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1. 发明申请

WO2006044492A2 METHODS FOR GENERATING RAT EMBRYO-DERIVED CELL LINES AND GENETIC MODIFICATION OF RAT GENOME 审中-公开
标题翻译：产生大鼠胚胎来源细胞系的方法和大鼠基因组的遗传修饰
公开(公告)号：WO2006044492A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/036742
申请日：2005-10-14
申请人： INGENIOUS TARGETING LABORATORY, INC. , HE, Wei , WENG, Wei
发明人： HE, Wei , WENG, Wei
IPC分类号： C12N15/52 , C12N5/06
CPC分类号： C12N5/0606 , A01K2217/075 , A01K2227/105 , C12N2501/155 , C12N2501/235 , C12N2502/13
摘要： The present invention provides novel methods for isolating rat embryo-derived cells and modifying the genome of the rat cells which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a "targeting DNA); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.
摘要翻译：本发明提供了用于分离大鼠胚胎来源的细胞和修饰大鼠细胞基因组的新方法，其通常包括以下步骤：构建DNA分子，其中期望的序列修饰包含在区段 DNA（“靶向DNA”）; 将靶向DNA构建体导入细胞（例如通过显微注射，电穿孔，转染或磷酸钙沉淀）; 并选择其中通过同源重组将所需序列修饰引入基因组的细胞。

2. 发明申请

WO2004073432A3 MATERNITY AND/OR NURSING BREAST SUPPORT FOR FASHIONABLE WOMEN’S APPAREL 审中-公开
公开(公告)号：WO2004073432A3
公开(公告)日：2004-09-02
申请号：PCT/US2004/004856
申请日：2004-02-18
申请人： NURTUREBRA LLC
发明人： SCHNEIDER, Loretta, Lynn , HARTE, Roslyn
IPC分类号： A41C3/04
摘要： This invention provides women's apparel having a unique and improved maternity and/or nursing breast support and enables the wearer to comfortably unsecure and secure a flap on a bra cup upon completion of nursing. The main inventive feature is a dynamic noncontinuous or hanging bra support system made with a plurality of fabric members triangular in shape to allow a sizeable opening in each brassiere cup. The fabric members in each cup are joined at the upper end and create vertically oriented openings for maximum breast exposure that allow access to the breast and at the same time leave room for expansion of the breasts. The upper edges of the triangular cups are diagonally oriented, and the cups are attached only partially, at the lower portion to narrow regions of a stretchable band and/or laterally, to the side, thus providing flexibility, support and comfort for the wearer.

3. 发明申请

WO2004049275A2 AN ILLUMINATED SIGNALING DEVICE 审中-公开
标题翻译：照明信号装置
公开(公告)号：WO2004049275A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/037497
申请日：2003-11-20
申请人： THOMAS, Ivia, V.
发明人： THOMAS, Ivia, V.
IPC分类号： G08B
CPC分类号： G09F21/02
摘要： The present invention relates to portable signaling devices used for attracting attention and/or signaling messages. The devices are made of fluorescent material which illuminates brightly with a battery operated light, to display a variety of signals, logos, legends, messages and the like, to attract attention to the user. The present invention is to aide pedestrians in need of transportation, especially in urban city settings, to display a variety of signals to attract attention to themselves to hail a vehicle, while maintaining their safety.
摘要翻译：本发明涉及用于吸引注意力和/或信令消息的便携式信令设备。这些设备由荧光材料制成，用电池操作的灯光明亮地照亮，显示各种信号，标识，图例，信息等，以吸引用户注意。本发明是为了帮助需要交通的行人，尤其是城市城市中的行人，在保持其安全性的同时，显示各种信号以吸引注意力来保护车辆。

4. 发明申请

WO2003006042A1 PEPTIDE FOR REGULATION OF TISSUE PLASMINOGEN ACTIVATOR 审中-公开
标题翻译：用于调节组织培养基激活剂的肽
公开(公告)号：WO2003006042A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/020077
申请日：2002-06-24
申请人： THROMBOTECH LTD. , KARMALI, Rashida, A. , HIGAZI, Abd. Al-Roof
发明人： HIGAZI, Abd. Al-Roof
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K38/49 , A61K38/57 , A61K2300/00
摘要： The present invention relates to the polypeptide, the use of the polypeptide in the prevention and/or treatment of side effects induced by plasminogen activators, specifically tPA or uPA. The invention further relates to combination compositions and/or therapy regimens, comprising the polypeptide and one or more currently used plasminogen activators, and methods to achieve improved fibrinolytic efficacy as well as reducing their side effects.
摘要翻译：本发明涉及多肽，多肽在预防和/或治疗由纤溶酶原激活剂特别是tPA或uPA诱导的副作用中的用途。本发明还涉及包含多肽和一种或多种目前使用的纤溶酶原激活剂的组合组合物和/或治疗方案，以及实现改善的纤维蛋白溶解功效以及降低其副作用的方法。

