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1. 发明申请

WO2022163384A1 MEASURING METHOD AND MEASURING DEVICE FOR INFLAMMATION INDEX PARAMETER OF BLOOD SAMPLE 审中-公开
公开(公告)号：WO2022163384A1
公开(公告)日：2022-08-04
申请号：PCT/JP2022/001079
申请日：2022-01-14
申请人： NIHON KOHDEN CORPORATION
发明人： NAGAI, Yutaka
IPC分类号： G01N33/68 , G01N15/00 , G01N33/49 , G01N33/80
摘要： A method for measuring an inflammation index parameter of a blood sample includes: measuring an erythrocyte sedimentation rate (ESR) from the blood sample; measuring an inflammation marker different from the ESR from the blood sample; and calculating an inflammation index parameter, which serves as an index of inflammation, based on the measured value of the ESR and the measured value of the inflammation marker.

2. 发明申请

WO2021256377A1 CELL CULTURE SUBSTRATE 审中-公开
公开(公告)号：WO2021256377A1
公开(公告)日：2021-12-23
申请号：PCT/JP2021/022134
申请日：2021-06-10
申请人： TERUMO KABUSHIKI KAISHA
发明人： XU, Zhe , HIRAHARA, Ichiro , ANZAI, Takao
IPC分类号： C12M1/00 , C12M23/20
摘要： The present invention is to provide a means for improving cell adhesion to a hydrophobic polymer substrate. Provided is a cell culture substrate comprising a coating layer containing a polymer having a structural unit (1) derived from furfuryl (meth)acrylate represented by the following Formula (1) and having a weight average molecular weight of 200,000 or more, on at least one surface of a polymer substrate having surface free energy of less than 33 mJ/m2.

3. 发明申请

WO2020036205A1 CELL CULTURE SUBSTRATE 审中-公开
公开(公告)号：WO2020036205A1
公开(公告)日：2020-02-20
申请号：PCT/JP2019/031985
申请日：2019-08-14
申请人： TERUMO KABUSHIKI KAISHA
发明人： ANZAI, Takao , HIRAHARA, Ichiro
IPC分类号： C12M1/00
摘要： To provide a means capable of obtaining further excellent cellular adhesiveness than in a case where a surface of a cell culture substrate (cell culture vessel) is coated using polytetrahydrofurfuryl acrylate (PTHFA). Provided is a cell culture substrate comprising a coating layer on at least one side of a polymer substrate, wherein the coating layer includes a copolymer comprising more than 20% by mole and less than 100% by mole of a structural unit (1) derived from furfuryl (meth)acrylate represented by Formula (1) and more than 0% by mole and less than 80% by mole of a structural unit (2) derived from ethylenically unsaturated monomer having a hydroxyl group (the total of the structural unit (1) and the structural unit (2) is 100% by mole).

4. 发明申请

WO2018225229A1 PARENTERAL AQUEOUS PHARMACEUTICAL COMPOSITION 审中-公开
公开(公告)号：WO2018225229A1
公开(公告)日：2018-12-13
申请号：PCT/JP2017/021392
申请日：2017-06-08
申请人： TERUMO KABUSHIKI KAISHA , PHOSPHAGENICS LIMITED
发明人： IWAKIRI, Chisato , EL-TAMIMY, Mahmoud , GAVIN, Paul
IPC分类号： A61K9/00 , A61K47/22 , A61K47/26 , A61K9/08 , A61K31/05
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/05 , A61K47/22 , A61K47/26
摘要： To provide a parenteral aqueous pharmaceutical composition containing a highly lipid-soluble drug which has suppressed occurrence of white cloudiness or precipitation even after the composition is stored at a room temperature (i.e., 1 to 30 o C). A parenteral aqueous pharmaceutical composition containing propofol, a solubilizing agent, and water in which the solubilizing agent contains polysorbate 80, polysorbate 20, mono(tocopheryl) phosphate, and di(tocopheryl) phosphate, total content of polysorbate 80 and polysorbate 20 is 20 w/v% or less, content mass ratio of polysorbate 80 relative to polysorbate 20 (content mass of polysorbate 80/content mass of polysorbate 20) is 1.80 to 7.0, total content of mono(tocopheryl) phosphate and di(tocopheryl) phosphate is more than 0.20 w/v% but less than 0.74 w/v%, and pH is more than 5.0 but less than 7.0.

