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1. 发明申请

WO2005021779A1 MASS SPECTROMETRY METHODS FOR SIMULTANEOUS DETECTION OF METABOLIC ENZYME ACTIVITY AND METABOLITE LEVELS 审中-公开
标题翻译：用于同时检测代谢酶活性和代谢物水平的质谱方法
公开(公告)号：WO2005021779A1
公开(公告)日：2005-03-10
申请号：PCT/US2004/028238
申请日：2004-08-30
申请人： PERKINELMER LAS, INC. , CERDA, Blas
发明人： CERDA, Blas
IPC分类号： C12Q1/00
CPC分类号： C12Q1/00 , G01N33/6893 , G01N2800/04
摘要： The present invention provides a method for detecting a metabolic disorder in an individual. The method involves (a) contacting a sample containing (i) one or more metabolically indicative enzymes and (ii) one or more metabolic analytes, with one or more substrates for said one or more enzymes to produce a reaction admixture, under conditions in which at least one of said enzymes is capable of acting on a corresponding substrate to generate at least one product; (b) contacting said reaction admixture with a reagent that inhibits the ability of said one or more enzymes to act on a corresponding substrate, wherein said one or more metabolic analytes and said at least one product are soluble in said reagent; to produce a test sample and (c) determining the presence or amount of said one or more metabolic analytes and said at least one product contained in said test sample using mass spectrometry, wherein a determined presence or amount of said one or more metabolic analytes and said at least one product correlates with presence or absence of said metabolic disorder.
摘要翻译：本发明提供一种检测个体代谢紊乱的方法。该方法包括：（a）将含有（i）一种或多种代谢指示酶的样品和（ii）一种或多种代谢分析物与一种或多种用于所述一种或多种酶的底物接触以产生反应混合物，其条件是所述酶中的至少一种能够作用于相应的底物以产生至少一种产物; （b）使所述反应混合物与抑制所述一种或多种酶作用于相应底物的能力的试剂接触，其中所述一种或多种代谢分析物和所述至少一种产物可溶于所述试剂中; 以产生测试样品和（c）使用质谱法测定所述测试样品中所含的一种或多种代谢分析物和所述至少一种产品的存在或量，其中确定的所述一种或多种代谢分析物的存在或量，以及所述至少一种产物与所述代谢紊乱的存在或不存在相关。

2. 发明申请

WO2004087054A2 METHODS FOR MODULATING GASTRIC SECRETION USING PROKINETICIN RECEPTOR ANTAGONISTS. 审中-公开
标题翻译：使用ProKinein受体拮抗剂调节胃分泌的方法。
公开(公告)号：WO2004087054A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/009255
申请日：2004-03-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ZHOU, Quo-Yong
发明人： ZHOU, Quo-Yong
IPC分类号： A61K
CPC分类号： C07K14/47
摘要： The invention provides methods of modulating gastric acid secretion by administering an amount of a prokineticin receptor antagonist effective to alter one or more indicia of gastric acid secretion, wherein the antagonist contains an amino acid sequence at least 80% identical to amino acids to 7 to 77 of SEQ ID NO:3, which includes (a) the 10 conserved cysteine residues of SEQ ID NO:3, and (b) from 0 to 9 of amino acids 78 to 86 of SEQ ID NO:3, wherein amino acids 1 to 6 of the antagonist do not consist of amino acids AVITGA (SEQ ID NO:21). In another embodiment, the antagonist contains an amino acid sequence at least 80% identical to amino acids to 7 to 77 of SEQ ID NO:6, which includes (a) the 10 conserved cysteine residues of SEQ ID NO:6, and (b) from 0 to 4 of amino acids 78 to 81 of SEQ ID NO:6, wherein amino acids 1 to 6 of the antagonist do not consist of amino acids AVITGA (SEQ ID NO:21).
摘要翻译：本发明提供了通过施用一定量的有效改变一种或多种胃酸分泌标记的促动素原受体拮抗剂调节胃酸分泌的方法，其中所述拮抗剂含有与氨基酸至7至77个至少80％相同的氨基酸序列其包含（a）SEQ ID NO：3的10个保守的半胱氨酸残基和（b）SEQ ID NO：3的氨基酸78至86的0至9，其中氨基酸1至 6的拮抗剂不由氨基酸AVITGA（SEQ ID NO：21）组成。在另一个实施方案中，拮抗剂含有与SEQ ID NO：6的氨基酸至7至77至少80％相同的氨基酸序列，其包括（a）SEQ ID NO：6的10个保守的半胱氨酸残基，和（b ）SEQ ID NO：6的氨基酸78至81的0至4，其中拮抗剂的氨基酸1至6不由氨基酸AVITGA（SEQ ID NO：21）组成。

