中-公开
公开(公告)号：WO2021023797A1
公开(公告)日：2021-02-11
申请号：PCT/EP2020/072066
申请日：2020-08-05
申请人： ELEKTA LIMITED
发明人： FLINT, Chris , VEGA, German , RICHARDSON, Keith , CHIAP, Alessandra
IPC分类号： A61N5/10
摘要： Disclosed herein is a method of determining the nature of a fault in a radiotherapy device comprising a linear accelerator. The radiotherapy device is configured to provide therapeutic radiation to a patient. The radiotherapy device comprises a bending magnet assembly arranged to direct a beam of electrons toward a target to produce said radiation. A first sensor is configured to provide signals indicative of voltage at a first region of the bending magnet assembly. The method comprises receiving voltage values derived from the signals from the first sensor and processing the voltage values; wherein processing the voltage values comprises determining whether the voltage values meet at least one threshold criterion; and, based on the processing of the signals, determining whether the nature of the fault is associated with the bending magnet.

6. 发明申请

WO2021001414A1 PEPTIDE-MHC COMPLEXES 审中-公开
公开(公告)号：WO2021001414A1
公开(公告)日：2021-01-07
申请号：PCT/EP2020/068491
申请日：2020-07-01
申请人： IMMUNOCORE LIMITED
发明人： BLICHER, Thomas Holberg , DE SOUZA, Victoria Arena
IPC分类号： C07K14/74
摘要： The present invention provides a stabilised peptide-MHC (pMHC) complex, such as a peptide-HLA-E complex. The complex has a non-native linkage, such as a disulphide bond, between the C terminal anchor residue of the peptide, and an amino acid residue in the F pocket of the MHC binding groove.

7. 发明申请

WO2020079440A1 FOOD ALTERNATIVE PRODUCT AND PROCESS 审中-公开
公开(公告)号：WO2020079440A1
公开(公告)日：2020-04-23
申请号：PCT/GB2019/052970
申请日：2019-10-17
申请人： PLANT MEAT LTD
发明人： SHARMAN, Pete , SHOVEL, Andy , WILD, Florian
IPC分类号： A21C11/16 , A23J3/14 , A23J3/16 , A23J3/22 , A23P30/20 , A23P30/25
摘要： There is disclosed a high moisture extrusion apparatus suitable for manufacturing foodstuffs. The apparatus includes an extruder barrel comprising an inlet port for input of a first material into the extruder barrel, an injection port for input of a second material into the extruder barrel, an outlet port for output of a combination of the first and second material from the extruder barrel. The injection port is located intermediate to the inlet and outlet port, and closer to the outlet port than the inlet port.

8. 发明申请

WO2019175289A1 PULSED ELECTROMAGNETIC FIELD DEVICE AND METHOD OF TREATMENT 审中-公开
公开(公告)号：WO2019175289A1
公开(公告)日：2019-09-19
申请号：PCT/EP2019/056359
申请日：2019-03-13
申请人： H A INVESTORS LIMITED
发明人： MAYO, John Charles , HUNT, Thomas
IPC分类号： A61N1/40 , A61N1/32 , A61N1/36 , A61N1/02 , A61N1/06
摘要： A method including use of physiological data from an individual to determine the emission pattern of a pulsed electromagnetic field "PEMF" so that the pattern is personalised to the physiological needs of the individual. The PEMF emission pattern may have a parameter which is calculated based on the physiological data from the individual to cause the physiological state of the individual to be altered or maintained beneficially. The physiological state of the individual can be moved to or towards (or maintained at) an ideal state more effectively than if the physiological data from the individual is not used to determine the PEMF emission pattern. The method may include calculating the PEMF emission pattern based on both idealised data and the physiological data from the individual to produce the PEMF in an intermediate target pattern. The method may also include a feedback loop for continually updating the PEMF emission pattern based on up-to-date physiological data from the individual so as to gradually or incrementally alter the physiological state of the individual. The method may also include the use of the feedback loop for recording of the physiological effect of various PEMF emission patterns on multiple individuals belonging to a subset of the population and determining, using aggregates of the recorded data, improved algorithms for generating more effective PEMF emission patterns for individuals belonging to the same subset.