5. 发明申请

WO2009048157A1 SURFACE TREATMENT METHOD FOR WATER-ABSORBENT RESIN 审中-公开
标题翻译：吸水树脂的表面处理方法
公开(公告)号：WO2009048157A1
公开(公告)日：2009-04-16
申请号：PCT/JP2008/068688
申请日：2008-10-08
申请人： NIPPON SHOKUBAI CO., LTD. , MITSUKAMI, Yoshiro , IWAMURA, Taku
发明人： MITSUKAMI, Yoshiro , IWAMURA, Taku
IPC分类号： C08J3/24 , C08J3/12
CPC分类号： C08J3/245 , C08J2300/14
摘要： Provided is a method that is capable of producing a surface treated water-absorbent resin excellent in water-absorbing characteristics (in particular, absorption capacity against pressure or fluid permeability), at low temperature and in a short period of time, at low cost and by a safe method. In a surface treatment method for a water-absorbent resin having a surface cross-linking step for subjecting a water-absorbent resin to surface cross-linking in the presence of a radical polymerization initiator and water, is provided. In the surface cross-linking step, activated energy beam having a wavelength of equal to or shorter than ultraviolet ray is not irradiated to a reaction system of surface cross-linking, and the surface cross-linking step is carried out so that water content of the water-absorbent resin after the surface cross-linking step is larger than that before the surface cross-linking step.
摘要翻译：提供一种能够以低成本制造在低温和短时间内具有优异的吸水特性（特别是压力或流体渗透性的吸收能力）的表面处理吸水性树脂的方法，以及通过安全的方法。在具有用于在自由基聚合引发剂和水的存在下对吸水性树脂进行表面交联的表面交联步骤的吸水性树脂的表面处理方法。在表面交联工序中，波长等于或小于紫外线的活化能量束不照射到表面交联反应体系，进行表面交联步骤，使得表面交联工序后的吸水性树脂大于表面交联工序前的吸水性树脂。

6. 发明申请

WO2021157710A1 PARTICLE ANALYSIS METHOD AND PARTICLE ANALYZER 审中-公开
公开(公告)号：WO2021157710A1
公开(公告)日：2021-08-12
申请号：PCT/JP2021/004376
申请日：2021-02-05
申请人： NIHON KOHDEN CORPORATION
发明人： NAGAI, Yutaka
IPC分类号： G01N15/00 , G01N21/00 , G01N15/02 , G01N15/05 , G01N21/64 , G01N15/14 , G01N33/48 , G01N33/80 , G01N33/50
摘要： Provided is a means capable of obtaining more clinically useful information when particles contained in a blood sample are analyzed using a metachromatic orthochromatic dye. In a particle analysis method of analyzing particles contained in a blood sample, the particles are stained with a metachromatic orthochromatic dye, the stained particles are irradiated with light, intensity of a first fluorescence derived from a stacking component of the metachromatic orthochromatic dye and intensity of a second fluorescence derived from an intercalation component of the metachromatic orthochromatic dye are measured, the first fluorescence and the second fluorescence being emitted by each particle contained in the blood sample, the intensity of the first fluorescence and the intensity of the second fluorescence emitted by each of the particles are normalized by the size of each of the particles to obtain a fluorescence concentration of each of the first fluorescence and the second fluorescence in each of the particles, each of the particles is clustered into a plurality of particle clusters including at least two of an erythrocyte cluster, a platelet cluster and a nucleated cell cluster, in a two-dimensional plot of the fluorescence concentration obtained by the normalization, and an RNA amount histogram in which the intensity of the first fluorescence is a class and a DNA amount histogram in which the intensity of the second fluorescence is a class are created for at least one particle cluster included in the plurality of particle clusters.

7. 发明申请

WO2020036206A1 CELL CULTURE SUBSTRATE 审中-公开
公开(公告)号：WO2020036206A1
公开(公告)日：2020-02-20
申请号：PCT/JP2019/031986
申请日：2019-08-14
申请人： TERUMO KABUSHIKI KAISHA
发明人： ANZAI,Takao , HIRAHARA, Ichiro
IPC分类号： C12M1/00
摘要： The invention is to provide a means capable of achieving both cellular adhesiveness and antithrombogenicity with balance. Provided is a cell culture substrate comprising a coating layer on at least one side of a polymer substrate, wherein the coating layer includes a copolymer having 5 to 65% by mole of a structural unit (1) derived from alkoxyalkyl (meth)acrylate of Formula (1) and 95 to 35% by mole of a structural unit (2) derived from furfuryl (meth)acrylate of Formula (2) (the total of the structural unit (1) and the structural unit (2) is 100% by mole).