3. 发明申请

WO2004009836A3 PR/SET-DOMAIN CONTAINING NUCLEIC ACIDS, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE 审中-公开
公开(公告)号：WO2004009836A3
公开(公告)日：2004-01-29
申请号：PCT/US2003/022509
申请日：2003-07-18
申请人： THE BURNHAM INSTITUTE , HUANG, Shi
发明人： HUANG, Shi
IPC分类号： C12N15/00 , C12N5/10 , C12N1/21 , C07H21/00 , C12Q1/68 , C12P21/06 , C07K14/00 , C12N9/00
摘要： The present invention provides an isolated nucleic acid molecule encoding a PFM/SET polypeptide. Also provided is an isolated nucleic acid molecule encoding a functional fragment of a PFM/SET polypeptide that contains a SET domain of a PFM/SET polypeptide of the invention. Further provided by the invention are PFM/SET polypeptides, and functional fragments thereof that contain a SET domain of a PFM/SET polypeptide. The invention also provides PFM/SET antibodies, PFM/SET modulatory compounds, and related methods. The molecules of the invention can be used in methods of screening for a compound that modulates PFM/SET polypeptide histone methyltransferase activity and to modulate cell proliferation to prevent or treat proliferative disorders, including cancer. Additionally, the molecules and methods of the invention can be used to diagnose and prognose proliferative disorders.

4. 发明申请

WO2003081209A3 IDENTIFICATION OF LIGANDS FOR A RECEPTOR FAMILY AND RELATED METHODS 审中-公开
公开(公告)号：WO2003081209A3
公开(公告)日：2003-10-02
申请号：PCT/US2003/008724
申请日：2003-03-20
申请人： TRIAD THERAPEUTICS, INC. , YU, Lin , DONG, Qing , PIERRE, Fabrice
发明人： YU, Lin , DONG, Qing , PIERRE, Fabrice
IPC分类号： G01N33/53
摘要： The invention provides a method of identifying a population of bi-ligands to receptors in a receptor family. The method can include the steps of generating a first population of molecules comprising a specificity ligand having binding activity for a receptor in a receptor family, the specificity ligand attached to a first plurality of chemical moieties at a position on the specificity ligand to direct the specificity ligand to a specificity site and the chemical moieties to a conserved site of the receptor; screening the population of molecules for binding to the receptor; and identifying a bi.ligand having increased binding activity for the receptor relative to the specificity ligand alone, thereby identifying a common ligand having binding activity for the receptor. The method can further include the steps of generating a second population of molecules comprising the common ligand attached to a second plurality of chemical moieties.

5. 发明申请

WO2003065034A1 GENE DISCOVERY FOR THE SYSTEM ASSIGNMENT OF GENE FUNCTION 审中-公开
标题翻译：基因功能的系统分配基因发现
公开(公告)号：WO2003065034A1
公开(公告)日：2003-08-07
申请号：PCT/US2003/002956
申请日：2003-01-31
申请人： THE INSTITUTE FOR SYSTEMS BIOLOGY , HOOD, Leroy, E. , SIEGEL, Andrew, F. , IDEKER, Trey, E.
发明人： HOOD, Leroy, E. , SIEGEL, Andrew, F. , IDEKER, Trey, E.
IPC分类号： G01N33/48
CPC分类号： G06F19/18 , Y10S707/99943
摘要： The invention provides a method for assigning a cellular function to a component of a biochemical system. The method involves (a) determining a multidimensional shape space for one or more components of a biochemical system in a reference state; (b) perturbing a component within said biochemical system; (c) determining a perturbed multidimensional shape space for one or more components of a pathway in said perturbed biochemical system, and (d) identifying a multidimensional coordinate point corresponding to a component of said perturbed pathway altered between reference and perturbed multidimensional shape spaces, said identified component being assigned a cellular function of said perturbed pathway.
摘要翻译：本发明提供了一种将细胞功能分配给生化系统的组分的方法。该方法包括确定用于参与状态的生物化学系统的一个或多个组分的多维形状空间b扰乱所述生物化学系统内的组分c确定扰动的生物化学系统中的一个或多个组分的扰动多维形状空间，以及d识别对应于在参考和扰动多维形状空间之间改变的所述扰动路径的分量的多维坐标点，所述识别的分量被分配为所述扰动路径的细胞功能。

