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1. 发明申请

WO2010138855A1 NOVEL COMPOUNDS AND SYNTHESIS OF TELLURIUM-DERIVATIZED OLIGONUCLEOTIDES FOR STRUCTURAL AND FUNCTIONAL STUDIES 审中-公开
标题翻译：新型化合物和用于结构和功能研究的细胞衍生的寡核苷酸的合成
公开(公告)号：WO2010138855A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036639
申请日：2010-05-28
申请人： SENA RESEARCH, INC. , HUANG, Zhen , SHENG, Jia , HASSAN, Abdalla, E. A.
发明人： HUANG, Zhen , SHENG, Jia , HASSAN, Abdalla, E. A.
IPC分类号： C07H19/073 , C07H21/04
CPC分类号： C07H19/073 , C07H5/08 , C07H21/04
摘要： Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of counducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.
摘要翻译：公开了式（I）的化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐。还公开了制备式（I）化合物，其衍生物或其互变异构体或所述化合物或所述互变异构体的药学上可接受的盐的方法。进一步公开的是产生药物发现和研究的方法包括在调查中应用式（I）化合物，其衍生物或互变异构体，或所述化合物或所述互变异构体的药学上可接受的盐。

2. 发明申请

WO2007101174A3 DIGITAL MAGNETOFLUIDIC DEVICES AND METHODS 审中-公开
公开(公告)号：WO2007101174A3
公开(公告)日：2007-09-07
申请号：PCT/US2007/062842
申请日：2007-02-27
申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , HERNANDEZ, Sonia, Melle , GOMEZ, Ana, N. , PICRAUX, S., Thomas , GUST, John, Devens , HAYES, Mark , LINDSAY, Solitaire , GARCIA, Antonio, A. , WANG, Joseph , VAZQUEZ-ALVAREZ, Terannie
发明人： HERNANDEZ, Sonia, Melle , GOMEZ, Ana, N. , PICRAUX, S., Thomas , GUST, John, Devens , HAYES, Mark , LINDSAY, Solitaire , GARCIA, Antonio, A. , WANG, Joseph , VAZQUEZ-ALVAREZ, Terannie
IPC分类号： B32B9/00
摘要： Disclosed are devices and methods for moving and controlling droplets of fluids on hydrophobic surfaces through the use of magnetic fields. For example, droplets can be moved, immobilized, dispensed, coalesced, and/or divided. Also disclosed is a digital magnetofluidic device comprising a hydrophobic surface; a magnetically active fluid droplet in contact with the surface; and a magnetic field coupled with at least a portion of the droplet. Also disclosed is a digital isoelectric focusing method using the devices and methods. Also disclosed are digital microelectrochemical detection methods and digital microelectrochemical reaction methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

3. 发明申请

WO2006105106A2 GENES CONTROLLING WINTER DORMANCY IN PERENNIALS AND USES THEREOF 审中-公开
标题翻译：控制冬季冬季运动的基因及其用途
公开(公告)号：WO2006105106A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011310
申请日：2006-03-28
申请人： CLEMSON UNIVERSITY RESEARCH FOUNDATION , BEILENBERG, Douglas G. , REIGHARD, Gregory L. , ABBOT, Albert G.
发明人： BEILENBERG, Douglas G. , REIGHARD, Gregory L. , ABBOT, Albert G.
IPC分类号： A01H5/00
CPC分类号： C07K14/4728 , C12N15/8261 , Y02A40/146
摘要： Provided herein are compositions and methods for modulating winter dormancy in a perennial plant using the herein disclosed winter dormancy genes and variants and homologues thereof.
摘要翻译：本文提供了使用本文公开的冬季休眠基因及其变体和同系物来调控多年生植物中冬季休眠的组合物和方法。

4. 发明申请

WO2006060079A3 METHODS AND COMPOSITIONS FOR TREATING NEPHROGENIC DIABETES INSIPIDUS 审中-公开
公开(公告)号：WO2006060079A3
公开(公告)日：2006-06-08
申请号：PCT/US2005/038231
申请日：2005-10-21
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , KISHORE, Bellamkonda, K. , CARLSON, Noel, G. , KOHAN, Donald, E. , NELSON, Raoul, D.
发明人： KISHORE, Bellamkonda, K. , CARLSON, Noel, G. , KOHAN, Donald, E. , NELSON, Raoul, D.
IPC分类号： A61K31/10
摘要： Disclosed are compositions and methods for treating nephrogenic diabetes insipidus and for induction of diuretic effect.