5. 发明申请

WO2002062887A1 DESIGN AND SYNTHESIS OF INSTANT-DEGRADABLE PLASTICS 审中-公开
标题翻译：即时可塑性塑料的设计与合成
公开(公告)号：WO2002062887A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/003126
申请日：2002-02-04
申请人： KARMALI, Rashida, A. , ROSEN, Oren
发明人： ROSEN, Oren
IPC分类号： C08K5/37
CPC分类号： C08K5/37 , C08G18/3863
摘要： A novel class of instantly degradable synthetic polymeric plastics having the characteristics and properties of conventional forms of plastics is developed by providing the disulfide and sulfenyl derivatives of the plastic compounds with latent nucleophilic properties. These novel plastic products are made from a variety of compositions of polymers and their compatible nontoxic modifiers. The resulting novel instant degradable plastic products retain latent solubility properties that are triggered upon mild chemical reaction, thus enabling cost effective and facile recycling of plastic refuge.
摘要翻译：通过提供具有潜在亲核性质的塑料化合物的二硫化物和亚硫酰基衍生物，开发出具有常规塑料形式的特性和性质的一类新颖的可即时降解的合成聚合物塑料。这些新型塑料制品由各种聚合物组合物及其相容的无毒改性剂制成。所得到的新颖的即时可降解塑料产品保留了在温和化学反应时触发的潜在溶解性质，从而使得塑料避难所能够成本有效和轻松地回收利用。

6. 发明申请

WO2008063259A1 CIRCULARLY KNIT UNDERGARMENT HAVING KNIT-IN SUPPORT PANELS AND DERRIERE CUP FULLNESS 审中-公开
标题翻译：具有针织支撑面板和DERRIERE CUP FULLNESS的圆形针织底座
公开(公告)号：WO2008063259A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/019811
申请日：2007-09-12
申请人： KENNEDY, Amanda
发明人： KENNEDY, Amanda
IPC分类号： A41C1/00
CPC分类号： D04B1/243
摘要： This invention discloses circularly knit undergarments, said under garments having an anterior tummy region, a posterior stretching from the waist to the gluteal region, and two outer-regions corresponding to the outer thigh region, each of said regions includes knit-in support panels to minimize appearance of undesirable bulges The posterior region further includes a plurality of derriere cups to slim and shape the lower half of the body to a younger tone and to provide a natural appearance to the derriere, hips and tummy In a preferred embodiment the body of the undergarment is made with material that is seamlessly woven, for example, light weight micro fiber nylon or LYCRA spandex, and includes a gusset that is made of cotton and micro fiber nylon to prevent moisture build up between the legs The under garments are finished in ribbing located at their terminal ends.
摘要翻译：本发明公开了一种圆形针织内衣，所述下部衣物具有前腹部区域，从腰部向臀部区域延伸的后部，以及对应于外侧大腿区域的两个外部区域，每个所述区域包括编织的支撑面板，最小化不期望的隆起的外观后部区域还包括多个排水杯，以使身体的下半部分变薄和成形为较年轻的色调，并为臀部，臀部和腹部提供自然的外观。在优选实施例中，内衣由无缝织造的材料制成，例如轻质微纤维尼龙或LYCRA氨纶，并包括由棉和微纤维尼龙制成的角撑板，以防止腿部之间的积水。位于其终点。

7. 发明申请

WO2005074676A1 GENETIC MODIFICATION OF C57 MICE 审中-公开
标题翻译： C57 MICE的遗传修饰
公开(公告)号：WO2005074676A1
公开(公告)日：2005-08-18
申请号：PCT/US2005/003027
申请日：2005-01-27
申请人： INGENIOUS TARGETING LABORATORY, INC. , HE, Wei , WENG, Wei
发明人： HE, Wei , WENG, Wei
IPC分类号： A01K67/00
CPC分类号： A01K67/0275 , A01K2227/105 , C12N15/873 , C12N2517/10
摘要： The present invention relates generally to the field of generating genetically modified C57 mice. More particularly, the present invention pertains to 1) blastocyst-derived mouse embryonic stem cell (ES) cell lines including, but not limited to, the IC1, IC2, IAC1, IAC2, IAC3, IAC4, IAC5, IAC6, IAC7 or IAC8 ES cell line, 2) to efficient methods of making genetically modified C57 mice by introducing the modified C57 ES cells into the mouse blastocysts of either the same mouse strain and/or color of albino C57 strain, or other C57 strain, to generate genetically modified novel, useful and hereto unknown models of C57 mice, and to methods for identifying the chimerism of chimeras which can be not known by coat color.
摘要翻译：本发明一般涉及生产转基因C57小鼠的领域。更具体地说，本发明涉及1）囊胚衍生的小鼠胚胎干细胞（ES）细胞系，包括但不限于IC1，IC2，IAC1，IAC2，IAC3，IAC4，IAC5，IAC6，IAC7或IAC8 ES 细胞系，2）通过将修饰的C57ES细胞引入与白化C57株或其他C57株相同的小鼠品系和/或颜色的小鼠胚泡中来生产经遗传修饰的C57小鼠的有效方法，以产生转基因小鼠，有用的和未知的C57小鼠模型，以及用于鉴定嵌合体的嵌合体的方法，其可以不被外壳颜色所知。