8. 发明申请

WO2013140734A1 X-RAY TRANSMISSIVE BIO-ELECTRODE 审中-公开
标题翻译： X射线透射生物电极
公开(公告)号：WO2013140734A1
公开(公告)日：2013-09-26
申请号：PCT/JP2013/001497
申请日：2013-03-08
申请人： NIHON KOHDEN CORPORATION
发明人： ODAKA, Ryugo
IPC分类号： A61N1/04
CPC分类号： A61N1/046
摘要： [PROBLEM] To provide a bio-electrode using an electrode element which enables to transmit X-rays, has corrosion resistance against the conductive gel, which is a component member of the bio-electrode, and also is low price. [SOLUTION] It is attained by a bio-electrode containing: conductive gel; an electrode element; a cable for electrically connecting the bio-electrode and external devices; wherein the electrode element is a thin film formed by using an Al alloy which transmits X-rays and has corrosion resistance against the conductive gel. [SELECTED DRAWING]: FIG. 1
摘要翻译： [问题]为了提供使用能够透射X射线的电极元件的生物电极，对作为生物电极的成分的导电性凝胶具有耐腐蚀性，并且价格低廉。 [解决方案]通过含有导电凝胶的生物电极实现; 电极元件; 用于电连接生物电极和外部装置的电缆; 其中所述电极元件是通过使用透射X射线并对导电凝胶具有耐腐蚀性的Al合金形成的薄膜。 [选择的图]： 1

9. 发明申请

WO2021157711A1 PARTICLE ANALYSIS METHOD AND PARTICLE ANALYZER 审中-公开
公开(公告)号：WO2021157711A1
公开(公告)日：2021-08-12
申请号：PCT/JP2021/004377
申请日：2021-02-05
申请人： NIHON KOHDEN CORPORATION
发明人： NAGAI, Yutaka
IPC分类号： G01N15/14 , G01N33/48 , G01N33/50 , G01N33/80
摘要： Provided is a means capable of obtaining more clinically useful information when particles contained in a blood sample are analyzed using a metachromatic orthochromatic dye. In a particle analysis method of analyzing particles contained in a blood sample, the particles are stained with a metachromatic orthochromatic dye, the stained particles are irradiated with light, intensity of a first fluorescence derived from a stacking component of the metachromatic orthochromatic dye and intensity of a second fluorescence derived from an intercalation component of the metachromatic orthochromatic dye are measured, the first fluorescence and the second fluorescence being emitted by each particle contained in the blood sample, the intensity of the first fluorescence and the intensity of the second fluorescence emitted by each of the particles are normalized by the size of each of the particles to obtain a fluorescence concentration of each of the first fluorescence and the second fluorescence in each of the particles, each of the particles is clustered into a plurality of particle clusters including at least two of an erythrocyte cluster, a platelet cluster and a nucleated cell cluster, in a two-dimensional plot of the fluorescence concentration obtained by the normalization, and a size histogram in which the size of each particle included in the particle cluster is a class is created for at least one particle cluster included in the plurality of particle clusters.

10. 发明申请

WO2021054262A1 METHOD FOR EVALUATING A COATING STATE OF EITHER AN ADSORBENT OF A SAMPLE PROTEIN OR AN ADSORPTION STATE OF A SAMPLE PROTEIN 审中-公开
公开(公告)号：WO2021054262A1
公开(公告)日：2021-03-25
申请号：PCT/JP2020/034523
申请日：2020-09-11
申请人： TERUMO KABUSHIKI KAISHA
发明人： XU, Zhe , ANZAI, Takao
IPC分类号： G01N21/64 , G01N33/543 , G01N21/77 , G01N21/78
摘要： A method for evaluating a coating state of either an adsorbent of a sample protein (40) or an adsorption state of the sample protein, the method comprising: providing a polymer substrate 1 (10) having a coating layer (20) containing the adsorbent of the sample protein and a fluorescent dye formed on at least one surface of the polymer substrate, and irradiating the substrate 1 with light to detect a color state 1 of the substrate 1; providing a polymer substrate 2 having a first coating layer (20) containing the adsorbent of the sample protein and a fluorescent dye and a second coating layer (30) containing a protein detection reagent (31) which conjugates with the sample protein, the first and second coating layers being sequentially formed on at least one surface of the polymer substrate, and irradiating the substrate 2 with light to detect a color state 2 of the substrate 2; providing a polymer substrate 3 having a coating layer containing the adsorbent of the sample protein and a fluorescent dye formed on at least one surface of the polymer substrate, introducing a sample containing the sample protein, which absorbs the irradiated light, onto the substrate 3 to obtain a substrate 4, and irradiating the substrate 4 with light to detect a color state 3 of the substrate 4; providing a polymer substrate 5 having a coating layer containing the adsorbent of the sample protein and a fluorescent dye formed on at least one surface of the polymer substrate, introducing a sample containing the sample protein (40) onto the substrate 5 to obtain a substrate 6, introducing the protein detection reagent (31) which has a higher degree of light absorption than that of the sample protein and which conjugates with the sample protein onto the polymer substrate 6 to obtain a substrate 7, and irradiating the substrate 7 with light to detect a color state 4 of the substrate 7;and comparing the color state 4 with the color states 1, 2 or 3 to evaluate a coating state of the adsorbent of the sample protein or the adsorption state of the sample protein.

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