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1. 发明申请

WO2018218137A1 PD-1 AND CTLA-4 DUAL INHIBITOR PEPTIDES 审中-公开
公开(公告)号：WO2018218137A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/034625
申请日：2018-05-25
申请人： LEIDOS, INC.
发明人： GUTIERREZ, Gabriel M. , KOTRAIAH, Vinayaka , PHARES, Timothy , PANNUCCI, James
IPC分类号： C07K14/705 , A61K38/17
摘要： This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

2. 发明申请

WO2017027665A1 TREATMENT OF CANCER USING A COMBINATION OF ENZALUTAMIDE AND A CYP3A4 INDUCER 审中-公开
标题翻译：使用环丙沙星和CYP3A4诱导剂联合治疗癌症
公开(公告)号：WO2017027665A1
公开(公告)日：2017-02-16
申请号：PCT/US2016/046476
申请日：2016-08-11
申请人： MEDIVATION PROSTATE THERAPEUTICS, INC.
发明人： GIBBONS, Jacqueline
IPC分类号： A61K31/4166 , A61K31/438 , A61K31/496 , A61K31/515 , A61K31/55 , A61K45/06 , A61P35/00
CPC分类号： A61K31/4166 , A61K31/438 , A61K31/496 , A61K31/515 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： This disclosure provides a dosage regimen for co-administration of enzalutamide and a strong CYP3A4 inducer in the treatment of cancer.
摘要翻译：该公开内容提供了用于共同给予恩扎洛胺和强CYP3A4诱导剂治疗癌症的剂量方案。

3. 发明申请

WO2013067151A1 TREATMENT METHODS USING DIARYLTHIOHYDANTOIN DERIVATIVES 审中-公开
标题翻译：使用二乙醇胺衍生物的治疗方法
公开(公告)号：WO2013067151A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/063016
申请日：2012-11-01
申请人： MEDIVATION PROSTATE THERAPEUTICS, INC.
发明人： PROTTER, Andrew, A. , HUNG, David, T. , CHAKRAVARTY, Sarvajit , BERNALES, Sabastian
IPC分类号： A01N43/54 , A61K45/00
CPC分类号： A61K31/496 , A61K31/4166 , A61K31/4439 , A61K39/00
摘要： The disclosure describes compounds useful for treating disorders involving androgen, estrogen, and/or progesterone receptors.
摘要翻译：本公开描述了可用于治疗涉及雄激素，雌激素和/或孕激素受体的疾病的化合物。

4. 发明申请

WO2013066440A1 TREATMENT OF BREAST CANCER 审中-公开
标题翻译：治疗乳腺癌
公开(公告)号：WO2013066440A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/048471
申请日：2012-07-27
申请人： MEDIVATION PROSTATE THERAPEUTICS, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO , PROTTER, Andrew A. , RICHER, Jennifer , COCHRANE, Dawn
发明人： PROTTER, Andrew A. , RICHER, Jennifer , COCHRANE, Dawn
IPC分类号： A01N47/28 , A61K31/17
CPC分类号： A61K31/4184 , A61K31/4166
摘要： The disclosure describes the use of one or more compounds that fall within the scope of one or more of structural formulae I, II, III, IV, V, or VI for treating triple negative breast Compounds useful for treating breast cancer include those compounds of formulae I, II, III, IV, V, or VI that inhibit proliferation of breast cancer cells and/or lead to the death of breast cancer cells, especially triple negative breast cancer.
摘要翻译：本公开描述了一种或多种落入结构式I，II，III，IV，V或VI中的一种或多种范围内的化合物在治疗三阴性乳房化合物中的用途，治疗乳腺癌包括抑制乳腺癌细胞增殖和/或导致乳腺癌细胞死亡，尤其是三阴性乳腺癌的式I，II，III，IV，V或VI的化合物。

5. 发明申请

WO2009073788A1 COMPOSITIONS AND METHODS FOR TREATING MENOPAUSAL FEMALES 审中-公开
标题翻译：用于治疗男性阴茎的组合物和方法
公开(公告)号：WO2009073788A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085540
申请日：2008-12-04
申请人： FIRESTONE, Leigh, H.
发明人： FIRESTONE, Leigh, H.
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： A61K31/445
摘要： Compositions comprising vanilloid receptor ligands are used for treating human females experiencing symptoms of menopause. The vanilloid receptor ligand composition can be a sustained release formulation of the drug in order to control the release of the drug to the patient over an extended period of time. Methods of treating menopausal patients include administering compositions comprising a vanilloid receptor ligand.
摘要翻译：包含香草素受体配体的组合物用于治疗经历更年期症状的人类雌性。香草素受体配体组合物可以是药物的持续释放制剂，以便在更长的时间内控制药物释放给患者。治疗绝经患者的方法包括施用包含香草素受体配体的组合物。

6. 发明申请

WO2009039484A1 TREATMENT AND PREVENTION OF ISCHEMIC BRAIN INJURY 审中-公开
标题翻译：治疗和预防脑缺血损伤
公开(公告)号：WO2009039484A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/077201
申请日：2008-09-22
申请人： THE JOHNS HOPKINS UNIVERSITY , DORÉ, Sylvain
发明人： DORÉ, Sylvain
IPC分类号： C12Q1/00
CPC分类号： G01N33/88 , G01N2800/2871
摘要： The invention provides methods of identifying agents for treating and preventing ischemic brain injury.
摘要翻译：本发明提供鉴定用于治疗和预防缺血性脑损伤的药剂的方法。