8. 发明申请

WO2004021942A1 COMPOSITIONS COMPRISING MICROSPHERES WITH ANTI-INFLAMMATORY PROPERTIES FOR HEALING OF OCULAR TISSUES 审中-公开
标题翻译：包含具有用于治疗眼组织的抗炎性质的微球的组合物
公开(公告)号：WO2004021942A1
公开(公告)日：2004-03-18
申请号：PCT/US2003/027769
申请日：2003-09-04
申请人： POLYHEAL LTD , KARMALI, Rashida, A.
发明人： RITTER, Vladimir , RITTER, Marina , TENDLER, Mark , FEITELBERG, Lev
IPC分类号： A61F13/00
CPC分类号： A61K9/1635
摘要： The present invention relates to compositions of microspheres suitable for application to ocular injuries and inflammation, and to methods of use of the compositions alone or in combination with other agents in the prevention and treatment of ocular injuries and inflammation. The compositions, which increase the rate of healing, can be used to treat injuries and inflammation , including but not limited to those caused by foreign bodies, infections, burns, lesions, lacerations, ischemia, injuries from blunt trauma, traumatic hyphema, sympathetic ophthalmia, injuries from radiant energy, cataracts, corneal erosions or optic nerve injuries, and in procedures such as post-trabeculectomy (filtering surgery), post pterygium surgery; post ocular adnexa trauma and surgery, post intraocular surgery, post vitrectomy, post retinal detachment or post retinotomylectomy.
摘要翻译：本发明涉及适用于眼部损伤和炎症的微球的组合物，以及单独或与其它试剂组合使用组合物在预防和治疗眼损伤和炎症中的方法。增加愈合率的组合物可用于治疗损伤和炎症，包括但不限于由异物引起的感染，烧伤，损伤，撕裂，局部缺血，由钝性创伤引起的损伤，创伤性上皮，交感性眼炎，辐射能，白内障，角膜糜烂或视神经损伤的伤害，以及小梁切除术后（过滤手术），翼状ium肉手术后的手术; 眼后附件创伤和手术，眼内手术，玻璃体后切除术，视网膜后剥离术或视网膜切除术后切除术。

9. 发明申请

WO2002074574A1 SEATING DEVICE FOR MANEUVERING A BODY PART 审中-公开
标题翻译：用于移动身体部位的装置
公开(公告)号：WO2002074574A1
公开(公告)日：2002-09-26
申请号：PCT/US2002/003763
申请日：2002-02-07
申请人： RICHARD LEW INC. , LEW, Richard
发明人： LEW, Richard
IPC分类号： B60N2/02
CPC分类号： A61G15/00 , A61G15/02 , A61G15/12 , A61G15/125 , A61G2203/12
摘要： A seating device (1) for maneuvering a body part comprising a fully adjustable chair including a base assembly (11), an occupant supporting assembly and an elevator assembly (16) including drive mechanisms (15) for raising, lowering and tilting the occupant supporting assembly. The chair has a head rest (5), leg rest (6), chest rest and a plurality of arm rests (8). The chair has full adjustment in all axes: rotation around a vertical central axis; vertical height adjustment; fully adjustable seat back for proper lumbar support; and tilt of the seat. The base assembly includes a power unit biased toward the floor. The invention permits support of the occupant with a full range of adjustment so that the occupant can have proper positioning for selected medical procedures and body part positions.
摘要翻译：一种用于操纵身体部分的座椅装置（1），其包括完全可调节的椅子，其包括基座组件（11），乘员支撑组件和升降机组件（16），所述升降机组件包括用于升高，降低和倾斜乘员支撑部件。椅子有一个头枕（5），腿部休息（6），胸部休息和多个扶手（8）。椅子在所有轴上进行全面调整：围绕垂直中心轴旋转; 垂直高度调整; 完全可调的座椅靠背适合腰部支撑; 并倾斜座椅。基座组件包括偏向地板的动力单元。本发明允许对乘员进行全面的调整，以便乘客能够对选定的医疗程序和身体部位进行适当的定位。

10. 发明申请

WO2002050766A3 APPARATUS AND MANAGEMENT SYSTEM FOR EFFICIENT COLLECTION OF TRASH AND THE LIKE 审中-公开
公开(公告)号：WO2002050766A3
公开(公告)日：2002-06-27
申请号：PCT/US2001/049400
申请日：2001-12-17
申请人： ENVIRONMENTAL SYSTEMS, LTD. , KARMALI, Rashida, A. , NADIR, Ami
发明人： NADIR, Ami
IPC分类号： G06F17/60
摘要： An apparatus and electronic system for optimizing a trash pick-up schedule of a plurality of trash compactors is disclosed. The system comprises the steps of measuring the weight of trash in a trash compactor; calculating from said trash weight a targeted trash weight optimal for pick up; predicting a pick-up time based on said trash weight and said optimal trash weight; transmitting a signal to a fleet management unit; calculating a pick-up schedule for said plurality of trash compactors; generating a bill containing accounting information for said trash compactor unit; and generating a warning when said trash compactor unit malfunctions. The system permits efficient trash pick-up based on customer needs and accordingly provides a cost-effective and environmentally friendly system.

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