6. 发明申请

WO2007022074A3 ASSAY PARTICLES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007022074A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/031615
申请日：2006-08-11
申请人： PERKINELMER LAS, INC. , PATTON, Wayne, F.
发明人： PATTON, Wayne, F.
IPC分类号： G01N33/573 , G01N33/553
摘要： The invention provides assay particles useful, for example, for detecting analytes and binding molecule interactions. One type of assay particle includes a core portion encased by a shell portion, wherein the shell portion comprises an inorganic phosphor that binds selectively to a target molecule. Another type of an assay particle includes a core portion encased by a shell portion, and a coat portion covering the shell portion, wherein the coat portion comprises an inorganic phosphor that binds selectively to a target molecule. A further type of assay particle includes a core portion encased by a shell portion, and a coat portion covering the shell portion, wherein the coat portion comprises an inorganic phosphor and a target selective binding moiety, and wherein the assay particle is buoyant in aqueous media. An additional type of assay particle includes a core portion encased by a shell portion, and a coat portion covering the shell portion, wherein the shell portion comprises an inorganic phosphor and the coat portion comprises a target selective binding moiety, and wherein the assay particle is buoyant in aqueous media. Also provided are kits and related methods.

7. 发明申请

WO2006014424A3 METHODS AND COMPOSITIONS FOR DETECTING AND ISOLATING PHOSPHORYLATED MOLECULES USING HYDRATED METAL OXIDES 审中-公开
公开(公告)号：WO2006014424A3
公开(公告)日：2006-02-09
申请号：PCT/US2005/023810
申请日：2005-07-06
申请人： PERKINELMER LAS, INC. , PATTON, Wayne, F. , MIKULSKIS, Alvydas , EVA, Golenko
发明人： PATTON, Wayne, F. , MIKULSKIS, Alvydas , EVA, Golenko
IPC分类号： G01N1/18
摘要： The invention provides methods for detecting and isolating phosphomolecules using phosphoaffinity materials that comprise a hydrated metal oxide. In an embodiment, a method for detecting a phosphomolecule in a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is capable of binding to the phosphoaffinity material to form a phosphomolecule-phosphoaffinity material complex, and (b) detecting formation of a phosphomolecule-phosphoaffinity material complex, thereby detecting a phosphomolecule in the sample. In another embodiment, a method for isolating a phosphomolecule from a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is capable of binding to the phosphoaffinity material to form a phosphomolecule-phosphoaffinity material complex, wherein the hydrated metal oxide comprises yttrium, and (b) separating the phosphomolecule-phosphoaffinity material complex from the sample, thereby isolating the phosphomolecule from the sample.

8. 发明申请

WO2004082714A1 METHODS FOR TREATING OCULAR INFLAMMATION BY NEUTRALIZING CXCL10 ACTIVITY 审中-公开
标题翻译：通过中和CXCL10活性治疗眼部炎症的方法
公开(公告)号：WO2004082714A1
公开(公告)日：2004-09-30
申请号：PCT/US2003/023838
申请日：2003-07-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA , LANE, Thomas, E. , CARR, Daniel, J.
发明人： LANE, Thomas, E. , CARR, Daniel, J.
IPC分类号： A61K39/395
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/34 , C07K2317/76 , G01N2333/52 , G01N2500/00
摘要： The invention provides a method of reducing ocular inflammation in an individual susceptible to ocular inflammation. The method involves administering to the individual an effective amount of a neutralizing agent specific for CXCL10. Also provided is a method for reducing spread of viral infection within ocular tissues of an individual susceptible to ocular viral infection, which involves administering to the individual an effective amount of a neutralizing agent specific for CXCL10. Further provided is a method of extending corneal graft survival following corneal transplantation in an individual, which involves administering to said individual an effective amount of a neutralizing agent specific for CXCL10. Additionally, the invention provides a method for identifying a compound for reducing ocular inflammation in an animal.
摘要翻译：本发明提供了减轻易患眼部炎症的个体的眼部炎症的方法。该方法包括向个体施用有效量的对CXCL10特异性的中和剂。还提供了减少易患眼病毒感染的个体的眼组织内的病毒感染传播的方法，其涉及向个体施用有效量的对CXCL10特异性的中和剂。进一步提供了在个体中角膜移植后延长角膜移植物存活的方法，其涉及向所述个体施用有效量的对CXCL10特异性的中和剂。另外，本发明提供了鉴定用于减少动物眼部炎症的化合物的方法。