5. 发明申请

WO2006042143A2 GLYCINE RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH GLYCINE RIBOSWITCHES 审中-公开
标题翻译：甘氨酸核糖开关，用于其的方法以及与甘氨酸核糖开关一起使用的组合物
公开(公告)号：WO2006042143A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036218
申请日：2005-10-07
申请人： YALE UNIVERSITY , BREAKER, Ronald, R. , BARRICK, Jeffrey , MANDAL, Maumita
发明人： BREAKER, Ronald, R. , BARRICK, Jeffrey , MANDAL, Maumita
IPC分类号： A61K48/00
CPC分类号： C12N15/85 , C12N15/115 , C12N15/67 , C12N2310/16 , C12N2310/3519 , C12N2840/002 , C12N2840/102 , C12N2840/55
摘要： It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural "riboswitches" (created by using various nucleic acid engineering strategies) can be employed as designer genetic switches that are controlled by specific effector compounds. Such effector compounds that activate a riboswitch are referred to herein as trigger molecules. The natural switches are targets for antibiotics and other small molecule therapies. In addition, the architecture of riboswitches allows actual pieces of the natural switches to be used to construct new non-immunogenic genetic control elements, for example the aptamer (molecular recognition) domain can be swapped with other non-natural aptamers (or otherwise modified) such that the new recognition domain causes genetic modulation with user-defined effector compounds. The changed switches become part of a therapy regimen-turning on, or off, or regulating protein synthesis. Newly constructed genetic regulation networks can be applied in such areas as living biosensors, metabolic engineering of organisms, and in advanced forms of gene therapy treatments.
摘要翻译：已经发现某些天然mRNA用作代谢物敏感性遗传开关，其中RNA直接结合小有机分子。该结合过程改变了mRNA的构象，其通过各种不同的机制引起基因表达的改变。这些天然“核糖开关”的修饰版本（通过使用各种核酸工程策略创建）可以用作受特定效应物化合物控制的设计者遗传开关。这种激活核糖开关的效应物化合物在本文中被称为触发分子。天然开关是抗生素和其他小分子疗法的靶标。另外，核糖开关的结构允许使用天然开关的实际片段来构建新的非免疫原性遗传控制元件，例如适体（分子识别）结构域可以与其他非天然适体交换（或以其他方式修饰）使得新的识别域导致用户定义的效应子化合物的遗传调节。改变的开关成为治疗方案的一部分 - 开启，关闭或调节蛋白质合成。新构建的基因调控网络可应用于生物传感器，生物体代谢工程以及基因治疗等高级形式领域。

6. 发明申请

WO2004071461A3 TRA16 A TR4/TR2 REPRESSOR 审中-公开
公开(公告)号：WO2004071461A3
公开(公告)日：2004-08-26
申请号：PCT/US2004/004445
申请日：2004-02-13
申请人： UNIVERSITY OF ROCHESTER , CHANG, Chawnshang
发明人： CHANG, Chawnshang
IPC分类号： A61K38/00 , A61K38/16 , C07K2/00 , C07K14/00
摘要： Disclosed are compositions and methods related to TR2, TR4, androgen receptor, and estrogen receptor, and TRA16 and the interactions between these proteins.