9. 发明申请

WO2018091861A1 GRAPHICAL USER INTERFACE FOR SINGLE-INPUT CONTROLS IN A RACING GAME ON A TOUCHSCREEN DEVICE 审中-公开
公开(公告)号：WO2018091861A1
公开(公告)日：2018-05-24
申请号：PCT/GB2017/052862
申请日：2017-09-25
申请人： SPACE APE GAMES (UK) LTD
发明人： RAEBURN, John Joseph Barclay , COURTNEY, Stephen , YANG, Tony , MILLER, Samuel Robert , JONES, Martyn Charles , MEJIAS STOTT, Thomas James , SULLIVAN, Adam
IPC分类号： A63F13/2145 , A63F13/426 , A63F13/803
CPC分类号： A63F13/2145 , A63F13/426 , A63F13/803
摘要： A method of providing a user interface on a touch-screen display of an electronic device is disclosed, the user interface enabling user control in a video game of a participant in a race, the race occurring in a virtual environment shown on the touch-screen display, a direction of motion of the participant in the environment being changeable according to a position of a contact location of a thumb of the user on the touch-screen display, wherein a position of the contact location to a first side of a central region on the touch-screen display corresponds to a left-turn of the participant, and a position of the contact location to the other side of the central region corresponds to a right-turn of the participant, wherein alignment of the contact location with the central region corresponds to maintaining a present direction of motion of the participant, wherein a rate of the change of direction of motion of the participant is incrementally adjustable by the user according to a distance away from the central region of the contact location.

10. 发明申请

WO2018083505A1 PEPTIDES 审中-公开
标题翻译：肽
公开(公告)号：WO2018083505A1
公开(公告)日：2018-05-11
申请号：PCT/GB2017/053350
申请日：2017-11-07
申请人： IMMUNOCORE LIMITED
发明人： POWLESLAND, Alex , CHILLAKURI, Chandramouli , SANGANI, Dhaval , HOOD, Graham , GALFRE, Elena
IPC分类号： C07K14/47 , A61K39/00
摘要： The present invention provides a peptide comprising, consisting essentially of or consisting of (i) the amino acid sequence KMPEAGEEQPQV (SEQ ID NO: 1); (ii) the amino acid sequence ISQTPGINL (SEQ ID NO: 2); or (iii) the amino acid sequence of SEQ ID NO: 1 or 2 with the exception of 1, 2 or 3 amino acid substitutions and/or 1, 2 or 3 amino acid insertions, and/or 1, 2 or 3 amino acid deletions, wherein the peptide forms a complex with a Major Histocompatibility Complex (MHC) molecule. Also provided are a complex of the peptide a Major Histocompatibility Complex (MHC) molecule, a nucleic acid molecule comprising a nucleic acid sequence encoding the peptide, a vector comprising such a nucleic acid sequence, a cell comprising such a vector and a binding moiety that binds the peptide.
摘要翻译：（i）氨基酸序列KMPEAGEEQPQV（SEQ ID NO：1）;和（ii）氨基酸序列KMPEAGEEQPQV（SEQ ID NO：1）。（ii）氨基酸序列ISQTPGINL（SEQ ID NO：2）; 或（iii）除了1,2或3个氨基酸取代和/或1,2或3个氨基酸插入和/或1,2或3个氨基酸之外的SEQ ID NO：1或2的氨基酸序列其中该肽与主要组织相容性复合体（MHC）分子形成复合物。还提供了肽主要组织相容性复合物（MHC）分子的复合物，包含编码肽的核酸序列的核酸分子，包含此类核酸序列的载体，包含此类载体的细胞和结合部分结合肽。

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