9. 发明申请

WO2004058051A2 ANDROGEN-REGULATED GENES AND USES FOR DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE NEOPLASTIC CONDITIONS 审中-公开
标题翻译：用于诊断，预防和治疗前列腺增生症状的原发性基因和用途
公开(公告)号：WO2004058051A2
公开(公告)日：2004-07-15
申请号：PCT/US2003/040741
申请日：2003-12-19
申请人： THE INSTITUTE FOR SYSTEMS BIOLOGY , AEBERSOLD, Rudolf, H. , WRIGHT, Michael, E.
发明人： AEBERSOLD, Rudolf, H. , WRIGHT, Michael, E.
IPC分类号： A61B
CPC分类号： G01N33/57434 , G01N2333/726 , G01N2500/00
摘要： The invention provides a method for diagnosing or predicting susceptibility to a prostate neoplastic condition in an individual. The method involves (a) determining a level of RDC1 in a sample from the individual, and (b) comparing the level of RDC1 in the sample to a reference level of RDC1, wherein a level of RDCl in the sample 2-fold or more higher than the reference level indicates the presence of,or susceptibility to, a prostate neoplastic condi tion in the individual.
摘要翻译：本发明提供了用于诊断或预测个体对前列腺肿瘤病症的易感性的方法。该方法包括（a）确定来自个体的样品中RDC1的水平，和（b）将样品中RDC1的水平与RDC1的参考水平进行比较，其中样品中的RDCl水平为2倍以上高于参考水平表明个体中前列腺肿瘤病症的存在或易感性。

10. 发明申请

WO2004022710A2 METHODS OF MODULATING CELL DEATH BASED ON THE BIT1/AES REGULATORY PATHWAY 审中-公开
标题翻译：基于BIT1 / AES法规路径调节细胞死亡的方法
公开(公告)号：WO2004022710A2
公开(公告)日：2004-03-18
申请号：PCT/US2003/027710
申请日：2003-09-05
申请人： THE BURNHAM INSTITUTE , JAN, Yiwen , MATTER, Michelle , PAI, Jih-Tung , RUOSLAHTI, Erkki
发明人： JAN, Yiwen , MATTER, Michelle , PAI, Jih-Tung , RUOSLAHTI, Erkki
IPC分类号： C12N
CPC分类号： C07K14/4747 , C07K14/4703 , C07K14/4705
摘要： The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or active fragment thereof, with an agent under conditions that allow the Bit1 polypeptide or active fragment thereof to associate with the AES polypeptide or active fragment thereof; and detecting an altered association of the Bit1 polypeptide or active fragment thereof and the AES polypeptide or active fragment thereof, where an altered association indicates that the agent is an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. Such an effective agent can modulate apoptosis and can be a useful therapeutic agent.
摘要翻译：本发明提供了鉴定改变Bit1多肽与AES多肽的缔合的有效试剂的方法。该方法通过使Bit1多肽或其活性片段和AES多肽或其活性片段与允许Bit1多肽或其活性片段与AES多肽或其活性片段缔合的条件与试剂接触来实施; 并检测Bit1多肽或其活性片段和AES多肽或其活性片段的改变的关联，其中改变的缔合表明该试剂是改变Bit1多肽与AES多肽的缔合的有效试剂。这种有效的药剂可以调节细胞凋亡并且可以是有用的治疗剂。

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