7. 发明申请

WO2009143150A2 INTESTINAL ALKALINE PHOSPHATASE MODULATORS AND USES THEREOF 审中-公开
标题翻译：碱性碱性磷酸酶调节剂及其用途
公开(公告)号：WO2009143150A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/044511
申请日：2009-05-19
申请人： BURNHAM INSTITUTE FOR MEDICAL RESEARCH , MILLAN, Jose, Luis , NARISAWA, Sonoko , SERGIENKO, Eduard
发明人： MILLAN, Jose, Luis , NARISAWA, Sonoko , SERGIENKO, Eduard
IPC分类号： A61K31/416
CPC分类号： A61K31/415 , A61K31/404 , A61K31/416 , A61K31/4162 , A61K31/4196
摘要： Disclosed are modulators, i.e., activators and inhibitors, of Intestinal Alkaline Phosphatase (IAP). Also disclosed are methods for treating bacterial infections of the intestinal tract and methods for maintaining the health of the intestinal tract using IAP activators. Further disclosed are methods to assist in weight gain of emaciated patients and those having reduced or negligible fat absorption using IAP inhibitors.
摘要翻译：公开了肠内碱性磷酸酶（IAP）的调节剂，即活化剂和抑制剂。还公开了治疗肠道细菌感染的方法和使用IAP激活剂维持肠道健康的方法。进一步公开的是帮助减轻患者体重增加的方法和使用IAP抑制剂减少或可忽略的脂肪吸收的方法。

8. 发明申请

WO2008097859A2 APPARATUS FOR MEASURING CRITICAL FLICKER FUSION FREQUENCY AND METHODS OF USING SAME 审中-公开
标题翻译：用于测量关键闪点熔融频率的装置及其使用方法
公开(公告)号：WO2008097859A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/052832
申请日：2008-02-01
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , KATZ, Bradley, J. , BORGMEIER, Paul, R.
发明人： KATZ, Bradley, J. , BORGMEIER, Paul, R.
IPC分类号： G06T7/20
CPC分类号： A61B5/161
摘要： Apparatuses and methods are provided for measuring the critical flicker fusion frequency of a subject. The apparatus in one aspect comprises two or more light sources, each flickering at a different predetermined frequency. The subject selects one light source from an array of light sources defining a first range of frequencies, the selection representing the light source of lowest frequency that appears as fused to the subject. The frequencies of the light sources are adjusted to second predetermined frequencies defining a second range. The subject selects the light source of lowest frequency that appears as fused to the subject. The frequency value of the second selection can be assigned as the subject's critical flicker fusion frequency.
摘要翻译：提供了用于测量受试者的关键闪烁融合频率的装置和方法。一个方面中的装置包括两个或更多个光源，每个光源以不同的预定频率闪烁。受试者从限定第一频率范围的光源阵列中选择一个光源，该选择代表出现为与被摄体融合的最低频率的光源。将光源的频率调整到限定第二范围的第二预定频率。被摄对象选择出现与被摄体融合的最低频率的光源。可以将第二选择的频率值分配为被摄体的临界闪烁融合频率。

9. 发明申请

WO2007061876A2 METHODS AND COMPOSITIONS INVOLVING INTRINSIC GENES 审中-公开
标题翻译：涉及本征基因的方法和组合物
公开(公告)号：WO2007061876A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/044737
申请日：2006-11-17
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , ELLIS, Matthew , PEROU, Charles, M. , ERNARD, Philip
发明人： ELLIS, Matthew , PEROU, Charles, M. , ERNARD, Philip
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Disclosed are compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer.
摘要翻译：公开了与检测和分类癌症有关的与内在基因组和方法和组合物相关的组合物和方法。

10. 发明申请

WO2010148212A2 SHORT TELOMERE LENGTH ON CHROMOSOME 9P IS STRONGLY ASSOCIATED WITH BREAST CANCER RISK 审中-公开
标题翻译：染色体9P的长度长度与乳腺癌风险密切相关
公开(公告)号：WO2010148212A2
公开(公告)日：2010-12-23
申请号：PCT/US2010/039013
申请日：2010-06-17
申请人： GEORGETOWN UNIVERSITY , ZHENG, Yun-ling
发明人： ZHENG, Yun-ling
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/52
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Disclosed are compositions and methods related to assessing the risk of cancer, such as breast cancer, through analyzing the length of telomeres, such as chromosome 9p telomere, such as the short arm of the 9p telomere. If the 9p arm is shorter than normal, the risk of cancer is increased.
摘要翻译：公开了通过分析端粒长度（例如9p端粒末端，例如9p端粒短臂）来评估癌症风险（例如乳腺癌）的组合物和方法。如果9p臂比正常时短，癌症的风险就会增加。

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