7. 发明申请

WO2009029707A1 METABOLIC REGULATORS 审中-公开
标题翻译：代谢调节剂
公开(公告)号：WO2009029707A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/074597
申请日：2008-08-28
申请人： PLANT SENSORY SYSTEM, LLC. , TURANO, Frank J. , TURANO, Kathleen A.
发明人： TURANO, Frank J. , TURANO, Kathleen A.
IPC分类号： C07K1/00
CPC分类号： C12N15/62 , C07K2319/00 , C12N15/8257
摘要： The present invention provides methods to make soluble or membrane-anchored metabolic regulators for use in prokaryotes or eukaryotes. The present invention provides methods of expressing novel protein constructs that bind to specific metabolites to control their availability in the cell. The invention utilizes bacterial periplasmic binding proteins, or domains from prokaryotic and eukaryotic proteins that are functionally similar to the bacterial periplasmic binding proteins, fused together and/or fused to a peptide that encodes a transmembrane domain. Changes in metabolite availability will result in altered metabolism or receptor activity to improve growth, yield, crop quality, or tolerance to biotic and abiotic stress.
摘要翻译：本发明提供了制备用于原核生物或真核生物的可溶性或膜锚定代谢调节剂的方法。本发明提供了表达与特异性代谢物结合以控制其在细胞中的可用性的新型蛋白质构建体的方法。本发明利用与编码跨膜结构域的肽融合在一起和/或融合的细菌周质结合蛋白的功能上类似的原核和真核蛋白质的细菌周质结合蛋白或结构域。代谢物可用性的变化将导致代谢或受体活性的改变，以改善生长，产量，作物质量或对生物和非生物胁迫的耐受性。

8. 发明申请

WO2007050734A1 PROTEIN KINASE A REPORTERS USEFUL IN HIGH THROUGHPUT ASSAYS 审中-公开
标题翻译：蛋白激酶在高通量测定中有用的报告人
公开(公告)号：WO2007050734A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/041741
申请日：2006-10-26
申请人： THE JOHNS HOPKINS UNIVERSITY , ZHANG, Jin , NI, Qiang , ALLEN, Michael, David
发明人： ZHANG, Jin , NI, Qiang , ALLEN, Michael, David
IPC分类号： C07K14/435
CPC分类号： C07K14/43595 , Y10S436/80
摘要： Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially therapeutic compounds.
摘要翻译：用于获得具有高空间和时间分辨率的蛋白激酶A活性测量的蛋白激酶A报告可用于高通量测定以鉴定潜在的治疗性化合物。

9. 发明申请

WO2002066684A2 GENOME-BASED PERSONALIZED MEDICINE 审中-公开
标题翻译：基于基因的个人化医学
公开(公告)号：WO2002066684A2
公开(公告)日：2002-08-29
申请号：PCT/US2002/004686
申请日：2002-02-19
申请人： THE JOHNS HOPKINS UNIVERSITY , VOGELSTEIN, Bert , KINZLER, Kenneth, W. , YAN, Hai , PAPADOPOULOS, Nickolas
发明人： VOGELSTEIN, Bert , KINZLER, Kenneth, W. , YAN, Hai , PAPADOPOULOS, Nickolas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12N2503/00 , C12Q2600/106 , C12Q2600/156
摘要： Individual alleles can be isolated from every chromosome within somatic cell hybrids generated from a single fusion event. Nucleic acids or proteins from the hybrids can be analyzed for polymorphisms to provide unambiguous determinations. Information thus obtained can be used to develop and implment personalized medical interventions for individuals having particular polymorphic markers.
摘要翻译：可以从单个融合事件产生的体细胞杂交体内的每个染色体分离个体等位基因。可以分析来自杂交体的核酸或蛋白质的多态性以提供明确的测定。由此获得的信息可用于为具有特定多态性标记的个体开发和隐含个性化医疗干预。

10. 发明申请

WO2002064739A2 A CYTOKINE RELATED STRUCTURALLY TO IL-17 审中-公开
标题翻译：与IL-17结构相关的细胞因子
公开(公告)号：WO2002064739A2
公开(公告)日：2002-08-22
申请号：PCT/US2002/003858
申请日：2002-02-11
申请人： JOHNS HOPKINS UNIVERSITY , HUANG, Shau-Ku , GERMINO, Gregory , ESSAYAN, David, M. , ONUCHIC, Luiz, F. , KAWAGUCHI, Mio , LI, Xiao-Dong
发明人： HUANG, Shau-Ku , GERMINO, Gregory , ESSAYAN, David, M. , ONUCHIC, Luiz, F. , KAWAGUCHI, Mio , LI, Xiao-Dong
IPC分类号： C12N
CPC分类号： C07K14/54 , A61K38/00
摘要： The cytokine ML-1 is a target for treating airway inflammation. Candidate therapeutic agents for treating airway inflammation can be screened for the ability to bind to an ML-1 protein or polynucleotide, from the ability to decrease functional properties of ML-1, or for the ability to decrease ML-1 gene expression. Pharmaceutical compositions comprising such reagents can be used to treat airway inflammation associated with a variety of lung disorders, such as asthma, chronic obstructive pulmonary disease, emphysema, allergic inflammatory responses, and cystic fibrosis.
摘要翻译：细胞因子ML-1是治疗气道炎症的靶标。用于治疗气道炎症的候选治疗剂可以筛选与ML-1蛋白或多核苷酸结合的能力，从降低ML-1的功能性能或降低ML-1基因表达的能力的能力。包含这些试剂的药物组合物可用于治疗与多种肺部疾病相关的气道炎症，例如哮喘，慢性阻塞性肺病，肺气肿，过敏性炎症反应和囊性纤维化。

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